CN113855653A - Medicinal and edible aerosol inhalation product with lung clearing function and preparation method thereof - Google Patents
Medicinal and edible aerosol inhalation product with lung clearing function and preparation method thereof Download PDFInfo
- Publication number
- CN113855653A CN113855653A CN202111418152.XA CN202111418152A CN113855653A CN 113855653 A CN113855653 A CN 113855653A CN 202111418152 A CN202111418152 A CN 202111418152A CN 113855653 A CN113855653 A CN 113855653A
- Authority
- CN
- China
- Prior art keywords
- medicinal
- edible
- lung
- product
- clearing function
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicinal and edible atomization inhalation product with a lung-heat clearing function and a preparation method thereof. The manufacturing process comprises the following steps: the medicinal and edible composite raw materials are subjected to superfine grinding, distilled water and composite biological enzyme are added for enzymolysis, ethanol is used for extraction and precipitation after separation, then separation treatment is carried out, supernatant is merged and concentrated under reduced pressure, concentrated paste is subjected to solvent extraction and filtration, and finally the mixture is mixed with fragrance substances and compounded to obtain the medicinal and edible atomization inhalation product with the lung clearing function. The process can effectively extract effective components of the medicinal and edible composite raw materials, the effective components are inhaled into a human body through a respiratory tract by the atomization inhalation equipment, and the selected raw materials are medicinal and edible raw materials, so that the medicinal and edible composite raw materials can act on the lung more quickly, more accurately and more safely, can well relieve lung heat, and has good treatment effect on asthma, chronic tracheitis, chronic pharyngitis and the like.
Description
Technical Field
The invention belongs to the technical field of pharmaceutical dosage forms, and particularly relates to a medicinal and edible atomization inhalation product with a lung-heat clearing function and a preparation method thereof.
Background
The lung is the respiratory organ of the human body and also the important hematopoietic organ of the human body, is positioned in the chest cavity, is positioned on the left and the right, and is covered on the heart. The lung has five lobes, three on the left and two on the right. The lung lobes are delicate and not resistant to cold and heat, so they are easy to invade by pathogens, so they are also called delicate organs. Once the lung is inhaled with bacteria, viruses, fungi and the like to damage the lung function, in the past, the dirty objects are not removed in time, and irreversible damage can be caused. If the lung is not cleared timely for a long time, the lung will cause respiratory diseases, immunity decline, low mood and other adverse effects.
In recent years, attention and attention are increasingly paid to the repair effect of food and medicine raw materials and components thereof on sub-health of human bodies. The food can play a role in clearing away the lung-heat, but has slow effect. If the food and medicine raw materials directly act on the lung through the respiratory tract, the lung clearing effect can be achieved more quickly and accurately. At present, a product for treating natural edible and medicinal raw materials with homology of medicine and food is especially lacked, and the natural edible and medicinal raw materials are regulated by fragrance substances and inhaled into the body through a respiratory tract to relieve lung heat, and relieve asthma, chronic tracheitis, chronic pharyngitis and other symptoms. Therefore, there is a need to develop an aerosol inhalation product with fast action, no toxic side effects and lung clearing function.
Disclosure of Invention
The invention provides a medicinal and edible atomization inhalation product with a lung-heat clearing function and a preparation method thereof.
Firstly, the medicinal and edible composite raw materials are mixture of five or more of honeysuckle, heartleaf houttuynia herb, emblic leafflower fruit, fragrant solomonseal rhizome, mint, dandelion, sophora flower bud, purslane, kudzuvine root, stevia, dark plum fruit, purple perilla, wrinkled gianthyssop herb, liquorice and lily, wherein the honeysuckle, the heartleaf houttuynia herb, the mint, the liquorice and the lily are preferably selected as 3:1:2:2: 2. The medicinal and edible composite raw materials are subjected to superfine grinding for 20min-30min until the fineness reaches more than 1500 meshes.
Adding 9 times volume of distilled water into the medicinal and edible composite superfine powder, adding two or more of acid cellulase, acid pectinase, acid protease, amylase and lipase according to the addition amount of 1% respectively, carrying out enzymolysis at 50-60 ℃ and pH value of 4.5-6.5, and carrying out enzymolysis and stirring for 2-3 hours to obtain an enzymolysis solution.
Centrifuging the enzymolysis solution at 8000-10000 r/min for 10-20 min, and collecting supernatant.
Extracting the precipitate with ethanol by refluxing the precipitate with anhydrous ethanol at 80-100 deg.C for 2-4 hr.
Centrifuging the ethanol extractive solution at 8000-10000 r/min for 10-20 min, and mixing the obtained supernatant with the enzymolysis supernatant.
And carrying out reduced pressure rotary evaporation on the combined supernatant at the temperature of 60-80 ℃, concentrating until the Baume degree is 41.5-43.0, and finishing concentration to obtain the concentrated paste.
Adding the concentrated paste into a mixed solvent of glycerol and propylene glycol 2:1, stirring for dissolving, and filtering to obtain a dissolved solution.
Mixing the dissolved solution and oleum Menthae essential oil to obtain medicinal and edible aerosol inhalation product with lung clearing effect
The invention has the advantages that the active ingredients of the medicinal and edible composite raw materials can be effectively extracted through biological enzyme enzymolysis and ethanol extraction, the taste is adjusted through fragrance substances, and the compounded aerosol inhalation product is safe, takes effect quickly and has better taste than oral medicines.
Drawings
FIG. 1: mean cough latency and mean number of coughs for each group of mice.
Detailed Description
The present invention will be further described with reference to the following specific examples, but the present invention is not limited thereto, and all technical solutions similar to or the same as the present application belong to the present invention.
Example 1
1. Mixing flos Lonicerae, herba Houttuyniae, herba Menthae, Glycyrrhrizae radix, and Bulbus Lilii at ratio of 3:1:2:2:2, and superfine wall-breaking pulverizing;
2. 100 g of the superfine crushed powder is taken and 900 g of distilled water is added;
3. adjusting pH to 5.0 with acid or alkali;
4. adding 0.1g of acidic cellulase and 0.1g of acidic pectinase while stirring, and stirring for enzymolysis for 2 hours at the temperature of 55 ℃;
5. centrifuging the enzymolysis liquid at 10000r/min for 10min, and collecting the supernatant;
6. adding 900 g of absolute ethyl alcohol into the precipitate, and refluxing for 2 hours at 100 ℃;
7. centrifuging the ethanol extractive solution at 10000r/min for 10min, and mixing the obtained supernatant with the enzymolysis supernatant;
8. carrying out reduced pressure rotary evaporation on the combined supernatant at the temperature of 70 ℃, concentrating to the Baume degree of 42.0, and finishing concentration;
9. adding the concentrated paste into a mixed solvent of 2.5 weight parts of glycerol and 2:1 propylene glycol, stirring for dissolving, filtering, adding peppermint essential oil, mixing and compounding to obtain the medicinal and edible atomization inhalation product with the lung clearing function.
Example 2
1. Mixing flos Lonicerae, herba Houttuyniae, herba Menthae, Glycyrrhrizae radix, and Bulbus Lilii at ratio of 3:1:2:2:2, and superfine wall-breaking pulverizing;
2. 100 g of the superfine crushed powder is taken and 900 g of distilled water is added;
3. adjusting pH to 5.5 with acid or alkali;
4. adding 0.1g of acid cellulase and 0.1g of acid protease while stirring, and stirring and carrying out enzymolysis for 2 hours at the temperature of 55 ℃;
5. centrifuging the enzymolysis liquid at 10000r/min for 10min, and collecting the supernatant;
6. adding 900 g of absolute ethyl alcohol into the precipitate, and refluxing for 2 hours at 100 ℃;
7. centrifuging the ethanol extractive solution at 10000r/min for 10min, and mixing the obtained supernatant with the enzymolysis supernatant;
8. carrying out reduced pressure rotary evaporation on the combined supernatant at the temperature of 70 ℃, concentrating to the Baume degree of 42.0, and finishing concentration;
9. adding the concentrated paste into a mixed solvent of 5 weight parts of glycerol and 2:1 propylene glycol, stirring for dissolving, filtering, adding peppermint essential oil, mixing and compounding to obtain the medicinal and edible atomization inhalation product with the lung clearing function.
Example 3
1. Mixing flos Lonicerae, herba Houttuyniae, herba Menthae, Glycyrrhrizae radix, and Bulbus Lilii at ratio of 3:1:2:2:2, and superfine wall-breaking pulverizing;
2. 100 g of the superfine crushed powder is taken and 900 g of distilled water is added;
3. adjusting pH to 6.0 with acid or alkali;
4. adding 0.1g of acid cellulase and 0.1g of amylase while stirring, and stirring and carrying out enzymolysis for 2 hours at the temperature of 55 ℃;
5. centrifuging the enzymolysis liquid at 10000r/min for 10min, and collecting the supernatant;
6. adding 900 g of absolute ethyl alcohol into the precipitate, and refluxing for 2 hours at 100 ℃;
7. centrifuging the ethanol extractive solution at 10000r/min for 10min, and mixing the obtained supernatant with the enzymolysis supernatant;
8. carrying out reduced pressure rotary evaporation on the combined supernatant at the temperature of 70 ℃, concentrating to the Baume degree of 42.0, and finishing concentration;
9. adding the concentrated paste into a mixed solvent of 7.5 weight parts of glycerol and 2:1 propylene glycol, stirring for dissolving, filtering, adding peppermint essential oil, mixing and compounding to obtain the medicinal and edible atomization inhalation product with the lung clearing function.
Example 4
1. Mixing flos Lonicerae, herba Houttuyniae, herba Menthae, Glycyrrhrizae radix, and Bulbus Lilii at ratio of 3:1:2:2:2, and superfine wall-breaking pulverizing;
2. 100 g of the superfine crushed powder is taken and 900 g of distilled water is added;
3. adjusting pH to 6.5 with acid or alkali;
4. adding 0.1g of acid protease and 0.1g of amylase while stirring, and stirring and carrying out enzymolysis for 2 hours at the temperature of 55 ℃;
5. centrifuging the enzymolysis liquid at 10000r/min for 10min, and collecting the supernatant;
6. adding 900 g of absolute ethyl alcohol into the precipitate, and refluxing for 2 hours at 100 ℃;
7. centrifuging the ethanol extractive solution at 10000r/min for 10min, and mixing the obtained supernatant with the enzymolysis supernatant;
8. carrying out reduced pressure rotary evaporation on the combined supernatant at the temperature of 70 ℃, concentrating to the Baume degree of 42.0, and finishing concentration;
9. adding the concentrated paste into a mixed solvent of 10 weight parts of glycerol and 2:1 propylene glycol, stirring for dissolving, filtering, adding peppermint essential oil, mixing and compounding to obtain the medicinal and edible atomization inhalation product with the lung clearing function.
Functional evaluation
1. Experimental Material
1) The inhalation type medicinal and edible preparation with the effects of clearing lung and relieving cough is prepared according to the preparation methods of the examples 1, 2, 3 and 4;
2) 60C-57 mice, male, 6 weeks, 18-22g in body weight;
3) strong ammonia water;
4) a suction machine.
Experiment grouping
Mice were randomly divided into 6 groups of 10 mice each, and the inhalation therapy was administered as follows:
example 1: the preparation is inhaled for 1 hour every day for 7 days;
example 2: the preparation is inhaled for 1 hour every day for 7 days;
example 3: the preparation is inhaled for 1 hour every day for 7 days;
example 4: the preparation is inhaled for 1 hour every day for 7 days;
solvent group: 1 hour of glycerol + propylene glycol solvent inhalation treatment;
blank group: there is no inhalation therapy.
Experimental methods
Parameters of the suction machine: inhalation time 3S, rest time 237S, inhalation volume 55ml, inhaled every 4 minutes for a total of 1 hour for 7 days. Cough tests were performed 1 hour after the last inhalation: a glass plate was placed in 1/3 containing a filter paper having a diameter of 10cm, 0.15 mL of concentrated ammonia water was added and dropped on the filter paper, and a 1000-mL beaker was quickly inverted, and then the mouse was placed in the beaker while the timer was started. The incubation period of cough induction (time from placing in a beaker to the beginning of cough) and the number of cough times (with contraction of abdominal muscle and mouth opening of the mouse as cough indexes) of the mouse within 2min were recorded.
Results of the experiment
The research results in figure 1 show that the medicines in the groups of examples 1 to 4 can obviously prolong the cough incubation period of the mice with ammonia water induced cough and reduce the cough frequency, and have obvious difference with the solvent group and the blank group.
Claims (10)
1. A medicinal and edible atomization inhalation product with a lung-heat clearing function and a preparation method thereof are characterized in that the preparation method comprises the following steps: the method comprises the following steps: firstly, carrying out superfine grinding on medicinal and edible composite raw materials, adding distilled water and composite biological enzyme into the obtained medicinal and edible composite raw material superfine powder for enzymolysis, separating enzymolysis liquid, then extracting precipitate with ethanol, carrying out separation treatment, combining supernate, carrying out reduced pressure concentration, extracting concentrated paste by using a solvent, filtering, and finally mixing and compounding with fragrance substances to obtain the medicinal and edible atomization inhalation product with the lung-clearing function.
2. The medicinal and edible aerosol inhalation product with a lung-heat clearing function and the preparation method thereof according to claim 1, wherein the medicinal and edible composite raw materials are a mixture of five or more of honeysuckle, houttuynia cordata, emblic leafflower fruit, fragrant solomonseal rhizome, mint, dandelion, sophora flower bud, purslane, kudzu vine root, stevia rebaudiana, dark plum, perilla, wrinkled gianthyssop herb, liquorice and lily, wherein the preferable ratio of honeysuckle, houttuynia cordata, mint, liquorice and lily is 3:1:2:2: 2.
3. The medicinal and edible aerosol inhalation product with lung clearing function as claimed in claim 1, wherein the medicinal and edible composite raw materials are pulverized by ultramicro wall breaking for 20min-30min to fineness of more than 1500 meshes.
4. The medicinal and edible aerosol inhalation product with lung clearing function as claimed in claim 1, wherein 9 times volume of distilled water is added into medicinal and edible composite superfine powder, two or more of acidic cellulase, acidic pectinase, acidic protease, amylase and lipase are added according to 1% of addition amount respectively, enzymolysis temperature is 50-60 ℃, pH value is 4.5-6.5, enzymolysis and stirring are carried out for 2-3 hours, and enzymatic hydrolysate is obtained.
5. The product of claim 1, wherein the enzymatic hydrolysate is separated by centrifugation at 8000-10000 r/min for 10-20 min, and the supernatant is ready for use.
6. The product of claim 1, wherein the ethanol extraction of the precipitate is performed by refluxing the precipitate with anhydrous ethanol at 80-100 deg.C for 2-4 hr.
7. The product of claim 1, wherein the ethanol extract is further processed by centrifugation at 8000-10000 r/min for 10-20 min, and the supernatant is combined with the enzymatic supernatant.
8. The medicinal and edible aerosol inhalation product with lung clearing function as claimed in claim 1, wherein the concentration under reduced pressure is rotary evaporation under reduced pressure at 60-80 deg.C, and concentration is carried out to Baume degree of 41.5-43.0, and concentrated paste is obtained after concentration.
9. The product of claim 1, wherein the solvent is glycerol mixed with propylene glycol 2:1, the concentrated extract is added into the solvent, stirred and dissolved, and filtered to obtain a solution.
10. The product of claim 1, wherein the aromatic substance is peppermint essential oil; the medicinal and edible aerosol inhalation product with lung-heat clearing function and the preparation method thereof according to claim 1, wherein the medicinal and edible aerosol inhalation product with lung-heat clearing function is obtained by mixing and compounding the filtered solution and the peppermint essential oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111418152.XA CN113855653A (en) | 2021-11-26 | 2021-11-26 | Medicinal and edible aerosol inhalation product with lung clearing function and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111418152.XA CN113855653A (en) | 2021-11-26 | 2021-11-26 | Medicinal and edible aerosol inhalation product with lung clearing function and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113855653A true CN113855653A (en) | 2021-12-31 |
Family
ID=78985391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111418152.XA Withdrawn CN113855653A (en) | 2021-11-26 | 2021-11-26 | Medicinal and edible aerosol inhalation product with lung clearing function and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113855653A (en) |
-
2021
- 2021-11-26 CN CN202111418152.XA patent/CN113855653A/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104258193B (en) | A kind of pharmaceutical composition for treating neurasthenia and prevention senile dementia | |
| JP2022545288A (en) | Tea composition for prevention, improvement or effect of respiratory disease and pharmaceutical composition containing the same | |
| CN112587595B (en) | Traditional Chinese medicine composition for clearing heat and relieving exterior syndrome and preparation method thereof | |
| CN102000127B (en) | Preparation method of chimonanthus inhibited acetylcholinesterase active part and application thereof | |
| CN113730479A (en) | Composition with health care function and preparation method and application thereof | |
| CN113303493A (en) | Plant-derived bacteriostatic essential oil for electronic atomization rod and preparation method thereof | |
| CN102764294B (en) | Cough relieving and sputum eliminating combination and preparation method thereof | |
| CN113855653A (en) | Medicinal and edible aerosol inhalation product with lung clearing function and preparation method thereof | |
| CN102188635A (en) | Method for preparing infantile lung clearing and phlegm eliminating preparation | |
| CN109432199A (en) | A kind of Chinese medicine composition and preparation method thereof for treating acute cough | |
| CN107129869A (en) | Smooth breathing essential oil and preparation method and application | |
| WO2018090276A1 (en) | Chinese medicine composition for prevention and treatment of combined allergic rhinitis and asthma syndrome and preparation method thereof | |
| CN113288955A (en) | Spray and preparation method and application thereof | |
| CN108969580B (en) | Preparation method and application of blue cloth total tannin | |
| CN107751863A (en) | A kind of aloes lozenge and preparation method thereof | |
| CN105796855A (en) | Traditional Chinese medicine capable of treating acute bronchitis | |
| CN101721450B (en) | Application of oriental cocklebur root chloroform extract used for treating peritonitis | |
| PH12018000449A1 (en) | A traditional chinese medicine composition for treating viral influenza and preparation method | |
| CN102908383B (en) | Method for preparing antivenom oral liquid | |
| CN109381607A (en) | A kind of pharmaceutical composition and its preparation process treated blood disease and merge bacterium infection | |
| CN106963833B (en) | Medicine for treating cold of children and adults and preparation method thereof | |
| CN107669746B (en) | Anti-influenza virus traditional Chinese medicine extract and application thereof | |
| CN114425058B (en) | Traditional Chinese medicine composition for treating rhinitis and preparation method, medicine and preparation thereof | |
| CN101538334B (en) | Method for extracting medicinal large leaf moss polysaccharide | |
| CN103083376B (en) | Can be used for the Rhizoma Ligustici extract for the treatment of rhinitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20211231 |