CN113967245A - Traditional Chinese medicine ointment for treating acne and preparation method thereof - Google Patents

Traditional Chinese medicine ointment for treating acne and preparation method thereof Download PDF

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CN113967245A
CN113967245A CN202111530492.1A CN202111530492A CN113967245A CN 113967245 A CN113967245 A CN 113967245A CN 202111530492 A CN202111530492 A CN 202111530492A CN 113967245 A CN113967245 A CN 113967245A
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于博宇
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Affiliated School Of National University Of Science And Technology Qingdao
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

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Abstract

The invention provides a traditional Chinese medicine ointment for treating acne and a preparation method thereof, and solves the problems of poor acne treatment effect and long treatment time in the prior art. A traditional Chinese medicine ointment for treating acne comprises the following raw materials in parts by weight: 6-14 parts of dried ginger, 5-20 parts of ginseng, 15-25 parts of monkshood, 13-24 parts of eucommia bark, 18-34 parts of folium artemisiae argyi, 20-36 parts of honeysuckle and 18-24 parts of pericarpium zanthoxyli. The traditional Chinese medicine ointment has the effects of clearing away heat and toxic materials, detoxifying, expelling dampness and activating blood circulation, can be directly acted on an affected part, can effectively resist inflammation, disinfect, moisten and protect skin, has curative effects on different people with different constitutions and acnes with different causes at different periods, and has no toxic or side effect. The traditional Chinese medicine ointment provided by the invention is used for treatment, the curative effect is better, through clinical use, the period of treating acne by using the traditional Chinese medicine ointment provided by the invention is 3-7 days, and the period of using antiviral drugs is 7-14 days.

Description

Traditional Chinese medicine ointment for treating acne and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine ointment for treating acne and a preparation method thereof.
Background
Acne is also called whelk, and facial acne is whelk growing on the face, which is a common dermatosis and is commonly seen in teenagers and also occurs in the adult stage. Facial acne is mainly caused by various skin lesions such as comedo, papule, pustule, nodule and the like, and is also suppurative seriously, so that the facial acne needs to be treated in time. It is a multifactorial disease, and the onset of the disease is mainly related to factors such as sex hormone level, sebaceous gland mass secretion, propionibacterium acnes proliferation, follicular sebaceous gland duct parakeratosis and inflammation. With the arrival of the adolescence, the acne grows repeatedly due to various habits of life and diet, the facial beauty of people is greatly influenced, psychological factors of self-mutuality are caused sometimes, the acne can be better prevented and treated only by correctly recognizing the cause of the acne, and the skin care product is only used for assisting in nursing the acne.
Acne occurs in close relation to factors such as hyperseborrhea, blockage of pilosebaceous ducts, bacterial infection and inflammatory reactions. After adolescence, the level of androgen, particularly testosterone, in a human body is rapidly increased, the development of sebaceous glands is promoted, and a large amount of sebum is produced. If the grease can not be discharged in time to block pores, the anaerobic bacterium propionibacterium acnes can be greatly proliferated to destroy epidermal cells to trigger inflammatory reaction.
The traditional Chinese medicine theory considers that the acne is better developed in young people, and the young people are yang-heat bodies and are easy to generate lung heat. The human with weak spleen and stomach inherently has poor transport and transformation capability, is incapable of transporting and transforming after eating, generates dampness in vivo, generates heat after long-term stagnation, finally forms phlegm after heat and dampness interweaving, finally the lung channel wind heat and the spleen and stomach damp heat, and phlegm and stasis are accumulated together to rise to the face to generate acne; secondly, acne is caused by exuberant liver fire, stagnation of liver qi, liver wood is used for restraining spleen soil, liver qi discomfort damages spleen and stomach, spleen and stomach are weak, transportation and transformation are not feasible, water dampness is not generated, blood stasis is accumulated in the body, heat is generated, and liver depression transforms into fire to form acne. Acne is formed when hot, inflammatory papules and pustules are formed when wet, and nodulocysts are formed when stasis occurs. According to pathogenesis development, the traditional Chinese medicine holds that the occurrence of acne is mainly related to lung, spleen, stomach, liver and large intestine. Therefore, the treatment principle is to evacuate lung heat, harmonize yin and yang, relieve depression and regulate spleen, clear heat, remove toxicity, remove blood stasis and dampness.
The current situation of prevention and treatment at home and abroad:
1. western medicine generally treats acne on a graded basis. Mild acne is usually treated with tretinoin cream or gel. The benzoyl peroxide gel can kill propionibacterium acnes and has no drug resistance. For moderate acne, oral antibiotics should be combined. For severe cases, isotretinoin is administered orally.
2. Hormone therapy: hormone therapy is mainly used for people with severe facial acne.
3. Treatment with traditional Chinese medicines: the traditional Chinese medicine prescription is orally taken, so that dampness, heat, fire, inflammation and toxicity in a body are deeply cleared, and the root cause of acne is blocked.
4. Photodynamic belongs to local treatment and has no side effect on the whole body. The purposes of preventing relapse and formation of pox scars, pockmarks and scars are achieved.
The medicines have long treatment time, insignificant curative effect, easy relapse and certain side effect on human bodies.
Disclosure of Invention
The invention provides a traditional Chinese medicine ointment for treating acne and a preparation method thereof, which takes the unique advantages of traditional Chinese medicine property channel tropism theory, introduces channels into medicine, is applied and directly acts on an affected part, and solves the problems of poor acne treatment effect and long treatment time in the prior art.
The technical scheme of the invention is realized as follows: a traditional Chinese medicine ointment for treating acne comprises the following raw materials in parts by weight:
6-14 parts of dried ginger, 5-20 parts of ginseng, 15-25 parts of monkshood, 13-24 parts of eucommia bark, 18-34 parts of folium artemisiae argyi, 20-36 parts of honeysuckle and 18-24 parts of pericarpium zanthoxyli.
Preferably, the traditional Chinese medicine composition comprises 3-10 parts of dried ginger, 3-15 parts of ginseng, 10-20 parts of monkshood, 10-20 parts of eucommia ulmoides, 15-30 parts of folium artemisiae argyi, 15-30 parts of honeysuckle and 15-20 parts of pericarpium zanthoxyli.
The pharmacological effects of the traditional Chinese medicine raw materials for treating acne are as follows:
dried ginger: pungent in flavor and warm in nature, enter spleen, stomach, kidney, heart and lung meridians. Has the effects of warming middle-jiao to dispel cold, restoring yang to remove meridian obstruction, warming lung and eliminating fluid retention, and is the main drug for warming middle-jiao. The book of entries: it is indicated for cold with abdominal pain, aversion to heat, cholera, fullness and distention, wind pathogen with all toxic materials, qi formation between skin and saliva and blood. "
Modern pharmacological studies: rhizoma Zingiberis has tranquilizing, analgesic, antiinflammatory, anticoagulant, anoxia resisting, and other effects, and has effects on cardiovascular function, adrenal cortex function, and digestive system.
Ginseng: ginseng is sweet, slightly bitter and warm in flavor, and enters spleen, lung, heart and kidney meridians. Has effects in invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, and tranquilizing mind. Mainly treats qi deficiency and desire for desertion, weak pulse, spleen qi deficiency, middle-jiao sinking, lung deficiency and cough, short breath and hypodynamia, body fluid consumption and thirst, deficiency heat and thirst, insomnia and amnesia, palpitation and sallow complexion due to blood deficiency.
Modern pharmacological studies: the ginsenoside in Ginseng radix can promote phagocytosis of reticuloendothelial system, and increase concentration of nonspecific antibody in mouse serum. In addition, ginseng has certain functions of promoting gonadal function, promoting protein synthesis, resisting tumor, oxidation, aging, liver injury, gastric ulcer, fatigue, stress, radiation, mutation, hemostasis and the like.
Monkshood: a interior-warming Chinese medicine is pungent, sweet, big-heat and toxic. It is ascribed to heart, kidney and spleen meridians. Radix Aconiti lateralis has effects of restoring yang, relieving collapse, invigorating fire, tonifying yang, dispelling cold, and relieving pain. Clinically, Fu Zi is mainly used for yang-depletion syndrome due to decline of yang-qi and faint pulse; it can also be used for treating yang qi deficiency; it can also be used for treating arthralgia due to wind-cold-dampness and arthralgia.
Modern pharmacological studies: the monkshood has obvious inhibition effect on an acute inflammation model. The aconite decoction has obvious inhibition effect on ear inflammation of mice caused by croton oil and foot swelling of rats caused by formaldehyde, egg white, histamine, carrageen and the like. Aconitine alkaloids also have antiinflammatory effect. In addition, experiments show that the aconite itself may have corticoid-like effects besides stimulating the pituitary-adrenal cortex system.
Eucommia ulmoides: sweet, slightly pungent, warm, mild, non-toxic and bitter. Enter liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, prevent abortion. It is indicated for soreness and pain of lumbar and knees, atrophy and weakness of feet and knees, dribbling urination, itching of vulva, vaginal bleeding, threatened abortion, and hypertension.
Modern pharmacological studies: the eucommia bark can resist the immunosuppression effect of the cortisone oxide and has the function of regulating the cellular immune balance; because the raw eucommia bark contains a plurality of tanning materials and has strong immunization function on various microorganisms in the nature, the raw eucommia bark can be smashed and externally applied to avoid trauma infection.
Folium artemisiae argyi: pungent, bitter and warm. It enters liver, spleen and kidney meridians.
The main effects and actions
Warming channels and stopping bleeding: can be used for treating hematemesis, epistaxis, metrorrhagia, menorrhagia, and fetal hemorrhage, and can be used for treating deficiency-cold hemorrhage;
dispelling cold and relieving pain: abdominal cold pain, irregular menstruation and infertility due to cold womb;
externally used for eliminating dampness and relieving itching: skin pruritus, eczema, pruritus vulvae, scabies, etc.
Modern pharmacological studies: the folium Artemisiae Argyi contains volatile oil with antiallergic effect. In addition, tannin, flavone, alcohol, polysaccharide, trace elements and other organic components are also provided, and the elements can regulate the requirements of various aspects of the human body. The folium Artemisiae Argyi has antibacterial, antiviral, antiasthmatic, antitussive, expectorant, antiallergic, hemostatic, anticoagulant, and immunity enhancing effects.
Honeysuckle flower: being sweet and cold in nature, it enters lung, heart and stomach meridians. Has the effects of clearing away heat and toxic materials, dispersing pathogenic accumulation, and relieving swelling. Can be used for treating various heat diseases such as fever, rash, speckle, toxic heat, skin ulcer, carbuncle, and sore throat.
Modern pharmacological studies: the effective components of the honeysuckle mainly comprise organic acids, flavonoids, triterpenoid saponins, volatile oils and various trace elements, and the honeysuckle has the pharmacological effects of resisting bacteria and viruses, relieving fever and resisting inflammation, regulating immunity, protecting liver and gallbladder, reducing blood fat, resisting fertility, stopping bleeding, resisting allergy, resisting tumor and the like.
Pericarpium zanthoxyli: pungent, numb and warm in flavor. It enters spleen, stomach and kidney meridians. Can warm spleen and stomach, and improve abdominal psychroalgia, emesis and diarrhea caused by spleen and stomach cold. It can be used for treating eczema and pruritus vulvae by external application.
Modern pharmacological studies: the volatile oil in fructus Zanthoxyli has antibacterial and bactericidal effects on dermatophytes and part of deep fungi, and can be used for treating scabies, eczema, and skin pruritus.
The invention also provides a preparation method of the traditional Chinese medicine ointment for treating acne, which comprises the following steps:
1) weighing the formula raw materials in corresponding parts by weight, drying, and grinding into powder with granularity not less than 300 meshes by using a wall breaking grinding machine;
2) putting the medicinal powder obtained in the step 1) into a pottery, and soaking the medicinal powder for 24 hours by using white vinegar;
3) boiling the soaked medicament for 24 hours with strong fire, and then decocting for 60 minutes with slow fire to obtain a paste medicament;
4) and adding vaseline into the paste medicament, blending, cooling to obtain a finished product, and storing in a sealed glass bottle to be stored in a refrigerator.
4. The method for preparing a Chinese medicinal ointment for treating acne as claimed in claim 3, wherein:
in the step 2), the white vinegar and the medicinal powder are mixed according to the weight ratio of 2: weighing at a ratio of 1.
5. The method for preparing a Chinese medicinal ointment for treating acne as claimed in claim 3, wherein:
the using amount of the medicament and the vaseline in the step 4) is 3: 1.
the invention has the beneficial effects that:
1. overcomes the limitations of the current acne treatment effect, the limitation of the treatment mode and the serious side effect of the treatment medicine.
2. The traditional Chinese medicine ointment provided by the invention is used for treatment, is directly acted on an affected part due to the external ointment, does not need to be hospitalized, can be used at home, and is simple and convenient to use and economical compared with skin care products used on the market.
3. The traditional Chinese medicine ointment provided by the invention has higher safety, is safer than oral medicines and intravenous medicines for other external medicines, and has no components with side effects such as anti-virus medicines and hormones.
4. The traditional Chinese medicine ointment provided by the invention is directly acted on the affected part for treatment, is quick and effective, can promote the skin and soft tissue of the recovered part to be tender and regenerated, and has low treatment cost and higher treatment cost of antiviral drugs, hormones and the like.
5. The traditional Chinese medicine ointment provided by the invention is used for treatment, the curative effect is better, through clinical use, the period of treating acne by using the traditional Chinese medicine ointment provided by the invention is 3-7 days, and the period of using antiviral drugs is 7-14 days.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
A traditional Chinese medicine ointment for treating acne comprises the following raw materials in parts by weight:
3-10 parts of dried ginger, 3-15 parts of ginseng, 10-20 parts of monkshood, 10-20 parts of eucommia bark, 15-30 parts of folium artemisiae argyi, 15-30 parts of honeysuckle and 15-20 parts of pericarpium zanthoxyli.
The technical scheme of the invention is described in detail by the following embodiments:
example one
A traditional Chinese medicine ointment for treating acne comprises the following raw materials in parts by weight:
3 parts of dried ginger, 3 parts of ginseng, 10 parts of monkshood, 10 parts of eucommia bark, 15 parts of folium artemisiae argyi, 15 parts of honeysuckle and 15 parts of pericarpium zanthoxyli.
Example two
A traditional Chinese medicine ointment for treating acne comprises the following raw materials in parts by weight:
5 parts of dried ginger, 4 parts of ginseng, 13 parts of monkshood, 12 parts of eucommia bark, 17 parts of folium artemisiae argyi, 18 parts of honeysuckle and 17 parts of pericarpium zanthoxyli.
EXAMPLE III
A traditional Chinese medicine ointment for treating acne comprises the following raw materials in parts by weight:
7 parts of dried ginger, 10 parts of ginseng, 15 parts of monkshood, 16 parts of eucommia bark, 22 parts of folium artemisiae argyi, 24 parts of honeysuckle and 18 parts of pericarpium zanthoxyli.
Example four
A traditional Chinese medicine ointment for treating acne comprises the following raw materials in parts by weight:
8 parts of dried ginger, 12 parts of ginseng, 16 parts of monkshood, 16 parts of eucommia bark, 24 parts of folium artemisiae argyi, 24 parts of honeysuckle and 18 parts of pericarpium zanthoxyli.
EXAMPLE five
A traditional Chinese medicine ointment for treating acne comprises the following raw materials in parts by weight:
9 parts of dried ginger, 13 parts of ginseng, 18 parts of monkshood, 18 parts of eucommia bark, 26 parts of folium artemisiae argyi, 27 parts of honeysuckle and 19 parts of pericarpium zanthoxyli.
EXAMPLE six
A traditional Chinese medicine ointment for treating acne comprises the following raw materials in parts by weight:
10 parts of dried ginger, 15 parts of ginseng, 20 parts of monkshood, 20 parts of eucommia bark, 30 parts of folium artemisiae argyi, 30 parts of honeysuckle and 20 parts of pericarpium zanthoxyli.
The invention also provides a preparation method of the traditional Chinese medicine ointment for treating acne, which comprises the following steps:
1) weighing the formula raw materials in corresponding parts by weight, drying, and grinding into powder with granularity not less than 300 meshes by using a wall breaking grinding machine;
2) putting the medicinal powder obtained in the step 1) into a pottery, and soaking the medicinal powder for 24 hours by using white vinegar;
3) boiling the medicament soaked in white vinegar for 24 hours with strong fire, and decocting with slow fire for 60 minutes to obtain a paste medicament;
4) and adding vaseline into the paste medicament, blending, cooling to obtain a finished product, and storing in a sealed glass bottle to be stored in a refrigerator.
The application method of the traditional Chinese medicine paste prepared by the invention comprises the following steps: cleaning the affected part with alcohol, and applying the plaster for 24-72 hr. It is administered externally for 3-7 days according to acne degree and area of patients.
Clinical application test of the ointment of the invention
According to the formula of the traditional Chinese medicine raw material components for treating acne in the embodiment 1-7, the traditional Chinese medicine ointment for treating acne prepared according to the method is tested in clinical application.
54 acne patients in the period from 8 months in 2018 to 8 months in 2021 were selected, wherein 27 men and 27 women were selected, the age was 15-20 years, and the average age was about 17 years. Case inclusion criteria: red acne is frequently generated at one or more parts of forehead, cheekbone, cheek, mouth periphery, back, etc., or part of acne is fused into a piece; occasionally bleeding, desquamation or white pus spots on the top; pale red or red tongue, thin yellow or yellow greasy coating, slippery pulse; cases cover varying degrees of acne conditions from mild to severe.
Dividing patients into 6 groups, and respectively applying the ointment prepared according to the raw material component formula of the above examples 1-6 to 9 patients per group for treatment, wherein the ointment is continuously applied in the treatment period within 10 days, and based on acne patients with different degrees, the redness and swelling are obviously reduced after 24 hours, and the pain is relieved; after 72 hours, pus is broken and discharged, and pain disappears; the application is stopped after 4 or 5 days, the affected part scabs 7 days later, and the scabs fall off 10 days after the severe state of the disease, and the acne disappears.
The 6 prepared traditional Chinese medicine ointments are respectively applied to the 6 groups of patients, and the follow-up results at the end of treatment and 6 months after the end are shown in the following table:
Figure BDA0003411361470000071
Figure BDA0003411361470000081
the results show that the ointment for treating the acne has good curative effect and does not relapse in the later period.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (5)

1. The traditional Chinese medicine ointment for treating acne is characterized by comprising the following raw materials in parts by weight:
6-14 parts of dried ginger, 5-20 parts of ginseng, 15-25 parts of monkshood, 13-24 parts of eucommia bark, 18-34 parts of folium artemisiae argyi, 20-36 parts of honeysuckle and 18-24 parts of pericarpium zanthoxyli.
2. The traditional Chinese medicine ointment for treating acne as claimed in claim 1, which is characterized in that:
3-10 parts of dried ginger, 3-15 parts of ginseng, 10-20 parts of monkshood, 10-20 parts of eucommia bark, 15-30 parts of folium artemisiae argyi, 15-30 parts of honeysuckle and 15-20 parts of pericarpium zanthoxyli.
3. A preparation method of a traditional Chinese medicine ointment for treating acne is characterized by comprising the following steps:
1) weighing the formula raw materials in corresponding parts by weight, drying, and grinding into powder with granularity not less than 300 meshes by using a wall breaking grinding machine;
2) putting the medicinal powder obtained in the step 1) into a pottery, and soaking the medicinal powder for 24 hours by using white vinegar;
3) boiling the medicament soaked in white vinegar for 24 hours with strong fire, and decocting with slow fire for 60 minutes to obtain a paste medicament;
4) and adding vaseline into the paste medicament, blending, cooling to obtain a finished product, and storing in a sealed glass bottle to be stored in a refrigerator.
4. The method for preparing a Chinese medicinal ointment for treating acne as claimed in claim 3, wherein:
in the step 2), the white vinegar and the medicinal powder are mixed according to the weight ratio of 2: weighing at a ratio of 1.
5. The method for preparing a Chinese medicinal ointment for treating acne as claimed in claim 3, wherein:
the using amount of the medicament and the vaseline in the step 4) is 3: 1.
CN202111530492.1A 2021-12-15 2021-12-15 Traditional Chinese medicine ointment for treating acne and preparation method thereof Pending CN113967245A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109865017A (en) * 2019-04-11 2019-06-11 中国医学科学院北京协和医院 A kind of paste and preparation method thereof of easy-to-use treatment acne
CN109865028A (en) * 2019-04-11 2019-06-11 中国医学科学院北京协和医院 A kind of Chinese medicinal ointment and preparation method thereof for the treatment of acne easy to carry, easy-to-use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109865017A (en) * 2019-04-11 2019-06-11 中国医学科学院北京协和医院 A kind of paste and preparation method thereof of easy-to-use treatment acne
CN109865028A (en) * 2019-04-11 2019-06-11 中国医学科学院北京协和医院 A kind of Chinese medicinal ointment and preparation method thereof for the treatment of acne easy to carry, easy-to-use

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