CN1138821A - Fodder and drinking water additive for improving the resistance to stress and immunity of useful animals - Google Patents
Fodder and drinking water additive for improving the resistance to stress and immunity of useful animals Download PDFInfo
- Publication number
- CN1138821A CN1138821A CN95191289A CN95191289A CN1138821A CN 1138821 A CN1138821 A CN 1138821A CN 95191289 A CN95191289 A CN 95191289A CN 95191289 A CN95191289 A CN 95191289A CN 1138821 A CN1138821 A CN 1138821A
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- China
- Prior art keywords
- drinking water
- feed
- water additive
- vitamin
- immunity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
- C12Y111/01—Peroxidases (1.11.1)
- C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Fodder In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Feed For Specific Animals (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention concerns a fodder and drinking water additive for improving the resistance to stress and immunity of useful animals. The additive comprises lysozyme and/or the pharmaceutically harmless salts thereof as the principal component and a peroxidase-containing substance, in particular horseradish-peroxidase.
Description
The present invention relates to a kind of feed or drinking water additive of lysozyme, it is used to improve domestic animal resistance to stress and immunity.
Can recognize a kind of preparation and production method thereof that is used for livestock reproduction from DE-A1-3934010, described preparation contains lysozyme, vitamin, antioxidant and medicine acceptable carrier.Use this preparation, will avoid various diseases to occur.
Some the time since, the feed or the drinking water additive that improve the immunity of domestic animal or useful animals have been studied and have tested, this additive is used for farthest reducing or alleviate the appearance of special bacterial strain or to the requirement of body immune system, particularly in the nervous stage of domestic animal.The serious anxiety of brood be in piggy wean and when grouping or carriage load are overweight again, or in calf is fattened during the feed variation.In addition, every kind of chronic disease or the wound that each is lasting all make the body anxiety of domestic animal, and the growth rate of domestic animal is descended.In so nervous stage, the body of animal obviously increases burden.In addition, any other the time, animal also can be in the state of hiding defence capability fragility, so may be responsive especially to the effect of potential pathogenic agent and pathogenic germ and other harmful reagent.Above-mentioned all pathogenicity diseases can be easy to take place, and may directly reduce the growth rate of domestic animal, and this usually causes great economic loss for the raiser.
At present, people attempt to use the antibiotic method of sterilization at the important stage of animal-breeding by preventative or back preventative (metaphylactic) and treat tension-causing factor and disease factor, for example in first day after the piggy wean or at chicken life.But for bacteriostat and chemotherapeutant, a kind of effective immune system of (priori) supposition suppresses the growth of bacterium especially for elimination in advance.In the stage of the serious burden of domestic animal, this immune system does not always exist naturally.Except uncertain by the health status of treatment animal, antibiotic use also has such shortcoming, the waiting period that existing later in the antibiotic administration, the waiting period of must observing this before animal can be used as food supply.Waiting period, determine that by the rule that relates to the healthy animal metabolism metabolism of obvious ill animal and healthy animal have very big difference, fixing the waiting period in, its metabolism usually is not in the state that makes the antibiotic degraded.So, must carry out repeatedly residue contrast accurately, with the food of guaranteeing to make the consumer is not constituted danger by this animal.
And, must consider that also after after a while, the bacterial strain of many bacteriums will become and tolerate the antibiotic of being used, so the effect of these medicines can descend.After this, must increase antibiotic dosage, prolong the waiting period that it making again.Generally speaking, the shortcoming of administration of antibiotics medicine not only relates to residue problem, toxicity problem or animal drug resistance problem, and relevant with the public's health, and people can abandon administration of antibiotics in the future in a word.
In GB-A2002780, the salt that has proposed to use lysozyme is as the feed addictive of fattening chicken, thereby acquisition is to the digestion process of poultry and the positive effect of protein adsorption.And, openly can observe the reduction of the tension-causing factor of chicken, and can imagine and reduce the antibiotic dosage by using lysozyme.But generally speaking, treatment of chicken or prevention are not enough to eliminate fully the tension-causing factor and the immunity that usually show in the domestic animal raising and descend, and are not enough to avoid fully give the domestic animal administration of antibiotics between anxiety increase or immunity decrement phase.
So, the present invention aims to provide a kind of feed or drinking water additive of improved lysozyme, this additive is used to improve the resistance to stress and the immunity of useful animals, make domestic animal administration of antibiotics not during anxiety increases, only by additive of the present invention is added in feed and the drinking water, reach the immunity and the growth rate that improve domestic animal simultaneously.In order to address this problem, feed of the present invention or drinking water additive are main to be characterised in that, this feed or drinking water additive contain as the lysozyme of key component and/or the acceptable salt of its medicine, and the material that contains peroxidase (particularly horseradish peroxidase).
Because feed of the present invention or drinking water additive contain as the lysozyme of key component and/or the acceptable salt of its medicine and the material that contains peroxidase (particularly horseradish peroxidase), effect is that synergy by these two kinds of materials in feed or the drinking water additive reaches preferably, and it is good to estimate that its effect is done the time spent separately than these two kinds of materials.This point is a particular importance because until do not find now the broad base of lysozyme therapeutical uses because this enzyme only right and wrong special or inborn resistance system in a factor.The only limited activity of in these factors each (belonging to these factors) as lactoferrin and newborn peroxidase, the factor that exists in the system is many more, and its effect is just effective more.Effect when the material that contains peroxidase (particularly horseradish peroxidase) of Tian Jiaing can improve the lysozyme individualism in addition, horseradish peroxidase and lactoperoxidase and other peroxidase all belong to this fermentoid, and they quicken the oxidation of oxygenatedchemicals.For example, in phagocytosis, the mechanism of two kinds of main inactivation bacteriums is effective especially:
1. bacterium and product thereof and other germs are by the hydrolysis inactivation of lysozyme and other hydrolases.This mechanism is particularly suitable for macrophage; And
2. bacterium is subjected to the peroxide oxydasis and attacks (NADPH-oxide enzyme, superoxide dismutase, myeloperoxidase etc.), and wherein particularly neutrophilic granulocytic enzyme system is based on this deactivation mechanism.
Feed of the present invention or drinking water additive preferably also contain one or more vitamins that are selected from vitamin A, cholecalciferol, vitamin E, Cobastab, vitamin C, niacinamide, Ca-D-pantothenate.By vitamin being added in feed or the drinking water, other functions of body are produced exceeding lysozyme and contain excitation beyond the material of peroxidase.For example under ascorbic situation, to the phagozytic activity of the leucozytes of reticuloendothelial system and the excitation that antagonist generates.Feed or drinking water additive preferably contain vitamin E, and its quantity is 5～50g/kg additive.Known that by vitamin E the general disease to biology has many useful effects.Vitamin E generates the stabilisation that at first relates to unrighted acid as fat-soluble iuntercellular antioxidant by stoping poisonous lipoprotein.Vitamin E still is a kind of important protection factor to blood vessel and erythrocyte membrane, and it also shows many distinctive vitamin functions as the physiology antioxidant, as improving fecundity.Vitamin E also can stop muscle deterioration and hepatonecrosis, and according to the current research result, this point may be interpreted as its detoxification.In the used dosage of the present invention, produce owing to increase antibody, can reach by vitamin E and improve immunity and phagocytotic effect.And in feed of the present invention or drinking water additive, vitamin E particularly works as the physiology antioxidant, and, particularly by guarantee the effect of lysozyme for lysozyme generation reproducibility environment, in this case, lysozyme can show its whole effect.
All act on or significantly improve immunity in order to reach it, this feed or drinking water additive should contain lactoferrin and/or plant extract especially, particularly the leachate of echinaceae puys. and/or eleutherococcus and/or baptisia and/or contain the plant extract of thiocyanate.In plant extract, preferably contain echinaceae puys., eleuhterococcus and baptisia, its ratio of component is 1: 2: 1.The plant extract (as sinigrin) that contains thiocyanate can be by obtaining among the seed Sinapis nigrae.Also contain lactoferrin in this feed or the drinking water additive, it is a kind ofly can show bactericidal action and bacteriostasis in conjunction with the protein of iron.On the one hand, lactoferrin can kill special bacterium, and on the other hand, lactoferrin can be competed the iron that body provides with bacterium, therefore stops the growth of bacterium by iron in conjunction with active and bacteriostasis.Because this effect, lactoferrin helps the antibacterial action of lysozyme and peroxidase, so that total effect of two kinds of materials can further strengthen.In addition, lactoferrin is a kind of growth substance that helps, because it excites alkali to be attached on the DNA.Owing to this reason, by lactoferrin being added to the growth rate that can improve domestic animal in feed of the present invention or the drinking water additive.
The plant extract that preferably contains in feed or drinking water additive is used for strengthening immunity, particularly improves total effect of contained material in feed or the drinking water additive and makes feed or drinking water additive has wideer effect more completely.The effect that these plant extracts strengthen immunity is not based on the effect of single material, and is based on the effect of this class material, and it can connect with the acceptor of immunocyte.Its irritation cell produces metabolite, this product and immune other component interactions, thus, can improve total effect of feed or drinking water additive by the material that adds plant extract, particularly echinaceae puys. or eleutherococcus and/or baptisia and/or contain the sulfo-cyanate.
According to the present invention, this feed or drinking water additive contain 0.5～20% (weight) lisozima, 0.5～15% (weight) horseradish peroxidase, 0.1～5% (weight) vitamin E and 0.5～15% (weight) plant extract and lactoferrin specifically except that inert carrier.Because the use of above-mentioned quantity material, might obtain a kind of like this feed or drinking water additive, the growth rate that it almost improves immunity comprehensively, greatly strengthens specific immunity system (particularly when brood weaned, this system is incomplete development still) and improve described brood comprehensively.In addition, provide main feed ingredient with lactose (for example simultaneously as inert carrier) for the health of brood.With feed of the present invention or drinking water additive, also may alleviate or avoid because the defence capability weakness that causes of the immune system of incomplete development and acute and chronic disease still, its tolerance chemotherapy usually, because by adding feed of the present invention or drinking water additive, the domestic animal particularly immune system of brood is significantly strengthened.
Further specify the present invention with following embodiment, in this embodiment, use to fertile chicken test preparation in the mode of drinking water.
Embodiment
As test preparation, the per kilogram preparation uses 22g lysozyme, 22g horseradish peroxidase, 5g vitamin E and 20g to contain the plant extract of 5g echinaceae puys., 10g eleutherococcus and 5g baptisia and the mixture of 931g inert carrier.
5 weeks of test duration, test two groups of chickens, 11200 chickens of test group, 16320 chickens of contrast groups, they all belong to the Ross-208 kind, and they are raised under the same conditions and fat up, and different is that test group is accepted feed of the present invention or drinking water additive.
Be added in the drinking water test mixture and administration as follows:
The 3rd day 30g/1000 the chicken in birth back
The 5th day 30g/1000 the chicken in birth back
The 17th day 50g/1000 the chicken in birth back
The 20th day 50g/1000 the chicken in birth back
The 31st day 100g/1000 the chicken in birth back
The 34th day 100g/1000 the chicken in birth back
The result lists following table 1 in.Compare with contrast groups, the service test preparation, feed conversion rate improves 9%.
Table 1
Test preparation group control group is fattened fate 37 38 and is fattened chicken
Begin 11.200 16.320
Finish 10.970 15.879
Lose 230 441
＝2,05％ ＝2,70％
Test preparation group control group weighs 17.388,0 26.322,8 its quality I, 16.692 25.269,8 quality II 696 1.053,0 when finishing
=4,00%=4,00% feed total burn-off 27.980kg 46.710kg food conversion 1,61 1,77
=91%=100% flesh generate carefully visual balance carefully skin carefully peck at ability carefully stomach fat general to increase 103 104 colors good yellowish with standard phase weight/power ratio
The reason of good results that causes helping improving the fatty conversion ratio more than 9% of growth rate is that test preparation has improved immunity, and the energy of experimental animal can be used for putting on flesh rather than is used for defence and infects.
Claims (6)
1. a feed or drinking water additive that is used to improve the lysozyme of domestic animal resistance to stress and immunity, it is characterized in that this feed or drinking water additive contain as the lysozyme of key component and/or the acceptable salt of its medicine and the material that contains peroxidase (particularly horseradish peroxidase).
2. according to the feed or the drinking water additive of claim 1, it is characterized in that it also contains and is selected from vitamin A, cholecalciferol, vitamin E, Cobastab, vitamin C, niacinamide, C
aOne or more vitamins of-D-pantothenate.
3. according to the feed or the drinking water additive of claim 2, it is characterized in that this feed or drinking water additive contain vitamin E, its quantity is 5～50g/Kg additive.
4. according to each feed or drinking water additive in the claim 1,2 or 3, it is characterized in that, described feed or drinking water additive also contain lactoferrin and/or plant extract, particularly plant extract that is obtained by echinaceae pyus. and/or eleutherococcus and/or baptisia and/or the plant extract that contains the sulfo-cyanate.
5. according to each feed or drinking water additive in the claim 1～4, it is characterized in that, except that inert carrier, it contains 0.5～20% (weight) lysozyme salt acidulants, 0.5～15% (weight) horseradish peroxidase, 0.1～5% (weight) vitamin E and 0.5～15% (weight) plant extract and lactoferrin.
6. according to the feed or the drinking water additive of claim 4 or 5, it is characterized in that in plant extract, the ratio of component of echinaceae puys., eleutherococcus and baptisia is 1: 2: 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0044394U AT506U1 (en) | 1994-11-22 | 1994-11-22 | FEEDING MATERIALS DRINKING WATER ADDED TO IMPROVE THE STRESS RESISTANCE AND IMMUNITY OF FARM ANIMALS |
| ATGM443/94 | 1994-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1138821A true CN1138821A (en) | 1996-12-25 |
Family
ID=3490752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95191289A Pending CN1138821A (en) | 1994-11-22 | 1995-11-21 | Fodder and drinking water additive for improving the resistance to stress and immunity of useful animals |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0740509A1 (en) |
| JP (1) | JPH11514205A (en) |
| KR (1) | KR100218977B1 (en) |
| CN (1) | CN1138821A (en) |
| AT (1) | AT506U1 (en) |
| AU (1) | AU3835295A (en) |
| BR (1) | BR9506556A (en) |
| CA (1) | CA2181365A1 (en) |
| CZ (1) | CZ285631B6 (en) |
| HR (1) | HRP950567A2 (en) |
| HU (1) | HUT76362A (en) |
| IL (1) | IL115918A (en) |
| MX (1) | MX9602848A (en) |
| PL (1) | PL315570A1 (en) |
| SK (1) | SK89296A3 (en) |
| TW (1) | TW349848B (en) |
| WO (1) | WO1996015682A1 (en) |
| YU (1) | YU73795A (en) |
| ZA (1) | ZA959716B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103583896A (en) * | 2013-11-04 | 2014-02-19 | 南京温氏畜禽有限公司 | Broiler chicken anti-stress health-care drinking water, and preparation method and using method thereof |
| CN106666108A (en) * | 2017-02-07 | 2017-05-17 | 佛山市正典生物技术有限公司 | Vitamin molecule microemulsion containing lysozyme and preparation method of microemulsion |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19751181A1 (en) * | 1997-11-19 | 1999-05-27 | Guenter Schiedermair | Supplementary feedstuff |
| US6096307A (en) * | 1997-12-11 | 2000-08-01 | A. Glenn Braswell | Compositions for immunostimulation containing Echinacea angustofolia, bromelain, and lysozyme |
| DK172775B1 (en) * | 1998-03-12 | 1999-07-12 | Diarex V G Andresen | Animal feed additives containing a flavanoid-containing mimosa extract and animal feed containing the same and method t |
| CA2346075A1 (en) * | 1998-10-15 | 2000-04-20 | Dsm N.V. | Antimicrobial enzymes in animal feed |
| NZ527924A (en) * | 1999-01-29 | 2005-01-28 | Mars Uk Ltd | Antioxidant compositions and methods for companion animals |
| KR100414899B1 (en) * | 2001-09-05 | 2004-01-13 | 전병국 | A method of preparing isotonic drink for the baby using eucommia ulmoides |
| DE102004005788A1 (en) * | 2004-02-06 | 2005-09-01 | Riemser Arzneimittel Ag | Preparations containing Echinacea extracts and thiocyanate |
| CN107637698A (en) * | 2017-10-20 | 2018-01-30 | 天津市畜牧兽医研究所 | A kind of compound premixed feed being added in lactation calf acidifying milk and its application |
| KR20240009564A (en) | 2022-07-13 | 2024-01-23 | 재단법인 전남바이오진흥원 | Animal feed composition and animal feed for stress prevention and promotion of melatonin secretion. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2118420B (en) * | 1982-04-20 | 1986-01-02 | Licencia Talalmanyokat | Fodder additive for the keeping of small animals and a process for the improvement of the meat quality |
| GB2132466B (en) * | 1982-12-22 | 1986-10-15 | Impro Products Inc | Whey product and method for obtaining same |
| DK501686A (en) * | 1986-10-20 | 1988-04-21 | Otto Melchior Poulsen | ENZYME CONTAINING BACTERICIDIC AGENTS AND DENTALS AND SPECIAL TREATMENTS CONTAINING IT |
| FI77773C (en) * | 1986-12-19 | 1989-05-10 | Suomen Sokeri Oy | Fermentation process for silage. |
| DE3727735A1 (en) * | 1987-08-20 | 1989-03-02 | Henkel Kgaa | CHICKEN EGG TASTE IMPROVEMENT |
| FI83151C (en) * | 1988-06-17 | 1991-06-10 | Cultor Oy | Fermentative process and additive for food preservation |
| HU202762B (en) * | 1988-10-12 | 1991-04-29 | Reanal Finomvegyszergyar | Process for producing compositions containing lizozime and vitamines for stock-raising utilizaiton |
| AT400792B (en) * | 1989-06-13 | 1996-03-25 | Egger Franz | Lactic-acid-bacteria-containing feedstuff additive and process for its production |
| AT398362B (en) * | 1990-06-06 | 1994-11-25 | Erber Erich Ing | Feed additive and process for its production |
| GB9200891D0 (en) * | 1992-01-16 | 1992-03-11 | Mann Stephen P | Formulation of microorganisms |
-
1994
- 1994-11-22 AT AT0044394U patent/AT506U1/en not_active IP Right Cessation
-
1995
- 1995-10-30 TW TW084111449A patent/TW349848B/en active
- 1995-11-08 IL IL11591895A patent/IL115918A/en not_active IP Right Cessation
- 1995-11-15 ZA ZA959716A patent/ZA959716B/en unknown
- 1995-11-20 HR HRGM443/94A patent/HRP950567A2/en not_active Application Discontinuation
- 1995-11-21 CZ CZ961974A patent/CZ285631B6/en not_active IP Right Cessation
- 1995-11-21 PL PL95315570A patent/PL315570A1/en unknown
- 1995-11-21 WO PCT/AT1995/000224 patent/WO1996015682A1/en not_active Application Discontinuation
- 1995-11-21 EP EP95936377A patent/EP0740509A1/en not_active Ceased
- 1995-11-21 AU AU38352/95A patent/AU3835295A/en not_active Abandoned
- 1995-11-21 CN CN95191289A patent/CN1138821A/en active Pending
- 1995-11-21 BR BR9506556A patent/BR9506556A/en not_active IP Right Cessation
- 1995-11-21 JP JP8516376A patent/JPH11514205A/en active Pending
- 1995-11-21 HU HU9601974A patent/HUT76362A/en unknown
- 1995-11-21 KR KR1019960703933A patent/KR100218977B1/en not_active IP Right Cessation
- 1995-11-21 CA CA002181365A patent/CA2181365A1/en not_active Abandoned
- 1995-11-21 SK SK892-96A patent/SK89296A3/en unknown
- 1995-11-22 YU YU73795A patent/YU73795A/en unknown
-
1996
- 1996-07-18 MX MX9602848A patent/MX9602848A/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103583896A (en) * | 2013-11-04 | 2014-02-19 | 南京温氏畜禽有限公司 | Broiler chicken anti-stress health-care drinking water, and preparation method and using method thereof |
| CN103583896B (en) * | 2013-11-04 | 2015-06-24 | 南京温氏畜禽有限公司 | Broiler chicken anti-stress health-care drinking water, and preparation method and using method thereof |
| CN106666108A (en) * | 2017-02-07 | 2017-05-17 | 佛山市正典生物技术有限公司 | Vitamin molecule microemulsion containing lysozyme and preparation method of microemulsion |
Also Published As
| Publication number | Publication date |
|---|---|
| YU73795A (en) | 1998-05-15 |
| AU3835295A (en) | 1996-06-17 |
| IL115918A0 (en) | 1996-01-31 |
| BR9506556A (en) | 1997-10-28 |
| JPH11514205A (en) | 1999-12-07 |
| CZ285631B6 (en) | 1999-10-13 |
| HRP950567A2 (en) | 1997-04-30 |
| WO1996015682A1 (en) | 1996-05-30 |
| CA2181365A1 (en) | 1996-05-30 |
| HUT76362A (en) | 1997-08-28 |
| PL315570A1 (en) | 1996-11-12 |
| CZ197496A3 (en) | 1996-10-16 |
| SK89296A3 (en) | 1996-12-04 |
| AT506U1 (en) | 1995-12-27 |
| EP0740509A1 (en) | 1996-11-06 |
| MX9602848A (en) | 1998-08-30 |
| KR100218977B1 (en) | 1999-10-01 |
| TW349848B (en) | 1999-01-11 |
| ZA959716B (en) | 1996-05-29 |
| IL115918A (en) | 1999-12-31 |
| HU9601974D0 (en) | 1996-09-30 |
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| C53 | Correction of patent of invention or patent application | ||
| CB02 | Change of applicant information |
Address after: Fort Austria Applicant after: ING. Erich Erber Kommanditgesellschaft Address before: Austria porthan Applicant before: Earl and Dean of Engineering GmbH & Co. kg |
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