CN113876855A - Traditional Chinese medicine compound preparation for preventing and treating chicken coccidiosis and preparation method thereof - Google Patents
Traditional Chinese medicine compound preparation for preventing and treating chicken coccidiosis and preparation method thereof Download PDFInfo
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- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a traditional Chinese medicine compound preparation for preventing and treating chicken coccidiosis, and relates to the technical field of poultry breeding. The traditional Chinese medicine compound preparation comprises the following raw materials in parts by weight: 1-1.2 parts of dichroa febrifuga, 1-1.2 parts of hairyvein agrimony, 0.8-1 part of sweet wormwood herb, 0.8-1 part of humifuse euphorbia herb, 0.5-0.8 part of radix sophorae flavescentis, 1-1.2 parts of purslane and 0.8-1 part of Chinese magnoliavine fruit. The Chinese medicinal compound preparation is applied to the chicken coccidiosis, can quickly take effect, has high cure rate, is extracted from pure Chinese medicaments, and has no side effect or drug resistance.
Description
Technical Field
The invention relates to the technical field of poultry breeding, in particular to a traditional Chinese medicine compound preparation for preventing and treating chicken coccidiosis and a preparation method thereof.
Background
The coccidiosis of the chicken is an important disease which endangers the chicken industry, the morbidity of the chicks is 50-70%, the mortality of the chicks is 20-30%, and the growth and development of the chicks are hindered after the chicks are cured. Infection of adult chickens affects weight gain and egg production. Coccidiosis can destroy intestinal mucosa, cause intestinal canal inflammation, epithelial cell disintegration, digestive dysfunction, generate toxic substance, and cause autointoxication. The chickens suffering from the essence loss, the drooping of wings and the bow waist are mainly caused by excessive drinking, little eating, bloody stool, anemia, dehydration and death in different degrees, and the production performance is reduced. The poultry industry worldwide loses about 20 billion pounds per year of coccidiosis.
The existing medicines for preventing and treating chicken coccidiosis have the defects of easy generation of drug resistance and side effects and the like, for example, the amproline acts on the first-generation schizont of coccidium, only has the treatment effect, does not have the prevention effect, is easy to resist the drug, and can cause nervous symptoms due to the side effects; the sulfonamides act on the first-generation schizont of the coccidium, only have treatment effect, no prevention effect, easy drug resistance and side effect capable of causing kidney swelling; diclazuril can be used for preventing and treating coccidiosis simultaneously, has small side effect, but is easy to generate drug resistance.
Therefore, it is a problem to be solved by those skilled in the art to provide a drug with less side effects and no drug resistance.
Disclosure of Invention
In view of the above, the invention provides a traditional Chinese medicine compound preparation for preventing and treating chicken coccidiosis and a preparation method thereof. The traditional Chinese medicine compound preparation is suitable for various coccidiosis development periods, can quickly stop bleeding and prevent further progress of disease, has an obvious curative effect on treating chicken coccidiosis, and can be used for preventing chicken coccidiosis and chicken enteritis without side effects and drug resistance.
In order to achieve the purpose, the invention adopts the following technical scheme:
a traditional Chinese medicine compound preparation for preventing and treating chicken coccidiosis comprises the following raw materials in parts by weight: 1-1.2 parts of dichroa febrifuga, 1-1.2 parts of hairyvein agrimony, 0.8-1 part of sweet wormwood herb, 0.8-1 part of humifuse euphorbia herb, 0.5-0.8 part of radix sophorae flavescentis, 1-1.2 parts of purslane and 0.8-1 part of Chinese magnoliavine fruit.
As a preferred technical scheme, the traditional Chinese medicine compound preparation comprises the following raw materials in parts by weight: 1.2 parts of dichroa, 1 part of hairyvein agrimony, 0.8 part of sweet wormwood, 0.8 part of humifuse euphorbia herb, 0.8 part of lightyellow sophora root, 1 part of purslane and 1 part of Chinese magnoliavine fruit.
The dichroa febrifuga is bitter, pungent and cold in taste; it enters lung, liver and heart meridians; the function is mainly used for checking malaria and robbing phlegm. The agrimony is bitter, astringent and mild in nature; heart and liver meridian entered; the functions are mainly used for astringing and stopping bleeding, checking malaria, stopping dysentery and detoxifying. Sweet wormwood herb is bitter, pungent and cold in property; it enters liver and gallbladder meridians; the functions are mainly used for clearing away summer heat, removing steaming and preventing malaria. The humifuse euphorbia herb is pungent and mild in nature and taste; it enters liver and large intestine meridians; the functions are mainly to clear away heat and toxic material, cool blood and stop bleeding. Kuh-seng is bitter in nature and cold in taste; the channels of heart, liver, stomach, large intestine and bladder; the functions are mainly used for clearing heat and drying dampness, killing parasites and promoting urination. Purslane is sour and cold in nature; the large intestine meridian, liver, spleen and heart; the functions are mainly used for clearing away heat and toxic material, promoting diuresis and removing dampness, and dissipating blood and eliminating swelling. Schisandra chinensis is sour and warm in nature. It enters lung, kidney and heart meridians. The functions are mainly used for astringing lung and nourishing kidney, promoting the production of body fluid and arresting sweating, controlling nocturnal emission and stopping diarrhea, and calming heart and tranquilizing.
The invention also aims to provide a preparation method of the traditional Chinese medicine compound preparation, which comprises the following steps:
(1) pretreatment: cutting the raw materials, and mixing according to a proportion;
(2) soaking and decocting: adding 5 times of water, soaking for 3 hr, heating to boil, decocting for 2 hr, and filtering to obtain decoction; adding 3 times of water, heating to boil, decocting for 2 hr under slightly boiling state, and filtering to obtain second decoction;
(3) concentration: mixing the first decoction and the second decoction, concentrating under reduced pressure until the relative density is more than or equal to 1.10, and cooling to obtain extract;
(4) preparation: adding purified water to required amount, and stirring to obtain Chinese medicinal compound preparation (1ml is 2g crude drug).
As the preferable technical scheme of the invention, the pretreatment in the step (1) further comprises the steps of sorting the raw materials and selecting high-quality medicinal materials for later use.
As a preferable technical scheme of the invention, the soaking temperature in the step (2) is 10-30 ℃.
As the preferable technical scheme of the invention, the preparation in the step (4) also comprises the addition of sodium benzoate accounting for 0.3 percent of the weight of the traditional Chinese medicine compound preparation.
As the preferable technical scheme of the invention, the method also comprises a step of inspecting and filling, wherein the Chinese herbal compound preparation obtained in the step (4) is inspected, filled after being inspected to be qualified, and then a finished product is inspected again.
The invention also aims to provide a using method of the traditional Chinese medicine composition, wherein each bottle of liquid medicine is 500ml, 300L of water is added for use, and 3000 broilers, or 1200 broilers, or 5000 egg-laying broilers, or 1000 egg-laying broilers can be treated by concentrating drinking water for 4-6 hours in the morning. The medicine is used for 3-5 days.
According to the technical scheme, compared with the prior art, the invention discloses a traditional Chinese medicine compound preparation for preventing and treating chicken coccidiosis. The Chinese medicinal compound preparation is applied to the chicken coccidiosis, can quickly take effect, has high cure rate, is extracted from pure Chinese medicaments, and has no side effect or drug resistance.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The raw materials used in the examples of the present invention are all commercially available and the sources thereof are not limited. The methods not mentioned are all conventional methods, and are not described in detail herein.
Example 1
(1) Pretreatment:
all raw materials are optimized, impurities are removed, and the raw materials are cut into sections smaller than 3 cm.
Weighing 1.2 parts of antifeverile dichroa root, 1 part of hairyvein agrimony, 0.8 part of sweet wormwood herb, 0.8 part of humifuse euphorbia herb, 0.8 part of lightyellow sophora root, 1 part of purslane and 1 part of Chinese magnoliavine fruit, and uniformly mixing.
(2) Soaking and decocting: adding 5 times of water, soaking at 20 deg.C for 3 hr, heating to boil, decocting for 2 hr, and filtering to obtain decoction; adding 3 times of water, heating to boil, decocting for 2 hr under slightly boiling state, and filtering to obtain second decoction;
(3) concentration: mixing the first decoction and the second decoction, concentrating under reduced pressure until the relative density is more than or equal to 1.10, and cooling to obtain extract;
(4) preparation: adding purified water and 0.3 wt% of sodium benzoate, stirring uniformly, and carrying out semi-finished product inspection; and (3) filling after the inspection is qualified, wherein the specification is 500 ml/bottle, the sealing is required to be tight, and then inspecting the finished product to obtain the traditional Chinese medicine compound preparation (1ml is equivalent to 2g of crude drug) after the inspection is qualified.
Example 2
(1) Pretreatment:
all raw materials are optimized, impurities are removed, and the raw materials are cut into sections smaller than 3 cm.
Weighing 1 part of antifeverile dichroa root, 1 part of hairyvein agrimony, 0.8 part of sweet wormwood herb, 0.8 part of humifuse euphorbia herb, 0.5 part of lightyellow sophora root, 1 part of purslane and 0.8 part of Chinese magnoliavine fruit, and uniformly mixing.
(2) Soaking and decocting: adding 5 times of water, soaking at 10 deg.C for 3 hr, heating to boil, decocting for 2 hr, and filtering to obtain decoction; adding 3 times of water, heating to boil, decocting for 2 hr under slightly boiling state, and filtering to obtain second decoction;
(3) concentration: mixing the first decoction and the second decoction, concentrating under reduced pressure until the relative density is more than or equal to 1.10, and cooling to obtain extract;
(4) preparation: adding purified water and 0.3 wt% of sodium benzoate, stirring uniformly, and carrying out semi-finished product inspection; and (3) filling after the inspection is qualified, wherein the specification is 500 ml/bottle, the sealing is required to be tight, and then inspecting the finished product to obtain the traditional Chinese medicine compound preparation (1ml is equivalent to 2g of crude drug) after the inspection is qualified.
Example 3
(1) Pretreatment:
all raw materials are optimized, impurities are removed, and the raw materials are cut into sections smaller than 3 cm.
Weighing 1.2 parts of antifeverile dichroa root, 1.2 parts of hairyvein agrimony, 1 part of sweet wormwood herb, 1 part of humifuse euphorbia herb, 0.8 part of lightyellow sophora root, 1.2 parts of purslane and 1 part of Chinese magnoliavine fruit, and uniformly mixing.
(2) Soaking and decocting: adding 5 times of water, soaking at 30 deg.C for 3 hr, heating to boil, decocting for 2 hr, and filtering to obtain decoction; adding 3 times of water, heating to boil, decocting for 2 hr under slightly boiling state, and filtering to obtain second decoction;
(3) concentration: mixing the first decoction and the second decoction, concentrating under reduced pressure until the relative density is more than or equal to 1.10, and cooling to obtain extract;
(4) preparation: adding purified water and 0.3 wt% of sodium benzoate, stirring uniformly, and carrying out semi-finished product inspection; and (3) filling after the inspection is qualified, wherein the specification is 500 ml/bottle, the sealing is required to be tight, and then inspecting the finished product to obtain the traditional Chinese medicine compound preparation (1ml is equivalent to 2g of crude drug) after the inspection is qualified.
Effect example 1 (safety test)
Safety tests are carried out on the traditional Chinese medicine compound preparation obtained in the example 1, and the safety tests comprise tests of new use safety, dosage safety, other medicine compatibility safety and the like.
The use safety is as follows: in clinical use, the product is applied to 7-12-day-old broiler chickens, 25-30-day-old egg chickens, 55-60-day-old young chickens and laying hen groups after the development respectively, has no toxic or side effect, and does not influence the growth and the egg laying rate of the chicken groups.
Dose safety: in clinical application, according to the disease condition, the product is used in a normal dosage (300L water/bottle), an amount of 1/3(200L water/bottle) and a double dosage (150L water/bottle). Has no side effect on chicken flocks.
The compatibility safety is as follows: when the composition is clinically applied, the composition is combined with intestinal tract treatment medicines, and antibacterial medicines, antiviral medicines and coccidiostat medicines have no adverse reaction and incompatibility.
Effect example 2 (Effect test)
In a certain farm of Hebei Shijiazhuang, 15000 high peak laying hens have slow food intake in clinic, cockscomb becomes light in color, laying rate is reduced slowly, feces have red rotten meat samples and are convenient to eat, and small intestine coccidium is diagnosed, 15 bottles/day of the Chinese herbal compound preparation in the embodiment 1 is used, and the Chinese herbal compound preparation is matched with enteritis drugs for use for 4 days, so that the food intake is recovered to be normal, the feces have normal color, and the laying rate is gradually recovered and increased.
Effect example 3 (Effect test)
26000 chickens with meat impurity of 817 in a certain farm in Shandong Jinnan, are bred in cages, are 16 days old, have low feed intake and are not close to the day, and stand dead chickens are respectively arranged in the farm, and the excrement contains tomato-like excrement, feed excrement and slender excrement. The clinical diagnosis is as follows: small intestinal coccidiosis and enteritis, treatment regimen: example 1A compound Chinese medicinal preparation is 10 bottles (used for four days) per day, 15 bottles (used for three days) per day, and the three days of return visit have obvious effect, improve the feed intake, obviously improve the feces, and restore the chicken flocks to normal on the 5 th day.
Effect example 4 (Effect test)
The prevention test of the traditional Chinese medicine compound preparation in example 1 on coccidiosis is carried out in a plurality of broiler farms in Shandong near-Yi market, the product is added into drinking water of 9-11-day-old broiler flocks and is used according to 300L of water/bottle for 3 days, the coccidiosis can be effectively prevented, the general prevention effect can last to 27-28 days old (the prevention effect of products of other manufacturers can reach 15-20 days old), the prevention effect can reach 30 days old after individual management, and the feed-meat ratio in the later period can be reduced by 0.1-0.5 percent compared with that without the product.
The embodiments are described in a progressive manner in the specification, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (6)
1. A traditional Chinese medicine compound preparation for preventing and treating chicken coccidiosis is characterized by comprising the following raw materials in parts by weight: 1-1.2 parts of dichroa febrifuga, 1-1.2 parts of hairyvein agrimony, 0.8-1 part of sweet wormwood herb, 0.8-1 part of humifuse euphorbia herb, 0.5-0.8 part of radix sophorae flavescentis, 1-1.2 parts of purslane and 0.8-1 part of Chinese magnoliavine fruit.
2. The compound traditional Chinese medicine preparation as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight: 1.2 parts of dichroa, 1 part of hairyvein agrimony, 0.8 part of sweet wormwood, 0.8 part of humifuse euphorbia herb, 0.8 part of lightyellow sophora root, 1 part of purslane and 1 part of Chinese magnoliavine fruit.
3. The preparation method of the compound traditional Chinese medicine preparation of claim 1 or 2, which is characterized by comprising the following steps:
(1) pretreatment: cutting the raw materials, and mixing according to a proportion;
(2) soaking and decocting: adding 5 times of water, soaking for 3 hr, heating to boil, decocting for 2 hr while maintaining slightly boiling state, and filtering to obtain first decoction; adding 3 times of water, heating to boil, decocting for 2 hr under slightly boiling state, and filtering to obtain second decoction;
(3) concentration: mixing the first decoction and the second decoction, concentrating under reduced pressure until the relative density is more than or equal to 1.10, and cooling to obtain extract;
(4) preparation: adding purified water to the required dosage, and stirring uniformly to obtain the traditional Chinese medicine compound preparation.
4. The method according to claim 3, wherein the step (1) of pre-treating further comprises sorting the raw materials and selecting high-quality herbs for use.
5. The method according to claim 3, wherein the soaking temperature in the step (2) is 10 to 30 ℃.
6. The method of claim 3, wherein the formulating of step (4) further comprises adding 0.3% wt sodium benzoate.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274314A (en) * | 2011-08-13 | 2011-12-14 | 江西中成药业集团有限公司 | Evergreen coccidian powder and preparation method thereof |
| CN104208238A (en) * | 2013-09-29 | 2014-12-17 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof |
| CN108210610A (en) * | 2016-12-13 | 2018-06-29 | 河南后羿实业集团有限公司 | It is a kind of to be used to treat drug of coccidiosis of livestock and poultry and preparation method thereof |
| CN108210764A (en) * | 2016-12-13 | 2018-06-29 | 河南后羿实业集团有限公司 | A kind of Chinese medicine composition for treating chicken coccidiasis and preparation method thereof |
-
2021
- 2021-10-21 CN CN202111228814.7A patent/CN113876855A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274314A (en) * | 2011-08-13 | 2011-12-14 | 江西中成药业集团有限公司 | Evergreen coccidian powder and preparation method thereof |
| CN104208238A (en) * | 2013-09-29 | 2014-12-17 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof |
| CN108210610A (en) * | 2016-12-13 | 2018-06-29 | 河南后羿实业集团有限公司 | It is a kind of to be used to treat drug of coccidiosis of livestock and poultry and preparation method thereof |
| CN108210764A (en) * | 2016-12-13 | 2018-06-29 | 河南后羿实业集团有限公司 | A kind of Chinese medicine composition for treating chicken coccidiasis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 魏凤仙等: "五味子及其提取物在养殖业中的应用研究进展", 《河南农业科学》 * |
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