CN113893252A - 用于治疗结晶性关节病症的cxcr-2抑制剂 - Google Patents

用于治疗结晶性关节病症的cxcr-2抑制剂 Download PDF

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Publication number
CN113893252A
CN113893252A CN202111152242.9A CN202111152242A CN113893252A CN 113893252 A CN113893252 A CN 113893252A CN 202111152242 A CN202111152242 A CN 202111152242A CN 113893252 A CN113893252 A CN 113893252A
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CN
China
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
cxcr
pyrimidin
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Pending
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CN202111152242.9A
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English (en)
Chinese (zh)
Inventor
帕耶尔·纳纳瓦蒂
杰弗里·迈纳
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Ardea Biociences Inc
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Ardea Biociences Inc
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Publication of CN113893252A publication Critical patent/CN113893252A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202111152242.9A 2016-03-11 2017-03-09 用于治疗结晶性关节病症的cxcr-2抑制剂 Pending CN113893252A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662307348P 2016-03-11 2016-03-11
US62/307,348 2016-03-11
CN201780029205.4A CN109152780B (zh) 2016-03-11 2017-03-09 用于治疗结晶性关节病症的cxcr-2抑制剂

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CN201780029205.4A Division CN109152780B (zh) 2016-03-11 2017-03-09 用于治疗结晶性关节病症的cxcr-2抑制剂

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Publication Number Publication Date
CN113893252A true CN113893252A (zh) 2022-01-07

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CN202111152242.9A Pending CN113893252A (zh) 2016-03-11 2017-03-09 用于治疗结晶性关节病症的cxcr-2抑制剂
CN201780029205.4A Active CN109152780B (zh) 2016-03-11 2017-03-09 用于治疗结晶性关节病症的cxcr-2抑制剂

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Country Link
US (1) US10772886B2 (enExample)
EP (1) EP3426253A4 (enExample)
JP (2) JP6883917B2 (enExample)
CN (2) CN113893252A (enExample)
AU (1) AU2017231832B2 (enExample)
BR (1) BR112018068393A2 (enExample)
CA (1) CA3017345A1 (enExample)
CO (1) CO2018010880A2 (enExample)
MX (1) MX386771B (enExample)
WO (1) WO2017156270A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113893252A (zh) 2016-03-11 2022-01-07 阿迪亚生命科学公司 用于治疗结晶性关节病症的cxcr-2抑制剂
WO2019055509A1 (en) * 2017-09-12 2019-03-21 Ardea Biosciences, Inc. INHIBITORS OF CXCR-2 FOR THE TREATMENT OF DISORDERS
US11136315B2 (en) 2018-01-11 2021-10-05 Medshine Discovery Inc. CXCR2 antagonist
WO2021004531A1 (zh) * 2019-07-11 2021-01-14 南京明德新药研发有限公司 一种cxcr2拮抗剂的晶型及其应用
KR102260478B1 (ko) * 2019-08-19 2021-06-02 연세대학교 산학협력단 일나트륨 요소화물 결정 용해용 조성물
TW202210068A (zh) * 2020-06-05 2022-03-16 美商雅力思提雅治療公司 用於治療家族性地中海型發熱病的cxcr-2抑制劑
WO2022162021A1 (en) * 2021-01-27 2022-08-04 Astrazeneca Ab Verinurad compositions and methods of use

Citations (1)

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CN103781781A (zh) * 2011-07-12 2014-05-07 阿斯利康(瑞典)有限公司 作为趋化因子受体调节剂的n-(6-((2r,3s)-3,4-二羟基丁-2-基氧基)-2-(4-氟苄基硫基)嘧啶-4-基)-3-甲基氮杂环丁烷-1-磺酰胺

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BRPI0514735B8 (pt) 2004-08-28 2021-05-25 Astrazeneca Ab derivados de pirimidino sulfonamida como moduladores do receptor de quimiocina.
AU2008206231A1 (en) * 2007-01-19 2008-07-24 Takeda Pharmaceuticals U.S.A., Inc. Methods for preventing or reducing the number of gout flares using xanthine oxidoreductase inhibitors and anti-inflammatory agents
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CN102159555A (zh) 2008-07-16 2011-08-17 阿斯利康(瑞典)有限公司 嘧啶基氨磺酰衍生物及其治疗趋化因子介导的疾病的用途
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BR112018068393A2 (pt) 2019-01-15
CA3017345A1 (en) 2017-09-14
AU2017231832B2 (en) 2021-11-11
CN109152780B (zh) 2021-10-01
JP7126014B2 (ja) 2022-08-25
AU2017231832A1 (en) 2018-10-04
EP3426253A4 (en) 2019-11-06
JP2019507791A (ja) 2019-03-22
WO2017156270A1 (en) 2017-09-14
EP3426253A1 (en) 2019-01-16
JP6883917B2 (ja) 2021-06-09
MX2018010946A (es) 2019-05-23
CN109152780A (zh) 2019-01-04
MX386771B (es) 2025-03-19
US20180235964A1 (en) 2018-08-23
US10772886B2 (en) 2020-09-15
JP2021121600A (ja) 2021-08-26
CO2018010880A2 (es) 2018-10-22

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