CN113960304A - Full-automatic immunofluorescence detection device convenient to test paper strip pops out - Google Patents
Full-automatic immunofluorescence detection device convenient to test paper strip pops out Download PDFInfo
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- CN113960304A CN113960304A CN202111288998.6A CN202111288998A CN113960304A CN 113960304 A CN113960304 A CN 113960304A CN 202111288998 A CN202111288998 A CN 202111288998A CN 113960304 A CN113960304 A CN 113960304A
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- 238000012360 testing method Methods 0.000 title claims abstract description 105
- 238000001514 detection method Methods 0.000 title claims abstract description 48
- 238000010166 immunofluorescence Methods 0.000 title claims abstract description 26
- 238000005070 sampling Methods 0.000 claims abstract description 31
- 238000004140 cleaning Methods 0.000 claims abstract description 21
- 238000006243 chemical reaction Methods 0.000 claims description 49
- 238000003860 storage Methods 0.000 claims description 7
- 230000001360 synchronised effect Effects 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims 1
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- 239000002994 raw material Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 6
- 238000012986 modification Methods 0.000 description 5
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- 238000011161 development Methods 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000010276 construction Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000012123 point-of-care testing Methods 0.000 description 2
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- 238000006467 substitution reaction Methods 0.000 description 2
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
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- 238000003745 diagnosis Methods 0.000 description 1
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- 210000002966 serum Anatomy 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
Abstract
The invention discloses a full-automatic immunofluorescence detection device convenient for a test strip to pop up, which comprises a sample placing module, wherein the sample placing module comprises a shell, a sampling box and a cleaning piece, an operation chamber is arranged in the shell, a base is arranged at the bottom of the operation chamber, the sampling box and the cleaning piece are arranged on the base, and the cleaning piece is positioned on one side of the sampling box; the sample loading module comprises a driving motor, an X-axis driving rail, a Y-axis driving rail and a Z-axis driving arm, wherein the X-axis driving rail is fixedly installed on the base, the driving motor is positioned on one side of the X-axis driving rail and connected with the X-axis driving rail, the Y-axis driving rail is vertically installed on the X-axis driving rail and is in sliding connection with the X-axis driving rail, and the Z-axis driving arm is vertically installed on the Y-axis driving rail and is in sliding connection with the Y-axis driving rail; the invention solves the problem of in vitro quantitative detection, has higher detection efficiency and avoids manual misoperation.
Description
Technical Field
The invention relates to the technical field of immunofluorescence detection, in particular to a full-automatic immunofluorescence detection device convenient for a test strip to pop up.
Background
The fluorescence immunoassay quantitative analyzer has the main functions of: the method is used for in vitro quantitative detection of the content of various items such as various proteins, antigens and the like in human serum, plasma, whole blood or urine, and is used for providing real and accurate data basis for diagnosis, prevention, treatment and health monitoring of clinical diseases.
In order to meet the requirements of the current medical industry on Point-of-care testing (Point-of-care testing), achieve the aim of quickly obtaining an accurate test result, remove complicated operation procedures, reduce the influence of errors or mistakes caused by manual operation on the result, and improve the test speed, a full-automatic fluorescence immunoassay quantitative analyzer is an inevitable trend in the development of the current instruments.
However, most of the existing fluorescence immunoassay quantitative detection instruments on the market belong to semi-automatic instruments or manual detection instruments.
Disclosure of Invention
This section is for the purpose of summarizing some aspects of embodiments of the invention and to briefly introduce some preferred embodiments. In this section, as well as in the abstract and the title of the invention of this application, simplifications or omissions may be made to avoid obscuring the purpose of the section, the abstract and the title, and such simplifications or omissions are not intended to limit the scope of the invention.
The present invention has been made in view of the problems occurring in the prior art.
Therefore, the technical problem to be solved by the invention is that most of immunofluorescence detection devices on the market are semi-automatic instruments, the operation is inconvenient, and the accuracy is low.
In order to solve the technical problems, the invention provides the following technical scheme: a full-automatic immunofluorescence detection device convenient for test strip ejection comprises a sample placement module, wherein the sample placement module comprises a shell, a sampling box and a cleaning piece, an operation chamber is arranged in the shell, a base is arranged at the bottom of the operation chamber, the sampling box and the cleaning piece are installed on the base, and the cleaning piece is located on one side of the sampling box; sample loading module, sample loading module includes driving motor, X axle drive rail, Y axle drive rail and Z axle actuating arm, X axle drive rail fixed mounting be in on the base, driving motor is located X axle drive rail one side is connected X axle drive rail, Y axle drive rail is installed perpendicularly X axle drive rail and with X axle drive rail sliding connection, Z axle actuating arm is installed perpendicularly on the Y axle drive rail and with Y axle drive rail sliding connection.
As a preferable scheme of the full-automatic immunofluorescence detection apparatus facilitating the test strip to pop up, the invention comprises: the top of the X-axis driving rail is provided with a sliding rail, one end of the Y-axis driving rail is connected with the sliding rail in a sliding manner, the other end of the Y-axis driving rail faces the side of the sampling box, a sliding groove is arranged on the Y-axis driving rail, and the Z-axis driving arm vertically penetrates through the sliding groove and is connected with the sliding groove in a sliding manner through a motor
As a preferable scheme of the full-automatic immunofluorescence detection apparatus facilitating the test strip to pop up, the invention comprises: the test tube rack is characterized in that a sampling needle is arranged at the bottom of the Z-axis driving arm, a plurality of test tube racks are arranged in the sampling box, test tubes are mounted on the test tube racks, and the sampling needle faces the test tubes.
As a preferable scheme of the full-automatic immunofluorescence detection apparatus facilitating the test strip to pop up, the invention comprises: still include reaction module and detection module, reaction module and detection module all install on the base, X axle drive rail one side is hugged closely the shell inner wall, the region of opposite side are provided with sampling box, washing piece, reaction module and detection module, it is located to wash between sampling box and the reaction module.
As a preferable scheme of the full-automatic immunofluorescence detection apparatus facilitating the test strip to pop up, the invention comprises: the reaction module includes reaction dish, injector and test paper strip sample introduction piece, the reaction dish rotates to be installed on the base and reaction dish bottom set up synchronous machine, the injector distributes on the reaction dish and correspond with the reaction dish, the test paper strip sample introduction piece inserts in the slot, detection module installs on the base and aim at the reaction dish with the reaction dish cooperation.
As a preferable scheme of the full-automatic immunofluorescence detection apparatus facilitating the test strip to pop up, the invention comprises: the test strip sample injection piece comprises a box, a test strip socket and a lifting seat, wherein a containing groove is formed in the box, one surface of the box, facing the center of the reaction disc, is provided with an outlet, and the other surface of the box is provided with an inlet; the test paper strip test device is characterized in that limiting strips are vertically arranged on the inner walls of the inlet and the outlet in the accommodating groove, the lifting seat is located in the accommodating groove, and the test paper strip socket is located on the lifting seat.
As a preferable scheme of the full-automatic immunofluorescence detection apparatus facilitating the test strip to pop up, the invention comprises: the test paper strip advances appearance piece still includes conveyer belt and first gear, first gear top protrusion sets up the pivot, the pivot is connected the storage tank roof, first gear bottom protrusion sets up the rotary pipe, the symmetrical protrusion in storage tank bottom sets up the lead screw, the lead screw rotates to set up and passes the lift seat, the lead screw top sets up the conveying gear, the conveyer belt is connected two the conveying gear, first gear is located between the conveyer belt and with the conveyer belt cooperation.
As a preferable scheme of the full-automatic immunofluorescence detection apparatus facilitating the test strip to pop up, the invention comprises: the test paper strip sample injection piece further comprises a push block and a second gear, the bottom of the second gear protrudes to extend and is connected with the bottom wall of the containing groove, the top of the second gear protrudes to form a connecting pipe, the second gear is of an obtuse-angle fan-shaped structure and is meshed with the push block, the bottom of the push block is slidably connected with the bottom wall of the containing groove, and one end of the push block is connected with the inner wall of the inlet side through a spring.
As a preferable scheme of the full-automatic immunofluorescence detection apparatus facilitating the test strip to pop up, the invention comprises: the test paper strip sample inlet piece further comprises a movable rod and a third gear, the movable rod is located between the two lead screws, a sleeve is arranged on the side wall of the containing groove in a protruding mode, the movable rod penetrates through the sleeve, a square plate is arranged on the side wall of the containing groove, the third gear is rotatably installed on the square plate and in threaded fit with the movable rod, the top end of the movable rod is in fit with the rotating pipe, and the bottom end of the rotating pipe is in fit with the connecting pipe.
As a preferable scheme of the full-automatic immunofluorescence detection apparatus facilitating the test strip to pop up, the invention comprises: the bottom of the test strip socket is provided with a convex strip, the convex strip can penetrate through the lifting seat to be matched with the push block, and the inlet and the outlet are both hinged with elastic sheet door plates.
The invention has the beneficial effects that: the invention solves the problems of manual and semi-automatic in-vitro quantitative detection, and the full-automatic detection method is used, so that the detection efficiency is higher, the trouble of manual operation is avoided, and the storage tightness of the test strip is ensured.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive exercise. Wherein:
FIG. 1 is an assembly view of the sample placement module structure and sample loading module in a first embodiment.
FIG. 2 is a view showing the construction of a sample loading block and the assembly of a reaction block and a detection block in the first embodiment.
FIG. 3 is an assembly view of a reaction module in a first embodiment.
FIG. 4 is a structural view of a reaction module in a second embodiment.
Fig. 5 is a view showing the rotational connection of the gears inside the case in the second embodiment.
Fig. 6 is a structure diagram of the transmission connection between the movable rod and the screw rod in the box in the second embodiment.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways than those specifically described and will be readily apparent to those of ordinary skill in the art without departing from the spirit of the present invention, and therefore the present invention is not limited to the specific embodiments disclosed below.
Furthermore, reference herein to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one implementation of the invention. The appearances of the phrase "in one embodiment" in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments.
Example 1
Referring to fig. 1 to 3, a first embodiment of the present invention provides a full-automatic immunofluorescence detection apparatus facilitating test strip ejection, which includes a sample placement module 100 and a sample loading module 200.
The sample placing module 100 comprises a casing 101, a sampling box 102 and a cleaning piece 103, wherein an operation chamber 101a is arranged in the casing 101, a base 101b is arranged at the bottom of the operation chamber 101a, the sampling box 102 and the cleaning piece 103 are arranged on the base 101b, and the cleaning piece 103 is positioned on one side of the sampling box 102.
The sample loading module 200 includes a driving motor 201, an X-axis driving rail 202, a Y-axis driving rail 203, and a Z-axis driving arm 204, wherein the X-axis driving rail 202 is fixedly mounted on the base 101b, the driving motor 201 is located at one side of the X-axis driving rail 202 and connected to the X-axis driving rail 202, the Y-axis driving rail 203 is vertically mounted on the X-axis driving rail 202 and slidably connected to the X-axis driving rail 202, and the Z-axis driving arm 204 is vertically mounted on the Y-axis driving rail 203 and slidably connected to the Y-axis driving rail 203.
Further, the X-axis drive rail 202 is disposed against the inner wall of the housing 101, and the rest of the sample cassette 102, the cleaning member 103, and other equipment are disposed on the other side of the X-axis drive rail 202, so that the movement of the Y-axis drive rail 203 and the Z-axis drive arm 204 can operate the equipment in other areas.
Further, a slide rail 202a is arranged at the top of the X-axis driving rail 202, the slide rail 202a is arranged along the length direction of the X-axis driving rail 202, one end of the Y-axis driving rail 203 is slidably connected to the slide rail 202a, the other end of the Y-axis driving rail faces the area of the side where the sample cassette 102 is located, the Y-axis driving rail 203 is perpendicular to the X-axis driving rail 202 and can move along the slide rail 202a in the X-axis direction, a sliding groove 203a is arranged on the Y-axis driving rail 203, the Z-axis driving arm 204 vertically penetrates through the sliding groove 203a and is slidably connected to the Y-axis driving rail 203 through a motor, the Z-axis driving arm 204 can move telescopically in the Y-axis direction along the sliding groove 203a, and meanwhile, the Z-axis driving arm 204 can move up and down in the vertical direction, i.e., the Z-axis direction.
Further, the bottom of the Z-axis driving arm 204 is provided with a sampling needle 204a, a plurality of test tube racks 102a are arranged in the sampling box 102, test tubes 102b are mounted on the test tube racks 102a, and the sampling needle 204a can move downwards towards the test tubes 102b to suck the test solution from the test tubes 102 b.
The cleaning member 103 is located at one side of the sampling box 102, and can be cleaned in the cleaning member 103 after the test tube 102b and the sampling needle 204a are used, the cleaning member 103 includes a cleaning pool 103a and a recovery pool 103b, and the recovery pool 103b is used for recovering the used test tube 102b and the sampling needle 204 a.
The device is characterized by further comprising a reaction module 300 and a detection module 400, wherein the reaction module 300 and the detection module 400 are both installed on the base 101b, one side of the X-axis driving rail 202 is tightly attached to the inner wall of the shell 101, the sampling box 102, the cleaning piece 103, the reaction module 300 and the detection module 400 are arranged in the area of the other side, and the cleaning piece 103 is located between the sampling box 102 and the reaction module 300.
Further, the reaction module 300 includes a reaction tray 301, a sample injector 302 and a test strip sample injector 303, the reaction tray 301 is rotatably mounted on a base 101b, a synchronous motor 301a is disposed at the bottom of the reaction tray 301, the synchronous motor 301a drives the reaction tray 301 to rotate, the sample injector 302 is disposed in a plurality and distributed with the reaction tray 301 as a center, a slot 302a is disposed on the sample injector 302, the test strip sample injector 303 is inserted into the slot 302a, the detection module 400 is mounted on the base 101b and matched with the reaction tray 301 in alignment with the reaction tray 301, specifically, the sample injector 302 is disposed on the reaction tray 301, the bottom of the sample injector 302 is fixedly connected with the base 101b, when the reaction tray 301 rotates, the sample injector 302 is fixed, a test slot 301b is disposed at the circumference of the reaction tray 301, a plurality of test strips are stored in the sample injector 303, the test strip sample injector 303 is inserted into the slot 302a, and when the reaction tray 301 rotates, the test slot 301b can correspond to the test strip sample piece 303 in the rotation process, the test strip sample piece 303 can pop up an internal test strip, so that the test strip enters the test slot 301b of the reaction disc 301, then the synchronous motor 301a drives the synchronous motor to rotate to the area where the sampling box 102 is located, then the sample loading module 200 acts, solution in the test tube 102b is loaded onto the test strip, then the area where the detection module 400 is located is rotated, the detection module 400 detects the test strip to obtain a data result, the reaction disc 301 is in the rotation process, the test strip in the test strip sample piece 303 can be continuously popped up, so that the test slots 301b on the reaction disc 301 are fully distributed, and therefore one test slot is used for testing in turn.
Example 2
Referring to fig. 4 to 6, in a second embodiment of the present invention, which is based on the previous embodiment, the test strip sample piece 303 includes a box 303a, a test strip socket 303b and a lifting base 303c, and the test strip socket 303b and the lifting base 303c are installed in the box 303a for storing the test strip and ejecting the test strip.
The containing groove 303a-1 is arranged in the box 303a, one side of the box 303a facing the center of the reaction tray 301 is provided with an outlet 303a-2, the other side of the box 303a is provided with an inlet 303a-3, the inlet 303a-3 is positioned right above the box 303a, the outlet 303a-2 is positioned right below the box 303a, the test strip sockets 303b and the lifting seat 303c are arranged in the containing groove 303a-1, the test strips are placed in the containing groove 303a-1 from the inlet 303a-3 and then popped out from the outlet 303a-2, the test strips can be stored in the test strip sockets 303b, a plurality of test strip sockets 303b can be arranged and stacked on the lifting seat 303c, and after the lifting seat 303c at the lowest part is popped out, the previous test strip socket 303b falls down and then pops out.
Furthermore, two limiting strips 303a-4 are vertically arranged on the inner walls of the containing groove 303a-1, which are positioned at the inlet 303a-3 and the outlet 303a-2, the lifting seat 303c is positioned in the containing groove 303a-1, the test strip socket 303b is positioned on the lifting seat 303c, and the test strip socket 303b can be just limited between the two limiting strips 303a-4 when entering from the inlet 303 a-3.
The test strip sample inlet member 303 further comprises a conveyor belt 303d and a first gear 303e, the bottoms of the accommodating grooves 303a-1 are symmetrically provided with screw rods 303a-5 in a protruding manner, the screw rods 303a-5 are rotatably arranged and pass through the lifting seat 303c and are in threaded connection with the lifting seat 303c, the first gear 303e is positioned between the two screw rods 303a-5, specifically, the top of the first gear 303e is provided with a rotating shaft 303e-1 in a protruding manner, the rotating shaft 303e-1 is connected with the top wall of the accommodating groove 303a-1, the bottom of the first gear 303e is provided with a rotating pipe 303e-2 in a protruding manner, the tops of the two screw rods 303a-5 are provided with conveying gears 303a-6, the conveyor belt 303d is connected with the two conveying gears 303a-6, the first gear 303e is positioned between the conveyor belts 303d and is matched with the conveyor belt 303d, the first gear 303e can drive the conveyor belt 303d to move when rotating, and then the two screw rods 303a-5 are driven to rotate, and because the screw rods 303a-5 are in threaded connection with the lifting seat 303c, when the screw rods 303a-5 rotate, the lifting seat 303c can move up and down along the screw rods 303a-5, so that the test strip socket 303b on the lifting seat 303c can be driven from the space above the accommodating groove 303a-1 to the space below the accommodating groove 303 a-1.
Furthermore, the test strip sample inlet member 303 further comprises a push block 303f and a second gear 303g, the bottom of the second gear 303g is provided with a connecting shaft in a protruding manner and extends to be connected with the bottom wall of the containing groove 303a-1, the top of the second gear 303g is provided with a connecting pipe 303g-1 in a protruding manner, the connecting pipe 303g-1 corresponds to the rotating pipe 303e-2 up and down, the second gear 303g is engaged with the push block 303f in an obtuse fan-shaped structure, the bottom of the push block 303f is slidably connected with the bottom wall of the containing groove 303a-1, one end of the push block 303f is connected with the inner wall of the inlet 303a-3 side through a spring A, the push block 303f can be driven to advance when the second gear 303g rotates, because the number of teeth on the second gear 303g only exists on the arc edge of the push block 303f, when the second gear 303g rotates, the push block 303f compresses the spring A, and can be disengaged after rotating through a certain angle, so that the pushing block 303f is pushed by the compressed spring a to push the test strip socket 303b out.
Further, the test strip sample inlet member 303 further comprises a movable rod 303h and a third gear 303k, the movable rod 303h is positioned between the two screw rods 303a-5, a sleeve B is convexly arranged on the side wall of the containing groove 303a-1, the movable rod 303h penetrates through the sleeve B, a square plate C is arranged on the side wall of the containing groove 303a-1, the third gear 303k is rotatably arranged on the square plate C and is in threaded fit with the movable rod 303h, the top end of the movable rod 303h is matched with the rotating tube 303e-2, the bottom end of the rotating tube 303e-2 is matched with the connecting tube 303g-1, the movable rod 303h is driven to move up and down when the third gear 303k rotates, the upward moving top end of the movable rod 303h is inserted into the rotating tube 303e-2 and drives the first gear 303e to rotate when the movable rod 303k rotates forward, the two screw rods 303a-5 are driven to rotate to convey the lifting seat 303C downward indirectly through the matching of the conveying belt 303d and the conveying gear 303a-6, one or more test strips can be inserted into the test strip socket 303b, the test strip socket 303b is inserted into the accommodating groove 303a-1 from the inlet 303a-3 and placed on the lifting seat 303c, the bottom of the test strip socket 303b is provided with a convex strip D, the convex strip D can pass through the lifting seat 303c and be matched with the push block 303f, a plurality of convex strips D can be stacked on the lifting seat 303c and be matched with the push block 303f when the lifting seat 303c is conveyed to the bottommost part.
Then the third gear 303k rotates reversely, the top end of the movable rod 303h and the rotating pipe 303e-2 can be reversely and easily disengaged, the bottom end of the movable rod 303h moves downwards to be inserted into the connecting pipe 303g-1 to drive the second gear 303g to rotate to move the push block 303f to the side of the spring A, the bottom of the push block 303f is in sliding connection with the bottom wall of the accommodating groove 303a-1, and after the engagement is released, the push block 303f is popped out to push the test strip socket 303b to pop out the outlet 303 a-2.
Specifically, the up-and-down movement of the movable rod 303h is realized by the push rod motor 305, the movable rod 303h is provided with a ring block 303h-3, the ring block 303h-3 is respectively sleeved with a first sleeve plate 306 and a second sleeve plate 307, the first sleeve plate 306 is sleeved on the movable rod 303h and is positioned above the ring block 303h-3, the second sleeve plate 307 is sleeved on the movable rod 303h and is positioned below the ring block 303h-3, the first sleeve plate 306 and the second sleeve plate 307 are movably arranged, the push rod motor 305 can be positioned in the accommodating groove 303a-1 and connected with the second sleeve plate 307 through the first sleeve plate 306, the push rod motor 305 can drive the up-and-down movement, when moving upwards, the second sleeve plate 307 is limited by the ring block 303h-3 to drive the movable rod 303h to move upward and downward, the first sleeve 306 is limited by the ring block 303h-3 to drive the movable rod 303h to move downwards.
Then, the movable rod 303h is provided with an upper gear ring 303h-4 and a lower gear ring 303h-4, when the top of the movable rod 303h extends into the rotating pipe 303e-2 to be matched, the lower gear ring 303h-4 is matched with the third gear 303k to rotate, and when the bottom of the movable rod 303h extends into the connecting pipe 303g-1 to be matched, the upper gear ring 303h-4 is matched with the third gear 303k to rotate, so that the movable rod 303h moves up and down and rotates.
The inlet 303a-3 and the outlet 303a-2 are both hinged with an elastic piece door panel E, so that the interior of the accommodating groove 303a-1 is ensured to be sealed.
It is important to note that the construction and arrangement of the present application as shown in the various exemplary embodiments is illustrative only. Although only a few embodiments have been described in detail in this disclosure, those skilled in the art who review this disclosure will readily appreciate that many modifications are possible (e.g., variations in sizes, dimensions, structures, shapes and proportions of the various elements, values of parameters (e.g., temperatures, pressures, etc.), mounting arrangements, use of materials, colors, orientations, etc.) without materially departing from the novel teachings and advantages of the subject matter recited in this application. For example, elements shown as integrally formed may be constructed of multiple parts or elements, the position of elements may be reversed or otherwise varied, and the nature or number of discrete elements or positions may be altered or varied. Accordingly, all such modifications are intended to be included within the scope of this invention. The order or sequence of any process or method steps may be varied or re-sequenced according to alternative embodiments. In the claims, any means-plus-function clause is intended to cover the structures described herein as performing the recited function and not only structural equivalents but also equivalent structures. Other substitutions, modifications, changes and omissions may be made in the design, operating conditions and arrangement of the exemplary embodiments without departing from the scope of the present inventions. Therefore, the present invention is not limited to a particular embodiment, but extends to various modifications that nevertheless fall within the scope of the appended claims.
Moreover, in an effort to provide a concise description of the exemplary embodiments, all features of an actual implementation may not be described (i.e., those unrelated to the presently contemplated best mode of carrying out the invention, or those unrelated to enabling the invention).
It should be appreciated that in the development of any such actual implementation, as in any engineering or design project, numerous implementation-specific decisions may be made. Such a development effort might be complex and time consuming, but would nevertheless be a routine undertaking of design, fabrication, and manufacture for those of ordinary skill having the benefit of this disclosure, without undue experimentation.
It should be noted that the above-mentioned embodiments are only for illustrating the technical solutions of the present invention and not for limiting, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions may be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, which should be covered by the claims of the present invention.
Claims (9)
1. The utility model provides a full-automatic immunofluorescence detection device convenient to test paper strip pops out which characterized in that: comprises the steps of (a) preparing a mixture of a plurality of raw materials,
the sample placing module (100) comprises a shell (101), a sampling box (102) and a cleaning piece (103), wherein an operation chamber (101a) is arranged in the shell (101), a base (101b) is arranged at the bottom of the operation chamber (101a), the sampling box (102) and the cleaning piece (103) are installed on the base (101b), and the cleaning piece (103) is positioned on one side of the sampling box (102);
the sample loading module (200) comprises a driving motor (201), an X-axis driving rail (202), a Y-axis driving rail (203) and a Z-axis driving arm (204), wherein the X-axis driving rail (202) is fixedly installed on the base (101b), the driving motor (201) is located on one side of the X-axis driving rail (202) and is connected with the X-axis driving rail (202), the Y-axis driving rail (203) is vertically installed on the X-axis driving rail (202) and is in sliding connection with the X-axis driving rail (202), and the Z-axis driving arm (204) is vertically installed on the Y-axis driving rail (203) and is in sliding connection with the Y-axis driving rail (203);
still include reaction module (300) and detection module (400), reaction module (300) and detection module (400) are all installed on base (101b), X axle drive rail (202) one side is hugged closely shell (101) inner wall, and the region of opposite side is provided with sample box (102), cleaning member (103), reaction module (300) and detection module (400), cleaning member (103) are located between sample box (102) and reaction module (300).
2. The full-automatic immunofluorescence detection device convenient for test strip to pop up of claim 1, characterized in that: the top of the X-axis driving rail (202) is provided with a sliding rail (202a), one end of the Y-axis driving rail (203) is connected with the sliding rail (202a) in a sliding mode, the other end of the Y-axis driving rail faces the side where the sampling box (102) is located, a sliding groove (203a) is formed in the Y-axis driving rail (203), and the Z-axis driving arm (204) vertically penetrates through the sliding groove (203a) and is connected with the sliding groove (203a) in a sliding mode through a motor.
3. The fully-automatic immunofluorescence assay device of claim 1 or 2, wherein the device facilitates test strip ejection, comprising: the bottom of the Z-axis driving arm (204) is provided with a sampling needle (204a), the sampling box (102) is internally provided with a plurality of test tube racks (102a) in an arrangement mode, test tubes (102b) are mounted on the test tube racks (102a), and the sampling needle (204a) faces the test tubes (102 b).
4. The full-automatic immunofluorescence detection device convenient for test strip to pop up of claim 3, characterized in that: reaction module (300) includes reaction dish (301), injector (302) and test paper strip sample introduction spare (303), reaction dish (301) rotate to be installed on base (101b) and reaction dish (301) bottom set up synchronous machine (301a), injector (302) distribute on reaction dish (301) and correspond with reaction dish (301), set up slot (302a) on injector (302), test paper strip sample introduction spare (303) insert in slot (302a), detection module (400) are installed on base (101b) and aim at reaction dish (301) with reaction dish (301) cooperation.
5. The full-automatic immunofluorescence detection device convenient for test strip to pop up of claim 4, characterized in that: the test strip sample inlet part (303) comprises a box (303a), a test strip socket (303b) and a lifting seat (303c), wherein a containing groove (303a-1) is arranged in the box (303a), one surface of the box (303a) facing the center of the reaction disc (301) is provided with an outlet (303a-2), and the other surface of the box (303a) is provided with an inlet (303 a-3);
the inner walls of the inlet (303a-3) and the outlet (303a-2) in the containing groove (303a-1) are vertically provided with limiting strips (303a-4), the lifting seat (303c) is located in the containing groove (303a-1), and the test strip socket (303b) is located on the lifting seat (303 c).
6. The full-automatic immunofluorescence detection device convenient for test strip to pop up of claim 5, characterized in that: the test strip sample entry member (303) further comprises a conveyor belt (303d) and a first gear (303e), the top of the first gear (303e) is convexly provided with a rotating shaft (303e-1), the rotating shaft (303e-1) is connected with the top wall of the accommodating groove (303a-1), the bottom of the first gear (303e) is convexly provided with a rotating pipe (303e-2), the bottom of the containing groove (303a-1) is symmetrically convexly provided with screw rods (303a-5), the screw rod (303a-5) is rotatably arranged and penetrates through the lifting seat (303c), the top of the screw rod (303a-5) is provided with a transmission gear (303a-6), the conveying belt (303d) is connected with two conveying gears (303a-6), and the first gear (303e) is positioned between the conveying belts (303d) and matched with the conveying belts (303 d).
7. The full-automatic immunofluorescence detection device convenient for test strip to pop up of claim 6, characterized in that: the test paper strip advances appearance piece (303) still includes ejector pad (303f), second gear (303g), the protrusion of second gear (303g) bottom extends and connects storage tank (303a-1) diapire, the protrusion of second gear (303g) top sets up connecting pipe (303g-1), second gear (303g) be obtuse angle fan-shaped structure with ejector pad (303f) meshing, ejector pad (303f) bottom with storage tank (303a-1) diapire sliding connection, the one end of ejector pad (303f) with import (303a-3) side inner wall passes through spring (A) and connects.
8. The full-automatic immunofluorescence detection device convenient for test strip to pop up of claim 7, characterized in that: the test paper strip advances appearance piece (303) still includes movable rod (303h) and third gear (303k), movable rod (303h) are located between two lead screws (303a-5), the protrusion sets up sleeve pipe (B) on storage tank (303a-1) lateral wall, movable rod (303h) pass the sleeve pipe, set up square plate (C) on storage tank (303a-1) lateral wall, third gear (303k) rotate install square plate (C) go up and with movable rod (303h) screw-thread fit, movable rod (303h) top with commentaries on classics pipe (303e-2) cooperation, commentaries on classics pipe (303e-2) bottom with connecting pipe (303g-1) cooperation.
9. The full-automatic immunofluorescence detection device convenient for test strip to pop up of claim 8, characterized in that: the bottom of the test strip socket (303b) is provided with a convex strip (D), the convex strip (D) can pass through the lifting seat (303c) and the push block (303f) to be matched, and the inlet (303a-3) and the outlet (303a-2) are both hinged with an elastic sheet door panel (E).
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