CN113893253A - 用于治疗braf-v600相关的疾病的plx-8394或plx-7904 - Google Patents

用于治疗braf-v600相关的疾病的plx-8394或plx-7904 Download PDF

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Publication number
CN113893253A
CN113893253A CN202111224724.0A CN202111224724A CN113893253A CN 113893253 A CN113893253 A CN 113893253A CN 202111224724 A CN202111224724 A CN 202111224724A CN 113893253 A CN113893253 A CN 113893253A
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braf
cancer
mutation
inhibitors
cell
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Chinese (zh)
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帕拉巴哈·N·易卜拉欣
张超
韦恩·斯皮维克
张嘉忠
吴国贤
林杰克
赵汉纳
马里卡·尼斯派
史松源
托德·尤英
张颖
吉迪恩·博拉格
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Plexxikon Inc
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Plexxikon Inc
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P35/00—Antineoplastic agents
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CN202111224724.0A 2015-05-22 2016-05-20 用于治疗braf-v600相关的疾病的plx-8394或plx-7904 Pending CN113893253A (zh)

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US201562165813P 2015-05-22 2015-05-22
US62/165,813 2015-05-22
CN201680033004.7A CN107801378A (zh) 2015-05-22 2016-05-20 用于治疗braf‑v600相关的疾病的plx‑8394或plx‑7904

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CN201680033004.7A Pending CN107801378A (zh) 2015-05-22 2016-05-20 用于治疗braf‑v600相关的疾病的plx‑8394或plx‑7904

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EP (1) EP3297630A1 (enExample)
JP (2) JP2018515570A (enExample)
KR (1) KR20180006447A (enExample)
CN (2) CN113893253A (enExample)
BR (1) BR112017025045A2 (enExample)
CA (1) CA2986739C (enExample)
TW (1) TWI812581B (enExample)
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CN107801378A (zh) 2018-03-13
TW201707704A (zh) 2017-03-01
JP2022058398A (ja) 2022-04-12
CA2986739C (en) 2023-03-14
KR20180006447A (ko) 2018-01-17
CA2986739A1 (en) 2016-12-01
US9814714B2 (en) 2017-11-14
EP3297630A1 (en) 2018-03-28
JP2018515570A (ja) 2018-06-14
BR112017025045A2 (pt) 2018-08-07
TWI812581B (zh) 2023-08-21
WO2016191296A1 (en) 2016-12-01
US20160339025A1 (en) 2016-11-24

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Application publication date: 20220107