CN113893253A - 用于治疗braf-v600相关的疾病的plx-8394或plx-7904 - Google Patents

用于治疗braf-v600相关的疾病的plx-8394或plx-7904 Download PDF

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Publication number
CN113893253A
CN113893253A CN202111224724.0A CN202111224724A CN113893253A CN 113893253 A CN113893253 A CN 113893253A CN 202111224724 A CN202111224724 A CN 202111224724A CN 113893253 A CN113893253 A CN 113893253A
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braf
cancer
mutation
inhibitors
cell
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Chinese (zh)
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帕拉巴哈·N·易卜拉欣
张超
韦恩·斯皮维克
张嘉忠
吴国贤
林杰克
赵汉纳
马里卡·尼斯派
史松源
托德·尤英
张颖
吉迪恩·博拉格
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Plexxikon Inc
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Plexxikon Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN202111224724.0A 2015-05-22 2016-05-20 用于治疗braf-v600相关的疾病的plx-8394或plx-7904 Pending CN113893253A (zh)

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US201562165813P 2015-05-22 2015-05-22
US62/165,813 2015-05-22
CN201680033004.7A CN107801378A (zh) 2015-05-22 2016-05-20 用于治疗braf‑v600相关的疾病的plx‑8394或plx‑7904

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CN201680033004.7A Pending CN107801378A (zh) 2015-05-22 2016-05-20 用于治疗braf‑v600相关的疾病的plx‑8394或plx‑7904

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US (1) US9814714B2 (enExample)
EP (1) EP3297630A1 (enExample)
JP (2) JP2018515570A (enExample)
KR (1) KR20180006447A (enExample)
CN (2) CN113893253A (enExample)
BR (1) BR112017025045A2 (enExample)
CA (1) CA2986739C (enExample)
TW (1) TWI812581B (enExample)
WO (1) WO2016191296A1 (enExample)

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CN107801378A (zh) 2018-03-13
US20160339025A1 (en) 2016-11-24
US9814714B2 (en) 2017-11-14
BR112017025045A2 (pt) 2018-08-07
CA2986739C (en) 2023-03-14
TW201707704A (zh) 2017-03-01
WO2016191296A1 (en) 2016-12-01
CA2986739A1 (en) 2016-12-01
TWI812581B (zh) 2023-08-21
EP3297630A1 (en) 2018-03-28
JP2022058398A (ja) 2022-04-12
JP2018515570A (ja) 2018-06-14
KR20180006447A (ko) 2018-01-17

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Application publication date: 20220107