CN113956245A - 克莱拉尼的晶型及其使用方法 - Google Patents

克莱拉尼的晶型及其使用方法 Download PDF

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Publication number
CN113956245A
CN113956245A CN202110642513.2A CN202110642513A CN113956245A CN 113956245 A CN113956245 A CN 113956245A CN 202110642513 A CN202110642513 A CN 202110642513A CN 113956245 A CN113956245 A CN 113956245A
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China
Prior art keywords
crystalline form
cancer
powder
peaks
diffraction pattern
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CN202110642513.2A
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English (en)
Chinese (zh)
Inventor
维奈·简
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Arog Pharmaceuticals LLC
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Arog Pharmaceuticals LLC
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Publication of CN113956245A publication Critical patent/CN113956245A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202110642513.2A 2020-07-20 2021-06-09 克莱拉尼的晶型及其使用方法 Pending CN113956245A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063053921P 2020-07-20 2020-07-20
US63/053,921 2020-07-20
PCT/US2021/033618 WO2022019998A1 (en) 2020-07-20 2021-05-21 Crystal forms of crenolanib and methods of use thereof
USPCT/US2021/033618 2021-05-21

Publications (1)

Publication Number Publication Date
CN113956245A true CN113956245A (zh) 2022-01-21

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ID=79291977

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110642513.2A Pending CN113956245A (zh) 2020-07-20 2021-06-09 克莱拉尼的晶型及其使用方法

Country Status (7)

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US (3) US11713310B2 (enExample)
EP (1) EP4181923A4 (enExample)
JP (2) JP2023536068A (enExample)
CN (1) CN113956245A (enExample)
CA (1) CA3186319A1 (enExample)
TW (2) TW202613103A (enExample)
WO (1) WO2022019998A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022019998A1 (en) 2020-07-20 2022-01-27 Arog Pharmaceuticals, Inc. Crystal forms of crenolanib and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
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CN1678604A (zh) * 2002-08-28 2005-10-05 辉瑞产品公司 可用作抗增殖剂的新苯并咪唑衍生物
CN1809556A (zh) * 2003-06-24 2006-07-26 辉瑞产品公司 1－[2－(苯并咪唑－1－基)喹啉－8－基]哌啶－4－基胺衍生物的制备方法
CN105294719A (zh) * 2015-11-18 2016-02-03 乳源瑶族自治县大众药品贸易有限公司 一种氨基喹唑啉类衍生物的二对甲苯磺酸盐及其晶型
CN105555272A (zh) * 2013-01-07 2016-05-04 Arog药物股份有限公司 用于治疗flt3突变型增殖性疾病的crenolanib

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AU744939B2 (en) 1997-09-26 2002-03-07 Merck & Co., Inc. Novel angiogenesis inhibitors
UA75055C2 (uk) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
US6960590B2 (en) 2000-10-17 2005-11-01 Merck & Co. Inc. Orally active salts with tyrosine kinase activity
TWI238824B (en) 2001-05-14 2005-09-01 Novartis Ag 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives
WO2003024969A1 (en) 2001-09-14 2003-03-27 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2003024931A1 (en) 2001-09-14 2003-03-27 Merck & Co., Inc. Tyrosine kinase inhibitors
TWI259081B (en) 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
PT1441737E (pt) 2001-10-30 2006-12-29 Dana Farber Cancer Inst Inc Derivados de estrutura como inibidores da actividade do receptor de tirosina cinase flt3
DE60205776T2 (de) 2001-12-27 2006-06-14 Theravance Inc Indolinon-derivative als protein-kinasehemmer
PE20040522A1 (es) 2002-05-29 2004-09-28 Novartis Ag Derivados de diarilurea dependientes de la cinasa de proteina
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
AU2003262642B2 (en) 2002-08-14 2010-06-17 Vertex Pharmaceuticals Incorporated Protein kinase inhibitors and uses thereof
EP2573079A3 (en) 2002-08-23 2015-03-11 Novartis AG Benzimidazole quinolinones and uses thereof
WO2004039782A1 (ja) 2002-10-29 2004-05-13 Kirin Beer Kabushiki Kaisha Ｆｌｔ３自己リン酸化を阻害するキノリン誘導体およびキナゾリン誘導体並びにそれらを含有する医薬組成物
SG148864A1 (en) 2002-11-13 2009-01-29 Chiron Corp Methods of treating cancer and related methods
AR042052A1 (es) 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
US7226919B2 (en) 2002-12-18 2007-06-05 Vertex Pharmaceuticals Inc. Compositions useful as inhibitors of protein kinases
JP6407504B2 (ja) 2012-09-21 2018-10-17 アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 恒常的に活性であるリン酸化型ｆｌｔ３キナーゼの阻害方法
US10835525B2 (en) 2012-09-26 2020-11-17 Arog Pharmaceuticals, Inc. Method of inhibiting mutant C-KIT
TWI599356B (zh) 2012-09-26 2017-09-21 安羅格製藥有限責任公司 抑制突變型ｃ－ｋｉｔ的方法
KR20180074792A (ko) 2016-11-02 2018-07-03 아로그 파마슈티칼스, 인코퍼레이티드 돌연변이 연관된 flt3 돌연변이된 증식성 장애를 치료하기 위한 크레노라닙
CN110840893A (zh) * 2018-12-13 2020-02-28 安罗格制药有限责任公司 含克莱拉尼的药物组合物及其用途
US11471451B2 (en) 2019-08-19 2022-10-18 Arog Pharmaceuticals, Inc. Uses of crenolanib
WO2022019998A1 (en) 2020-07-20 2022-01-27 Arog Pharmaceuticals, Inc. Crystal forms of crenolanib and methods of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1678604A (zh) * 2002-08-28 2005-10-05 辉瑞产品公司 可用作抗增殖剂的新苯并咪唑衍生物
CN1809556A (zh) * 2003-06-24 2006-07-26 辉瑞产品公司 1－[2－(苯并咪唑－1－基)喹啉－8－基]哌啶－4－基胺衍生物的制备方法
CN105555272A (zh) * 2013-01-07 2016-05-04 Arog药物股份有限公司 用于治疗flt3突变型增殖性疾病的crenolanib
CN105294719A (zh) * 2015-11-18 2016-02-03 乳源瑶族自治县大众药品贸易有限公司 一种氨基喹唑啉类衍生物的二对甲苯磺酸盐及其晶型

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Publication number Publication date
WO2022019998A1 (en) 2022-01-27
US11713310B2 (en) 2023-08-01
TWI905226B (zh) 2025-11-21
US20230339918A1 (en) 2023-10-26
JP2026116949A (ja) 2026-07-14
US20220017500A1 (en) 2022-01-20
JP2023536068A (ja) 2023-08-23
US20260159506A1 (en) 2026-06-11
US12486256B2 (en) 2025-12-02
CA3186319A1 (en) 2022-01-27
EP4181923A4 (en) 2024-08-07
EP4181923A1 (en) 2023-05-24
TW202216696A (zh) 2022-05-01
TW202613103A (zh) 2026-04-01

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