CN113966395B - 工程化的生产细胞系及其制备和使用方法 - Google Patents

工程化的生产细胞系及其制备和使用方法 Download PDF

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CN113966395B
CN113966395B CN202080028310.8A CN202080028310A CN113966395B CN 113966395 B CN113966395 B CN 113966395B CN 202080028310 A CN202080028310 A CN 202080028310A CN 113966395 B CN113966395 B CN 113966395B
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cell line
raav
seq
expression
production
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CN113966395A (zh
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奥布里·R·蒂尔南
尼古拉斯·里查兹
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Altraginx Pharmaceuticals
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    • C12N2750/14011—Parvoviridae
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CN202080028310.8A 2019-04-12 2020-04-09 工程化的生产细胞系及其制备和使用方法 Active CN113966395B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962833548P 2019-04-12 2019-04-12
US62/833,548 2019-04-12
US201962839207P 2019-04-26 2019-04-26
US62/839,207 2019-04-26
US202062979483P 2020-02-21 2020-02-21
US62/979,483 2020-02-21
PCT/US2020/027489 WO2020210507A1 (en) 2019-04-12 2020-04-09 Engineered producer cell lines and methods of making and using the same

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CN113966395B true CN113966395B (zh) 2025-07-04

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KR (1) KR20210152514A (https=)
CN (1) CN113966395B (https=)
AU (1) AU2020270960B2 (https=)
BR (1) BR112021020391A2 (https=)
CA (1) CA3136246A1 (https=)
CO (1) CO2021013699A2 (https=)
IL (1) IL287106A (https=)
MX (1) MX2021012489A (https=)
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US12054738B2 (en) 2020-07-30 2024-08-06 Shape Therapeutics Inc. Stable cell lines for inducible production of rAAV virions
US20250019721A1 (en) 2021-08-11 2025-01-16 Ultragenyx Pharmaceutical Inc. Compositions and methods for treating a muscular dystrophy
TW202323529A (zh) 2021-10-18 2023-06-16 美商再生元醫藥公司 包括腺病毒相關病毒聚核苷酸的真核細胞
US20250019668A1 (en) 2021-10-29 2025-01-16 Ultragenyx Pharmaceutical Inc. Engineered cell lines for increased production of recombinant adeno-associated virus (raav)
WO2025078616A1 (en) * 2023-10-12 2025-04-17 Cevec Pharmaceuticals Gmbh Cellular factors affecting recombinant aav production
WO2025226558A1 (en) 2024-04-22 2025-10-30 Ultragenyx Pharmaceutical Inc. Multi-step filtration and clarification methods for recombinant adeno-associated virus purification
WO2026078664A1 (en) 2024-10-10 2026-04-16 Instituto De Biologia Experimental E Tecnológica (Ibet) Transcription factor enhancing recombinant adeno-associated virus production, products, methods and uses thereof

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US20200325455A1 (en) 2020-10-15
US12018288B2 (en) 2024-06-25
CO2021013699A2 (es) 2021-10-29
JP7560475B2 (ja) 2024-10-02
EP4603579A3 (en) 2025-12-10
MX2021012489A (es) 2021-11-12
EP4603579A2 (en) 2025-08-20
US20240376440A1 (en) 2024-11-14
TW202104593A (zh) 2021-02-01
KR20210152514A (ko) 2021-12-15
CA3136246A1 (en) 2020-10-15
CN113966395A (zh) 2022-01-21
IL287106A (en) 2021-12-01
JP7706607B2 (ja) 2025-07-11
PH12021552577A1 (en) 2022-04-04
AU2020270960A1 (en) 2021-11-04
JP2022526646A (ja) 2022-05-25
JP2024107295A (ja) 2024-08-08
EP3953458A1 (en) 2022-02-16
AU2020270960B2 (en) 2026-01-29
SG11202110904PA (en) 2021-10-28
WO2020210507A1 (en) 2020-10-15
TWI859216B (zh) 2024-10-21
BR112021020391A2 (pt) 2022-02-08

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