CN113848339B

CN113848339B - Sample analysis apparatus and sample analysis method

Info

Publication number: CN113848339B
Application number: CN202111163524.9A
Authority: CN
Inventors: 李昌利; 高智诚; 雷德杰
Original assignee: Maccura Medical Electronics Co Ltd
Current assignee: Maccura Medical Electronics Co Ltd
Priority date: 2020-09-30
Filing date: 2021-09-30
Publication date: 2024-06-21
Anticipated expiration: 2041-09-30
Also published as: CN113848340B; CN216285338U; CN216117652U; CN112326981A; CN113848339A; CN113848340A; WO2022068897A1; CN113848341A; CN216117651U; CN216133083U; CN216285339U

Abstract

The application discloses a sample analysis device and a sample analysis method. The sample analysis equipment is used for detecting samples in the reaction container and comprises a first conveying assembly, a second conveying assembly and a suction needle assembly, wherein the first conveying assembly is provided with a preset path for conveying the reaction container, and a first position and a second position which are distributed at intervals are arranged on the preset path; the second conveying assembly is provided with an annular path for conveying the reaction container, wherein third positions and fourth positions which are distributed at intervals are arranged on the annular path, and the fourth positions are adjacent to the second positions; the suction needle assembly is used for adding the sucked liquid to the reaction container at the third position and/or the first position, and is also used for sucking the liquid from the reaction container at the second position and adding the sucked liquid to the reaction container at the fourth position. The sample analysis equipment provided by the application has the advantages of small occupied space and high detection efficiency, and can realize detection in multiple modes.

Description

Sample analysis apparatus and sample analysis method

Technical Field

The present application relates to the field of medical diagnosis technology, and in particular, to a sample analysis apparatus and a sample analysis method.

Background

In the field of medical diagnosis, when a sample analysis device analyzes a sample such as blood or urine, it is necessary to load the sample together with a reagent into a reaction container and then detect the sample. Different reaction vessels may need to undergo different loading, incubation, detection, etc., and thus need to be transported through a pipeline to achieve batch detection operations. The existing sample analysis equipment has the problems that the distance between working positions which are mutually cooperated is large, so that the movement displacement of a manipulator, a instillation device and the like is large, and the whole occupied space of the sample analysis equipment is large.

In view of the foregoing, there is a need for a sample analysis apparatus and a sample analysis method to solve the above-mentioned problems.

Disclosure of Invention

The embodiment of the application provides sample analysis equipment and a sample analysis method, which can reduce the displacement distance of a suction needle assembly and reduce the occupied space of the sample analysis equipment by adjacently arranging working positions with cooperative relationship.

In a first aspect, there is provided a sample analysis apparatus comprising:

The first conveying assembly is provided with a preset path for conveying the reaction container, and a first position and a second position which are distributed at intervals are arranged on the preset path;

the second conveying assembly is provided with an annular path for conveying the reaction container, and a third position and a fourth position which are distributed at intervals are arranged on the annular path, and the fourth position is adjacent to the second position;

The suction needle assembly is used for adding the sucked liquid to the reaction container at the third position and/or the first position and also is used for sucking the liquid from the reaction container at the second position and adding the sucked liquid to the reaction container at the fourth position.

In a second aspect, there is provided a sample analysis method, the sample analysis method being applied to a sample analysis apparatus as described above, the method comprising:

When the operation mode of the sample analysis equipment is the first mode, controlling the first conveying assembly and the second conveying assembly to move, and controlling the suction needle assembly to add a sample to the reaction container positioned at the first position;

Detecting a sample added into a reaction container at a first position;

controlling the suction needle assembly to suck the liquid in the reaction vessel at the second position into the reaction vessel at the fourth position, wherein the liquid in the reaction vessel at the second position at least comprises the sample detected at the first position;

and when the operation mode of the sample analysis device is the second mode, controlling the second conveying assembly to move, and controlling the suction needle assembly to add the sample to the reaction container positioned at the third position.

Compared with the prior art, the preset path of the first conveying component and the annular path of the second conveying component are arranged, so that the reaction container can move along the preset path and the annular path, and the flexibility of movement of the reaction container is improved; the suction needle assembly is arranged to move at each position, and liquid is sucked or injected into the reaction container at each position according to the requirement, so that the operation mode of the sample analysis equipment is enriched; by arranging the second position adjacent to the fourth position, the movement stroke of the suction needle assembly is short, the occupied space of the sample analysis equipment is small, and the detection efficiency of the sample analysis equipment is greatly improved.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments of the present application will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present application, and other drawings may be obtained according to these drawings without inventive effort to a person of ordinary skill in the art.

FIG. 1 is a schematic top view of a portion of a sample analysis device according to an embodiment of the present application;

FIG. 2 is a schematic perspective view of a reaction vessel according to an embodiment of the present application;

FIG. 3 is a schematic view of a portion of the first conveyor assembly of the embodiment of FIG. 2;

FIG. 4 is a schematic view of a portion of the second conveyor assembly of the embodiment of FIG. 2;

FIG. 5 is a schematic view showing a partial perspective structure of a sample analyzer according to an embodiment of the present application;

FIG. 6 is a schematic perspective view of another portion of a sample analysis device according to an embodiment of the present application;

FIG. 7 is a schematic cross-sectional view of a sample detection module according to an embodiment of the application;

FIG. 8 is a schematic view of a partial perspective view of a spacing member according to an embodiment of the present application;

FIG. 9 is a schematic perspective view of a limiting seat according to an embodiment of the present application;

FIG. 10 is a schematic perspective view of a first transporter in accordance with an embodiment of the present application;

FIG. 11 is a partial perspective view of a second transporter and a second conveyor in accordance with an embodiment of the present application;

FIG. 12 is a schematic view of a partial perspective view of a wheel according to an embodiment of the present application;

FIG. 13 is a schematic cross-sectional view of a wheel according to an embodiment of the present application;

FIG. 14 is a schematic perspective view of a blocking member and a second transporter in accordance with an embodiment of the present application;

FIG. 15 is a schematic perspective view of a blocking member according to an embodiment of the present application;

FIG. 16 is a flow chart of a sample analysis method according to an embodiment of the application;

FIG. 17 is a partial flow chart of a sample analysis method according to an embodiment of the application;

FIG. 18 is a detailed flowchart of step S21 of the sample analysis method according to an embodiment of the present application;

FIG. 19 is a schematic view of a transport vehicle according to an embodiment of the present application;

Fig. 20 is a schematic structural view of a transport vehicle according to another embodiment of the present application.

Detailed Description

Features and exemplary embodiments of various aspects of the application are described in detail below. In the following detailed description, numerous specific details are set forth in order to provide a thorough understanding of the application. It will be apparent, however, to one skilled in the art that the present application may be practiced without some of these specific details. The following description of the embodiments is merely intended to provide a better understanding of the application by showing examples of the application.

It should be noted that, without conflict, the embodiments of the present application and features of the embodiments may be combined with each other. The embodiments will be described in detail below with reference to the accompanying drawings.

The embodiment of the application provides sample analysis equipment which is used for detecting and analyzing a sample to be detected so as to obtain a corresponding detection result. The sample to be tested can be a solid sample or a liquid sample, and when the liquid sample is tested, the liquid sample needs to be placed in a test tube on a sample rack. Liquid samples such as blood regular samples, C-reactive protein (CRP), push-tab samples, saccharification samples, urine samples, cerebrospinal fluid samples, or hydrothorax and ascites samples, etc. Among them, a sample analyzer for detecting blood, which is commonly used, may also be called a coagulation analyzer, is an instrument for performing coagulation and anticoagulation, fibrinolysis, and antifibrinolytic function analysis on blood. For convenience of description, the sample analysis device will be described with reference to a coagulation analyzer as an example.

Referring to fig. 1 and 2, in one aspect, the present application provides a sample analysis apparatus comprising: the first conveying assembly 1, the second conveying assembly 2 and the suction needle assembly (not shown), wherein the first conveying assembly 1 is provided with a preset path for conveying the reaction container 4, and a first position P1 and a second position P2 which are distributed at intervals are arranged on the preset path; the second conveying assembly 2 is provided with an annular path for conveying the reaction container 4, wherein a third position P3 and a fourth position P4 which are distributed at intervals are arranged on the annular path, and the fourth position P4 is adjacent to the second position P2; the suction needle assembly is used for adding the sucked liquid to the reaction vessel 4 at the third position P3 and/or the first position P1, and is also used for sucking the liquid from the reaction vessel 4 at the second position P2 and adding the sucked liquid to the reaction vessel 4 at the fourth position P4.

The first and second transport assemblies 1, 2 may be provided on a mounting table 6. The first conveying component 1 can be a guide rail paved according to a preset path and a transport vehicle moving along the guide rail, wherein the transport vehicle carries the reaction container 4 to move; of course, the first conveying assembly 1 may also be a conveying belt arranged according to a preset path, and the conveying belt drives the reaction container 4 to move. The second conveyor assembly can likewise be a guide rail laid along a circular path, and a transport carriage moving along the guide rail, but can also be a conveyor belt arranged along a circular path, which drives the reaction vessel 4 to move. The transport manner of the first transport assembly and the second transport assembly is specifically adopted to transport the reaction vessel 4, and the present embodiment is not limited.

The preset path may be an L-shaped path as shown in fig. 3, or may be an arc-shaped path, a circular path, an irregular path, or the like. The circular path may be a rounded rectangular path as shown in fig. 4, or may be a circular path, an elliptical path, an irregular circular path, or the like. When the preset path is not a circular path, the first conveying component 1 can convey the reaction container 4 to move bidirectionally along the preset path, and when the preset path is a circular path, the first conveying component 1 and the second conveying component can convey the reaction container 4 to move bidirectionally or unidirectionally so as to realize the movement of the reaction container 4 between all working positions.

With continued reference to fig. 1 and 2, the preset path and the annular path are each provided with a plurality of working positions, and the reaction vessel 4 can stay for a period of time at each working position, so that other working units can conveniently take the reaction vessel 4 or process the liquid in the reaction vessel 4. The first position, the second position, the third position and the fourth position are all working positions, and other working positions except the first position, the second position, the third position and the fourth position can be set. The suction needle assembly can be moved between a plurality of working positions to suck or inject liquid into the reaction vessels 4 located at different positions. In order to facilitate the movement of the suction needle assembly, the first conveying assembly 1 and the second conveying assembly 2 may be disposed in the same horizontal plane, and the movement interference of the reaction vessel 4 conveyed by the first conveying assembly 1 and the reaction vessel 4 conveyed by the second conveying assembly 2 may not occur by controlling the operation speed of the reaction vessel 4 conveyed by the first conveying assembly 1 and the reaction vessel 4 conveyed by the second conveying assembly 2 by spacing the first conveying assembly 1 and the second conveying assembly 2 by a certain distance or by a metronome or the like. Of course, the first conveying assembly 1 and the second conveying assembly 2 may not be disposed in the same plane as required.

The suction needle assembly can be positioned in the reaction vessel at the working position and can suck the liquid in the reaction vessel or inject the sample into the reaction vessel. The first position P1 and the third position P3 may be sample filling positions, that is, the suction needle assembly may place the sucked liquid sample in the reaction vessel 4 located at the first position P1 and/or the third position P3, and may also fill the reaction vessel 4 at the first position P1 and/or the third position P3 with a desired reagent. The second position P2 and the fourth position P4 are disposed adjacent to each other, and the suction needle assembly can suck the liquid from the reaction vessel 4 at the second position P2 and add the liquid into the reaction vessel 4 at the fourth position P4, wherein the liquid can be a sample transported from the first position P1 to the second position P2, a mixture of the sample and the reagent, or a reaction product of the sample and the reagent after being subjected to certain treatment conditions, and the like. Likewise, the suction needle assembly can also inject the required reagents into the reaction vessel 4 located at the second position P2 and the reaction vessel 4 located at the fourth position P4 to facilitate the subsequent detection. Specifically, the suction needle assembly sucks the sample in the reaction vessel 4 located at the second position P2 into the reaction vessel 4 located at the fourth position P4, and then sucks the reagent into the reaction vessel 4 located at the fourth position P4. The application does not limit the distance between the second position P2 and the fourth position P4, and only needs to close enough to the second position P2 and the fourth position P4, so that the suction needle assembly can conveniently move between the second position P2 and the fourth position P4, and the moving distance of the suction needle assembly can be reduced.

According to the application, the preset path of the first conveying assembly 1 and the annular path of the second conveying assembly 2 are arranged, so that the reaction container 4 can move along the preset path and the annular path, and the flexibility of movement of the reaction container 4 is improved; the suction needle assembly is arranged to move among the working positions, and liquid is sucked or injected into the reaction container 4 of each working position according to the requirement, so that the operation mode of the sample analysis equipment is enriched; by arranging the second position P2 adjacent to the fourth position P4, the movement stroke of the suction needle assembly is reduced, the occupied space of the sample analysis equipment is small, and the detection efficiency of the sample analysis equipment is greatly improved.

Further, the preset path is further provided with a first in-out position Q1, the annular path is further provided with a second in-out position Q2 adjacent to the first in-out position Q1, the second position P2 and the first position P1 are sequentially arranged at intervals along the preset path, and the second in-out position Q2, the third position P3 and the fourth position P4 are sequentially arranged at intervals along the annular path.

In order to ensure the accuracy of the detection result, a sample is correspondingly placed in one reaction container 4. So that the reaction vessel 4 can be directly discarded or can be reused after cleaning after detection. The first in-out position Q1 is a position where a new reaction container 4 enters a preset path, and a position where the reaction container 4 leaves the preset path after filling is completed. The second access point Q2 is also the position where a new reaction vessel 4 enters the annular path and where the filled reaction vessel 4 leaves the annular path. The reaction vessel 4 leaving the first inlet/outlet position Q1 and the second inlet/outlet position Q2 can enter other detection devices for further detection. The first in-out position Q1 and the second in-out position Q2 are disposed adjacently so that only one worker or one robot for taking and placing the reaction container 4 can be arranged near the first in-out position Q1 and the second in-out position Q2 to operate the reaction container 4 located at the first in-out position Q1 and the second in-out position Q2.

Referring to fig. 3 and 4 in combination, the preset path is disposed around the annular path, and the preset path and the annular path extend in the same plane, so that the overall layout structure of the sample analysis device is compact. For example, the annular path is a rounded rectangle, and the preset path may be an L-shaped path disposed around the rounded rectangle; the annular path is circular, and the preset path can be an arc shape arranged around the circular shape; the annular path is an irregular annular shape, and the preset path may be a curved path arranged around the irregular annular shape.

In an embodiment, the circular path includes a third transport section L3 provided with a second access location Q2 and a fourth transport section L4 provided with a fourth location P4, the third transport section L3 and the fourth transport section L4 being connected; the preset path comprises a first conveying section L1 provided with a first in-out position Q1 and a second conveying section L2 provided with a second position P2, the extending directions of the first conveying section L1 and the second conveying section L2 are intersected, the first conveying section L1 and a third conveying section L3 are oppositely arranged, and the second conveying section L2 and a fourth conveying section L4 are oppositely arranged. The preset path and the annular path are at least partially arranged relatively, and meanwhile, different working positions are arranged on the conveying sections extending along different directions, so that the overall layout structure of the sample analysis equipment is compact, meanwhile, different working positions on the same path are separated by a certain distance, the mutual influence of the corresponding processing processes of all working positions is avoided, and meanwhile, the suction needle assembly is convenient to position and fill or suck liquid.

Further, the annular path further comprises a fifth transportation section L5 provided with a third position P3, the fourth transportation section L4 is connected with the third transportation section L3 and the fifth transportation section L5, the fifth transportation section L5 and the third transportation section L3 are oppositely arranged at intervals, and the third position P3 is adjacent to the first position P1. The third position P3 is adjacent to the first position P1, so that the sample storage device for storing samples can be placed near the third position P3 and the first position P1, the movement stroke of the suction needle assembly is short, and the detection efficiency of the sample analysis device is greatly improved.

Still further, the annular path further includes a sixth transport section L6 provided with a fifth position P5, and the third transport section L3, the fourth transport section L4, the fifth transport section L5, and the sixth transport section L6 are connected end to end. The fifth position P5 may be a reagent filling position or an idle pause position, and since the transport sections connected by the annular path position 4 are connected to form a third transport section, a fourth transport section and a fifth transport section are all provided with working positions, in order to ensure that the injection or suction of the suction needle assembly is completed, the reaction container 4 needs to stay for a period of time at each working position, so that the idle pause position is set in the sixth transport section L6, so that each transport section is provided with a working position, and the transport beats of the second transport assembly 2 are conveniently set. When the sample analysis device works, the reaction container 4 can start to move along the annular path at the second in-out position Q2, and stop for a period of time when moving to the third position P3 at the end part of the fifth transportation section L5, the suction needle assembly fills the sample to be detected into the reaction container 4 at the third position P3, the second transportation assembly 2 moves continuously again to drive the reaction container 4 to the fourth position P4, the suction needle assembly fills the reagent into the reaction container 4 at the fourth position P4, and then moves to the second in-out position Q2 to leave the annular path for the reaction container 4. At least four reaction vessels 4 can be placed on the annular path at the same time, and the four reaction vessels 4 can stay at the third position P3, the fourth position P4, the second inlet and outlet position Q2 and the fifth position P5 for a period of time at the same time.

Referring to fig. 5, in an embodiment, the first position P1 is disposed at an end of the second conveying section L2 away from the first conveying section L1. When the sample analysis device works, the reaction container 4 can start to move along a preset path at the first in-out position Q1, and stop for a period of time when the reaction container 4 moves to the first position P1 at the end part of the second transportation section L2, the suction needle assembly fills the sample to be measured into the reaction container 4 at the first position P1, the first transportation assembly 1 moves in the opposite direction again, the reaction container 4 is driven to the second position P2, the suspension is stopped for a period of time, and the suction needle assembly sucks the sample to be measured in the reaction container 4 at the second position P2 into at least one reaction container 4 at the fourth position P4, so that the transfer of the sample to be measured is completed.

Referring to fig. 1 and 5, in an embodiment, the sample analysis apparatus further includes a sample detection module 5 disposed adjacent to the first position P1, the sample detection module 5 has a detection space 51, the first conveying component 1 can convey the reaction container 4 along the second conveying section L2 to insert into the detection space 51, that is, when the reaction container 4 moves to the first position P1, the sample detection module 5 can detect the reaction container 4, so that a complex tool for taking the reaction container 4 such as a mechanical arm is omitted, and the overall size of the sample analysis apparatus is reduced.

Referring to fig. 6 and 7 in combination, the sample detection module 5 includes a light receiver 52 and a light emitter 53 disposed at opposite intervals, a detection space 51 is formed between the light receiver 52 and the light emitter 53, the light emitter 53 is capable of emitting light to the reaction vessel 4 located at the first position P1, and the light receiver 52 is capable of receiving the light emitted from the reaction vessel 4. In this embodiment, the light emitter 53 can emit light with different wavelengths to the sample to be tested in the reaction container 4, and the light intensity received by the light receiver 52 can be used for qualitative and quantitative analysis of the sample to be tested.

Further, the light receiver 52 and the light emitter 53 are disposed at opposite intervals along the first direction X, the second transporting section L2 is disposed along the second direction Y, and the first transporting assembly 1 is capable of transporting the reaction container 4 to be inserted into the detection space 51 along the second direction Y, the first direction X and the second direction Y intersecting. The first transport section L1, the third transport section L3 and the fifth transport section L5 may be disposed together along the second direction Y, so that the components of the sample analysis apparatus are regularly distributed. Since the sample detection module 5 needs to detect the sample to be detected through the light receiver 52 and the light emitter 53, the reaction vessel 4 must be placed in the detection space 51 between the light receiver 52 and the light emitter 53, and the reaction vessel 4 is moved to the first position P1 in the second direction Y by the light receiver 52 and the light emitter 53 being disposed in the first direction X, the reaction vessel 4 can move in a straight line into the detection space 51 without any obstruction.

In one embodiment, the first conveyor assembly 1 includes a first conveyor belt 11 and a first carriage 12 that moves along a predetermined path along the first conveyor belt 11, and the second conveyor assembly 2 includes a second conveyor belt 21 and a second carriage 22 that moves along an endless path along the second conveyor belt 21. The first conveyor belt 11 and the second conveyor belt 21 may be identical or different in structure and material, and the second transport vehicle 22 and the first transport vehicle 12 may be identical or different in structure and material. However, when the reaction vessel 4 needs to be transported to the detection space 51, the first transporter 12 is not configured to prevent the sample detection module 5 from working, for example, the light emitted by the light emitter 53 is not blocked, and the light emitted by the light emitter 53 is not excessively reflected, so that the light receiver 52 is affected to receive the light transmitted by the reaction vessel 4.

The sample detection module 5 further includes a limiting member 54, where the limiting member 54 includes a first fixing seat 541 and a first limiting piece 542 that are disposed at opposite intervals, one of the light emitter 53 and the light receiver 52 is disposed on the first limiting piece 542, and the other is disposed on the first fixing seat 541, and the first fixing seat 541 and the first limiting piece 542 are used for limiting two opposite sides of the first transport vehicle 12 inserted into the detection space 51. Through setting up the relative both sides of first transport vechicle 12 of first fixing base 541 and first locating part 542 spacing, guarantee the stability in detection space 51 of reaction vessel 4 on the first transport vechicle 12, be favorable to going on of detection. While the first fixing base 541 and the first limiting member 542 may provide positions where the photo-emitter 53 and the photo-receiver 52 are installed, fixing the photo-emitter 53 and the photo-receiver 52.

The limiting member 54 further includes a second limiting piece 543 extending from the first limiting piece 542 to the first fixing base 541, and the first fixing base 541, the first limiting piece 542, and the second limiting piece 543 surround to form a limiting space 55 of the transport vehicle capable of limiting insertion into the detecting space 51. The spacing space 55 and the detection space 51 may be the same space, or partially overlapping spaces. The first carrier vehicle 12 is placed in the detection space 51 while the limit space 55 is being limited. The first fixing base 541, the first limiting member 542, and the second limiting member 543 limit the first carrier 12 on three sides.

Further, the limiting member 54 further includes a protrusion 544 protruding from the first limiting member 542, the second limiting member 543 is disposed opposite to the protrusion 544, and the first fixing base 541, the second limiting member 543, the first limiting member 542 and the protrusion 544 surround to form a limiting space 55, so that the first carrier 12 is four-sided limited, and a gap can be left between the protrusion 544 and the first fixing base 541 to form a filling opening for exposing the reaction container 4. Because the first conveyor belt 11 is a flexible element, displacement along the direction perpendicular to the plane along which the preset path is located may be generated during the movement of the first conveyor belt 11, in order to avoid friction between two sides of the first conveyor belt 11 and the protruding element 544 and the second limiting element 543, the protruding element 544 may not be disposed in the limiting member 54.

Referring to fig. 8 in combination, the first limiting member 542 has a light transmitting hole 548, and the light receiver 52 receives the light reflected from the reaction container 4 through the light transmitting hole 548, so as to prevent the first limiting member 542 from affecting the operation of the sample detection module 5.

The surface of the first limiting member 542 away from the first fixing base 541 is recessed to form a mounting hole 549 in communication with the light transmitting hole 548, and the light receiver 52 is disposed in the mounting hole 549. The wall surface of the mounting hole 549 can effectively prevent other light rays except for the reaction vessel 4 from interfering with the light receiver 52, and meanwhile, the light receiver 52 is arranged in the mounting hole 549, so that the volume of the sample detection module 5 is reduced.

The sample detection module 5 further includes a circuit board 56 electrically connected to the light receiver 52, the circuit board 56 is connected to the first limiting member 542, and the light receiver 52 is disposed between the first limiting member 542 and the circuit board 56. The first stopper 542 is connected to the circuit board 56, thereby fixing the circuit board 56, ensuring stable connection of the light receiver 52 to the circuit board 56.

The mounting table 6 is further used for supporting the limiting member 54 and the fixing piece 57 provided on the mounting table 6, one end of the circuit board 56 is connected with the first limiting piece 542, and the other end is connected with the fixing piece 57, so as to further stabilize the circuit board 56.

Referring to fig. 6, 7, 9 and 10, the sample detection module 5 further includes a limiting seat 546, and when the first transporter 12 is located in the limiting space 55, the limiting seat 546 is abutted to the first transporter 12 along the second direction Y, so as to limit the first transporter 12 on five sides.

The sample detection module 5 further comprises a plunger 547, the plunger 547 is connected with one end, close to the first transport vehicle 12 inserted into the detection space 51, of the limiting seat 546, the plunger 547 is used for being matched with the limiting hole 125 on the first transport vehicle 12, namely, the plunger 547 can be inserted into the limiting hole 125, and limiting capacity of the limiting seat 546 on the first transport vehicle 12 is improved. The plunger 547 is mounted in the stopper 546, fastened by a jackscrew, and is retractable. When the first carriage 12 moves to the first position P1, the plunger 547 can act on the reaction vessel 4 through the limiting hole 125, and the reaction vessel 4 is fixed under the interaction of the braking torque of the first conveying component 1 and the acting force of the plunger 547, so that the reaction vessel 4 does not shake in the working position. One skilled in the art can avoid damaging the reaction vessel 4 by selecting an appropriate material, load and travel of the plunger 547.

Along the direction of inserting the first carrier 12 into the spacing space 55, i.e. the second direction Y, the size of the opening of the spacing space 55 away from the spacing seat 546 is gradually reduced, so that the spacing seat 546 can guide the first carrier 12 through the size-graded opening, thereby facilitating the first carrier 12 to enter the spacing space 55.

The first transporter 12 has a first cavity 121 for accommodating the reaction container 4, and a first through hole 126 and a second through hole 127 which are communicated with the first cavity 121, the light emitter 53 emits light to the reaction container 4 through the first through hole 126, and the light receiver 52 receives the light refracted from the reaction container 4 through the second through hole 127, so that the first transporter 12 is prevented from affecting the detection operation of the sample detection module 5.

The first transporter 12 further includes a light guide 128 having a light-passing hole 129, the inner wall of the light-passing hole 129 is a black light-absorbing surface, the light guide 128 is sleeved in the first through hole 126 and the second through hole 127, the light emitter 53 emits light to the reaction container 4 through the light guide 128, and the light receiver 52 receives the light refracted from the reaction container 4 through the light guide 128. The black light absorbing surface can effectively prevent light emitted by the light emitter 53 from being reflected, and prevent the reflected light of the first transport vehicle 12 from entering the light receiver 52 to influence the detection result. The light guide 128, the light emitter 53, and the light receiver 52 may be coaxially disposed to reduce light loss. Further, the openings of the first through hole 126 and the second through hole 127 may be provided with mounting steps, and the shape of the light guide 128 is adapted to the mounting steps, so that the stability of the connection of the light guide 128 with the first through hole 126 and the second through hole 127 is increased.

Referring to fig. 1, 3 and 4, the first conveying assembly 1 further includes at least one driving wheel 13 and a plurality of driven wheels 14, an inner peripheral surface of the first conveying belt 11 is wound around the driving wheel 13 and the driven wheels 14, and an outer peripheral surface of the first conveying belt 11 is connected to the first transporting carriage 12. The driving wheel 13 and the driven wheel 14 are used for tensioning the first conveyor belt 11, the driving wheel 13 can be connected with a motor, the motor rotates, the driving wheel 13 drives the first conveyor belt 11 to rotate in a vertical plane, and a plurality of driven wheels 14 are matched with the driving wheel 13 to draw a running path of the first conveyor belt 11. The motor may be a stepping motor, and the movement and stop of the first conveyor belt 11 may be controlled by controlling the number of running steps of the motor. Alternatively, the motor is a servo motor, and controls the operation and stop of the first conveyor belt 11 when the first transporting carriage 12 reaches or leaves the working position. In an embodiment, 3 driving wheels are disposed adjacent to the first position P1 at two ends of the first transportation section L1, and a person skilled in the art may set the 3 driving wheels to be the driven wheel 14 or the driving wheel 13, respectively, according to needs.

Of course, the second conveying assembly 2 may be provided with a driving wheel 13 and a driven wheel 14 having the same structure with respect to the first conveying assembly 1. In an embodiment, at the connection between the third transportation section L3 and the fourth transportation section L4, the connection between the fourth transportation section L4 and the fifth transportation section L5, the connection between the fifth transportation section L5 and the sixth transportation section L6 are all provided with driving wheels, and those skilled in the art can set 4 driving wheels as the driven wheels 14 or the driving wheels 13, respectively, according to the needs.

Referring to fig. 12 and 13 in combination, the driving wheel 13 and the driven wheel 14 may have the same structure, except that the driving wheel 13 is connected to a motor, the driven wheel 14 is not connected to a motor, or the motor connected to the driven wheel 14 does not apply work to the driven wheel 14. The following describes the structure of the driven wheel 14 and the driving wheel 13 by taking a driving wheel structure as an example. The wheel includes: the wheel axle 131, the wheel body 132 sleeved outside the wheel axle 131, the bearing 133 arranged between the wheel axle 131 and the wheel body 132, and the base 134 sleeved outside the wheel axle 131. The base 134 and the wheel body 132 are arranged at two ends of the wheel shaft 131, the base 134 is in threaded connection with the mounting table 6, the wheel body 132 and the base 134 are respectively and independently arranged, good accurate positioning can be achieved, and radial load brought by the bearing 133 can be well borne. The outer surface of the wheel 132 is provided with gear teeth that cooperate with the first conveyor belt 11 or the second conveyor belt 21. The wheel also includes an E-clip 135 disposed on a side of the wheel 132 remote from the base 134 to secure the wheel 132, axle 131 and bearing 133.

Referring to fig. 10 and 10 in combination, fig. 10 is a schematic perspective view of a first transporter according to an embodiment of the present application, and fig. 11 is a schematic perspective view of a second transporter and a portion of a second conveyor according to an embodiment of the present application. In the present application, the first transporting carriage and the second transporting carriage have a certain similarity, and the first conveyor belt 11 and the second conveyor belt 21 have a certain similarity. The first transporting carriage 12 and the first conveyor belt 11 will be described below as examples. Unless otherwise specified, the second transporter 22 may have the same structure as the first transporter 12, and the second conveyor 21 may have the same structure as the first conveyor 11.

The inner circumference of the first conveyor belt 11 is provided with engagement teeth 113 engaged with the driving pulley 13, thereby preventing slipping between the first conveyor belt 11 and the driving pulley 13 and improving kinetic energy transmission energy efficiency. The first conveyor belt 11 includes a belt body 111 wound around the driving wheel 13 and the driven wheel 14 and at least one stopper belt 112 protruding from the belt body 111, and the stopper belt 112 is connected to the first transport vehicle 12. The stopper belt 112 moves along with the belt body 111, the first transportation vehicle 12 moves along with the stopper belt 112, and a plurality of stopper belts 112 may be provided on the first conveyor belt 11 to simultaneously transport a plurality of first transportation vehicles 12.

The first carrier 12 includes a connecting portion 122 and a receiving portion 123, the connecting portion 122 is connected to the stopper band 112, the receiving portion 123 has a first cavity 121 in which the reaction vessel 4 is placed, the connecting portion 122 is located outside the detection space 51 when the first carrier 12 is in the first position P1, and the receiving portion 123 is inserted into the detection space 51 through the opening.

The length of the first carriage 12 may be longer than that of the second carriage 22, and since the first position P1 is provided at the end of the second transport section L2, when the first carriage 12 is moved to the first position P1, a part of the first carriage 12 is connected to and opposed to the first conveyor belt 11, and a part of the first carriage 12 in which the reaction container 4 is placed is not opposed to the first conveyor belt 11 but is inserted into the detection space 51. The length of the first carriage 12 needs to be adapted to the dimensions of the detection space 51 to ensure that the reaction vessel 4 can be fully inserted into the detection space 51 for detection.

The connecting portion 122 is recessed near the side wall of the band 111 to form a connecting groove 124, and the stopper band 112 is inserted into the connecting groove 124 and connected to the wall surface of the connecting groove 124. Threaded holes can be formed in two side walls of the connecting groove 124, and the first transport vehicle 12 can be fixed on the blocking belt 112 through screws, so that the locking force of the screws is not directly applied to the belt body 111, and the situation that the posture of the first transport vehicle 12 changes due to the stress deformation of the belt body 111 is avoided.

Since the number of working positions of the second conveyor assembly 2 may be different from the number of working positions of the first conveyor assembly 1, the number of the stopper belts 112 may also be different. In one embodiment, the second conveyor belt 21 may be provided with 4 stopper belts 112 simultaneously to connect 4 second transporting vehicles 22. In a certain stationary state, the second carriage 22 may rest at the third position P3, the fourth position P4, the second in-out position Q2, and the fifth position P5, respectively.

Further, the sample analysis device further comprises a blocking member 23 having a limiting slot 24, wherein the blocking member 23 is at least arranged at any one of the third position P3, the fourth position P4 and the second position P2, and the limiting slot 24 is used for limiting the first transport vehicle 12 and/or the second transport vehicle 22. Because the first conveyor belt 11 and the second conveyor belt 21 have certain flexibility, the reaction container 4 does not have to stably stay at each working position, and the first transport vehicle 12 or the second transport vehicle 22 can be stabilized through the blocking member 23, so that the stability of the reaction container 4 is ensured, and the injection or the suction of the liquid by the suction needle assembly is facilitated.

Still further, the blocking member 23 includes a stopper 231 and a first plate 232 disposed opposite to each other, and the stopper 231 and the first plate 232 are used to limit opposite sides of the first transporter 12 or the second transporter 22. In one embodiment, the limiting block 231 and the first plate 232 limit the two oppositely disposed sidewalls of the first carriage 12 or the second carriage 22, and the first conveyor belt 11 and the second conveyor belt 21 pass between the limiting block 231 and the first plate 232.

Still further, the blocking member 23 further includes a second plate 233 disposed opposite to each other and a boss 234 protruding from the first plate 232, where the boss 234 and the second plate 233 are used for limiting opposite sides of the first transport vehicle 12 or the second transport vehicle 22, a filling opening for exposing the reaction container 4 is formed between the boss 234 and the limiting block 231, the first plate 232, the second plate 233 and the boss 234 form a limiting slot 24. In one embodiment, the second plate 233 and the boss 234 limit the oppositely disposed top and bottom walls of the first carrier 12 or the second carrier 22 such that four walls of the first carrier 12 or the second carrier 22 are each limited by the blocking member 23.

The opposite ends of the blocking member 23 have an inlet/outlet 235 through which the first carrier 12 or the second carrier 22 passes, and similarly to the sample detection module 5, the size of the inlet/outlet 235 of the blocking member 23 is gradually changed, so that the inlet/outlet 235 can guide the first carrier 12 or the second carrier 22, thereby facilitating the first carrier 12 or the second carrier 22 to enter the blocking member 23. Unlike the sample detection module 5, the blocking member 23 may perform bidirectional guiding, and the sample detection module 5 is unidirectional guiding.

The present application also provides another sample analysis apparatus comprising: a first conveying assembly 1, a second conveying assembly 2 and a suction needle assembly (not shown), wherein the first conveying assembly 1 is provided with a preset path for conveying the reaction container 4, and a first position P1 is arranged on the preset path; the second conveying assembly 2 has an annular path for transporting the reaction vessel 4, and a third position P3 is arranged on the annular path, and the first position P1 is adjacent to the third position P3; the pipette tip assembly is used to add the aspirated sample to the reaction container 4 at the third position P3 and/or the first position P1. So that the suction needle assembly moving between the third position P3 and the first position P1 can have a smaller moving stroke while the overall size of the suction needle assembly is smaller. In this embodiment, the sample analysis apparatus may still employ the aforementioned structures of the first transport assembly 1, the second transport assembly 2, and the suction needle assembly, differing only in the number and positions of the working positions.

Referring to fig. 1 and 2, the sample analysis apparatus further includes a photoelectric sensor 7 for sensing the first carriage 12 or the second carriage 22, and the photoelectric sensor 7 can determine the position of the first carriage 12 or the second carriage 22 and reset the first conveying assembly 1 and the second conveying assembly 2 to eliminate motor accumulated errors. The photoelectric sensor 7 can be a toggle sensor, a contact sensor and the like, and the contact sensor can effectively reduce the influence of the external environment on the work of the sensor.

In one embodiment, the pipette tip assembly comprises a first pipette tip for adding the aspirated sample into the reaction vessel 4 at the third position P3 and/or the first position P1 and a second pipette tip; the second suction needle is used for sucking the liquid in the reaction vessel 4 at the second position P2 and adding the liquid into the reaction vessel 4 at the fourth position P4, and is also used for adding the reagent into the reaction vessel 4 at the fourth position P4. The plurality of suction needles are provided so that the suction needle assembly can simultaneously suck or inject the reaction containers 4 at a plurality of working positions.

The sample analysis device further comprises a storage module (not shown) for storing a reagent, the second position P2, the fourth position P4 and the reagent sucking position of the storage module are arranged on the same straight line, and the second suction needle moves along the straight line where the second position P2, the fourth position P4 and the reagent sucking position are located, so that the movement track of the second suction needle is simple, and the suction efficiency is high. It can be appreciated by those skilled in the art that the functions of the first suction needle and the second suction needle are different, so that the movement tracks of the first suction needle and the second suction needle are inconsistent, and meanwhile, the first suction needle and the second suction needle can be provided with different structures and sizes according to different requirements. The storage module is provided with at least one reagent sucking position, and when a plurality of reagent sucking positions exist, different reagents can be stored in each reagent sucking position so as to be sucked by the second suction needle.

In addition, each time the suction needle assembly absorbs a sample or a reagent, the sample or the reagent possibly sticks and stays on the suction needle assembly, the suction needle assembly needs to be cleaned, carrying pollution is avoided, and incorrect diagnosis results are generated to misguide doctors to cause misjudgment, so that the health of patients is endangered. Thus, the sample analysis device provided by the embodiment of the present application further comprises a first needle wash basin 81 arranged adjacent to the third position P3 and a second needle wash basin 82 arranged adjacent to the fourth position P4. After the suction needle assembly performs liquid suction or injection, the suction needle assembly can be moved to a nearest needle washing pool for washing so as to avoid reagent or sample pollution, and meanwhile, the moving distance of the suction needle assembly is reduced, and the detection efficiency is further improved.

In yet another embodiment, the sample analysis apparatus further comprises a transfer assembly for transferring the reaction vessel 4 located at the second access location Q2 and the first access location Q1. The transfer assembly may be specifically a gripping member to carry out transfer by gripping the reaction vessel 4, and the transferred reaction vessel 4 may be discarded or subjected to other tests such as magnetic bead test, immunonephelometry test, chromogenic substrate test, etc.

It can be appreciated by those skilled in the art that the sample analysis device provided by the application can also be provided with a solvent storage tank, an empty reaction container storage rack, and a heating module, a stirring module, an incubation module and the like which are at least arranged in one working position according to the requirements of each working position.

In a second aspect, the present application further provides a sample analysis method, which is applied to the sample analysis apparatus as described above, referring to fig. 16, and the method includes:

in the case where the operation mode of the sample analysis apparatus is the first mode, performing:

Step S11, controlling the first conveying assembly and the second conveying assembly to move, and controlling the suction needle assembly to add a sample to the reaction container positioned at the first position;

Step S12, detecting a sample added into the reaction container at the first position;

Step S13, controlling the suction needle assembly to suck the detected sample into a reaction container positioned in the second conveying assembly;

In the case where the operation mode of the sample analysis apparatus is the second mode, performing:

And S21, controlling the second conveying assembly to move, and controlling the suction needle assembly to add the sample to the reaction container positioned at the third position.

In this embodiment, the sample analysis apparatus has two operation modes, the first mode is that the first conveying component and the second conveying component move simultaneously, and the conveying beats of the first conveying component and the second conveying component are matched, so that the suction needle component can add a sample into the reaction container located at the first position and detect the sample in the reaction container, and further, the suction needle component can be controlled to suck the detected sample into the reaction container located at the fourth position at the second position. The second mode may be where only the second transport assembly is moved, or where the first transport assembly and the second transport assembly are moved independently of each other, and where the pipette tip assembly is only required to add a sample to the reaction vessel in the third position. Of course, those skilled in the art can also realize more working modes by controlling the operation of the first conveying assembly, the second conveying assembly and the suction needle assembly according to actual needs.

In step S12, the newly added sample may be detected by an optical method, or may be detected by a magnetic bead method, etc., and a person skilled in the art may detect the sample added at the first position by using a suitable detection method as required. The detection can be directly carried out on the newly added sample, or after the newly added sample is subjected to the treatments of incubation, stirring, adding a reaction reagent and the like, the detection can be carried out. Accordingly, when the suction needle assembly sucks the detected sample to the reaction container at the fourth position, the sample is sucked, and other reagents mixed with the sample are sucked at the same time.

According to the sample analysis method provided by the application, the movement modes of the first conveying assembly and the second conveying assembly are skillfully controlled, the injection and the suction of the suction needle assembly are controlled, and multiple working modes can be realized aiming at the same sample analysis equipment, so that different requirements of users are met. The sample analysis device provided by any of the above embodiments has the same technical effects, and will not be described here again.

Referring to fig. 17, in another embodiment, the sample analysis method further includes:

And step S3, receiving an operation mode instruction triggered by a user, and determining the operation mode of the sample analysis equipment according to the operation mode instruction.

The sample analysis device may perform step S11 or step S12 according to the determined operation mode. Specifically, the sample analysis device may provide a visual page, and the user may implement the trigger operation mode instruction according to the visual page pressing a control button, or touching a virtual button provided by the visual page, or the like.

The step S11 includes:

Step S111, controlling the first conveying component to move, conveying the reaction container positioned at the first in-out position to the first position, and suspending the first conveying component from moving for a first preset time;

in step S112, the suction needle assembly is controlled to add the sample to the reaction vessel located at the first position for a first preset time.

Step S12 includes:

in step S121, the sample detection module is controlled to detect the sample in the reaction vessel located at the first position, and generate detection information corresponding to the sample in the reaction vessel located at the first position.

Corresponding identification information can be set for each reaction container, and the generated detection information can be associated with the identification information corresponding to the reaction container, so that a user can inquire the corresponding detection information through the identification information.

The step S13 includes:

step S131, controlling the first conveying assembly to convey the detected reaction container at the first position to a second position along a preset path;

in step S132, the second conveying assembly is controlled to convey the reaction vessel to the fourth position along the annular path, and the suction needle assembly is controlled to suck the liquid in the reaction vessel at the second position into the reaction vessel at the fourth position.

In step S132, after the first conveying assembly conveys the reaction container to the second position, the operation is suspended for a second preset time, and the suction needle assembly may add the reagent to the reaction container located at the second position or directly suck the reagent and fill the reagent into the reaction container located at the fourth position within the second preset time.

In yet another embodiment, step S132 includes:

Step a, controlling a second conveying assembly to sequentially convey a plurality of reaction containers to a fourth position along a circular path;

And b, controlling the suction needle assembly to suck the sample in the reaction container at the second position, and sub-packaging the sample in the reaction containers sequentially passing through the second position.

After step a, further comprising:

And c, controlling the suction needle assembly to add reagent into the reaction container at the fourth position.

In this embodiment, the detected sample may be split into multiple reaction containers through the suction needle assembly, so that each reaction container may enter different detection structures respectively, and different types of detection may be implemented. Meanwhile, the suction needle assembly can also add reagents required by detection into each reaction container according to the detection type requirements of different reaction containers after sub-packaging, and the reagents are combined or reacted with the sample in the process that the reaction containers are conveyed to other detection structures from the fourth position, so that the detection efficiency is improved.

Referring to fig. 18, in an implementation, step S21 includes:

step S22, controlling the second conveying assembly to convey the reaction container along the annular path to sequentially pass through a third position and a fourth position;

In step S23, the suction needle assembly is controlled to add a sample to the reaction vessel located at the third position and to add a reagent to the reaction vessel located at the fourth position.

Specifically, the second conveying assembly can convey the reaction container to a third position along the annular path, pause conveying for a third preset time and control the suction needle assembly to add a sample to the reaction container positioned at the third position within the third preset time; the second conveying assembly conveys the reaction container from the third position to the fourth position along the annular path, pauses conveying for a fourth preset time and controls the suction needle assembly to add a required reagent to the reaction container positioned at the fourth position within the fourth preset time; the second conveying assembly conveys the reaction container from the fourth position to the second inlet and outlet positions along the annular path.

Referring to fig. 19 and 20, the present application further provides a carrier vehicle, which is configured to transport a reaction container along with a conveyor belt, and has a first cavity 121 for accommodating the reaction container, and a connecting portion 122 disposed at one side of the first cavity 121, and is configured to be fixedly connected to a preset position of the conveyor belt through the connecting portion 122. The vehicle provided by the present application may be used as the first vehicle 12 and/or the second vehicle 22 described above.

According to the transport vehicle of the embodiment of the application, the transport vehicle is provided with the first cavity 121 for accommodating the reaction container and the connecting part 122 arranged at one side of the first cavity 121, wherein the first cavity 121 is used for providing limit for the reaction container, so that the problems of easy dumping or shaking of the reaction container and the like are solved. The transport vehicle with the reaction container is integrally installed and fixed on the conveyor belt by the connecting part 122, the transport vehicle is driven by the conveyor belt, the transport vehicle loads the reaction container to achieve the conveying effect, and the problems of slipping, unstable conveying position and the like caused by directly placing the reaction container on the conveyor belt are avoided.

In some alternative embodiments, the transporter has a receptacle 123, the receptacle 123 having a first surface 123a and a second surface 123b disposed opposite in a third direction Z, and a third surface 123c and a fourth surface 123d connecting the first surface 123a and the second surface 123b and disposed opposite in a first direction X. Optionally, the second direction Y is perpendicular to the first direction X and the third direction Z.

The first cavity 121 is a cavity recessed from the second surface 123b in a partial region of the first surface 123a, and the connection portion 122 is disposed on the third surface 123c. Wherein the recess depth of the first cavity 121 in the third direction can be adjusted according to the height of the reaction vessel to be accommodated, and the first cavity 121 can limit the reaction vessel in the second direction and the first direction. For example, in use, when the carrier vehicle moves along the second direction along with the conveyor belt, the first cavity 121 can limit the reaction container in the second direction, and can prevent the reaction container from shaking in the conveying direction. And may penetrate in the third direction.

The opening of the first cavity 121 is disposed on the first surface 123a, and the connecting portion 122 is disposed on the third surface 123c, so that the connecting portion 122 and the first cavity 121 are kept away from each other, and mutual interference between the first cavity 121 and the connecting portion 122 is avoided.

In some alternative embodiments, the connecting portion 122 includes an extension 122a and a limiting section 122b, one end of the extension 122a is connected to the third surface 123c, the other end of the extension 122a is connected to the limiting section 122b, and the limiting section 122b and the third surface 123c are spaced apart along the first direction.

In these alternative embodiments, the carrier is mounted on the conveyor belt by the combined action of the extension section 122a and the limit section 122b, the limit section 122b and the third surface 123c are distributed at intervals along the first direction, and the connection groove 124 is formed between the limit section 122b and the third surface 123c, so that the carrier can be clamped and positioned by using the limit section 122b, and the problems of loose connection, falling off and the like of the carrier on the conveyor belt are avoided.

Referring to fig. 20, fig. 20 is a schematic structural diagram of a transport vehicle according to another embodiment of the application.

In some alternative embodiments, as shown in fig. 20, the spacing between the first cavity 121 and the third surface 123c is greater than the spacing between the first cavity 121 and the fourth surface 123 d. The opening of the first cavity 121 is located on the first surface 123a, the connecting portion 122 starts from the third surface 123c, and the distance between the first cavity 121 and the third surface 123c is larger than the distance between the first cavity 121 and the fourth surface 123d, so that the force applied to the connecting portion 122 of the conveyor belt and the carrier vehicle in the conveying motion process is transmitted to the first cavity 121 to be reduced, and unstable reaction containers caused by overlarge vibration deformation of the carrier vehicle in the first cavity 121 are avoided.

In addition, the distance between the first cavity 121 and the third surface 123c is larger than the distance between the first cavity 121 and the fourth surface 123d, so that the vehicle body of the vehicle is longer, and when the vehicle and the conveyor belt are matched, the connecting portion 122 of the vehicle is fixedly connected with the conveyor belt, and at least part of the vehicle can extend out of the conveyor belt to be matched with other structures. For example, as shown in fig. 6, when the connecting portion 122 of the carrier vehicle is fixedly connected to the first conveyor belt 11, at least part of the carrier vehicle can extend out of the first conveyor belt 11 and cooperate with the sample detection module 5.

Referring to fig. 3 in combination, the reaction vessel 4 includes ears 41. In some embodiments, as shown in fig. 19 and 20, the first surface 123a is convexly provided with support steps 12a, two support steps 12a are provided at both sides of the first cavity 121, and the two support steps 12a are spaced apart in the first direction, the support steps 12a serving to support the ears 41 of the reaction vessel 4.

In these alternative embodiments, when the reaction vessel 4 is placed within the first cavity 121 of the transporter, the support step 12a on the transporter supports the ears 41 of the reaction vessel 4 such that the ears 41 of the reaction vessel 4 are spaced a distance from the transporter first surface 123a, i.e., the ears 41 of the reaction vessel 4 hang above the transporter. Facilitating gripping of the reaction vessel 4 by the transfer module.

In some embodiments, as shown in fig. 19 and 20, the first surface 123a is further provided with a limiting boss 12b in a protruding manner, the limiting boss 12b is disposed on one side of the first cavity 121 and located between the two supporting steps 12a, and a guiding inclined surface 12b ' is disposed on the limiting boss 12b, wherein the limiting boss 12b has a middle portion disposed in the first direction and end portions disposed on both sides of the middle portion, and the guiding inclined surface 12b ' is disposed obliquely in a direction approaching the second surface 123b in a direction from the middle portion to the end portions, and the guiding inclined surface 12b ' may be a chamfer or an arc angle. The transport vehicle mainly has several working positions such as sample loading position, reagent position, screening position, reaction vessel business turn over position along with the conveyer belt conveying in-process, when the transport vehicle was advanced to a certain appointed station, need carry out actions such as sample loading or detection to the reaction vessel on the transport vehicle on a certain working position, it is fixed to need transport vehicle and reaction vessel this moment, so be provided with on a certain corresponding working position of conveyer belt and stop member 23.

As shown in fig. 14 and 15, the blocking member 23 is provided with a boss 234 that cooperates with the carrier spacing boss 12 b. When the transport vehicle just enters or just leaves the blocking member 23, the guide inclined plane 12b' of the limit boss 12b on the transport vehicle and the boss 234 on the blocking member 23 act together to play a role in buffering and flexible matching, so that the sample in the reaction container 4 is prevented from shaking or spilling due to instant impact when the transport vehicle enters or leaves the boss 234 at a certain station.

In some embodiments, the receiving portion 123 further includes two wall portions disposed opposite to each other in the third direction, and at least one of the two wall portions is provided with a through hole communicating with the first cavity 121.

When the two wall portions are provided with through holes, for example, the through holes include the first through hole 126 and the second through hole 127, the through holes in the two wall portions are on the same axis, and the through holes are used for allowing light on the sample detection module 5 to pass through.

In other embodiments, when a through hole is formed in one of the wall portions, for example, the through hole includes only the first through hole 126, the first through hole 126 is used for mounting an optical fiber, and a photoelectric sensor is disposed on the inner surface of the other wall portion aligned with the axis of the first through hole 126, and the photoelectric sensor may be attached to the other wall portion or fixed by other means such as bolts, and the sample in the reaction vessel 4 is irradiated by the detection light emitted from the optical fiber and transmitted to the photoelectric sensor, and the optical fiber sensor performs detection statistics on the result.

In some embodiments, as shown in fig. 20, a light guide member 128 is further disposed in the light-passing hole 129, the light guide member 128 has a light-passing hole 129, the light guide member 128 is attached to the inner wall of the through hole, and the light-passing hole 129 is communicated with the through hole. The light guide 128 may be made of black rubber, so that the light guide 128 does not reflect or refract light, and the influence of other light on the detection test is improved.

Optionally, the through hole is a stepped hole and includes a first section 126a and a second section 126b that are mutually communicated, the radial dimension of the second section 126b is smaller than the radial dimension of the first section 126a, and the second section 126b is located at a side of the first section 126a facing the first cavity 121; the light guide member 128 includes a first engaging section 128b and a second engaging section 128c which are mutually communicated, the first engaging section 128b is located in the first section 126a, the second engaging section 128c is located in the second section 126b, and a radial dimension of the first engaging section 128b is larger than a radial dimension of the second engaging section 128 c.

Optionally, an extension of the first engaging section 128b in the axial direction of the through hole is smaller than or equal to an extension of the first section 126a, so that the light guide 128 does not protrude from an outer surface of the wall facing away from the first cavity 121. When the light guide piece 128 is matched with the through hole, the light guide piece 128 is ensured not to protrude out of the outer surface of the wall part, so that the light guide piece 128 is integrally arranged in the through hole, and the light guide piece 128 cannot be collided and interfered by the transport vehicle in the conveying process of the transport vehicle on the transmission belt.

In some embodiments, as shown in fig. 20, a limiting aperture 125 is provided in the fourth surface 123d in communication with the first cavity 121. In these alternative embodiments, the stop 122b may be formed by a stop aperture 125, such as by extending the plunger 547 of FIG. 9 into the stop aperture 125 to stop the reaction vessel within the first chamber 121.

Optionally, a spacing between the limiting hole 125 and the second surface 123b is greater than a spacing between the limiting hole 125 and the first surface 123 a. The closer the reaction vessel 4 is to the opening of the first cavity 121, the more easily the reaction vessel 4 is shaken, and the spacing between the spacing hole 125 and the second surface 123b is larger than the spacing between the spacing hole 125 and the first surface 123a, so that the spacing hole 125 is disposed close to the opening of the first cavity 121, and the plunger 547 located in the spacing hole 125 can better spacing the reaction vessel 4.

Optionally, the limiting hole 125 is a cylindrical hole, and the center of the cross section of the limiting hole 125 is located at the middle of the first cavity 121 in the third direction. So that the stress of the reaction vessel 4 is more balanced, and the reaction vessel 4 in the first cavity 121 is not easy to shake.

In addition, the term "and/or" herein is merely an association relationship describing an association object, and means that three relationships may exist, for example, a and/or B may mean: a exists alone, A and B exist together, and B exists alone. In addition, the character "/" herein generally indicates that the front and rear associated objects are an "or" relationship.

It should be understood that in embodiments of the present application, "B corresponding to a" means that B is associated with a, from which B may be determined. It should also be understood that determining B from a does not mean determining B from a alone, but may also determine B from a and/or other information.

While the application has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the application. Therefore, the protection scope of the application is subject to the protection scope of the claims.

Claims

1. A sample analysis apparatus, which is a coagulation analyzer, for detecting a blood sample in a reaction vessel, comprising:

The sample detection module is used for detecting a blood sample in the reaction container at the first position;

A second transport assembly having an endless path for transporting the reaction vessel, the endless path having third and fourth locations disposed thereon in spaced apart relation, the fourth location being adjacent to the second location;

A suction needle assembly for adding the sucked liquid to the reaction vessel at the third position and/or the first position, and for sucking the liquid from the reaction vessel at the second position to the reaction vessel at the fourth position;

When the operation mode of the sample analysis device is a first mode, the first conveying assembly and the second conveying assembly move, the first conveying assembly is used for conveying the reaction container to the first position, and the suction needle assembly is used for adding a blood sample to the reaction container positioned at the first position;

the sample detection module is used for detecting a blood sample added into the reaction container at the first position;

The first conveying component is further used for conveying the detected reaction container positioned at the first position to the second position, and the suction needle component sucks the blood sample in the reaction container positioned at the second position and divides the blood sample into a plurality of reaction containers sequentially passing through the fourth position;

When the operation mode of the sample analysis apparatus is the second mode, the second transporting assembly moves, and the suction needle assembly is used for adding the blood sample to the reaction container at the third position.

2. The sample analysis device of claim 1, wherein the predetermined path is further provided with a first access location, the annular path is further provided with a second access location adjacent to the first access location, the second location, and the first location are sequentially spaced along the predetermined path, and the second access location, the third location, and the fourth location are sequentially spaced along the annular path.

3. The sample analysis device of claim 2, wherein the pre-set path is disposed about the annular path, the pre-set path extending in the same plane as the annular path.

4. The sample analysis device of claim 2, wherein the endless path comprises a third transport section provided with the second access location and a fourth transport section provided with the fourth location, the third transport section and the fourth transport section being connected;

The preset path comprises a first transportation section provided with a first in-out position and a second transportation section provided with a second position, the extending directions of the first transportation section and the second transportation section are intersected, the first transportation section and the third transportation section are oppositely arranged, and the second transportation section and the fourth transportation section are oppositely arranged.

5. The sample analysis device of claim 4, wherein the endless path further comprises a fifth transport section provided with the third location, the fourth transport section connecting the third transport section and the fifth transport section, the fifth transport section being disposed in opposed spaced relation to the third transport section, the third location being adjacent to the first location.

6. The sample analysis device of claim 5, further comprising a sixth transport section provided with a fifth location on the endless path, the third transport section, fourth transport section, fifth transport section, and sixth transport section being connected end to end.

7. The sample analysis device of claim 4, wherein the first location is disposed at an end of the second transport section remote from the first transport section, the sample analysis device further comprising a sample detection module disposed adjacent the first location, the sample detection module having a detection space into which the first transport assembly is capable of transporting the reaction vessel along the second transport section.

8. The sample analysis device of claim 7, wherein the sample detection module comprises a light receiver and a light emitter arranged at opposite intervals, the light receiver and the light emitter form the detection space therebetween, the light emitter can emit light to the reaction vessel at the first position, and the light receiver can receive the light emitted from the reaction vessel.

9. The sample analysis device of claim 8, wherein the light receiver and the light emitter are disposed in a first direction and the second transport section is disposed in a second direction, the first transport assembly capable of transporting the reaction vessel into the detection space in the second direction, the first direction and the second direction intersecting.

10. The sample analysis device of claim 1, wherein the first transport assembly comprises a first conveyor belt and a first carriage moving along the predetermined path with the first conveyor belt, and the second transport assembly comprises a second conveyor belt and a second carriage moving along the endless path with the second conveyor belt.

11. The sample analysis device of claim 10, further comprising a blocking member having a limiting slot, the blocking member being disposed in at least any one of the third position, the fourth position, and the second position, the limiting slot being for limiting the first transporter and/or the second transporter.

12. The sample analysis device of claim 11, wherein the blocking member comprises oppositely disposed stop blocks and first plates for limiting opposite sides of the first transport vehicle or the second transport vehicle.

13. The sample analysis device according to claim 12, wherein the blocking member further comprises a second plate member disposed opposite to each other and a boss protruding from the first plate member, the boss and the second plate member being configured to limit opposite sides of the first carrier or the second carrier, a filling opening for exposing the reaction container being formed between the boss and the stopper, the first plate member, the second plate member, and the boss forming the limit clamping groove.

14. The sample analysis device of claim 1, wherein the suction needle assembly comprises:

a first suction needle for adding the sucked blood sample into the reaction vessel at the third position and/or the first position;

And the second suction and discharge needle is used for sucking the liquid in the reaction container at the second position and adding the liquid into the reaction container at the fourth position.

15. The sample analysis device of claim 14, further comprising a storage module for storing a reagent, wherein the second position, the fourth position, and a reagent-sucking position of the storage module are disposed on a same line, and wherein the second suction needle moves along the line in which the second position, the fourth position, and the reagent-sucking position are disposed.

16. The sample analysis device of claim 1, further comprising a first needle wash basin disposed adjacent to the third location and a second needle wash basin disposed adjacent to the fourth location.

17. The sample analysis device of claim 2, further comprising a transfer assembly for transferring the reaction vessel in the second access location and the first access location.

18. A sample analysis method, characterized in that the sample analysis method is applied to the sample analysis apparatus according to any one of claims 1 to 17, the method comprising:

When the operation mode of the sample analysis device is a first mode, controlling the first conveying assembly and the second conveying assembly to move, and controlling the suction needle assembly to add a blood sample to the reaction container positioned at the first position by the first conveying assembly;

detecting a blood sample added to a reaction vessel located at the first location;

controlling the suction needle assembly to suck the detected sample in the reaction container into the reaction container positioned in the second conveying assembly;

when the operation mode of the sample analysis device is the second mode, controlling the second conveying assembly to move, and controlling the suction needle assembly to add a blood sample to the reaction container positioned at the third position;

wherein the step of controlling the suction needle assembly to suck the liquid in the detected reaction vessel into the reaction vessel located in the second transfer assembly comprises:

the first conveying component is controlled to convey the reaction container which is positioned at the first position and detected to the second position, and the suction needle component is controlled to suck the blood sample in the reaction container positioned at the second position and split the blood sample into a plurality of reaction containers which sequentially pass through the fourth position.

19. The method of claim 18, wherein the step of detecting the sample added to the reaction vessel at the first location comprises:

and controlling the sample detection module to detect the sample in the reaction container at the first position, and generating detection information corresponding to the sample in the reaction container at the first position.

20. The method of claim 18, wherein the step of controlling the suction needle assembly to suck the liquid in the detected reaction vessel to the reaction vessel located in the second transfer assembly comprises:

Controlling the first conveying assembly to convey the detected reaction container which is positioned at the first position to the second position along the preset path;

and controlling the second conveying assembly to convey the reaction container to the fourth position along the annular path, and controlling the suction needle assembly to suck the liquid in the reaction container at the second position into the reaction container at the fourth position.

21. The method of claim 20, wherein the step of controlling the second transport assembly to transport the reaction vessel along the endless path to the fourth location and controlling the suction needle assembly to suck the liquid from the reaction vessel at the second location into the reaction vessel at the fourth location comprises:

controlling the second transport assembly to sequentially transport a plurality of reaction vessels along the endless path to the fourth location;

And controlling the suction needle assembly to suck the blood sample in the reaction container at the second position, and sub-packaging the blood sample in a plurality of reaction containers sequentially passing through the second position.

22. The method of claim 21, wherein after the step of controlling the second transport assembly to sequentially transport a plurality of reaction vessels along the endless path to the second location, further comprising:

And controlling the suction needle assembly to add reagent to the reaction container positioned at the fourth position.

23. The method of claim 18, wherein the step of controlling movement of the second transport assembly and controlling the pipette tip assembly to add the blood sample to the reaction vessel in the third position comprises:

Controlling the second conveying assembly to convey the reaction vessel along the annular path to pass through a third position and a fourth position in sequence;

and controlling the suction needle assembly to add a blood sample to the reaction container positioned at the third position and add a reagent to the reaction container positioned at the fourth position.

24. The method of claim 18, further comprising:

and receiving an operation mode instruction triggered by a user, and determining the operation mode of the sample analysis equipment according to the operation mode instruction.