CN114200149A - Novel full-automatic plasma separating mechanism - Google Patents
Novel full-automatic plasma separating mechanism Download PDFInfo
- Publication number
- CN114200149A CN114200149A CN202111554481.7A CN202111554481A CN114200149A CN 114200149 A CN114200149 A CN 114200149A CN 202111554481 A CN202111554481 A CN 202111554481A CN 114200149 A CN114200149 A CN 114200149A
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- Prior art keywords
- centrifugal
- transfer tray
- driving device
- chuck
- automatic plasma
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- 238000012546 transfer Methods 0.000 claims abstract description 42
- 239000008280 blood Substances 0.000 claims abstract description 12
- 210000004369 blood Anatomy 0.000 claims abstract description 12
- 238000006073 displacement reaction Methods 0.000 claims description 22
- 230000001360 synchronised effect Effects 0.000 claims description 19
- 238000000926 separation method Methods 0.000 claims description 11
- 239000011324 bead Substances 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 description 8
- 238000003860 storage Methods 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 4
- 238000003018 immunoassay Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
Abstract
The invention relates to a novel full-automatic plasma separating mechanism, which comprises a centrifugal disc, a transfer tray and a centrifugal driving device arranged on one side of the transfer tray; the centrifugal driving device comprises a centrifugal driving motor and a centrifugal chuck arranged on an output shaft of the centrifugal driving motor, a through hole for the centrifugal chuck to pass through is arranged on the transfer tray, the centrifugal disk is matched with the centrifugal chuck, and a lifting device for enabling the centrifugal driving device to move up and down is further arranged on the centrifugal driving device; the invention utilizes the transfer tray to transfer the centrifugal disc to the centrifugal driving device, and utilizes the cooperation of the centrifugal chuck on the centrifugal driving device and the centrifugal disc to carry out centrifugal operation on blood in the centrifugal disc, thereby realizing the centrifugal function.
Description
Technical Field
The invention belongs to the technical field of detection equipment, and particularly relates to a novel full-automatic plasma separation mechanism.
Background
At present, plasma separation is carried out through a special centrifuge, blood needing to be subjected to plasma separation by an operator is put into the centrifuge, the plasma after the centrifugation is finished is taken out by the operator and put into a detection instrument, the whole process needs more manual operation, and the automation of the instrument is not facilitated.
The patent application with the publication number of CN109212240A discloses a high-flux full-automatic immunoassay instrument, which comprises a lower layer working unit, an upper layer working unit, a three-dimensional mechanical arm and a liquid transfer device arranged on the three-dimensional mechanical arm; the lower layer working unit comprises a sample area, a tip storage area and a waste material box which are arranged on the lower layer plate; the upper working unit comprises a cartridge clip storage area, a sample adding area, a ferry area, an incubation area and a detection area which are arranged on the upper plate.
Further, as disclosed in patent application No. CN113049801A, an immunoassay analyzer is disclosed, comprising: a frame; the reaction tray assembly is arranged on the rack and used for loading reaction cups and circulating the reaction cups; the sample needle assembly is arranged on the rack and used for reciprocating movement in a first direction to perform sampling and sample dividing, and the sample needle assembly is arranged above the reaction disc assembly to divide samples into the reaction cups; the reagent storage disc is arranged on the rack, is positioned on the side edge of the reaction disc assembly and is used for refrigerating and storing reagents; the reagent needle assembly is arranged on the frame in a swinging way, is positioned between the reaction disc assembly and the reagent storage disc and is used for taking and adding the reagent into the reaction cup; the HCT calculating component is arranged below the motion track of the sample needle component.
The analysis shows that the existing immunoassay analyzer can directly detect the plasma when in use, and the immunoassay analyzer does not have a matched plasma separation structure and is required to carry out the plasma separation operation on a centrifuge.
Disclosure of Invention
The invention aims to provide a novel full-automatic plasma separation mechanism to realize automatic separation operation.
The technical scheme adopted by the invention is as follows: a novel full-automatic plasma separation mechanism comprises a centrifugal disc, a transfer tray and a centrifugal driving device arranged on one side of the transfer tray;
the centrifugal driving device comprises a centrifugal driving motor and a centrifugal chuck arranged on an output shaft of the centrifugal driving motor, a through hole for the centrifugal chuck to pass through is formed in the transfer tray, the centrifugal chuck is matched with the centrifugal chuck, and a lifting device for enabling the centrifugal driving device to move up and down is further arranged on the centrifugal driving device.
Furthermore, a first gear is sleeved on an output shaft of the centrifugal driving motor, a second gear is arranged on one side of the centrifugal driving motor and arranged on the output shaft of the stepping motor, the stepping motor is connected with a displacement driving device, and the displacement driving device drives the second gear to move so as to enable the second gear to be meshed with or separated from the first gear.
Furthermore, the displacement driving device comprises a first synchronous belt and a first displacement driving motor for driving the first synchronous belt to move, the stepping motor is fixedly installed on a first sliding block, the first sliding block is arranged on a first guide rod in a sliding mode, and the first sliding block is fixedly connected with the first synchronous belt.
Further, the lifting device is a first screw motor.
Further, a top plate is arranged above the centrifugal driving device, and when the transfer tray moves to the position of the centrifugal driving device, the transfer tray is positioned below the top plate.
Furthermore, a spring glass bead structure is arranged on the centrifugal chuck, and a special-shaped hole corresponding to the centrifugal chuck is arranged on the centrifugal disk.
Furthermore, the transfer tray is arranged on a second guide rod through a second sliding block, the second guide rod is fixedly connected with a second synchronous belt, and a second displacement driving motor drives the second synchronous belt to run.
Furthermore, a containing barrel for placing the centrifugal disc is arranged on the other side of the transfer tray, a slotted hole is formed in the bottom of the containing barrel and one side of the containing barrel corresponding to the transfer tray, and a push plate corresponding to the slotted hole is arranged on the other side of the containing barrel; the push plate is arranged on a third guide rod through a third sliding block in a sliding mode, and the third sliding block is fixedly connected with a third synchronous belt driven by a third displacement driving motor; the height of the groove hole is higher than the thickness of one centrifugal disc and is smaller than the thickness of two centrifugal discs.
Furthermore, an electromagnet is arranged above the transfer tray, and a slide way is arranged below the transfer tray and at a position corresponding to the electromagnet.
Furthermore, blood adding holes are correspondingly arranged on the top plate and the centrifugal disc.
The invention has the positive effects that:
the invention utilizes the transfer tray to transfer the centrifugal disc to the centrifugal driving device, and utilizes the cooperation of the centrifugal chuck on the centrifugal driving device and the centrifugal disc to carry out centrifugal operation on blood in the centrifugal disc, thereby realizing the centrifugal function.
Meanwhile, the accommodating barrel is arranged, a plurality of centrifugal discs can be stacked in the accommodating barrel, and the centrifugal disc at the bottommost can be pushed onto the transfer tray by the aid of the push plate, so that automatic centrifugal disc loading operation is realized.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of a containment drum of the present invention;
FIG. 3 is a schematic view of a transfer tray according to the present invention;
FIG. 4 is a schematic diagram of the position of an electromagnet according to the present invention;
FIG. 5 is a schematic structural diagram of a centrifugal driving device according to the present invention.
Detailed Description
Example 1
As shown in fig. 1 to 5, the plasma separating mechanism of the present embodiment includes a transfer tray 12 for transferring the centrifugal tray 6 and a centrifugal driving device provided on one side of the transfer tray 12.
The centrifugal driving device comprises a centrifugal driving motor 18 and a centrifugal chuck 20 arranged on an output shaft of the centrifugal driving motor, the centrifugal driving motor 18 can move up and down under the driving of a lifting device, a through hole for the centrifugal chuck 20 to pass through is formed in the transfer tray 6, and a hole matched with the centrifugal chuck 20 is formed in the center of the centrifugal tray 6. In this embodiment, the lifting device is a first screw motor 17 arranged vertically.
Meanwhile, a first gear 19 is sleeved on an output shaft of the centrifugal driving motor 18 and below the centrifugal chuck 20, a stepping motor 23 is arranged on one side of the centrifugal driving motor 18, and a second gear 22 is arranged on an output shaft of the stepping motor 23. Meanwhile, a first guide rod 27 is further arranged, a first sliding block 25 is arranged on the first guide rod in a sliding mode, the first sliding block 25 is connected with a first synchronous belt 26, the first displacement driving motor 24 drives the first synchronous belt 26 to move, the first sliding block 25 is driven to move on the first guide rod 27 through the movement of the first synchronous belt 26, and the stepping motor 23 is fixedly installed on the first sliding block 25, so that the movement of the second gear 22 is achieved, and the engagement or disengagement of the second gear 22 and the first gear 19 is achieved.
Preferably, a spring bead structure is provided on the centrifugal chuck 20, a profiled hole corresponding to the centrifugal chuck 20 is provided on the centrifugal disk 6, and a top plate 21 is provided above the centrifugal chuck 20, the transfer tray 12 being located below the top plate 21 when the transfer tray 12 is moved to the centrifugal drive position.
The top plate 21 and the centrifugal disc 6 are correspondingly provided with blood adding holes 28.
In the embodiment, when the first screw motor 17 rotates, the centrifugal driving motor 18, the first gear 19 and the centrifugal chuck 20 can be jacked up, so that the centrifugal chuck 20 is inserted into the central positioning hole of the centrifugal disk 6, the centrifugal chuck 20 continues to jack up the centrifugal disk 6 until the upper surface of the centrifugal disk 6 abuts against the top plate 21, then the centrifugal chuck 20 continues to jack up, the centrifugal chuck 20 is inserted into the central hole of the centrifugal disk 6, the centrifugal chuck 20 is provided with a spring glass bead structure, and in addition, the centrifugal chuck 20 is matched with the central special-shaped hole of the centrifugal disk, the centrifugal chuck and the centrifugal disk are relatively fixed, then the screw motor 17 rotates in the reverse direction, the centrifugal disk 6 falls, when the centrifugal disk 6 is not in contact with the top plate 21 and the transfer tray 12, the first displacement driving motor 24 drives the first synchronous belt 26 to rotate, the first slide block 25 fixedly connected with the first synchronous belt 26 moves along the first guide rod 27, i.e. along the arrow direction shown in fig. 5, the stepping motor 23 fixed to the first slider 25 and the second gear 22 fixed to the shaft thereof move in the direction of the arrow until the second gear 22 is completely engaged with the first gear 19, the first displacement driving motor 24 stops rotating, then the stepping motor 23 rotates, the second gear 22 rotates to rotate the first gear 19 engaged therewith, and the first gear 19 is coaxial with the centrifugal chuck 20, so that the centrifugal chuck 20 rotates together with the centrifugal chuck 20, the centrifugal disk 6 is driven by the centrifugal chuck 20 to rotate, and when the blood adding hole on the centrifugal disk 6 is aligned with the center of the blood adding hole 28 on the top plate 21, the stepping motor 23 stops rotating, the centrifugal disk 6 stops rotating, and the blood adding operation is performed.
After the blood adding operation is completed, the first displacement driving motor 24 rotates in the opposite direction, so that the first synchronous belt 26 rotates in the direction opposite to the arrow, the second gear 22 is far away from the first gear 19, after the second gear 22 is completely separated from the first gear 19, the centrifugal driving motor 18 starts to rotate, and the centrifugal chuck 20 drives the centrifugal disc 6 to perform a centrifugal operation.
After centrifugation is finished, the first displacement driving motor 24 rotates to enable the second gear 22 to be completely meshed with the first gear 19, then the stepping motor 23 rotates to enable the blood adding hole of the centrifugal disc 6 to be aligned with the center of the blood adding hole 28 on the top plate 21, serum is extracted, after the operation is finished, the first displacement driving motor 24 rotates reversely to enable the second gear 22 to be completely separated from the first gear 19, then the screw motor 17 rotates to enable the centrifugal chuck 20 to fall, the centrifugal disc 6 falls, in the falling process, the centrifugal disc 6 is held by the centrifugal tray 12, the centrifugal chuck 20 continuously falls to be separated from the centrifugal disc 6, and when the centrifugal chuck 20 is completely separated from the positioning hole of the centrifugal disc 6 and the centrifugal tray 20 is lower than the lower surface of the centrifugal tray 12, the centrifugal tray 12 can hold the centrifugal disc 6 to perform disc withdrawing action.
Example 2
The embodiment is further limited on the basis of embodiment 1, in this embodiment, the transfer tray 12 is disposed on the second guide rod 11 through the second slider 9, the second guide rod 11 is fixedly connected with the second timing belt 13, and the second displacement driving motor 8 drives the second timing belt 13 to rotate.
Example 3
The embodiment is further limited on the basis of the embodiment 2, the accommodating barrel 7 is arranged on the other side of the transfer tray 12, the centrifugal discs 6 are stacked in the accommodating barrel 7, and the edge of the accommodating barrel 7 is provided with a rectangular groove in a convex shape for facilitating the storage and the taking of the circular centrifugal discs. A slotted hole is arranged at the bottom of the containing barrel 7 and at one side corresponding to the transfer tray 12, the height of the slotted hole is higher than the thickness of one centrifugal disc and is less than the thickness of two centrifugal discs, a push plate 4 corresponding to the position of the slotted hole is arranged at the other side of the containing barrel 7, and the centrifugal disc 6 at the lowest end in the containing barrel 7 can be pushed out of the slotted hole and pushed onto the transfer tray 12 by the push plate 4.
The push plate 4 is arranged on a third guide rod 5 through a third sliding block 3 in a sliding mode, and the third sliding block 3 is fixedly connected with a third synchronous belt 2 driven by a third displacement driving motor 1.
Meanwhile, an electromagnet 14 is arranged between the storage barrel 7 and the centrifugal driving device and above the transfer tray 12, a slide way 15 is arranged below the transfer tray 12 and at a position corresponding to the electromagnet 14, and a base plate 16 with an opening is arranged at the bottom end of the slide way 15.
When the centrifugal tray 12 carries the centrifugal disc 6 after the centrifugation is finished to move below the electromagnet 14 along the arrow direction shown in fig. 3, the extending end of the electromagnet 14 is inserted into the central hole of the centrifugal disc 6, the insertion depth is smaller than the thickness of the centrifugal disc 6, when the centrifugal tray 12 continues to move along the direction shown in the figure, the centrifugal disc 6 is blocked by the extending end of the electromagnet, the centrifugal disc 6 cannot continue to advance along with the centrifugal tray 12, and when the centrifugal disc 6 is separated from the centrifugal tray 12, the centrifugal disc falls into the slide way 15 below, meanwhile, the electromagnet 14 is closed, the centrifugal disc 6 continues to fall into the hole of the base plate 16 along the slide way 15, and the disc withdrawing action is finished.
The working process of the invention is as follows:
the third displacement driving motor 1 pushes the push plate 4 out of the centrifugal tray 6 at the bottommost layer in the centrifugal tray accommodating barrel 7 to the centrifugal tray 12 through belt transmission, then the second displacement driving motor 8 causes the centrifugal tray 12 to carry the centrifugal tray 6 to the centrifugal chuck 20 through belt transmission, and then the centrifugal tray 6 is jacked up from the centrifugal tray 12 through the matching motion of the centrifugal driving motor 18, the stepping motor 23, the second gear 22, the first gear 19 and the screw motor 17, and then the centrifugal tray 6 is centrifuged. After the centrifugation is finished, the centrifugal tray 6 is carried by the centrifugal tray 12 to return, in the returning process, when the centrifugal tray 6 reaches the position of the electromagnet 14, the extending end of the electromagnet 14 is inserted into the centrifugal tray hole to block the centrifugal tray 6 without blocking the centrifugal tray 12, so that the centrifugal tray 6 is separated from the centrifugal tray 12, and then the centrifugal tray 6 falls into the slide way 15 and slides to the hole position 16, so that the automatic tray returning operation is finished.
The whole process of the invention does not need to consider interference, and only a plurality of centrifugal discs are put into the containing barrel 7, thereby greatly improving the automation degree of the instrument.
At present, the technical scheme of the invention has been subjected to a pilot plant test, namely a small-scale test of the product before large-scale mass production; after the pilot test is finished, the investigation for the use of the user is carried out in a small range, and the investigation result shows that the satisfaction degree of the user is higher; the preparation of products for formal production for industrialization (including intellectual property risk early warning research) has been started.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. A novel full-automatic plasma separation mechanism is characterized by comprising a centrifugal disc (6), a transfer tray (12) and a centrifugal driving device arranged on one side of the transfer tray (12);
the centrifugal driving device comprises a centrifugal driving motor (18) and a centrifugal chuck (20) arranged on an output shaft of the centrifugal driving motor (18), a through hole for the centrifugal chuck (20) to pass through is formed in the transfer tray (12), the centrifugal disk (6) is matched with the centrifugal chuck (20), and a lifting device for enabling the centrifugal driving device to move up and down is further arranged on the centrifugal driving device.
2. The novel full-automatic plasma separating mechanism according to claim 1, wherein a first gear (19) is sleeved on an output shaft of the centrifugal driving motor (18), a second gear (22) is arranged on one side of the centrifugal driving motor (18), the second gear (22) is arranged on an output shaft of a stepping motor (23), the stepping motor (23) is connected with a displacement driving device, and the displacement driving device drives the second gear (22) to move so as to be meshed with or separated from the first gear (19).
3. The novel full-automatic plasma separating mechanism according to claim 2, wherein the displacement driving device comprises a first synchronous belt (26) and a first displacement driving motor (24) for driving the first synchronous belt (26) to move, the stepping motor (23) is fixedly installed on a first sliding block (25), the first sliding block (25) is slidably arranged on a first guide rod (27), and the first sliding block (25) is fixedly connected with the first synchronous belt (26).
4. The new type of fully automatic plasma separation mechanism according to claim 1, characterized in that the lifting device is a first lead screw motor (17).
5. A new type of fully automatic plasma separating mechanism according to claim 1, characterized in that a top plate (21) is provided above the centrifugal driving device, and the transfer tray (12) is located below the top plate (21) when the transfer tray (12) is moved to the centrifugal driving device position.
6. The novel full-automatic plasma separating mechanism according to claim 1 or 5, characterized in that the centrifugal chuck (20) is provided with a spring glass bead structure, and the centrifugal disk (6) is provided with a special-shaped hole corresponding to the centrifugal chuck (20).
7. The novel full-automatic plasma separating mechanism according to claim 1, wherein the transfer tray (12) is disposed on a second guide rod (11) through a second slide block (9), the second guide rod (11) is fixedly connected with a second synchronous belt (13), and the second displacement driving motor (8) drives the second synchronous belt (13) to rotate.
8. The novel full-automatic plasma separating mechanism is characterized in that a containing barrel (7) for placing a centrifugal disc is arranged on the other side of the transfer tray (12), a slotted hole is formed in the bottom of the containing barrel (7) and the side corresponding to the transfer tray (12), and a push plate (4) corresponding to the slotted hole is arranged on the other side of the containing barrel (7); the push plate (4) is arranged on the third guide rod (5) in a sliding mode through the third sliding block (3), and the third sliding block (3) is fixedly connected with the third synchronous belt (2) driven by the third displacement driving motor (1); the height of the groove hole is higher than the thickness of one centrifugal disc and is smaller than the thickness of two centrifugal discs.
9. The novel full-automatic plasma separating mechanism according to claim 1, characterized in that an electromagnet (14) is arranged above the transfer tray (12), and a slide (15) is arranged below the transfer tray (12) and corresponding to the electromagnet (14).
10. The novel full-automatic plasma separation mechanism according to claim 5, characterized in that the top plate (21) and the centrifugal disc (6) are correspondingly provided with blood adding holes (28).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111554481.7A CN114200149A (en) | 2021-12-17 | 2021-12-17 | Novel full-automatic plasma separating mechanism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111554481.7A CN114200149A (en) | 2021-12-17 | 2021-12-17 | Novel full-automatic plasma separating mechanism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114200149A true CN114200149A (en) | 2022-03-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111554481.7A Pending CN114200149A (en) | 2021-12-17 | 2021-12-17 | Novel full-automatic plasma separating mechanism |
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| Country | Link |
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| CN (1) | CN114200149A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115144576A (en) * | 2022-08-08 | 2022-10-04 | 中元汇吉生物技术股份有限公司 | Sample centrifugation mechanism and sample analyzer |
| CN115301417A (en) * | 2022-08-08 | 2022-11-08 | 中元汇吉生物技术股份有限公司 | Sample centrifugation mechanism and sample analyzer |
-
2021
- 2021-12-17 CN CN202111554481.7A patent/CN114200149A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115144576A (en) * | 2022-08-08 | 2022-10-04 | 中元汇吉生物技术股份有限公司 | Sample centrifugation mechanism and sample analyzer |
| CN115301417A (en) * | 2022-08-08 | 2022-11-08 | 中元汇吉生物技术股份有限公司 | Sample centrifugation mechanism and sample analyzer |
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