CN111939099A - Acne-removing moisturizing mask and preparation method thereof - Google Patents
Acne-removing moisturizing mask and preparation method thereof Download PDFInfo
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- CN111939099A CN111939099A CN202010919408.4A CN202010919408A CN111939099A CN 111939099 A CN111939099 A CN 111939099A CN 202010919408 A CN202010919408 A CN 202010919408A CN 111939099 A CN111939099 A CN 111939099A
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- sodium alginate
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- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 63
- 206010000496 acne Diseases 0.000 title claims abstract description 63
- 238000002360 preparation method Methods 0.000 title claims abstract description 38
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 33
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 83
- 239000000243 solution Substances 0.000 claims abstract description 62
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- 239000000661 sodium alginate Substances 0.000 claims abstract description 56
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 53
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of preparation of skin care products, and particularly relates to an acne-removing moisturizing mask and a preparation method thereof, wherein micromolecular sodium alginate is added into an aqueous extracting solution, stirred until the micromolecular sodium alginate is completely dissolved, and then skipjack elastin peptide, nisin and chlorella fermentation products are added, and ultrasonic oscillation is performed uniformly to obtain a mixed solution, namely phase A; then dispersing the oily extracting solution in denatured ethyl acetate to obtain a phase B; and slowly dripping the phase A into the phase B, homogenizing to obtain a spinning solution, and carrying out electrostatic spinning and post-treatment to obtain the mask product. The components in the facial mask have small molecular weight, good permeability, good air permeability, and good acne removing and moisturizing effects, and can be completely absorbed by skin.
Description
Technical Field
The invention belongs to the technical field of skin care product preparation. More particularly, relates to an acne-removing moisturizing mask and a preparation method thereof.
Background
Acne is commonly known as acne, also called as face blister, acne, wine thorn, acne and the like, and is a chronic inflammatory skin disease caused by inflammation due to the blockage of hair follicles and sebaceous glands. In adolescence, the level of male hormone is increased to stimulate sebaceous glands, so that sebum secretion function is abnormal and active, excessive sebum cannot be discharged in time, and stasis is accumulated in hair follicles to form lipid plugs. Since the symptom is common to young men and women, it is called "whelk". In fact, teenagers do not always have whelks, and the whelks do not always appear on the teenagers. Because the existing environment is seriously polluted, dust and the like in the air are directly contacted with the facial skin, the skin is easily adsorbed on the skin to block pores, and the computer radiation source influences the disorder of the endocrine system of a human body, so that the skin metabolism is irregular; the breeding of the acne can be caused by irregular diet, poor sleep, pressure and the like. Acne seriously affects beauty and life, so the acne-removing skin care product is favored by consumers for more and more years.
Acne removal is a comprehensive process that needs to satisfy several aspects: firstly, regulating oil secretion and improving the skin keratinization process; secondly, inhibiting the activity of acne bacillus, diminishing inflammation and promoting the healing of wound, and thirdly, the acne bacillus can play a role only by penetrating below the horny layer.
The existing acne removing methods have various methods, such as a method for treating acne by laser, which can rapidly destroy the propionibacterium acnes, effectively inhibit bacterial reproduction, and eliminate stimulation and destruction on tissues, but the laser treatment effect is too strong, and the acne is only destroyed by a physical method, so that the acne cannot be removed fundamentally; the existing acne removing method is safe and can play a role in regulating skin grease so as to remove acnes fundamentally, but the acne removing time is long, marks after the acne removing are not easy to completely remove, and the formula is to be improved; the acne is removed by using some western medicines such as salicylic acid, prednisone, dexamethasone and the like, and the western medicines have strong side effects and high cost.
In addition, the problem that the skin is very easy to neglect is also solved, the skin basic moisture retention is beneficial to improving the acne removing effect, the skin is drier and oily, fat particles are easily formed to block pores, acne caused by acne is formed, the skin can be effectively controlled to produce oil after the skin is fully moisturized, the skin can reach a water-oil balance health state, and water is the best 'scavenger' and helps to dredge the pores, soften the horny layer and enable the skin to have a good acne removing environment.
The facial mask temporarily isolates outside air and pollution by using a short time of covering the facial mask, the skin temperature is increased, the skin pore expansion is promoted, the sweat gland secretion and metabolism are promoted, the oxygen content of the skin is increased, the skin is favorable for removing products of epidermal cell metabolism and accumulated grease substances, the moisture in the facial mask permeates into the horny layer of the skin epidermis, the skin becomes soft, and the elasticity is increased. Therefore, the mask for removing acnes and moisturizing is a good choice, but the existing mask for removing acnes and moisturizing on the market is slow in effectiveness, and most mask products are pasted by base cloth and are poor in air permeability, so that the mask is adverse to removing acnes and moisturizing.
Disclosure of Invention
The invention aims to solve the technical problems of poor air permeability and poor acne removing and moisturizing effects of the existing acne removing and moisturizing mask and provides an acne removing and moisturizing mask and a preparation method thereof.
The invention aims to provide a preparation method of an acne-removing moisturizing mask.
The invention also aims to provide the acne-removing moisturizing mask prepared by the preparation method.
The above purpose of the invention is realized by the following technical scheme:
a preparation method of an acne-removing moisturizing mask comprises the steps of adding 1 part of small-molecular sodium alginate into an aqueous extracting solution by weight, stirring until the small-molecular sodium alginate is completely dissolved, adding 2-3 parts of skipjack elastin peptide, 1-1.5 parts of nisin and 0.8-1 part of chlorella fermentation product, and uniformly oscillating by ultrasonic waves to obtain a mixed solution, namely phase A; then dispersing the oily extracting solution in 5-8 parts of modified ethyl acetate to obtain a phase B; slowly dripping the phase A into the phase B, homogenizing to obtain spinning solution, performing electrostatic spinning, and performing post-treatment to obtain the acne-removing moisturizing facial mask; wherein the aqueous extract and the oily extract are prepared by the following method:
(1) firstly, crushing 15-20 parts of peel of fresh grapefruit, 2-3 parts of pepper and 1-2 parts of platycodon grandiflorum in a freezing wall-breaking mode respectively, and mixing to obtain mixed powder;
(2) and then pouring the mixed powder into deionized water with the weight of 8-10 times, heating, extracting, filtering to obtain an extracting solution, and performing oil-water separation to obtain an oily extracting solution and a water-based extracting solution.
Preferably, the preparation method of the small-molecule sodium alginate comprises the following steps: adding 1 part by weight of macromolecular sodium alginate into 75-85 parts by weight of deionized water at 75-80 ℃, stirring until the macromolecular sodium alginate is completely dissolved, then adding 0.4-0.6 part by weight of hydrogen peroxide, stirring and reacting at 60-70 ℃ for 20-22 hours, and carrying out alcohol precipitation to obtain the micromolecular sodium alginate; the weight average molecular weight of the macromolecular sodium alginate is 300-500 kDa.
Further preferably, the alcohol precipitation is carried out by adding absolute ethyl alcohol twice the volume of the reaction solution, precipitating, and centrifuging.
Preferably, the denatured ethyl acetate is prepared by the following method: adding 0.06-0.08 part of butanediol and 0.1-0.2 part of citric acid into 1 part of ethyl acetate by weight, and carrying out ultrasonic oscillation for 30-50 minutes to obtain the modified ethyl acetate. The dispersion of the phytosterol and the oily extracting solution can be realized by utilizing the ethyl acetate, but the ethyl acetate is volatile and can take away skin moisture, and the volatility can be reduced by adding butanediol, citric acid and the like.
Preferably, the dropping time of the phase A is 45-55 minutes.
Preferably, the process conditions of the homogenization treatment are as follows: homogenizing for 5-8 times by a high-pressure homogenizer under the conditions of 150-180 MPa and 50-60 ℃.
Preferably, the specific method of electrostatic spinning is as follows: the wire outlet is a No. 6 needle head, the voltage is 13-16 kV, the distance from the spray head to the receiver is 20-22 cm, the spray flow is 0.8-1 ml/h, and the relative humidity is lower than 40%.
Preferably, the post-treatment method comprises the following steps: and cutting the fiber membrane obtained by electrostatic spinning according to the shape of the required facial membrane, performing ultraviolet disinfection, and packaging.
Preferably, in the step (1), the peel of the fresh grapefruit is firstly cut into fruit peel shreds, so that the length is 2-4 cm, and the thickness is 1-2 mm.
Preferably, in the step (1), the specific method for freezing wall breaking is as follows: freezing the material to-20-25 ℃, transferring the material to a ball mill, and ball-milling the material by using the ball mill in a cooling gas atmosphere; wherein the temperature of the cooling gas is-20 to-25 ℃, the size of the grinding ball is 3 to 5mm, and the ball milling time is 2 to 3 hours.
Preferably, in the step (2), the extraction process conditions are as follows: heating and extracting for 15-20 minutes under the conditions of 0.1-0.2 MPa and 70-80 ℃.
The acne-removing moisturizing mask is prepared by the preparation method.
The invention has the following beneficial effects:
adding small-molecular sodium alginate into an aqueous extracting solution, stirring until the small-molecular sodium alginate is completely dissolved, adding skipjack elastin peptide, nisin and chlorella fermentation products, and uniformly oscillating by ultrasonic waves to obtain a mixed solution, namely an A phase; then dispersing the oily extracting solution in denatured ethyl acetate to obtain a phase B; and slowly dripping the phase A into the phase B, homogenizing to obtain a spinning solution, and carrying out electrostatic spinning and post-treatment to obtain the mask product. The components in the mask can directly permeate into the skin muscle base due to small molecular weight and can be completely absorbed by the skin, and tests prove that the components synergistically generate good acne removing and moisturizing effects.
1. The facial mask of the invention can be gradually dissolved and absorbed by the facial skin after being applied to the face, and more holes are generated along with the dissolution of the facial mask, so the air permeability is good. On one hand, the moisturizing and acne-removing effects are synergistically exerted through the absorption of all the components, and on the other hand, the problems of facial skin moisture loss, acne tightness and the like are effectively avoided due to good air permeability.
2. The invention adopts fat-soluble phase B to be included with water-soluble phase A, which is easier to be absorbed by skin, wherein the phase B is obtained by dispersing an oily extracting solution in denatured ethyl acetate. The oily extracting solution is extracted from peel of fresh grapefruit, pepper and platycodon grandiflorum, contains flavonoid bioactive substances such as grapefruit essential oil and grapefruit pericin, has a good antioxidation effect, promotes regular metabolism of skin, fundamentally improves the acne-removing and moisture-preserving effects, can block free radicals generated by peroxidation of substances in the skin while sterilizing and removing acne, prevents premature aging of the skin, repairs damaged cell tissues and effectively removes acne marks; the platycodon grandiflorum contains saponin, in the chemical structure of the saponin, aglycon has lipophilicity of different degrees, and sugar chains have strong hydrophilicity, so that the saponin becomes a surfactant, the phase A is dropwise added into the phase B to be fully emulsified, and a nanoparticle emulsion is formed by combining homogenization treatment, so that the nanoparticle emulsion is beneficial to skin absorption, and the platycodon grandiflorum can reduce anaphylactic reaction, enhance the sterilization effect and further improve the acne-removing and moisturizing effects; the tetrahydropiperine brought by the pepper is a natural skin penetration enhancer, is safe and efficient, and can help other active ingredients to be effectively absorbed by the skin in a short time.
3. The micromolecular sodium alginate in the phase A can effectively increase the water retention of the skin, is completely absorbed by the skin, improves the immune protection effect of the skin, repairs acne marks, and plays a role in removing acnes and moisturizing. Hydroxyl in the micromolecular sodium alginate and amino, carboxyl and the like in the skipjack elastin peptide and the nisin form hydrogen bond action, so that the mechanical property of the mask is greatly enhanced, and the mask is prevented from being damaged due to pulling in use.
4. The extraction source of the skipjack elastin peptide is the skipjack heart, the skipjack elastin peptide is composed of 2-20 amino acids, belongs to elastin peptide, and has the effects of promoting skin injury repair, blood vessel regeneration, promoting fibroblast proliferation and the like; the nisin is a small peptide consisting of 34 amino acids, and has strong inhibiting effect on gram-positive bacteria and the like. On one hand, the small molecular peptide has a better nutritional effect on the skin, has small molecular weight and is easy to absorb, and on the other hand, the sterilization and skin injury repair effects are beneficial to improving the acne removal effect.
5. The chlorella fermentation product is obtained by fermenting chlorella, is rich in protein, unsaturated fatty acid and various vitamins, and can promote skin metabolism, activate human cells, repair damaged genes, promote tissue growth, delay aging, eliminate free radicals in vivo, and further enhance the effects of removing acne and moisturizing.
Detailed Description
The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.
Unless otherwise indicated, reagents and materials used in the following examples are commercially available.
The bonito elastin peptide is purchased from Shanxi Yikang dragon biotechnology limited company, and the raw material source of the bonito elastin peptide is imported from Japan.
Example 1
A preparation method of a facial mask for removing acne and keeping moisture comprises adding 1kg of small molecular sodium alginate into aqueous extract, stirring to dissolve completely, adding 2kg of skipjack elastin peptide, 1.5kg of nisin and 0.8kg of chlorella fermentation product, and performing ultrasonic oscillation to obtain a mixed solution A; then dispersing the oily extracting solution in 8kg of modified ethyl acetate to obtain a phase B; slowly dripping the phase A into the phase B, homogenizing to obtain spinning solution, performing electrostatic spinning, and performing post-treatment to obtain the acne-removing moisturizing facial mask; wherein the aqueous extract and the oily extract are prepared by the following method:
(1) firstly, respectively crushing 15kg of peel of fresh grapefruit, 3kg of pepper and 1kg of platycodon grandiflorum in a freezing wall-breaking mode, and mixing to obtain mixed powder;
(2) then pouring the mixed powder into deionized water with the weight of 10 times, heating and extracting, filtering to obtain an extracting solution, and performing oil-water separation to obtain an oily extracting solution and a water-based extracting solution.
The preparation method of the micromolecular sodium alginate comprises the following steps: firstly, adding 1kg of macromolecular sodium alginate into 85kg of deionized water at 75 ℃, stirring until the macromolecular sodium alginate is completely dissolved, then adding 0.4kg of hydrogen peroxide, stirring and reacting for 20 hours at 70 ℃, and precipitating with ethanol to obtain the micromolecular sodium alginate; the weight average molecular weight of the macromolecular sodium alginate is 500 kDa.
The specific method of alcohol precipitation is to add absolute ethyl alcohol with the volume twice of the reaction solution, precipitate and centrifuge.
The preparation method of the denatured ethyl acetate comprises the following steps: adding 0.06kg of butanediol and 0.2kg of citric acid into 1kg of ethyl acetate, and carrying out ultrasonic oscillation for 30 minutes to obtain the modified ethyl acetate.
The dropping time of the A phase was 55 minutes.
The process conditions of the homogenization treatment are as follows: homogenizing at 150MPa and 60 deg.C for 5 times by high pressure homogenizer.
The specific method of electrostatic spinning is as follows: the wire outlet is a No. 6 needle head, the voltage is 16kV, the distance from the spray head to the receiver is 20cm, the spray flow is 1ml/h, and the relative humidity is lower than 40%.
The specific method of post-treatment is as follows: cutting the fiber membrane (thickness 0.3mm) obtained by electrostatic spinning according to the shape of the required facial membrane, performing ultraviolet disinfection, and packaging.
In the step (1), the peel of the fresh grapefruit is firstly cut into fruit peel shreds, so that the length is 2cm and the thickness is 2 mm.
In the step (1), the specific method for freezing and breaking the wall comprises the following steps: freezing the materials to-20 ℃, transferring the materials to a ball mill, and ball-milling the materials by using a grinding ball in a cooling gas atmosphere; wherein the temperature of the cooling gas is-20 ℃, the size of the grinding ball is 5mm, and the ball milling time is 2 hours.
In the step (2), the extraction process conditions are as follows: extracting under 0.2MPa and 70 deg.C for 20 min.
Example 2
A preparation method of a facial mask for removing acne and keeping moisture comprises adding 1kg of small molecular sodium alginate into aqueous extractive solution, stirring to dissolve completely, adding 3kg of skipjack elastin peptide, 1kg of nisin and 1kg of chlorella fermentation product, and performing ultrasonic oscillation to obtain mixed solution A; then dispersing the oily extracting solution in 5kg of modified ethyl acetate to obtain a phase B; slowly dripping the phase A into the phase B, homogenizing to obtain spinning solution, performing electrostatic spinning, and performing post-treatment to obtain the acne-removing moisturizing facial mask; wherein the aqueous extract and the oily extract are prepared by the following method:
(1) firstly, 20kg of peel of fresh grapefruit, 2kg of pepper and 2kg of platycodon grandiflorum are respectively crushed in a freezing wall-breaking mode and mixed to obtain mixed powder;
(2) then pouring the mixed powder into deionized water with the weight of 8 times, heating and extracting, filtering to obtain an extracting solution, and performing oil-water separation to obtain an oily extracting solution and a water-based extracting solution.
The preparation method of the micromolecular sodium alginate comprises the following steps: firstly, adding 1kg of macromolecular sodium alginate into 75kg of deionized water at the temperature of 80 ℃, stirring until the macromolecular sodium alginate is completely dissolved, then adding 0.6kg of hydrogen peroxide, stirring and reacting for 22 hours at the temperature of 60 ℃, and precipitating with ethanol to obtain the micromolecular sodium alginate; the weight average molecular weight of the macromolecular sodium alginate is 300 kDa.
The specific method of alcohol precipitation is to add absolute ethyl alcohol with the volume twice of the reaction solution, precipitate and centrifuge.
The preparation method of the denatured ethyl acetate comprises the following steps: adding 0.08kg of butanediol and 0.1kg of citric acid into 1kg of ethyl acetate, and oscillating for 50 minutes by ultrasonic waves to obtain the denatured ethyl acetate.
The dropping time of the A phase was 45 minutes.
The process conditions of the homogenization treatment are as follows: homogenizing for 8 times at 180MPa and 50 deg.C with a high pressure homogenizer.
The specific method of electrostatic spinning is as follows: the wire outlet is a No. 6 needle head, the voltage is 13kV, the distance from the spray head to the receiver is 22cm, the spray flow is 0.8ml/h, and the relative humidity is lower than 40%.
The specific method of post-treatment is as follows: cutting the fiber membrane (thickness 0.3mm) obtained by electrostatic spinning according to the shape of the required facial membrane, performing ultraviolet disinfection, and packaging.
In the step (1), the peel of the fresh grapefruit is firstly cut into fruit peel shreds, so that the length is 4cm and the thickness is 1 mm.
In the step (1), the specific method for freezing and breaking the wall comprises the following steps: freezing the materials to-25 ℃, transferring the materials to a ball mill, and ball-milling the materials by using a grinding ball in a cooling gas atmosphere; wherein the temperature of the cooling gas is-25 ℃, the size of the grinding ball is 3mm, and the ball milling time is 3 hours.
In the step (2), the extraction process conditions are as follows: extracting under 0.1MPa and 80 deg.C for 15 min.
Example 3
A preparation method of a facial mask for removing acne and keeping moisture comprises adding 1kg of small molecular sodium alginate into aqueous extract, stirring to dissolve completely, adding 2.5kg of skipjack elastin peptide, 1.3kg of nisin and 0.9kg of chlorella fermentation product, and performing ultrasonic oscillation to obtain mixed solution A; then dispersing the oily extracting solution in 6kg of modified ethyl acetate to obtain a phase B; slowly dripping the phase A into the phase B, homogenizing to obtain spinning solution, performing electrostatic spinning, and performing post-treatment to obtain the acne-removing moisturizing facial mask; wherein the aqueous extract and the oily extract are prepared by the following method:
(1) firstly, 18kg of peel of fresh grapefruit, 2.5kg of pepper and 1.5kg of platycodon grandiflorum are respectively crushed in a freezing wall-breaking mode and mixed to obtain mixed powder;
(2) then pouring the mixed powder into deionized water with the weight of 9 times, heating and extracting, filtering to obtain an extracting solution, and performing oil-water separation to obtain an oily extracting solution and a water-based extracting solution.
The preparation method of the micromolecular sodium alginate comprises the following steps: firstly, adding 1kg of macromolecular sodium alginate into 80kg of deionized water at 78 ℃, stirring until the macromolecular sodium alginate is completely dissolved, then adding 0.5kg of hydrogen peroxide, stirring and reacting for 21 hours at 65 ℃, and precipitating with ethanol to obtain the micromolecular sodium alginate; the weight average molecular weight of the macromolecular sodium alginate is 400 kDa.
The specific method of alcohol precipitation is to add absolute ethyl alcohol with the volume twice of the reaction solution, precipitate and centrifuge.
The preparation method of the denatured ethyl acetate comprises the following steps: adding 0.07kg of butanediol and 0.15kg of citric acid into 1kg of ethyl acetate, and oscillating for 40 minutes by ultrasonic waves to obtain the denatured ethyl acetate.
The dropping time of the A phase was 50 minutes.
The process conditions of the homogenization treatment are as follows: homogenizing for 6 times at 160MPa and 55 deg.C with a high pressure homogenizer.
The specific method of electrostatic spinning is as follows: the wire outlet is a No. 6 needle head, the voltage is 15kV, the distance from the spray head to the receiver is 21cm, the spray flow is 0.9ml/h, and the relative humidity is lower than 40%.
The specific method of post-treatment is as follows: cutting the fiber membrane (thickness 0.3mm) obtained by electrostatic spinning according to the shape of the required facial membrane, performing ultraviolet disinfection, and packaging.
In the step (1), the peel of the fresh grapefruit is firstly cut into fruit peel shreds, so that the length is 3cm and the thickness is 1.5 mm.
In the step (1), the specific method for freezing and breaking the wall comprises the following steps: freezing the materials to-22 ℃, transferring the materials to a ball mill, and ball-milling the materials by using a grinding ball in a cooling gas atmosphere; wherein the temperature of the cooling gas is-22 ℃, the size of the grinding ball is 4mm, and the ball milling time is 2.5 hours.
In the step (2), the extraction process conditions are as follows: extracting under 0.15MPa and 75 deg.C for 18 min.
Comparative example 1
A preparation method of facial mask comprises adding 1kg of small molecule sodium alginate into aqueous extractive solution, stirring to dissolve completely, adding 2kg of skipjack elastin peptide and 0.8kg of chlorella fermentation product, and ultrasonic oscillating to obtain mixed solution as phase A; then dispersing the oily extracting solution in 8kg of modified ethyl acetate to obtain a phase B; slowly dripping the phase A into the phase B, homogenizing to obtain spinning solution, performing electrostatic spinning, and performing post-treatment to obtain a facial mask; wherein the aqueous extract and the oily extract are prepared by the following method:
(1) firstly, respectively crushing 15kg of peel of fresh grapefruit, 3kg of pepper and 1kg of platycodon grandiflorum in a freezing wall-breaking mode, and mixing to obtain mixed powder;
(2) then pouring the mixed powder into deionized water with the weight of 10 times, heating and extracting, filtering to obtain an extracting solution, and performing oil-water separation to obtain an oily extracting solution and a water-based extracting solution.
The preparation method of the micromolecular sodium alginate comprises the following steps: firstly, adding 1kg of macromolecular sodium alginate into 85kg of deionized water at 75 ℃, stirring until the macromolecular sodium alginate is completely dissolved, then adding 0.4kg of hydrogen peroxide, stirring and reacting for 20 hours at 70 ℃, and precipitating with ethanol to obtain the micromolecular sodium alginate; the weight average molecular weight of the macromolecular sodium alginate is 500 kDa.
The specific method of alcohol precipitation is to add absolute ethyl alcohol with the volume twice of the reaction solution, precipitate and centrifuge.
The preparation method of the denatured ethyl acetate comprises the following steps: adding 0.06kg of butanediol and 0.2kg of citric acid into 1kg of ethyl acetate, and carrying out ultrasonic oscillation for 30 minutes to obtain the modified ethyl acetate.
The dropping time of the A phase was 55 minutes.
The process conditions of the homogenization treatment are as follows: homogenizing at 150MPa and 60 deg.C for 5 times by high pressure homogenizer.
The specific method of electrostatic spinning is as follows: the wire outlet is a No. 6 needle head, the voltage is 16kV, the distance from the spray head to the receiver is 20cm, the spray flow is 1ml/h, and the relative humidity is lower than 40%.
The specific method of post-treatment is as follows: cutting the fiber membrane (thickness 0.3mm) obtained by electrostatic spinning according to the shape of the required facial membrane, performing ultraviolet disinfection, and packaging.
In the step (1), the peel of the fresh grapefruit is firstly cut into fruit peel shreds, so that the length is 2cm and the thickness is 2 mm.
In the step (1), the specific method for freezing and breaking the wall comprises the following steps: freezing the materials to-20 ℃, transferring the materials to a ball mill, and ball-milling the materials by using a grinding ball in a cooling gas atmosphere; wherein the temperature of the cooling gas is-20 ℃, the size of the grinding ball is 5mm, and the ball milling time is 2 hours.
In the step (2), the extraction process conditions are as follows: extracting under 0.2MPa and 70 deg.C for 20 min.
Comparative example 2
A preparation method of facial mask comprises adding 1kg of small molecular sodium alginate into aqueous extractive solution, stirring to dissolve completely, adding 2kg of skipjack elastin peptide, 1.5kg of nisin, and 0.8kg of chlorella fermentation product, and performing ultrasonic oscillation to obtain mixed solution as phase A; then dispersing the oily extracting solution in 8kg of modified ethyl acetate to obtain a phase B; slowly dripping the phase A into the phase B, homogenizing to obtain spinning solution, performing electrostatic spinning, and performing post-treatment to obtain a facial mask; wherein the aqueous extract and the oily extract are prepared by the following method:
(1) firstly, respectively crushing 15kg of peel of fresh grapefruit and 1kg of platycodon grandiflorum in a freezing wall-breaking mode, and mixing to obtain mixed powder;
(2) then pouring the mixed powder into deionized water with the weight of 10 times, heating and extracting, filtering to obtain an extracting solution, and performing oil-water separation to obtain an oily extracting solution and a water-based extracting solution.
The preparation method of the micromolecular sodium alginate comprises the following steps: firstly, adding 1kg of macromolecular sodium alginate into 85kg of deionized water at 75 ℃, stirring until the macromolecular sodium alginate is completely dissolved, then adding 0.4kg of hydrogen peroxide, stirring and reacting for 20 hours at 70 ℃, and precipitating with ethanol to obtain the micromolecular sodium alginate; the weight average molecular weight of the macromolecular sodium alginate is 500 kDa.
The specific method of alcohol precipitation is to add absolute ethyl alcohol with the volume twice of the reaction solution, precipitate and centrifuge.
The preparation method of the denatured ethyl acetate comprises the following steps: adding 0.06kg of butanediol and 0.2kg of citric acid into 1kg of ethyl acetate, and carrying out ultrasonic oscillation for 30 minutes to obtain the modified ethyl acetate.
The dropping time of the A phase was 55 minutes.
The process conditions of the homogenization treatment are as follows: homogenizing at 150MPa and 60 deg.C for 5 times by high pressure homogenizer.
The specific method of electrostatic spinning is as follows: the wire outlet is a No. 6 needle head, the voltage is 16kV, the distance from the spray head to the receiver is 20cm, the spray flow is 1ml/h, and the relative humidity is lower than 40%.
The specific method of post-treatment is as follows: cutting the fiber membrane (thickness 0.3mm) obtained by electrostatic spinning according to the shape of the required facial membrane, performing ultraviolet disinfection, and packaging.
In the step (1), the peel of the fresh grapefruit is firstly cut into fruit peel shreds, so that the length is 2cm and the thickness is 2 mm.
In the step (1), the specific method for freezing and breaking the wall comprises the following steps: freezing the materials to-20 ℃, transferring the materials to a ball mill, and ball-milling the materials by using a grinding ball in a cooling gas atmosphere; wherein the temperature of the cooling gas is-20 ℃, the size of the grinding ball is 5mm, and the ball milling time is 2 hours.
In the step (2), the extraction process conditions are as follows: extracting under 0.2MPa and 70 deg.C for 20 min.
Comparative example 3
A preparation method of facial mask comprises adding 1kg of small molecular sodium alginate into aqueous extractive solution, stirring to dissolve completely, adding 2kg of skipjack elastin peptide, 1.5kg of nisin, and 0.8kg of chlorella fermentation product, and performing ultrasonic oscillation to obtain mixed solution as phase A; then dispersing the oily extracting solution in 8kg of modified ethyl acetate to obtain a phase B; slowly dripping the phase A into the phase B, homogenizing to obtain spinning solution, performing electrostatic spinning, and performing post-treatment to obtain a facial mask; wherein the aqueous extract and the oily extract are prepared by the following method:
(1) firstly, respectively crushing 15kg of peel of fresh grapefruit and 3kg of pepper in a freezing wall-breaking mode, and mixing to obtain mixed powder;
(2) then pouring the mixed powder into deionized water with the weight of 10 times, heating and extracting, filtering to obtain an extracting solution, and performing oil-water separation to obtain an oily extracting solution and a water-based extracting solution.
The preparation method of the micromolecular sodium alginate comprises the following steps: firstly, adding 1kg of macromolecular sodium alginate into 85kg of deionized water at 75 ℃, stirring until the macromolecular sodium alginate is completely dissolved, then adding 0.4kg of hydrogen peroxide, stirring and reacting for 20 hours at 70 ℃, and precipitating with ethanol to obtain the micromolecular sodium alginate; the weight average molecular weight of the macromolecular sodium alginate is 500 kDa.
The specific method of alcohol precipitation is to add absolute ethyl alcohol with the volume twice of the reaction solution, precipitate and centrifuge.
The preparation method of the denatured ethyl acetate comprises the following steps: adding 0.06kg of butanediol and 0.2kg of citric acid into 1kg of ethyl acetate, and carrying out ultrasonic oscillation for 30 minutes to obtain the modified ethyl acetate.
The dropping time of the A phase was 55 minutes.
The process conditions of the homogenization treatment are as follows: homogenizing at 150MPa and 60 deg.C for 5 times by high pressure homogenizer.
The specific method of electrostatic spinning is as follows: the wire outlet is a No. 6 needle head, the voltage is 16kV, the distance from the spray head to the receiver is 20cm, the spray flow is 1ml/h, and the relative humidity is lower than 40%.
The specific method of post-treatment is as follows: cutting the fiber membrane (thickness 0.3mm) obtained by electrostatic spinning according to the shape of the required facial membrane, performing ultraviolet disinfection, and packaging.
In the step (1), the peel of the fresh grapefruit is firstly cut into fruit peel shreds, so that the length is 2cm and the thickness is 2 mm.
In the step (1), the specific method for freezing and breaking the wall comprises the following steps: freezing the materials to-20 ℃, transferring the materials to a ball mill, and ball-milling the materials by using a grinding ball in a cooling gas atmosphere; wherein the temperature of the cooling gas is-20 ℃, the size of the grinding ball is 5mm, and the ball milling time is 2 hours.
In the step (2), the extraction process conditions are as follows: extracting under 0.2MPa and 70 deg.C for 20 min.
Test examples
The mask obtained in examples 1 to 3 and comparative example 1 was tested for air permeability (pressure 100Pa) with reference to GB/T5453-2007, and the mechanical properties of the mask obtained in examples 1 to 3 and comparative example 1 were tested, and the results are shown in Table 1.
TABLE 1 air permeability and mechanical Properties testing
| Air permeability (mm/s) | Breaking strength (cN/dtex) | Elongation at Break (%) | |
| Example 1 | 6122 | 4.0 | 12.8 |
| Example 2 | 6130 | 4.1 | 12.9 |
| Example 3 | 6126 | 4.3 | 13.1 |
| Comparative example 1 | 5917 | 2.5 | 8.7 |
As can be seen from Table 1, the masks obtained in examples 1 to 3 had good air permeability and good mechanical properties. Comparative example 1 omits nisin, affects the formation of hydrogen bonds, and the mechanical properties of the mask are poor.
The specific method for inspecting the acne removing and moisturizing performances of the facial masks obtained in the examples 1-3 and the comparative examples 1-3 is as follows:
70 women aged 25-40 years are selected and randomly divided into 7 groups, the masks of examples 1-3 and comparative examples 1-3 are respectively adopted for carrying out the acne removing and moisturizing performance investigation, and the rest 1 group is not treated as a control group. The results are shown in Table 2.
The application method of the mask comprises the following steps: the facial mask is used every night, the facial mask is taken out from a packaging bag and then directly pasted on the face, a layer of warm water with the temperature of 35-40 ℃ is uniformly sprayed on the surface of the facial mask by using a skin-care spraying pot, the facial mask gradually melts (the dissolving time is less than 10 minutes) and is absorbed by the skin, and the facial mask does not need to be cleaned after being used. The acne removing effect is examined after 2 months of continuous use.
Subjects cleaned their faces and wiped clean with a dry facial tissue. Before the formal test, the people should sit still in a room with the temperature of 25 ℃ and the humidity of 40RH percent for at least 30 minutes (the temperature and the humidity of the room are not changed during the test), and can not drink water. Left and right faces in the experiment were marked 3 x 3cm each2Test areas, which can be marked on the same side, are spaced 1cm apart. Both the test product and the blank (without any treatment) were randomly distributed on the left and right faces. Utilizing the multifunctional skin of CK company in GermanyMoisture content measurement with a tester (moisture test probe). Each area was assayed 15 times in parallel. The blank value of each test area is measured firstly, then the facial mask cut into the appropriate size is pasted in the test area by using a latex finger stall, a layer of warm water with the temperature of 35-40 ℃ is uniformly sprayed on the surface of the facial mask by using a skin care spray can, the facial mask gradually dissolves (the dissolving time is less than 10 minutes) and is absorbed by the skin, and the facial mask does not need to be cleaned after use. After 20 minutes, the moisture content of the area was measured, and data was recorded, and the amount of increase in moisture content was calculated by comparing the initial values. The results are shown in Table 2.
The evaluation indexes of the acne removing effect are as follows:
and (3) healing: regression of the skin lesion, or leaving only pigmentation;
the effect is shown: the skin damage is reduced by more than 60 percent;
the method has the following advantages: the skin damage is reduced by more than 20 percent;
and (4) invalidation: the skin loss subsides by less than 20%.
TABLE 2 examination of acne-removing and moisturizing effects
As can be seen from table 2, the masks obtained in examples 1 to 3 had good acne-removing and moisturizing effects.
Comparative example 1 omits nisin, loses its bactericidal effect, and the acne removing effect is obviously deteriorated; comparative example 2, pepper is omitted, the function of promoting the absorption of nutrient components is lost, and the acne removing and moisturizing effects are obviously deteriorated; comparative example 3 omitting platycodon grandiflorum, lacking its synergistic antibacterial action and emulsifying action, the acne removing and moisturizing effect was significantly poor.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (10)
1. The preparation method of the acne-removing moisturizing mask is characterized by comprising the following steps of adding 1 part by weight of small-molecular sodium alginate into an aqueous extracting solution, stirring until the small-molecular sodium alginate is completely dissolved, adding 2-3 parts by weight of bonito elastin peptide, 1-1.5 parts by weight of nisin and 0.8-1 part by weight of chlorella fermentation product, and uniformly oscillating by ultrasonic waves to obtain a mixed solution, namely phase A; then dispersing the oily extracting solution in 5-8 parts of modified ethyl acetate to obtain a phase B; slowly dripping the phase A into the phase B, homogenizing to obtain spinning solution, performing electrostatic spinning, and performing post-treatment to obtain the acne-removing moisturizing facial mask; wherein the aqueous extract and the oily extract are prepared by the following method:
(1) firstly, crushing 15-20 parts of peel of fresh grapefruit, 2-3 parts of pepper and 1-2 parts of platycodon grandiflorum in a freezing wall-breaking mode respectively, and mixing to obtain mixed powder;
(2) and then pouring the mixed powder into deionized water with the weight of 8-10 times, heating, extracting, filtering to obtain an extracting solution, and performing oil-water separation to obtain an oily extracting solution and a water-based extracting solution.
2. The preparation method of claim 1, wherein the preparation method of the small-molecule sodium alginate comprises the following steps: adding 1 part by weight of macromolecular sodium alginate into 75-85 parts by weight of deionized water at 75-80 ℃, stirring until the macromolecular sodium alginate is completely dissolved, then adding 0.4-0.6 part by weight of hydrogen peroxide, stirring and reacting at 60-70 ℃ for 20-22 hours, and carrying out alcohol precipitation to obtain the micromolecular sodium alginate; the weight average molecular weight of the macromolecular sodium alginate is 300-500 kDa.
3. The method according to claim 1, wherein the denatured ethyl acetate is prepared by the following method: adding 0.06-0.08 part of butanediol and 0.1-0.2 part of citric acid into 1 part of ethyl acetate by weight, and carrying out ultrasonic oscillation for 30-50 minutes to obtain the modified ethyl acetate.
4. The method according to claim 1, wherein the dropping time of the phase A is 45 to 55 minutes.
5. The method of claim 1, wherein the homogenization treatment is performed under the following process conditions: homogenizing for 5-8 times by a high-pressure homogenizer under the conditions of 150-180 MPa and 50-60 ℃.
6. The preparation method according to claim 1, wherein the specific method of electrospinning is: the wire outlet is a No. 6 needle head, the voltage is 13-16 kV, the distance from the spray head to the receiver is 20-22 cm, the spray flow is 0.8-1 ml/h, and the relative humidity is lower than 40%.
7. The preparation method according to claim 1, characterized in that the post-treatment comprises the following specific steps: and cutting the fiber membrane obtained by electrostatic spinning according to the shape of the required facial membrane, performing ultraviolet disinfection, and packaging.
8. The preparation method according to claim 1, wherein in the step (1), the specific method for freezing and breaking the wall is as follows: freezing the material to-20-25 ℃, transferring the material to a ball mill, and ball-milling the material by using the ball mill in a cooling gas atmosphere; wherein the temperature of the cooling gas is-20 to-25 ℃, the size of the grinding ball is 3 to 5mm, and the ball milling time is 2 to 3 hours.
9. The preparation method according to claim 1, wherein in the step (2), the extraction process conditions are as follows: heating and extracting for 15-20 minutes under the conditions of 0.1-0.2 MPa and 70-80 ℃.
10. An acne-removing moisturizing mask obtained by the preparation method of any one of claims 1-9.
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