CN113908191A

CN113908191A - Composition for treating chloasma and preparation method thereof

Info

Publication number: CN113908191A
Application number: CN202111175953.8A
Authority: CN
Inventors: 杨业; 吴芳
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-10-09
Filing date: 2021-10-09
Publication date: 2022-01-11

Abstract

The invention discloses a composition for treating chloasma and a preparation method thereof, belonging to the technical field of chloasma treatment preparations and comprising the following steps: (1) preparing extraction paste; (2) steam flash explosion; (3) carrying out high-pressure homogenization treatment on the micro jet flow; (4) ultrasonic-ultraviolet-magnetic field coupling treatment. The application provides a composition for treating chloasma and its preparation method, at first the raw materials that this application was selected are mild traditional chinese medicine of sexual condition and vegetables fruit, the raw materials safety, secondly this application is through combining application cryrogenic crushing, cold plasma handles, steam flash explosion, microjet high pressure homogenization treatment, techniques such as ultrasonic wave, promote the fusion between each raw materials, improve the bioavailability of raw materials, promote the interact between the raw materials, in the time of disinfecting, refine the finished product, easily absorb, thereby be favorable to each raw materials to be mutually synergistic effect on skin more, has apparent treatment to chloasma.

Description

Composition for treating chloasma and preparation method thereof

Technical Field

The invention belongs to the technical field of chloasma treatment preparations, and particularly relates to a composition for treating chloasma and a preparation method thereof.

Background

Chloasma is a common pigmentation disease occurring on the face, skin plague is better caused by zygomatic crest and forehead, and the chloasma is represented by yellowish to dark brown patches which are symmetrical and limited on the face. Clinically, the disease is mostly seen in middle-aged and young women, but only in a few males. Chloasma patients generally have no subjective symptoms and mainly affect the appearance of the patients. The etiology and pathogenesis of the disease are not clear up to now, and the disease is generally considered to be clinically common and difficult to treat because the disease is continuously difficult to cure with endocrine dyscrasia, heredity, oxygen free radicals, ultraviolet irradiation, mental factors, various factors such as contraceptive use, external cosmetics and the like. The chloasma skin damage rarely causes pain or discomfort to a patient, but the facial appearance is affected due to the chloasma skin damage, a certain psychological pressure is brought to the patient, and the skin damage is further aggravated due to the adverse effect, so that a plurality of treatment methods have little effect. Nowadays, the research on reagents for treating chloasma is more and more intensive, various reagents and health care products for treating chloasma on the market are also endless, but a common problem exists, more chemical reagents can be added in the selection of raw materials, some potential safety hazards can exist after long-term use, and in addition, the treatment effect is general, the treatment is difficult to cure, and only the obvious effect can be achieved. Although many studies on preparation of preparations by using plant ingredients exist at present, the processing technology is usually a conventional leaching and stirring mixing mode, so that the bioavailability of raw materials is not high on one hand, and the absorption effect of finished products is poor on the other hand.

For example, application No. CN201710545256.4 discloses a chloasma-removing composition, application, a compound preparation and a preparation method thereof. The invention discloses a chloasma-removing composition, which uses nicotinamide to inhibit melanin formation, uses tranexamic acid to inhibit melanin aggregation and resist inflammation while inhibiting vasodilatation, uses camellia yunnanensis alcohol extract to inhibit melanin formation and relieve irritation while inhibiting histamine release, uses panax notoginseng saponins to improve blood vessel microcirculation and improve skin tolerance, and can well relieve or treat mixed chloasma in a long-acting manner after reasonable proportioning of four components. The invention also provides a chloasma-removing compound preparation, which can realize effective co-dissolution of nicotinamide, tranexamic acid, panax notoginseng saponins and camellia Yunnanensis alcohol extract in the compound preparation, thereby relieving or treating mixed chloasma in a long-acting manner under the combined action, has no irritation, ensures that patients with allergic constitution can use the chloasma-removing compound preparation, and does not generate phase separation when the compound preparation is stored at room temperature. The invention also provides a preparation method of the chloasma-removing compound preparation and application of the chloasma-removing composition. The invention uses more chemical additives, and has certain safety.

Disclosure of Invention

The invention aims to solve the existing problems and provides a composition for treating chloasma and a preparation method thereof.

The invention is realized by the following technical scheme:

a preparation method of a composition for treating chloasma comprises the following steps:

(1) preparing an extraction paste:

A. weighing 30-40 parts of chamomile, 30-40 parts of dandelion, 8-14 parts of ginkgo leaves and 8-12 parts of angelica dahurica in corresponding parts by weight, putting the components in a cryogenic grinder for grinding treatment, and obtaining mixed powder for later use;

B. placing the mixed powder obtained in the operation A into cold plasma equipment for cold plasma treatment, and taking out for later use after the cold plasma treatment is completed;

C. placing the mixed powder treated by the cold plasma in the operation B into a Soxhlet extraction device for reflux extraction, and collecting an extracting solution and filter residues for later use;

D. purifying and concentrating the extracting solution obtained in the operation C to obtain leaching paste for later use;

(2) steam flash explosion:

weighing 7-9 parts of gordon euryale seed, 5-7 parts of snakegourd seed, 4-7 parts of passion fruit pulp, 3-5 parts of snakegourd pulp, 1-2 parts of lotus plumule and 3-5 parts of lotus leaf in corresponding parts by weight, sequentially placing the components in a continuous flash explosion machine, carrying out continuous flash explosion treatment, and taking out the obtained product to obtain a mixture A for later use;

(3) carrying out micro-jet high-pressure homogenization treatment:

weighing 1-2 parts by weight of lemon, 6-10 parts by weight of banana peel, 18-20 parts by weight of peach gum, 20-30 parts by weight of cucumber and 9-13 parts by weight of okra, placing the obtained filter residue and extract obtained in the step (1) and the obtained mixture A in the step (2) in a micro-jet high-pressure homogenizer together for high-pressure homogenization treatment, and filtering to obtain a homogenized product for later use;

(4) ultrasonic-ultraviolet-magnetic field coupling treatment:

and (4) placing the homogeneous product obtained in the step (3) in an ultraviolet environment, then immersing an ultrasonic probe into the homogeneous product, starting ultrasonic waves, and simultaneously communicating a direct-current magnetic field to carry out ultrasonic-ultraviolet-magnetic field coupling treatment.

Further, the temperature of the pulverizer is controlled to be-12 to-4 ℃ during the pulverizing treatment in the operation A in the step (1), and the pulverizing treatment time is 30 to 38 min.

Further, the power of the cold plasma treatment in the operation B of the step (1) is 80-120W, and the time of the cold plasma treatment is 6-10 min.

Further, the pressure of the flash explosion treatment in the step (2) is 30-36 MPa, and the number of flash explosion treatment is 12-14.

Further, the working pressure is controlled to be 100-120 MPa during the high-pressure homogenization treatment in the step (3).

Further, in the step (4), the frequency of the ultrasonic wave is controlled to be 30-50 kHz, the wavelength of the ultraviolet wave is 200-400 nm, the power of the magnetic field is 1000-1300W, and the processing time is 20-30 min.

Compared with the prior art, the invention has the following advantages:

1. this application places chamomile, dandelion, ginkgo leaf etc. in cryrogenic formula rubbing crusher jointly according to suitable proportion, shredding under the low temperature condition, utilize cryrogenic kibbling advantage, obtain the homogeneity mixed powder that refines, and this operation can not cause active ingredient in the raw materials, especially loss of volatile component, then effect through cold plasma, improve mixed powder's surface wettability, improve its surface activity, improve the permeability of cell, promote it in leaching process, effective component's dissolving out, thereby improve the bioavailability of raw materials.

2. According to the continuous flash explosion machine, gordon euryale seed, snakegourd fruit seed, passion fruit pulp and the like are sequentially placed in the continuous flash explosion machine for continuous flash explosion treatment, technical parameters of the flash explosion treatment are adjusted according to the composition ratio of the raw materials, the polymerization degree of cellulose is reduced, the interface effect among the raw materials is weakened through high-pressure steam, and even the interface effect among the raw materials is completely eliminated, so that the fusion among the raw materials is further promoted.

3. This application arranges lemon, banana peel, peach gum in microjet high pressure homogenizer according to suitable proportion with leaching liquor, extraction cream, flash explosion product jointly in, carries out high-speed collision in the oscillation intracavity of homogenizer, cuts rapidly, to filter residue make full use of, can prevent the oxidation that high-speed shearing force and raw materials exist in this application, can also make the component that does not leach in the filter residue obtain make full use of, finally obtains the homogeneity product that the homogeneity refines.

4. The homogeneous product is subjected to ultrasonic-ultraviolet-magnetic field coupling treatment, and the finished product is refined and easy to absorb while sterilizing, so that the treatment effect is further improved. Moreover, the coupled treatment can well avoid the phenomenon that a single treatment mode causes damage to raw materials, and the finally prepared finished product has the purposes of always proliferating the melanocytes and lightening the pigmentation.

5. The application provides a composition for treating chloasma and its preparation method, at first the raw materials that this application was selected are mild traditional chinese medicine of sexual condition and vegetables fruit, the raw materials safety, secondly this application is through combining application cryrogenic crushing, cold plasma handles, steam flash explosion, microjet high pressure homogenization treatment, techniques such as ultrasonic wave, promote the fusion between each raw materials, improve the bioavailability of raw materials, promote the interact between the raw materials, in the time of disinfecting, refine the finished product, easily absorb, thereby be favorable to each raw materials to be mutually synergistic effect on skin more, has apparent treatment to chloasma.

Detailed Description

(1) preparing an extraction paste:

A. weighing 30-40 parts of chamomile, 30-40 parts of dandelion, 8-14 parts of ginkgo leaves and 8-12 parts of angelica dahurica in corresponding parts by weight, putting the components into a cryogenic grinder for grinding treatment, controlling the temperature of the grinder to be-12 to-4 ℃, and the time of the grinding treatment to be 30-38 min, thus obtaining mixed powder for later use;

B. placing the mixed powder obtained in the operation A into cold plasma equipment for cold plasma treatment, wherein the power is 80-120W, and taking out for later use after treatment for 6-10 min;

(2) steam flash explosion:

weighing 7-9 parts of gordon euryale seed, 5-7 parts of snakegourd seed, 4-7 parts of passion fruit pulp, 3-5 parts of snakegourd pulp, 1-2 parts of lotus plumule and 3-5 parts of lotus leaf in corresponding parts by weight, sequentially placing the components in a continuous flash explosion machine, and carrying out continuous flash explosion treatment under the pressure of 30-36 MPa for 12-14 times, and taking out the mixture A for later use;

(3) carrying out micro-jet high-pressure homogenization treatment:

weighing 1-2 parts by weight of lemon, 6-10 parts by weight of banana peel, 18-20 parts by weight of peach gum, 20-30 parts by weight of cucumber and 9-13 parts by weight of okra, placing the obtained filter residue and extract obtained in the step (1) and the obtained mixture A obtained in the step (2) in a micro-jet high-pressure homogenizer together for high-pressure homogenization treatment, wherein the working pressure is 100-120 MPa, and filtering to obtain a homogenized product for later use;

(4) ultrasonic-ultraviolet-magnetic field coupling treatment:

and (3) placing the homogeneous product obtained in the step (3) in an ultraviolet environment, then immersing an ultrasonic probe into the homogeneous product, starting ultrasonic waves, and simultaneously communicating a direct-current magnetic field to perform ultrasonic-ultraviolet-magnetic field coupling treatment, wherein the frequency of the ultrasonic waves is controlled to be 30-50 kHz, the wavelength of ultraviolet is controlled to be 200-400 nm, the power of the magnetic field is controlled to be 1000-1300W, and the treatment time is 20-30 min.

For further explanation of the present invention, reference will now be made to the following specific examples.

Example 1

(1) preparing an extraction paste:

A. weighing 30 parts of chamomile, 30 parts of dandelion, 8 parts of ginkgo leaves and 8 parts of angelica dahurica in corresponding parts by weight, putting the mixture into a deep-cooling pulverizer for pulverizing, controlling the temperature of the pulverizer to be-12 ℃, and the pulverizing time to be 30min, thus obtaining mixed powder for later use;

B. placing the mixed powder obtained in the operation A in cold plasma equipment for cold plasma treatment with the power of 80W, and taking out for later use after 6min of treatment;

(2) steam flash explosion:

weighing 7 parts of gordon euryale seed, 5 parts of snakegourd seed, 4 parts of passion fruit pulp, 3 parts of snakegourd pulp, 1 part of lotus plumule and 3 parts of lotus leaf in corresponding parts by weight, sequentially placing the components in a continuous flash explosion machine, and carrying out continuous flash explosion treatment under the pressure of 30MPa for 12 times, and taking out the components to obtain a mixture A for later use;

(3) carrying out micro-jet high-pressure homogenization treatment:

weighing 1 part of lemon, 6 parts of banana peel, 18 parts of peach gum, 20 parts of cucumber and 9 parts of okra in corresponding parts by weight, placing the mixture A obtained in the step (2) and the filter residue and the extracting solution obtained in the step (1) in a micro-jet high-pressure homogenizer together for high-pressure homogenization treatment, wherein the working pressure is 100MPa, and filtering to obtain a homogenized product for later use;

(4) ultrasonic-ultraviolet-magnetic field coupling treatment:

and (3) placing the homogenized product obtained in the step (3) in an ultraviolet environment, immersing an ultrasonic probe into the homogenized product, starting ultrasonic waves, and simultaneously communicating a direct-current magnetic field to perform ultrasonic-ultraviolet-magnetic field coupling treatment, wherein the frequency of the ultrasonic waves is controlled to be 30kHz, the wavelength of the ultraviolet waves is controlled to be 200nm, the power of the magnetic field is 1000W, and the treatment time is 20 min.

Example 2

(1) preparing an extraction paste:

A. weighing 35 parts of chamomile, 35 parts of dandelion, 11 parts of ginkgo leaves and 10 parts of angelica dahurica in corresponding parts by weight, putting the mixture into a deep-cooling pulverizer for pulverizing, controlling the temperature of the pulverizer to be-8 ℃, and the pulverizing time to be 34min, thus obtaining mixed powder for later use;

B. placing the mixed powder obtained in the operation A in cold plasma equipment for cold plasma treatment with the power of 100W, and taking out for later use after 8min of treatment;

(2) steam flash explosion:

weighing 8 parts of gordon euryale seed, 6 parts of snakegourd seed, 5.5 parts of passion fruit pulp, 4 parts of snakegourd pulp, 1.5 parts of lotus plumule and 4 parts of lotus leaf in corresponding parts by weight, sequentially placing the components in a continuous flash explosion machine, and carrying out continuous flash explosion treatment under the pressure of 33MPa for 13 times to obtain a mixture A for later use;

(3) carrying out micro-jet high-pressure homogenization treatment:

weighing 1.5 parts of lemon, 8 parts of banana peel, 19 parts of peach gum, 25 parts of cucumber and 11 parts of okra in corresponding parts by weight, placing the mixture in a micro-jet high-pressure homogenizer together, then placing the filter residue and the extracting solution obtained in the step (1) operation c and the mixture A obtained in the step (2) in the micro-jet high-pressure homogenizer together for high-pressure homogenization treatment, wherein the working pressure is 110MPa, and filtering to obtain a homogeneous product for later use;

(4) ultrasonic-ultraviolet-magnetic field coupling treatment:

and (3) placing the homogenized product obtained in the step (3) in an ultraviolet environment, immersing an ultrasonic probe into the homogenized product, starting ultrasonic waves, and simultaneously communicating a direct-current magnetic field to perform ultrasonic-ultraviolet-magnetic field coupling treatment, wherein the frequency of the ultrasonic waves is controlled to be 40kHz, the wavelength of the ultraviolet waves is 300nm, the power of the magnetic field is 1150W, and the treatment time is 25 min.

Example 3

(1) preparing an extraction paste:

A. weighing 40 parts of chamomile, 40 parts of dandelion, 14 parts of ginkgo leaves and 12 parts of angelica dahurica in corresponding parts by weight, putting the mixture into a cryogenic grinder for grinding treatment, controlling the temperature of the grinder to be-4 ℃, and the grinding treatment time to be 38min, thus obtaining mixed powder for later use;

B. placing the mixed powder obtained in the operation A in cold plasma equipment for cold plasma treatment with the power of 120W, and taking out for later use after 10min of treatment;

(2) steam flash explosion:

weighing corresponding parts by weight of gordon euryale seed 9 parts, snakegourd seed 7 parts, passion fruit pulp 7 parts, snakegourd pulp 5 parts, lotus plumule 2 parts and lotus leaf 5 parts, sequentially placing the components in a continuous flash explosion machine, and carrying out continuous flash explosion treatment under the pressure of 36MPa for 14 times, and taking out the components to obtain a mixture A for later use;

(3) carrying out micro-jet high-pressure homogenization treatment:

weighing 2 parts of lemon, 10 parts of banana peel, 20 parts of peach gum, 30 parts of cucumber and 13 parts of okra in corresponding parts by weight, placing the mixture A obtained in the step (2) and the filter residue and the extracting solution obtained in the step (1) in a micro-jet high-pressure homogenizer together for high-pressure homogenization treatment, wherein the working pressure is 120MPa, and filtering to obtain a homogenized product for later use;

(4) ultrasonic-ultraviolet-magnetic field coupling treatment:

and (3) placing the homogenized product obtained in the step (3) in an ultraviolet environment, immersing an ultrasonic probe into the homogenized product, starting ultrasonic waves, and simultaneously communicating a direct-current magnetic field to perform ultrasonic-ultraviolet-magnetic field coupling treatment, wherein the frequency of the ultrasonic waves is controlled to be 50kHz, the wavelength of the ultraviolet waves is 400nm, the power of the magnetic field is 1300W, and the treatment time is 30 min.

Example 4

(1) preparing an extraction paste:

B. placing the mixed powder obtained in the operation A into a Soxhlet extraction device for reflux extraction, and collecting an extracting solution and filter residues for later use;

C. purifying and concentrating the extracting solution obtained in the operation B to obtain leaching paste for later use;

(2) steam flash explosion:

(3) carrying out micro-jet high-pressure homogenization treatment:

(4) ultrasonic-ultraviolet-magnetic field coupling treatment:

Example 5

(1) preparing an extraction paste:

(2) carrying out micro-jet high-pressure homogenization treatment:

weighing 8 parts of gordon euryale seed, 6 parts of snakegourd seed, 5.5 parts of passion fruit pulp, 4 parts of snakegourd pulp, 1.5 parts of lotus plumule, 4 parts of lotus leaf, 1.5 parts of lemon, 8 parts of banana peel, 19 parts of peach gum, 25 parts of cucumber and 11 parts of okra in corresponding parts by weight, putting the filter residue and the extracting solution obtained in the operation c in the step (1) into a micro-jet high-pressure homogenizer for high-pressure homogenization treatment, wherein the working pressure is 110MPa, and filtering to obtain a homogenized product for later use;

(3) ultrasonic-ultraviolet-magnetic field coupling treatment:

and (3) placing the homogenized product obtained in the step (2) in an ultraviolet environment, immersing an ultrasonic probe into the homogenized product, starting ultrasonic waves, and simultaneously communicating a direct-current magnetic field to perform ultrasonic-ultraviolet-magnetic field coupling treatment, wherein the frequency of the ultrasonic waves is controlled to be 40kHz, the wavelength of the ultraviolet waves is 300nm, the power of the magnetic field is 1150W, and the treatment time is 25 min.

Example 6

(1) preparing an extraction paste:

C. placing the mixed powder treated by the cold plasma in the operation B into a Soxhlet extraction device for reflux extraction, and collecting an extracting solution for later use;

(2) steam flash explosion:

(3) carrying out micro-jet high-pressure homogenization treatment:

weighing 1.5 parts of lemon, 8 parts of banana peel, 19 parts of peach gum, 25 parts of cucumber and 11 parts of okra in corresponding parts by weight, placing the components in a micro-jet high-pressure homogenizer together, then placing the mixture A obtained in the step (2) in the micro-jet high-pressure homogenizer together for high-pressure homogenization treatment, wherein the working pressure is 110MPa, and filtering to obtain a homogenized product for later use;

(4) ultrasonic-ultraviolet-magnetic field coupling treatment:

Example 7

(1) preparing an extraction paste:

(2) steam flash explosion:

(3) homogenizing:

weighing 1.5 parts of lemon, 8 parts of banana peel, 19 parts of peach gum, 25 parts of cucumber and 11 parts of okra in corresponding parts by weight, placing the obtained filter residue and extracting solution obtained in the step (1) and the obtained mixture A in the step (2) in a homogenizer together for normal-pressure homogenization treatment, wherein the working pressure is 110MPa, and filtering to obtain a homogenized product for later use;

(4) ultrasonic-ultraviolet-magnetic field coupling treatment:

Example 8

(1) preparing an extraction paste:

(2) steam flash explosion:

(3) carrying out micro-jet high-pressure homogenization treatment:

(4) ultrasonic treatment:

and (3) immersing an ultrasonic probe into the homogenized product, starting ultrasonic waves, and carrying out ultrasonic treatment, wherein the frequency of the ultrasonic waves is controlled to be 40kHz, and the treatment time is 25 min.

Example 9

(1) preparing an extraction paste:

(2) steam flash explosion:

(3) carrying out micro-jet high-pressure homogenization treatment:

(4) ultraviolet treatment:

and (4) placing the homogeneous product obtained in the step (3) in an ultraviolet environment, wherein the wavelength of ultraviolet is 300nm, and the treatment time is 25 min.

Example 10

(1) preparing an extraction paste:

(2) steam flash explosion:

(3) carrying out micro-jet high-pressure homogenization treatment:

(4) magnetic field treatment:

and (4) communicating a direct-current magnetic field to perform magnetic field treatment on the homogeneous product obtained in the step (3), controlling the power of the magnetic field to 1150W, and controlling the treatment time to be 25 min.

Example 11

(1) preparing an extraction paste:

(2) steam flash explosion:

(3) carrying out micro-jet high-pressure homogenization treatment:

(4) ultrasonic-ultraviolet coupling treatment:

and (3) placing the homogenized product obtained in the step (3) in an ultraviolet environment, then immersing an ultrasonic probe into the homogenized product, starting ultrasonic waves, and performing ultrasonic-ultraviolet coupling treatment, wherein the frequency of the ultrasonic waves is controlled to be 40kHz, the wavelength of the ultraviolet waves is 300nm, and the treatment time is 25 min.

Example 12

(1) preparing an extraction paste:

(2) steam flash explosion:

(3) carrying out micro-jet high-pressure homogenization treatment:

(4) ultrasonic-magnetic field coupling treatment:

and immersing an ultrasonic probe into the homogeneous product, starting ultrasonic waves, and communicating a direct-current magnetic field to perform ultrasonic-magnetic field coupling treatment, wherein the frequency of the ultrasonic waves is controlled to be 40kHz, the power of the magnetic field is 1150W, and the treatment time is 25 min.

Example 13

(1) preparing an extraction paste:

(2) steam flash explosion:

(3) carrying out micro-jet high-pressure homogenization treatment:

(4) ultraviolet-magnetic field coupling treatment:

and (4) placing the homogeneous product obtained in the step (3) in an ultraviolet environment, and then communicating a direct-current magnetic field to perform ultraviolet-magnetic field coupling treatment, wherein the wavelength of ultraviolet is controlled to be 300nm, the power of the magnetic field is 1150W, and the treatment time is 25 min.

Example 14

(1) preparing an extraction paste:

(2) steam flash explosion:

(3) carrying out micro-jet high-pressure homogenization treatment:

weighing 1.5 parts of lemon, 8 parts of banana peel, 19 parts of peach gum, 25 parts of cucumber and 11 parts of okra in corresponding parts by weight, placing the mixture in a micro-jet high-pressure homogenizer together, then placing the filter residue and the extracting solution obtained in the step (1) and the mixture A obtained in the step (2) in the micro-jet high-pressure homogenizer together for high-pressure homogenization treatment, wherein the working pressure is 110MPa, and filtering.

Control group

The application numbers are: CN201710545256.4 discloses a chloasma-removing composition, an application, a compound preparation and a preparation method thereof.

In order to compare the technical effects of the present application, the compositions were prepared by the methods of the above examples 2, 4 to 14 and the control group, respectively, and then the functional tests were performed, specifically:

first, evaluation of storage stability:

the compositions prepared in examples 2, 4 to 14 and the control method were put into storage tubes, respectively, and stored at 0 ℃, room temperature and 50 ℃ for 3 months, and then the tubes were opened to evaluate the storage stability of the toothpaste according to the following criteria.

Evaluation criteria for storage stability: first-stage: the separation of liquid can not be seen at all after 8-10 minutes; and (2) second stage: slightly see the separation of liquid in 5-7 minutes; third-stage: the separation of the liquid is clearly seen in 1-4 minutes.

The specific experimental comparative data are shown in the following table 1:

TABLE 1

	Score of
		Example 2	10
Example 4	9.2
		Example 5	8.5
Example 6	9.8
		Example 7	6.8
Example 8	8.9
		Example 9	9.2
Example 10	5.6
		Example 11	9.3
Example 12	9.7
		Example 13	9.1
Example 14	4.8
		Control group	6.8

As can be seen from the above table 1, the raw materials of the composition are reasonably matched, the reasonable preparation method is adopted to promote the homogeneous fusion of the raw materials, and the finally prepared finished product has good storage stability, so that the shelf life of the composition is prolonged to a great extent.

Second, testing the usage effect

210 testers with 30-50 years old and obvious hyperpigmentation on the face and neck are selected, then the selected testers are randomly divided into 16 groups with equal quality and quantity, each group of 30 testers is provided, after each tester thoroughly cleans the skin every day, the composition correspondingly prepared by each formula method is correspondingly and uniformly smeared on the skin with chloasma, the skin is gently flapped and used once in the morning and evening, each 28 days is a treatment course, 3 treatment courses are used, and then the using effect is judged.

Specific experimental comparison data are shown in table 2 below.

TABLE 2

Note: the effect is shown: the chloasma of the user is almost completely removed. The subjects have no allergy or other toxic and side effects; the method has the following advantages: the chloasma of a user is improved to some extent; and (4) invalidation: the chloasma of a user is not reduced and is not improved.

As can be seen from table 1 above, no allergy or other toxic and side effects occur in the process of using the composition prepared by the method of the present application, the effective rate is as high as 93.3%, and chloasma can be significantly improved.

Claims

1. A preparation method of a composition for treating chloasma is characterized by comprising the following steps:

(1) preparing an extraction paste:

(2) steam flash explosion:

(3) carrying out micro-jet high-pressure homogenization treatment:

(4) ultrasonic-ultraviolet-magnetic field coupling treatment:

2. The method for preparing a composition for treating chloasma according to claim 1, wherein the temperature of the pulverizer is controlled to be-12 to-4 ℃ during the pulverization treatment in the operation A of the step (1), and the pulverization treatment time is 30 to 38 min.

3. The method for preparing a composition for treating chloasma according to claim 1, wherein the power of the cold plasma treatment in the operation B of the step (1) is 80-120W, and the time of the cold plasma treatment is 6-10 min.

4. The method for preparing the composition for treating chloasma according to claim 1, wherein the pressure of the flash explosion treatment in the step (2) is 30-36 MPa, and the number of the flash explosion treatments is 12-14.

5. The method for preparing a composition for treating chloasma according to claim 1, wherein the working pressure during the high-pressure homogenization treatment in the step (3) is controlled to be 100 to 120 MPa.

6. The method for preparing the composition for treating chloasma according to claim 1, wherein the ultrasonic wave-ultraviolet-magnetic field coupling treatment in the step (4) is performed by controlling the frequency of the ultrasonic wave to be 30 to 50kHz, the wavelength of the ultraviolet wave to be 200 to 400nm, the power of the magnetic field to be 1000 to 1300W, and the treatment time to be 20 to 30 min.

7. A composition for treating chloasma, characterized by being prepared according to any one of claims 1 to 6.