CN113893305B - Traditional Chinese medicine composition for preventing and treating salpingitis of laying hens as well as preparation process and application thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating salpingitis of laying hens as well as preparation process and application thereof Download PDFInfo
- Publication number
- CN113893305B CN113893305B CN202111428854.6A CN202111428854A CN113893305B CN 113893305 B CN113893305 B CN 113893305B CN 202111428854 A CN202111428854 A CN 202111428854A CN 113893305 B CN113893305 B CN 113893305B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- laying hens
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 45
- 239000000203 mixture Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 208000007893 Salpingitis Diseases 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 10
- 239000004480 active ingredient Substances 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- 241000237502 Ostreidae Species 0.000 claims description 24
- 235000020636 oyster Nutrition 0.000 claims description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 20
- 239000000047 product Substances 0.000 claims description 19
- 239000000243 solution Substances 0.000 claims description 17
- 239000000706 filtrate Substances 0.000 claims description 14
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 11
- 241000207925 Leonurus Species 0.000 claims description 11
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 claims description 11
- 235000003805 Musa ABB Group Nutrition 0.000 claims description 11
- 240000008790 Musa x paradisiaca Species 0.000 claims description 11
- 241000764065 Persicaria capitata Species 0.000 claims description 11
- 235000015266 Plantago major Nutrition 0.000 claims description 11
- 244000261559 Smilax china Species 0.000 claims description 11
- 235000000485 Smilax china Nutrition 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 241000212948 Cnidium Species 0.000 claims description 10
- 235000013399 edible fruits Nutrition 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 9
- 239000000377 silicon dioxide Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 235000012239 silicon dioxide Nutrition 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
- 230000002378 acidificating effect Effects 0.000 claims description 6
- 238000001179 sorption measurement Methods 0.000 claims description 4
- 239000011259 mixed solution Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 21
- 230000008901 benefit Effects 0.000 abstract description 13
- 238000009395 breeding Methods 0.000 abstract description 11
- 230000001488 breeding effect Effects 0.000 abstract description 11
- 229940079593 drug Drugs 0.000 abstract description 10
- 239000000463 material Substances 0.000 abstract description 9
- 230000001976 improved effect Effects 0.000 abstract description 8
- 208000004880 Polyuria Diseases 0.000 abstract description 7
- 230000035619 diuresis Effects 0.000 abstract description 7
- 239000003242 anti bacterial agent Substances 0.000 abstract description 5
- 229940088710 antibiotic agent Drugs 0.000 abstract description 5
- 230000009467 reduction Effects 0.000 abstract description 5
- 230000001939 inductive effect Effects 0.000 abstract description 4
- 244000144972 livestock Species 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 4
- 230000002588 toxic effect Effects 0.000 abstract description 4
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 230000003115 biocidal effect Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 235000013601 eggs Nutrition 0.000 description 35
- 238000012360 testing method Methods 0.000 description 11
- 230000002950 deficient Effects 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000002994 raw material Substances 0.000 description 8
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 210000003734 kidney Anatomy 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- 241000287828 Gallus gallus Species 0.000 description 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000017448 oviposition Effects 0.000 description 5
- 239000011574 phosphorus Substances 0.000 description 5
- 229910052698 phosphorus Inorganic materials 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 210000003278 egg shell Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000010298 pulverizing process Methods 0.000 description 4
- WNGSUWLDMZFYNZ-UHFFFAOYSA-N Leonurine Chemical compound COC1=CC(C(=O)OCCCCN=C(N)N)=CC(OC)=C1O WNGSUWLDMZFYNZ-UHFFFAOYSA-N 0.000 description 3
- 241000238367 Mya arenaria Species 0.000 description 3
- 240000009022 Smilax rotundifolia Species 0.000 description 3
- 235000003205 Smilax rotundifolia Nutrition 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000002354 daily effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000273 veterinary drug Substances 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003746 feather Anatomy 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 235000013594 poultry meat Nutrition 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 230000008093 supporting effect Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000012805 animal sample Substances 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 244000144992 flock Species 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000006996 mental state Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 235000013613 poultry product Nutrition 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Reproductive Health (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating salpingitis of laying hens and a preparation process and application thereof, wherein active ingredients of the traditional Chinese medicine composition comprise substances prepared according to the following formula; the formula comprises the following traditional Chinese medicine components: herba Leonuri, herba Polygoni Capitati, rhizoma Smilacis chinensis, fructus Cnidii, herba plantaginis, and Concha Ostreae. The composition provided by the invention has the effects of clearing away heat and toxic materials, inducing diuresis with bland drugs and resisting inflammation, can be used for remarkably controlling salpingitis of laying hens in laying hen breeding and improving the quality of the laying hens, has a definite curative effect, and is suitable for antibiotic reduction in nonreactive breeding and livestock husbandry industries. Under the background that the use of antibiotics is limited and the antibiotics are controlled to be remained in animal products by the current national policy, the culture benefit can be improved, the egg quality is improved, and the method has huge market prospect and has obvious economic benefit and social benefit.
Description
Technical Field
The invention relates to the technical field of veterinary drugs, and in particular relates to a traditional Chinese medicine composition for preventing and treating salpingitis of laying hens, and a preparation process and application thereof.
Background
In the seventy-eight years of the last century, the laying hen industry in China has been vigorously developed, and the egg yield has been steadily at the first in the world since 1985. With the development of the laying hen technology, the specialized, facility, improved variety and marketized laying hen industry is basically completed, and the industry division system is relatively perfect. At present, the egg yield of China is about 2450 million tons. Eggs are indispensable protein food in daily life of people, the breeding economic benefit and the quality safety of the eggs are the most concerned problems of farmers and consumers respectively, and the key to improving the breeding benefit is how to improve the production performance of laying hens and the quality of the eggs. A large amount of antibiotics are frequently used in the disease prevention and treatment process of laying hens, so that the problems of standard exceeding of veterinary drug residues, drug resistance of bacteria, quality safety of livestock and poultry products and the like are easily caused, and serious risk potential hazards are caused to food quality safety, public health safety and ecological safety. The 'banning' of the feed is a great trend, and the feed is to be comprehensively 'banned' by 2020 in China.
Salpingitis is a common disease harmful to laying hens, and often causes the laying rate of the laying hens to be reduced, the number of defective eggs such as soft-shell eggs, blood spot eggs and eggshell eggs is increased, and the breeding profit is seriously influenced. Salpingitis is often closely related to dampness, heat and toxicity, and often causes phlegm stagnation, qi stagnation and blood stasis, and inhibits yang qi from running after long-term development, and shows symptoms of dampness syndrome or lower reproductive function and the like. The traditional Chinese medicine has the advantages of rich resources, low toxicity, low drug residue and the like, and becomes one of the best choices of 'replacing resistance' along with the comprehensive 'banning resistance' of the feed. China has a huge breeding industry market and rich traditional Chinese medicine resources, has a long-history traditional Chinese medicine research history, and has great development prospect along with the continuous progress of scientific technology. Therefore, the invention provides a traditional Chinese medicine composition for preventing and treating salpingitis of laying hens and a preparation process and application thereof, so as to effectively solve the problems of salpingitis and egg laying of the laying hens.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to solve the technical problem of providing a traditional Chinese medicine composition for preventing and treating salpingitis of laying hens aiming at the defects of the prior art.
The technical problem to be solved by the invention is to provide a preparation containing the traditional Chinese medicine composition.
The technical problem to be solved by the invention is to provide a preparation method of the traditional Chinese medicine composition.
The invention finally aims to solve the technical problem of providing the application of the traditional Chinese medicine composition and the preparation.
The invention idea is as follows: the compound Chinese medicine preparation is prepared with Chinese medicinal materials, and has the functions of clearing away heat and toxic material, promoting diuresis, promoting blood circulation to disperse blood clots, strengthening liver and invigorating kidney, and can prevent salpingitis caused by downward flow of heat and damp, improve microcirculation and rheological property of blood, promote the absorption and elimination of inflammation and necrosis tissue, reduce tissue proliferation and adhesion, speed the repair of damaged oviduct and ovary, strengthen liver and invigorate kidney, delay egg laying rate and raise egg laying rate.
In order to solve the first technical problem, the invention discloses a traditional Chinese medicine composition for preventing and treating salpingitis of laying hens, wherein active ingredients of the traditional Chinese medicine composition comprise substances prepared according to the following formula; the formula comprises the following traditional Chinese medicine components: herba Leonuri, herba Polygoni Capitati, rhizoma Smilacis chinensis, fructus Cnidii, herba plantaginis, and Concha Ostreae. In the formula, the motherwort herb is used as a monarch drug for inducing diuresis to alleviate edema, promoting blood circulation and removing blood stasis; the polygonum capitatum has the effects of removing dampness by light infiltration, and inducing diuresis for treating stranguria; the smilax china is used as a ministerial drug together with the two drugs of promoting diuresis, removing turbidity, detoxifying and dissipating blood stasis; fructus Cnidii has effects of eliminating dampness, dispelling pathogenic wind, warming yang and invigorating kidney; the plantain herb has the functions of promoting diuresis, eliminating dampness, clearing away heat and toxic materials; the oyster three medicines for calming the liver, suppressing yang, softening hardness and dissipating stagnation are used as assistant and guide medicines together. The combination of the medicines can effectively solve the problems of egg laying function reduction and eggshell quality reduction caused by salpingitis and kidney yang deficiency caused by the damp-heat syndrome of the laying hens, and simultaneously, the organic calcium and phosphorus in the oysters can improve the calcium and phosphorus balance of the laying hens.
Wherein the components comprise, by mass, 20-30 parts of motherwort, 20-30 parts of polygonum capitatum, 20-30 parts of smilax china, 20-30 parts of common cnidium fruit, 20-30 parts of plantain herb and 80-120 parts of oyster; preferably, the components comprise, by mass, 20 parts of motherwort, 20 parts of polygonum capitatum, 20 parts of smilax china, 20 parts of common cnidium fruit, 20 parts of plantain herb and 80 parts of oyster; further preferably, the components comprise 20g of motherwort, 20g of polygonum capitatum, 20g of smilax china, 20g of common cnidium fruit, 20g of plantain herb and 80g of oyster.
In order to solve the second technical problem, the invention discloses a preparation for preventing and treating salpingitis of laying hens, which comprises the traditional Chinese medicine composition.
Wherein, the preparation is in a unit dosage form suitable for nasal mucosa, oral mucosa, sublingual administration, oral administration, skin administration, injection administration or pulmonary inhalation.
In order to solve the third technical problem, the invention discloses a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
s1: according to the formula, crushing other components except oysters, performing reflux extraction by using an acidic alcohol solution, filtering to obtain filtrate, recovering ethanol, and adjusting the pH value to 6.5-7.5 by using sodium hydroxide for later use; decocting the residue with water for 2 times, filtering, and mixing the three filtrates; the pH value is preferably 7.0;
s2: concentrating the filtrate to obtain concentrated solution, adding silicon dioxide for adsorption and drying;
s3: and (8) mixing the dried product of S2 with oyster to obtain the product.
In step S1, the pulverization is to a coarse powder of about 2 mm.
In step S1, the extraction efficiency of leonurine hydrochloride can be effectively improved through reflux extraction of acidic alcohol solution, the damage to the effective components of the traditional Chinese medicine is reduced, and the product effect is enhanced.
In step S1, the acidic alcohol solution is a mixed solution of hydrochloric acid and ethanol.
Wherein the concentration of the hydrochloric acid is 0.02-0.08mol/L, and preferably 0.05 mol/L.
Wherein the concentration of the ethanol is 40-60%, and preferably 50%.
In step S1, the mass ratio of the solvent to the raw material is (4-8):1, preferably 6: 1.
In step S1, the reflux extraction time is 1-3h, preferably 2 h.
In the step S1, the process also comprises decoction, other water-soluble active ingredients in the decoction dregs can be completely extracted through the decoction, and all effects of the medicinal materials are effectively exerted; specifically, according to the formula, pulverizing the components except Concha Ostreae, reflux-extracting with acidic alcohol solution, filtering, decocting the obtained residue for several times, filtering again, and mixing the filtrates; concentrating the obtained filtrate to obtain concentrated solution; the temperature of the reflux extraction is 80 ℃; the temperature of the decoction is 100 ℃.
Wherein the number of times of decoction is 1-3, preferably 2.
Wherein the decoction is water decoction, and the mass ratio of water to the raw materials (other components except oyster) is (4-8) to 1, preferably 6 to 1.
Wherein the decoction time is 1-3h, preferably 2h, more preferably 2h for the first decoction and 1.5h for the second decoction.
In step S2, the concentration is carried out until the density is 1.05-1.08g/cm3。
In step S2, the concentration is performed by using a triple-effect concentrator, which can effectively shorten the concentration time and reduce the loss of effective components.
Wherein, the vacuum degree and the evaporation temperature of each effect in the triple-effect concentrator are as follows: first effect is-0.04 to-0.07 MPa, 85 ℃; second effect is-0.06 to-0.08 MPa, 75 ℃, third effect is-0.07 to-0.10 MPa, 65 ℃.
In step S2, the drying is performed by adsorption with particulate silica and paddle-screw drying. The product has good free-running property, the volume weight is close to that of the feed raw materials of corn flour and soybean meal, and the adding uniformity in the feed is good. The paddle spiral drying method has the advantages of large heating area, short drying time and low energy consumption.
Wherein the mass ratio of the concentrated solution to the silicon dioxide is 1 (0.5-3.5), preferably 1: 2.
In step S3, the oysters are crushed and sieved by 60-80 meshes.
In the step S3, the oysters are added, so that the effects of warming the kidney, supporting yang, dissipating stagnation and softening hardness of the oysters can be exerted, organic calcium and phosphorus in the oysters can be utilized by laying hens, and the quality of eggshells is improved.
Preferably, the preparation method comprises the steps of weighing 20-30 parts of motherwort, 20-30 parts of polygonum capitatum, 20-30 parts of smilax china, 20-30 parts of common cnidium fruit, 20-30 parts of plantain herb and 80-120 parts of oyster according to the weight proportion; pulverizing the above materials except Concha Ostreae into coarse powder of about 2 mm; adding 0.05mol/L diluted hydrochloric acid 50% ethanol solution, soaking for 60 minutes, extracting under reflux for 2 hours, wherein the mass ratio of the used solvent to the raw materials is 6:1, extracting the filtrate, recovering ethanol, and adjusting the pH value to 7.0 with sodium hydroxide for later use; decocting the residue with water for 2 times, wherein the weight ratio of water to the raw materials is 6:1, and the decocting time is 2 hr and 1.5 hr respectively; mixing filtrates, and concentrating to density of 1.05-1.08; adding silicon dioxide into the concentrated solution, mixing, drying at 60 ℃, and adding the silicon dioxide and the concentrated solution in a ratio of 1: 2; sieving the dried intermediate, adding Concha Ostreae powder, and mixing.
In order to solve the fourth technical problem, the invention also discloses application of the traditional Chinese medicine composition and the preparation in preparing products for preventing and treating salpingitis of laying hens and application in preparing products for improving the laying performance of the laying hens.
Wherein, the product comprises but is not limited to veterinary drugs and feed additives.
Has the advantages that: compared with the prior art, the invention has the following advantages:
(1) the preparation process of the invention adopts fractional extraction, adopts dilute hydrochloric acid ethanol solution to extract leonurine, and extracts other effective components by water, thus improving the extraction yield of the effective components; the drying time is shortened, the drying temperature is reduced, and the product fluidity is increased by adopting a silicon dioxide adsorption drying process; the oyster powder is not extracted, is directly crushed and compounded with extracted medicaments, plays the effects of warming the kidney, supporting yang, softening hardness and dissipating stagnation of the oyster, fully utilizes organic calcium and phosphorus in the oyster, supplements calcium and phosphorus for laying hens, and improves the quality of eggshells.
(2) The composition provided by the invention has the effects of clearing away heat and toxic materials, inducing diuresis with bland drugs and resisting inflammation, can be used for remarkably controlling salpingitis of laying hens in laying hen breeding and improving the quality of the laying hens, has a definite curative effect, and is suitable for antibiotic reduction in nonreactive breeding and livestock husbandry industries. Under the background that the use of antibiotics is limited and the antibiotics are controlled to be remained in animal products by the current national policy, the culture benefit can be improved, the egg quality is improved, and the method has huge market prospect and has obvious economic benefit and social benefit.
(3) The composition provided by the invention is a green and safe novel feed additive prepared from pure traditional Chinese medicines, and has the characteristics of safety, no side effect, quick response, no residue, obvious effect and the like.
Drawings
The foregoing and/or other advantages of the invention will become further apparent from the following detailed description of the invention when taken in conjunction with the accompanying drawings.
Fig. 1 shows the daily laying rate of the hens during the test period.
FIG. 2 shows the daily defective egg rate of each type of eggs, from top to bottom, in the test period, eggs with blood spots, eggs with sand shell, eggs with soft shell, eggs with broken shell and abnormal eggs.
Detailed Description
The experimental methods described in the following examples are all conventional methods unless otherwise specified; the reagents and materials are commercially available, unless otherwise specified.
Example 1
The formula of the components is as follows: weighing 20kg of motherwort, 20kg of polygonum capitatum, 20kg of chinaroot greenbrier, 20kg of common cnidium fruit, 20kg of plantain herb and 80kg of oyster according to parts by weight, and screening and cleaning.
The preparation process comprises the following steps:
(1) weighing the raw materials in parts by weight respectively; pulverizing the above materials except Concha Ostreae into coarse powder of about 2 mm; adding 0.05mol/L diluted hydrochloric acid 50% ethanol solution, soaking for 60 min, reflux extracting for 2 hr with the mass ratio of solvent to raw materials of 6:1, filtering to obtain filtrate and residue, extracting the filtrate, recovering ethanol, and adjusting pH to 7.0 with sodium hydroxide;
(2) decocting the residue with water for 2 times, wherein the weight ratio of water to the raw materials is 6:1, and the decocting time is 2 hr and 1.5 hr respectively;
(3) mixing filtrates, and concentrating to density of 1.05-1.08g/cm3(ii) a The vacuum degree and the evaporation temperature of each effect in the three-effect concentrator are as follows: first effect is-0.04 to-0.07 MPa, 85 ℃; second effect is-0.06 to-0.08 MPa, 75 ℃, third effect is-0.07 to-0.10 MPa, 65 ℃;
(4) adding silicon dioxide into the concentrated solution, mixing, drying at 60 ℃, and adding the silicon dioxide and the concentrated solution in a ratio of 1: 2;
(5) sieving the dried intermediate, adding 60 mesh Concha Ostreae powder, and mixing to obtain 155kg of product.
Example 2
The formula of the components is as follows: weighing 20kg of motherwort, 30kg of polygonum capitatum, 25kg of chinaroot greenbrier, 28kg of common cnidium fruit, 21kg of plantain herb and 95kg of oyster according to parts by weight, and screening and cleaning.
The preparation process is the same as in example 1.
Example 3
The formula of the components is as follows: weighing 26kg of motherwort, 22kg of polygonum capitatum, 29kg of chinaroot greenbrier, 23kg of common cnidium fruit, 25kg of plantain herb and 104kg of oyster according to parts by weight, and screening and cleaning.
The preparation process is the same as in example 1.
Example 4: clinical validation
1. Test drugs the water-soluble traditional Chinese medicine compound extracted in example 1.
2. The test animals are provided by a certain mechanized chicken farm in Nanjing, 60000 laying hens are bred in Su poultry No. 1, and the breeding mode is cage breeding with 5-7 feathers per cage. 24000 feathers of laying hens which are 90 weeks old, healthy, similar in weight and subjected to forced moulting are selected.
3. The test grouping test adopts an animal sample self-control method, wherein a blank control group (non-administration stage) is adopted before the administration of the laying hens, and an experimental control group (administration stage and withdrawal stage) is adopted after the administration. The grouping is shown in table 1.
Table 1: test grouping
4. Test method
The egg laying rate and defective egg rate of the chicken group and the number of various defective eggs (blood spot eggs, broken eggs, soft shell eggs, sand shell eggs and malformed eggs) in the sample range are measured by observing for 1 day before the test, and the mental states of the excrement and the chicken group are observed. From day 2, the patient is administered according to the requirement, the relevant indexes are recorded every day, the administration of the liquid medicine is stopped after 7 days, the relevant indexes of each group are continuously recorded for 3 days, and the test is finished. The survey index is shown in Table 2.
Table 2: survey index
5. Test results
5.1 example 1 extraction of Water-soluble Chinese medicinal Compound for improving laying rate of laying hens in laying period
The results are shown in fig. 1, and the test results show that the product of example 1 can improve the laying rate of the laying hens to a certain extent in the administration stage and a certain period of time after the withdrawal, and the increase of the laying rate can reach 5.25 percent at the lowest and 15 percent at the highest. It is noted that on day 1 and day 2 of withdrawal, the laying rate was reduced due to a sudden drop in air temperature as the chicken house suffered from typhoons, but was still higher than the laying rate without the drug. It is generally accepted that the optimum temperature for layer production is 19-22 deg.C, and below this temperature range, cold irritation may occur. The low temperature has great harm to the production performance of the laying hens, and can cause the reduction of the laying rate and the increase of the pecking rate.
5.2 example 1 improvement of defective egg rate and defective egg quantity of laying hens by extracting water-soluble Chinese medicinal compound
The results are shown in fig. 2, and the experimental results show that the product of example 1 can significantly reduce the number of defective eggs and the ratio of defective eggs to the total number of eggs laid per day. The defective egg rate reaches 32.222 ‰ in the non-administration stage, gradually decreases and stabilizes in the rest 11 days with administration of medicine, and stabilizes at 7.037 ‰ -8.394 ‰ in the later stage of experiment. The product of example 1 has the greatest effect on the shell-broken eggs and the shell-sanded eggs, and can reduce the rate of the shell-broken eggs by about 10 per thousand and the shell-sanded eggs by 8 per thousand.
The above results are combined: after the chicken flocks are used, the effect is fast, the laying rate is obviously increased, and the defective egg rate is obviously reduced. The product in the example 1 can improve the gastrointestinal tract function by resisting infection, resisting oxidation and enhancing immunity, and further regulate and control the reproductive hormone level, so that the production performance of the laying hens can be obviously improved. The product is pure traditional Chinese medicine, is safe and reliable to use, and can be widely applied to livestock and poultry breeding.
The invention provides a traditional Chinese medicine composition for preventing and treating salpingitis of laying hens, a preparation process and an application thought and a method thereof, and particularly provides a plurality of methods and ways for realizing the technical scheme. All the components not specified in the present embodiment can be realized by the prior art.
Claims (9)
1. The traditional Chinese medicine composition for preventing and treating salpingitis of the laying hens is characterized in that the active ingredients of the traditional Chinese medicine composition are prepared from the following traditional Chinese medicine components: herba Leonuri, herba Polygoni Capitati, rhizoma Smilacis chinensis, fructus Cnidii, herba plantaginis, and Concha Ostreae; the components comprise, by mass, 20-30 parts of motherwort, 20-30 parts of polygonum capitatum, 20-30 parts of smilax china, 20-30 parts of common cnidium fruit, 20-30 parts of plantain herb and 80-120 parts of oyster.
2. The traditional Chinese medicine composition for preventing and treating salpingitis of laying hens as claimed in claim 1, wherein the components comprise, by mass, 20 parts of motherwort herb, 20 parts of polygonum capitatum, 20 parts of smilax china, 20 parts of common cnidium fruit, 20 parts of plantain herb and 80 parts of oyster.
3. The traditional Chinese medicine composition for preventing and treating salpingitis of laying hens as claimed in claim 1, wherein the components comprise 20g of motherwort herb, 20g of polygonum capitatum, 20g of smilax china, 20g of common cnidium fruit, 20g of plantain herb and 80g of oyster.
4. A preparation for preventing and treating salpingitis of laying hens, which is characterized by comprising the traditional Chinese medicine composition of any one of claims 1 to 3.
5. A method for preparing the traditional Chinese medicine composition of any one of claims 1 to 3, which is characterized by comprising the following steps:
s1: according to the formula, crushing the components except the oysters, performing reflux extraction by using an acidic alcohol solution, and filtering to obtain filtrate and dregs; recovering ethanol from the obtained filtrate, and adjusting the pH value to 6.5-7.5 for later use; decocting the residue with water, filtering, and mixing filtrates;
s2: concentrating the filtrate to obtain concentrated solution, adding silicon dioxide for adsorption and drying;
s3: and (8) mixing the dried product of S2 with oyster to obtain the product.
6. The method for preparing the Chinese medicinal composition according to claim 5, wherein in step S1, the acidic alcohol solution is a mixed solution of hydrochloric acid and ethanol.
7. The method for preparing a Chinese medicinal composition according to claim 6, wherein the concentration of the hydrochloric acid is 0.02-0.08 mol/L.
8. The use of the Chinese medicinal composition of any one of claims 1-3, or the formulation of claim 4, in the preparation of a product for preventing and treating salpingitis of laying hens.
9. Use of the Chinese medicinal composition of any one of claims 1-3, or the preparation of claim 4, in the preparation of a product for improving laying performance of laying hens.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111428854.6A CN113893305B (en) | 2021-11-29 | 2021-11-29 | Traditional Chinese medicine composition for preventing and treating salpingitis of laying hens as well as preparation process and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111428854.6A CN113893305B (en) | 2021-11-29 | 2021-11-29 | Traditional Chinese medicine composition for preventing and treating salpingitis of laying hens as well as preparation process and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113893305A CN113893305A (en) | 2022-01-07 |
| CN113893305B true CN113893305B (en) | 2022-05-17 |
Family
ID=79195194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111428854.6A Active CN113893305B (en) | 2021-11-29 | 2021-11-29 | Traditional Chinese medicine composition for preventing and treating salpingitis of laying hens as well as preparation process and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113893305B (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658245A (en) * | 2009-08-26 | 2010-03-03 | 王直军 | Chinese medicinal feed additive for preventing and treating hen salpingitis |
| CN102379971B (en) * | 2011-11-22 | 2013-10-23 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating cage layer fatigue and preparation method thereof |
| CN104623535B (en) * | 2015-01-14 | 2018-02-09 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Chinese medicine composition for the disease drop egg treatment of laying hen and its preparation method and application |
| CN106974968A (en) * | 2017-04-19 | 2017-07-25 | 刘在农 | A kind of herbal composite and its compound method for being used to treat livestock and poultry disease of digestive system |
-
2021
- 2021-11-29 CN CN202111428854.6A patent/CN113893305B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN113893305A (en) | 2022-01-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104256056B (en) | Utilize animal feed prepared by glutamic acid fermentation waste material | |
| CN104758556B (en) | A kind of compound preparation and preparation method thereof of anti-Heat stress | |
| CN104256166A (en) | Functional feed for treating bovine bluetongue and preparation method thereof | |
| CN105995179A (en) | Preparing method for traditional Chinese medicine feed additive in laying hen growing period | |
| CN105995249A (en) | Banana prawn feed additive and preparation method thereof | |
| CN103598433A (en) | Feed capable of promoting Gaoyou duck to produce double-yolked eggs, and preparation method thereof | |
| CN102813850B (en) | Traditional Chinese medicine composition for preventing and treating poultry coccidiosis and preparation method of traditional Chinese medicine composition | |
| CN113893305B (en) | Traditional Chinese medicine composition for preventing and treating salpingitis of laying hens as well as preparation process and application thereof | |
| CN105030858A (en) | Cynomorium songaricum healthcare tablet and preparation method thereof | |
| CN107691301A (en) | A kind of method of fish fast-growth | |
| CN101238852B (en) | Chinese medicinal composition for growing and fattening of livestock and poultry and preparation thereof | |
| CN114886961A (en) | Traditional Chinese medicine composition for treating/preventing avian gout and preparation method and application thereof | |
| CN112544812A (en) | Mixed-strain fermentation type Chinese herbal medicine additive for laying hens in later period of laying, and preparation method and application thereof | |
| CN115531471B (en) | Composition for resisting African swine fever as well as preparation method and application thereof | |
| CN102144718B (en) | Selfheal extract feed additive and preparation method thereof | |
| CN104324302A (en) | Preparation method of anti-coccidiosis traditional Chinese medicine extract | |
| CN104324301A (en) | Anti-coccidiosis traditional Chinese medicine extract | |
| CN116832114B (en) | Traditional Chinese medicine composition for improving quality of male ducks semen and preparation method and application thereof | |
| CN107712327A (en) | A kind of health care sheep feed additive | |
| CN103655834B (en) | A kind of Chinese prescription preventing and treating pig ileitis and preparation method | |
| CN115381874B (en) | Traditional Chinese medicine composition and granule for treating chicken noninfectious diarrhea and preparation method thereof | |
| CN107467422A (en) | The disease-resistant feed of selenium-rich fish | |
| CN106306589A (en) | Feeding attraction carp feed and preparing method thereof | |
| CN105381336A (en) | Biological agent containing papaya extract and application thereof | |
| CN105876280A (en) | Fish feed additive |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |