CN113993858A - 二氨基嘧啶类化合物或其水合物的固体形式及其制备方法和用途 - Google Patents
二氨基嘧啶类化合物或其水合物的固体形式及其制备方法和用途 Download PDFInfo
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- CN113993858A CN113993858A CN202080032502.6A CN202080032502A CN113993858A CN 113993858 A CN113993858 A CN 113993858A CN 202080032502 A CN202080032502 A CN 202080032502A CN 113993858 A CN113993858 A CN 113993858A
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P13/00—Drugs for disorders of the urinary system
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- C—CHEMISTRY; METALLURGY
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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Abstract
本发明涉及5‑((2‑乙炔基‑5‑异丙基吡啶‑4‑基)氧基)嘧啶‑2，4‑二胺或其水合物的固体形式，制备所述固体形式的方法、包含所述固体形式的药物组合物，以及所述固体形式用于预防或治疗P2X3和/或P2X2/3受体拮抗剂调节的疾病的用途。
Description
PCT国内申请，说明书已公开。
Claims (11)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019085207 | 2019-04-30 | ||
| CNPCT/CN2019/085207 | 2019-04-30 | ||
| PCT/CN2020/087687 WO2020221275A1 (zh) | 2019-04-30 | 2020-04-29 | 二氨基嘧啶类化合物或其水合物的固体形式及其制备方法和用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113993858A true CN113993858A (zh) | 2022-01-28 |
| CN113993858B CN113993858B (zh) | 2024-05-28 |
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| CN202080032502.6A Active CN113993858B (zh) | 2019-04-30 | 2020-04-29 | 二氨基嘧啶类化合物或其水合物的固体形式及其制备方法和用途 |
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| Country | Link |
|---|---|
| US (1) | US20220204475A1 (zh) |
| EP (1) | EP3964505A4 (zh) |
| JP (1) | JP2022530889A (zh) |
| KR (1) | KR20220008284A (zh) |
| CN (1) | CN113993858B (zh) |
| AU (1) | AU2020265969A1 (zh) |
| BR (1) | BR112021021721A2 (zh) |
| CA (1) | CA3138234A1 (zh) |
| MX (1) | MX2021013300A (zh) |
| SG (1) | SG11202111907UA (zh) |
| TW (2) | TWI773987B (zh) |
| WO (1) | WO2020221275A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117186068A (zh) * | 2017-11-01 | 2023-12-08 | 北京泰德制药股份有限公司 | P2x3和/或p2x2/3受体拮抗剂、包含其的药物组合物及其用途 |
| CA3138235A1 (en) * | 2019-04-30 | 2020-11-05 | Beijing Tide Pharmaceutical Co., Ltd. | Salt of diaminopyrimidine compounds, and solid form thereof, preparation method therefor and use thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6230743B1 (ja) * | 2017-05-31 | 2017-11-15 | 持田製薬株式会社 | ヘテロシクリデンアセトアミド誘導体の結晶 |
| CA3041420A1 (en) * | 2016-12-22 | 2018-06-28 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Solid form of 4'-thio-2'-fluoronucleoside phosphamide compound and preparation method therefor and use thereof |
| CN108778280A (zh) * | 2016-11-07 | 2018-11-09 | 江苏恒瑞医药股份有限公司 | 一种GnRH受体拮抗剂的多晶型及其制备方法 |
| CN108778282A (zh) * | 2016-11-14 | 2018-11-09 | 江苏恒瑞医药股份有限公司 | 一种GnRH受体拮抗剂的结晶形式及其制备方法 |
| CN108779119A (zh) * | 2016-03-25 | 2018-11-09 | 传入制药公司 | 嘧啶及其变体、及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0508461B8 (pt) * | 2004-03-05 | 2021-05-25 | Hoffmann La Roche | diaminopirimidinas, seus usos, e composição farmacêutica |
| BRPI0611375A2 (pt) * | 2005-05-23 | 2010-08-31 | Novartis Ag | formas cristalinas e outras de sais de ácido láctico de 4-amino-5-flúor-3-[6-(4-metilpiperazin-1-il)-1h-benzimid azol-2-il]-1h-quinolin-2-ona |
| JP4850911B2 (ja) * | 2005-09-01 | 2012-01-11 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐ２ｘ３およびｐ２ｘ２／３モジュレーターとしてのジアミノピリミジン |
| BR112018068399A2 (pt) * | 2016-03-14 | 2019-01-15 | Afferent Pharmaceuticals Inc | pirimidinas e variantes das mesmas e usos para as mesmas |
| CN117186068A (zh) * | 2017-11-01 | 2023-12-08 | 北京泰德制药股份有限公司 | P2x3和/或p2x2/3受体拮抗剂、包含其的药物组合物及其用途 |
| US10457740B1 (en) * | 2018-01-29 | 2019-10-29 | Flagship Pioneering Innovations V, Inc. | Methods and compositions for treating cancer using P2RX2 inhibitors |
| CA3138235A1 (en) * | 2019-04-30 | 2020-11-05 | Beijing Tide Pharmaceutical Co., Ltd. | Salt of diaminopyrimidine compounds, and solid form thereof, preparation method therefor and use thereof |
-
2020
- 2020-04-29 WO PCT/CN2020/087687 patent/WO2020221275A1/zh unknown
- 2020-04-29 AU AU2020265969A patent/AU2020265969A1/en active Pending
- 2020-04-29 SG SG11202111907UA patent/SG11202111907UA/en unknown
- 2020-04-29 KR KR1020217038591A patent/KR20220008284A/ko unknown
- 2020-04-29 JP JP2021564188A patent/JP2022530889A/ja active Pending
- 2020-04-29 US US17/607,449 patent/US20220204475A1/en active Pending
- 2020-04-29 BR BR112021021721A patent/BR112021021721A2/pt unknown
- 2020-04-29 CN CN202080032502.6A patent/CN113993858B/zh active Active
- 2020-04-29 MX MX2021013300A patent/MX2021013300A/es unknown
- 2020-04-29 EP EP20798323.0A patent/EP3964505A4/en active Pending
- 2020-04-29 CA CA3138234A patent/CA3138234A1/en active Pending
- 2020-04-30 TW TW109114697A patent/TWI773987B/zh active
- 2020-04-30 TW TW111126506A patent/TWI806708B/zh active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108779119A (zh) * | 2016-03-25 | 2018-11-09 | 传入制药公司 | 嘧啶及其变体、及其用途 |
| CN108778280A (zh) * | 2016-11-07 | 2018-11-09 | 江苏恒瑞医药股份有限公司 | 一种GnRH受体拮抗剂的多晶型及其制备方法 |
| CN108778282A (zh) * | 2016-11-14 | 2018-11-09 | 江苏恒瑞医药股份有限公司 | 一种GnRH受体拮抗剂的结晶形式及其制备方法 |
| CA3041420A1 (en) * | 2016-12-22 | 2018-06-28 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Solid form of 4'-thio-2'-fluoronucleoside phosphamide compound and preparation method therefor and use thereof |
| JP6230743B1 (ja) * | 2017-05-31 | 2017-11-15 | 持田製薬株式会社 | ヘテロシクリデンアセトアミド誘導体の結晶 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020221275A1 (zh) | 2020-11-05 |
| BR112021021721A2 (pt) | 2021-12-28 |
| AU2020265969A1 (en) | 2021-12-16 |
| EP3964505A1 (en) | 2022-03-09 |
| MX2021013300A (es) | 2022-02-11 |
| TW202106675A (zh) | 2021-02-16 |
| JP2022530889A (ja) | 2022-07-04 |
| TWI773987B (zh) | 2022-08-11 |
| US20220204475A1 (en) | 2022-06-30 |
| KR20220008284A (ko) | 2022-01-20 |
| TW202241864A (zh) | 2022-11-01 |
| CA3138234A1 (en) | 2020-11-05 |
| EP3964505A4 (en) | 2022-12-21 |
| CN113993858B (zh) | 2024-05-28 |
| TWI806708B (zh) | 2023-06-21 |
| SG11202111907UA (en) | 2021-11-29 |
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