CN107356773B - A kind of chemical illumination immunity analysis instrument - Google Patents
A kind of chemical illumination immunity analysis instrument Download PDFInfo
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- CN107356773B CN107356773B CN201710507018.4A CN201710507018A CN107356773B CN 107356773 B CN107356773 B CN 107356773B CN 201710507018 A CN201710507018 A CN 201710507018A CN 107356773 B CN107356773 B CN 107356773B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0482—Transmission
- G01N2035/0484—Belt or chain
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The present invention relates to a kind of chemical illumination immunity analysis instruments, it include: agent formulation device, sample conveying device manages cup device automatically, emergency treatment device, reaction tray device, cleaning device, Sample Dilution device, shine measuring device, material collecting barrel, manipulator and sampling probe, sampling probe is drawn and conveying liquid can directly be swung in sample conveying device, emergency treatment device and Sample Dilution device;Manipulator can grasp and convey reaction cup, so that reaction cup is moved to reaction tray device from automatic reason cup device, move to cleaning device from reaction tray device, move to luminous measuring device from cleaning device, move to material collecting barrel from luminous measuring device;It is moved between each device by manipulator and sampling probe, transmits reaction cup and liquid, realize the automatic operation of entire immunoassay process, improve full-automatic degree.
Description
Technical field
The present invention relates to a kind of chemical illumination immunity analysis instruments, belong to the field of medical instrument technology.
Background technique
The most commonly used diagnostic method of medical domain --- in-vitro diagnosis at present refers to body fluid, the row of acquisition human body
Object, secretion progress chemical component or chemical reaction analysis are let out, to judge human lesion.Such as chemiluminometry divides
Son diagnosis.These diagnostic methods are all made of automatically or semi-automatically instrument and are loaded, analysis, and provide diagnosis report.However
Chemical illumination immunity analysis instrument the degree of automation of the prior art still has improved prospect.
Summary of the invention
The technical problem to be solved by the present invention is in order to overcome the problems referred above, providing a kind of higher chemistry of full-automatic degree
Luminescence immunoassay instrument.
The technical solution adopted by the present invention to solve the technical problems is: the present invention provides a kind of chemiluminescence immune assay
Instrument, comprising: agent formulation device, sample conveying device manage cup device automatically, emergency treatment device, reaction tray device, cleaning device,
Sample Dilution device, shine measuring device, material collecting barrel, manipulator and sampling probe;
Sampling probe is drawn and conveying liquid can directly be put in sample conveying device, emergency treatment device and Sample Dilution device
It is dynamic;
Manipulator can grasp and convey reaction cup, and reaction cup is made to move to reaction tray device from automatic reason cup device, from
Reaction tray device moves to cleaning device, moves to luminous measuring device from cleaning device, moves to collection from luminous measuring device
Charging basket;
Agent formulation device, for providing water purification and configuring cleaning solution supplying cleaning device and Sample Dilution device;
Sample conveying device, for sample to be tested to be transported to sample position, sampling probe can be incited somebody to action after reaching sample position
Sample is drawn and is filled into the reaction cup in reaction tray device;
Automatic reason cup device, for reaction cup to be transported to discharge position in reaction cup with vertical state, manipulator can be from
Reaction cup is picked up and is placed into reaction tray device by discharge position in reaction cup;
Material collecting barrel is set to analyzer bottom, for storing used reaction cup.
Preferably, chemical illumination immunity analysis instrument of the invention, sample conveying device include:
Conveying mechanism, including bottom plate, two parallel loading guides and the blanking guide rail being mounted on upper plate, are exposed to
Two of upper plate parallel feeding transmission belt and blanking transmission belt, are equipped with driving wheel between upper plate and lower plate, feeding passes
Defeated band and blanking transmission belt are respectively arranged on a pair of of driving wheel, and feeding transmission belt and blanking transmission belt are driven by power device and driven
Sample rack is moved respectively along loading guide and blanking guide rail;
Baffle has recessing groove, barcode scanning slot, relief hole, barcode scanning slot is to allow and sweep positioned at bottom plate one end of conveying mechanism
Code light passes through;
Pushing mechanism moves sample rack along baffle for pushing sample rack, comprising: pushing motor, pushing motor drive
Dynamic pushing plate is moved along baffle, to push sample rack;
Blocking mechanism, setting is in loading guide end, including stops driving part, and the blocking that upper plate bottom is arranged in is led
Rail, be arranged on guide rail be blocked driving part driving and along stop that guide rail moves and close to or far from baffle blocking it is sliding
Block stops to be provided with positive stop and backstop on sliding block, can accommodate a sample rack between positive stop and backstop, positive stop and
Backstop all has the raised position for protruding from upper plate and the non-bulging decline state in upper plate, and positive stop is far from baffle
It is on one side inclined-plane, backstop is inclined-plane close to the one side of baffle, so that when sample rack passes through positive stop, it can be by positive stop
Pressure, positive stop and backstop are with when stopping to move together with sliding block, and backstop is depressed by upper plate, and it is tight that positive stop pushes sample rack
Against baffle;
Cutting agency, for shifting the sample rack for being located at baffle end onto blanking guide rail, thus enable sample rack by
Blanking transmission belt drives, pushing motor, pushes guide rail, pushing motor drive rocker mechanism is to keep push plate past along pushing guide rail to do
Multiple movement, push plate can pass through relief hole to push the sample rack for being located at baffle side.
Preferably, chemical illumination immunity analysis instrument of the invention, managing cup device automatically includes,
Bracket component;
Discharging barrel is arranged on bracket component, and upper end has opening, and cross section gradually subtracts from top to bottom along the vertical direction
Small, there is partition in the logical centre of blowing, and discharging barrel is divided into two parts;
Cup assembly is pushed away, has from discharging barrel bottom and protrudes into the charging ram in discharging barrel, it can be under the driving of power device
It moves reciprocatingly, reaction cup is pushed into the holding tank of transfer block when charging ram moves reciprocatingly, the top of charging ram is V-arrangement
Slot;
Vertical transport component, with endless apron and setting transfer block on the conveyor belt, endless apron can be
Together with transfer block shuttling movement under the driving of power device, transfer block has a holding tank of side opening, the central axes of holding tank with
The angle of horizontal plane is 65 ° -70 °, and the bottom surface of holding tank and the angle of side are 50 ° -60 °;
Cup assembly out is arranged on bracket component, the side plate including two sides and the sole piece among side plate, out cup assembly
On into rim of a cup correspond on vertical transport component go out cup at, cup channel, the shape of sole piece are formed with out between side plate and sole piece
Variation makes to show that glass channel is followed successively by the first tilting section, the second tilting section, vertical section, the first tilting section from into rim of a cup to cup mouth
The central axes of bottom surface and the angle of horizontal plane be 65 ° -70 °, the bottom surface of the first tilting section and the angle of vertical side are
50 ° -60 °, vertical with the vertical side and angle with horizontal plane of the second tilting section is 70-80 °, on the side plate of vertical section two sides
Guide protrusions are formed, guide protrusions block the two sides of reaction cup;The top into rim of a cup on cup assembly is provided with into cup and keeps off out
Plate, cup assembly side is additionally provided with the backward channel for returning to reaction cup in discharging barrel out;Incline into the bottom edge of cup baffle with first
Tiltedly the bottom surface of section is parallel and 4- bigger than the height of reaction cup at a distance from the bottom surface of the first tilting section into the bottom edge of cup baffle
5mm;It is inclined-plane into the top surface of cup baffle, and parallel with the bottom surface of the first tilting section;Cup assembly further includes closing out cup channel out
Closed plate, the distance between the bottom edge of closed plate and the transmission surface of horizontal feed component are greater than reaction cup overhead height and are less than
Reaction cup total height.
Preferably, chemical illumination immunity analysis instrument of the invention, emergency treatment device, comprising: the sample of analyzer front opening
Room, the support plate being installed vertically on sample room's bottom plate are arranged in the sliding rail of support plate side, are slidably arranged on sliding rail
Sample plane, one or more blind holes for accommodating sample tubes are provided in sample plane, and sample plane is under external force and sliding along sliding rail
When dynamic, blind hole can be made to be located at adding outside analyzer and become between sample tube position and sample position inside analyzer
It changes;
The independent emergency treatment sampling hole corresponding to sample position is provided on workbench at the top of analyzer;
Rotating arm driving motor can drive rotation arm body to rotate the independent emergency treatment so that on sampling probe Alignment stage
Sampling hole;
Rear and front end is separately installed with the first limited block for stopping sample plane to skid off sliding rail and the second limit on sample room's bottom plate
Position block.
Preferably, chemical illumination immunity analysis instrument of the invention, reaction tray device include reacting disc mechanism, including cylinder,
The disk being rotatably arranged in cylinder, isometrical on disk to be placed with a circle reaction cup receiving hole, reaction cup can be placed in reaction
In cup receiving hole, the distance of two neighboring reaction cup receiving hole is the half of reaction cup width to 2/3 on disk;
Driving mechanism, for driving disk rotational;
Uniform shaking mechanism, be arranged in manipulator crawl position front end, it is as follows in uniform shaking mechanism it is identical
Feed mechanism and cutting agency are located at cylinder side, and feed mechanism is identical with the structure of cutting agency, but set relatively
It sets, includes rack, electromagnetic driver, the oscillating deck being hingedly arranged at, there are two parallel yoke, pendulum for setting on oscillating deck
Movable plate also passes through the telescopic rod that spring makes oscillating deck abut against electromagnetic driver always, and electromagnetic driver after by electricity, stretch by telescopic rod
Out, oscillating deck is pushed to swing, after electromagnetic driver power-off, telescopic rod is retracted;
Heating mechanism is located in cylinder and is located on four peripheral wall of disk, for heating reaction cup, preferably silica gel heating
Device.
Preferably, chemical illumination immunity analysis instrument of the invention, cleaning device, cleaning disc mechanism, imbibition mechanism for filling liquid and
Uniform shaking mechanism;
Cleaning disc mechanism includes:
Cylinder has circular reaction cup run channel;
Disk is rotatably arranged in cylinder, and isometrical on disk to be placed with a circle reaction cup receiving hole, reaction cup can
It is placed in reaction cup receiving hole;
Several magnetic pole groups, setting are sequentially arranged in cylinder along reaction cup traffic direction, are located at if each magnetic pole group has
The pole pairs of dry reaction cup run channel two sides is constituted, and each magnetic pole group at least have that there are two the magnetic positioned at reaction cup run channel two sides
Extremely right, the pole orientation of the magnet in each magnetic pole group in each pole pair is identical, the pole orientation phase of two neighboring pole pair
Instead, the pole pair setting height of the last one magnetic pole group gradually decreases, the latter pole pair height compared with previous pole pair
Decline 5-8mm;
Uniform shaking mechanism is located between two magnetic pole groups, comprising: lifting actuator, lifter plate are fixed on shaking for bottom of cylinder
Even actuator is arranged in the eccentric cup at the top of rocking bar, is fixed on cylinder by shaft coupling and the rocking bar for shaking up actuator and connecting
The elastic piece extending at the top of disk, be provided on elastic piece for covering the lid wheel at the top of reaction cup, lid wheel bottom has
Can extend into reaction cup circle wheel, the central axes of eccentric cup and the central axes of rocking bar are not conllinear, the central axes of eccentric cup with shake
The distance of the central axes of bar is the 1/4-1/5 of reaction cup width, and when shaking up to reaction cup, lifting actuator drives lifter plate
It rises, shakes up actuator, rocking bar, eccentric cup and risen with lifter plate, eccentric cup jacks up reaction cup, and bullet is resisted at the top of reaction cup
Property piece lid wheel, reaction cup fixes again, shakes up actuator starting later, shakes reaction cup by eccentric cup, makes reaction cup
Interior liquid shakes up;
The imbibition injection needle of imbibition mechanism for filling liquid can be extend into when needing imbibition and fluid injection each magnetic pole group last
In reaction cup on the corresponding position of a pole pair, after imbibition and fluid injection, then imbibition injection needle is taken out, remove last root
Outside imbibition injection needle, remaining imbibition injection needle all has the function of imbibition and fluid injection, last root imbibition injection needle only has
The function of imbibition.
Preferably, chemical illumination immunity analysis instrument of the invention, Sample Dilution device, comprising:
Mounting plate;
Purge chamber, it is fixed that there is the first cavity, there is dilution inlet on the roof of the first cavity on a mounting board,
Cleaning solution liquid outlet is offered on the bottom wall of first cavity;;
Cleaning pipe protrudes into the first cavity;
Cleaning pipe driving mechanism, on a mounting board, driving cleaning pipe is protruded into along its axial-movement with adjusting cleaning pipe for setting
The amount of protruding into of first cavity;
Rotating electric machine;
Diluted cup, setting in the first cavity, can rotate, and rotating to special angle under rotating electric machine driving
When diluted cup can be cleaned pipe alignment;
It is extend into the first cavity again after also there is the second cavity, cleaning pipe to pass through the second cavity in purge chamber, the second chamber
Inlet and outlet are provided in the cavity wall of body;
Cleaning pipe is respectively provided with sealing ring at the cavity wall for passing through the first cavity and the second cavity.
Preferably, chemical illumination immunity analysis instrument of the invention, the luminous measuring device includes: measuring chamber, and top is opened
Mouthful, inside has the accommodating chamber for accommodating reaction cup, and top is additionally provided with guide rail, and side has photon via hole, is equipped with switch cover
Actuator;
Top cover is slidably arranged on the guide rail at the top of measuring chamber, can be under the driving of switch cover actuator along guide rail
Movement is additionally provided with examination to change between the position that closed measurement chamber is open and the position of opening measuring chamber opening on top cover
Pipe is added in agent, when top cover is in the position of closed measurement chamber opening, is held by the way that pipe is added and injects liquid and can flow into be located to reagent
It receives in the reaction cup of chamber;
Photon counter is arranged at measuring chamber photon via hole, for acquiring the luminous generated light of reagent in reaction cup
Son;
Shutter structure is arranged between photon counter and measuring chamber, can be closed or opened photon via hole, including peace
Dress and the rotary drive on mounting plate, have the baffle of through-hole, also form sliding slot on baffle, are turned actuator driving and turned
Dynamic trundle is arranged in sliding slot, when trundle rotates, by the cooperation with sliding slot, moves horizontally baffle, to make to keep off
Through-hole on plate is overlapped or misplaces with photon via hole.
The beneficial effects of the present invention are: of the invention.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples.
Fig. 1 is the structural schematic diagram of the chemical illumination immunity analysis instrument of the embodiment of the present invention;
Fig. 2-1 is a kind of three-dimensional structure diagram of embodiment of sample of the present invention conveying device;
Fig. 2-2 is a kind of three-dimensional structure diagram of embodiment of baffle of the present invention;
Fig. 2-3 is a kind of three-dimensional structure diagram of embodiment of blocking mechanism of the present invention;
Fig. 2-4 is a kind of three-dimensional structure diagram of embodiment of cutting agency of the present invention.
Fig. 3-1 is the structural schematic diagram of the Cup arrangement machine structure of the embodiment of the present invention;
Fig. 3-2 be the embodiment of the present invention without charging basket when Cup arrangement machine structure structural schematic diagram;
Fig. 3-3 is the structural schematic diagram of the transfer block of the embodiment of the present invention;
Fig. 3-4 is the first tilting section of the embodiment of the present invention and the structural schematic diagram of the second tilting section;
Fig. 3-5 is the structural schematic diagram of the vertical section of the embodiment of the present invention;
Fig. 4-1 is the three-dimensional structure diagram with independent emergency treatment structure of the invention;
Fig. 4-2 is the three-dimensional structure diagram of the emergency treatment sample introduction module of independent emergency treatment structure of the invention;
Fig. 5-1 is a kind of three-dimensional structure diagram of embodiment of disc type reaction unit of the present invention;
Fig. 5-2 is a kind of three-dimensional structure diagram of embodiment of disc type reaction unit of the present invention;
Fig. 5-3 is a kind of three-dimensional structure diagram of embodiment of feed mechanism or cutting agency of the present invention;
Fig. 6-1 is a kind of three-dimensional structure diagram of embodiment of analyzer reagent cleaning device of the present invention;
Fig. 6-2 is the schematic diagram of disk upper magnetic pole arrangement of the present invention;
Fig. 6-3 is a kind of three-dimensional structure diagram of embodiment of present invention cleaning disc mechanism;
Fig. 6-4 is a kind of three-dimensional structure diagram of embodiment of uniform shaking mechanism of the present invention.
Fig. 7-1 show the positive structure schematic of sample of the present invention dilution device;
Fig. 7-2 show the structure schematic diagram of sample of the present invention dilution device.
Fig. 8-1 is a kind of three-dimensional knot of luminous measuring device (top cover closing) embodiment of analyzer single reaction cup of the present invention
Composition;
Fig. 8-2 is a kind of three-dimensional knot of luminous measuring device (top cover opening) embodiment of analyzer single reaction cup of the present invention
Composition;
Fig. 8-3 is a kind of three-dimensional structure diagram of embodiment when shutter structure of the present invention is opened;
Fig. 8-4 is a kind of three-dimensional structure diagram of embodiment when shutter structure of the present invention is closed.
Specific embodiment
In conjunction with the accompanying drawings, the present invention is further explained in detail.These attached drawings are simplified schematic diagram, only with
Illustration illustrates basic structure of the invention, therefore it only shows the composition relevant to the invention.
Embodiment
The present embodiment provides a kind of chemical illumination immunity analysis instruments, as shown in Figure 1: include: agent formulation device 1, sample
Conveying device 2, automatic to manage cup device 3, emergency treatment device 4, reaction tray device 5, cleaning device 6, Sample Dilution device 7, shine survey
Measure device 8, material collecting barrel 9, manipulator and sampling probe.
Sampling probe is drawn and conveying liquid can be between sample conveying device 2, emergency treatment device 4 and Sample Dilution device 7
It swings;
Manipulator can grasp and convey reaction cup, and reaction cup is made to move to reaction tray device 5 from automatic reason cup device 3,
Cleaning device 6 is moved to from reaction tray device 5, moves to luminous measuring device 8 from cleaning device 6, is transported from luminous measuring device 8
Move material collecting barrel 9.
-- agent formulation device 1, for providing water purification and configuring cleaning solution supplying cleaning device 6 and Sample Dilution device 7,
Divergence type cleaning solution liquid storing barrel 132 and system type cleaning solution liquid storing barrel 131, and supplied to cleaning device 6 and Sample Dilution device 7
Cleaning solution and water purification, comprising: peristaltic pump 121,122, diaphragm pump 133,134,135, divergence type cleaning solution match tubbing 111, system
Type cleaning solution matches tubbing 112, water purification liquid storing barrel 113, two peristaltic pumps 121,122, divergence type cleaning solution liquid storing barrel 132, system
Type cleaning solution liquid storing barrel 131, peristaltic pump 121,122 is respectively from divergence type cleaning solution liquid storing barrel 132 and system type cleaning solution liquid storage
Bucket 131 extract cleaning solutions to divergence type cleaning solution with tubbing 111, system type cleaning solution in tubbing 112, diaphragm pump 133 is from net
Water liquid storing barrel 113 extracts water purification and matches in tubbing 112 to divergence type cleaning solution with tubbing 111, system type cleaning solution, to prepare
Divergence type cleaning solution and system type cleaning solution, diaphragm pump 134,135 extract prepared divergence type cleaning solution and system type respectively
Cleaning solution is used for cleaning device 6 and Sample Dilution device 7;
-- sample conveying device 2, for sample to be tested to be transported to sample position, sampling probe can after reaching sample position
Sample is drawn and is filled into the reaction cup in reaction tray device 5, comprising:
Conveying mechanism 2100, as shown in Fig. 2-1, including bottom plate (being divided into upper plate and lower plate), it is mounted on bottom plate
Two parallel loading guides 2101 and blanking guide rail 2102 are exposed to two parallel 2103 Hes of feeding transmission belt of upper plate
Blanking transmission belt 2104, is equipped with driving wheel between upper plate and lower plate, feeding transmission belt 2103 and blanking transmission belt 2104 are each
It is arranged on a pair of of driving wheel, feeding transmission belt 2103 and blanking transmission belt 2104 are driven by power device and drive sample rack 1000
It is moved respectively along loading guide 2101 and blanking guide rail 2102;
Baffle 2300 positioned at bottom plate one end of conveying mechanism 2100, has recessing groove 2301, barcode scanning slot as Figure 2-3
2302, the function of relief hole 2303, recessing groove 2301 and relief hole 2303 hereinafter has narration, and barcode scanning slot 2302 is to allow and sweep
Code light passes through;
Pushing mechanism 2400 moves sample rack 1000 along baffle 2300, in this process for pushing sample rack 1000
In, barcode scanning, sampling are carried out to sample tube each on sample rack 1000 one by one, comprising: pushing motor 2402, pushing motor
2402 driving pushing plates 2401 move (baffle 2300 is moved along recessing groove 2301) along baffle 2300, to push sample rack
1000;
Blocking mechanism 2200, as shown in Fig. 2-2 and 2-3, setting is in 2101 end of loading guide, including stops driving part
2201, it is arranged in upper plate (upper plate is usually formed by being equipped with baffle 2300 and being equipped with two parts of guide rail 2101) bottom
Blocking guide rail 2203, be arranged in stop guide rail 2203 on being blocked driving part 2201 driving and along stop guide rail 2203 transport
It moves and blocking sliding block 2202 close or far from baffle 2300, positive stop 2211 is provided on the blocking sliding block 2202 with after
Block 2212 can accommodate a sample rack 1000, positive stop 2211 and backstop between positive stop 2211 and backstop 2212
2212 all have the raised position for protruding from upper plate and the non-bulging decline state in upper plate, as a kind of concrete implementation
Mode positive stop 2211 and backstop 2212 are arranged on elastic component (in the rotation axis of positive stop 2211 and backstop 2212
Torsional spring is set), elastic component is that positive stop 2211 and backstop 2212 provide elastic force, so that positive stop 2211 and backstop 2212 exist
Raised position is returned under no other external forces, one side of the positive stop 2211 far from baffle 2300 is inclined-plane, and backstop 2212 leans on
The one side of nearly baffle 2300 is inclined-plane, so that can press positive stop 2211 when sample rack 1000 is by positive stop 2211
Under (so that positive stop 2211 is become decline state from raised position, to prevent positive stop 2211 from stopping, sample rack 1000 is by before rear
Block 2211 recovers immediately raised position), it is rear to keep off when positive stop 2211 and backstop 2212 and blocking sliding block 2202 move together
Block 2212 by upper plate depress (backstop 2212 reach upper plate on there is no the position of hole, upper plate plate face effect under,
Backstop 2212 is set to become decline state from raised position), positive stop 2211 pushes sample rack 1000 against firmly baffle 2300;
Cutting agency 2500 is led for shifting the sample rack 1000 for being located at 2300 end of baffle onto blanking as in Figure 2-4
On rail 2102, so that sample rack 1000 be enable to be driven by blanking transmission belt 2104, pushing motor 2501 pushes guide rail 2503,
2501 drive rocker mechanism 2504 of pushing motor is to make push plate 2502 move reciprocatingly along promotion guide rail 2503,2502 energy of push plate
Enough across relief hole 2303 to push the sample rack 1000 for being located at 2300 side of baffle.
The transportational process of the present embodiment conveying device is as follows: sample rack 1000 is placed on to the feed position of loading guide 2101
It sets place (lower right side in figure), drives sample rack 1000 to reach at blocking mechanism 2200 when feeding transmission belt 2103 moves and (stop machine
Structure 2200 is located at position apart from 2300 distalmost end of baffle), firstly, sample rack 1000 can pass through and depress positive stop 2211, one
Denier sample rack 1000 crosses positive stop 2211,2211 protrusion of positive stop, and sample rack 1000 is fixed on positive stop 2211 with after
Between block 2212.Then, the sample rack 1000 at blocking mechanism 2200 will wait previous sample rack 1000 to be located at baffle
Whether the sample rack 1000 at 2300 is disposed, (be disposed by sensor once previous sample rack 1000 is disposed
Monitor, when sensor sensing no specimen frame 1000 at baffle 2300, just will start and stop driving part 2201), stop
Driving part 2201 will run that the connection sample rack 1000 of sliding block 2202 will be stopped to drive close baffle 2300 together,
Positive stop 2211 is depressed during this, and positive stop 2211 pushes sample rack 1000 against baffle 2300 is lived, and later, stops sliding block
2202 return to original position.Sample rack 1000 starts against baffle 2300, the pushing motor 2402 of pushing mechanism 2400 is lived, and pushes sample
It is moved along baffle 2300 for this 1000 and barcode scanning, sampling is carried out to sample tube each on sample rack 1000 one by one, after the completion sample
(also while being located at baffle 2300 end) is pushed at 2500 position of cutting agency for this 1000.Finally, cutting agency 2500
Pushing motor 2501 start, sample rack 1000 is shifted on blanking guide rail 2102, blanking transmission belt 2104 drive sample rack
1000 reach lower discharge position (upper right side in figure).Stop to supervise at driving part 2201 whether there is or not sample rack 1000 and by inductor
Survey, if stop driving part 2201 at no specimen frame 1000, can control feeding transmission belt 2103 by a sample rack 1000 from
Upper material position transport comes.
The sample conveying device of the present embodiment, sample rack 1000 is finally by blocking mechanism 2200, especially by positive stop
2211 and backstop 2212 is fixed transports at baffle 2300 (namely sample position), pass through baffle 2300 and backstop 2212
Fixed function, sample rack 1000 can be made to be kept fixed posture.There are feelings existing for sample rack 1000 at baffle 2300 simultaneously
Under condition, backstop 2212 can prevent next sample rack 1000 from entering at baffle 2300, guarantee that sampling is sequentially accurate and carry out.
-- automatic reason cup device 3, as shown in Fig. 3-1 and 3-2, for reaction cup to be transported to reaction cup with vertical state
Reaction cup discharge position can be picked up and be placed into reaction tray device 5 from reaction cup by discharge position, manipulator, including,
Bracket component 3200;
Discharging barrel 3100 is arranged on the bracket component 3200, and upper end has opening, horizontal from top to bottom along the vertical direction
Section is gradually reduced, and has partition among discharging barrel 3100, and discharging barrel 3100 is divided into two parts;
Cup assembly 3400 is pushed away, as shown in figure 3-2, has from 3100 bottom of discharging barrel and protrudes into pushing away in the discharging barrel 3100
Expect bar 3401, can move reciprocatingly under the driving of power device 3300, by reaction cup when charging ram 3401 moves reciprocatingly
It is pushed into the holding tank 35021 of transfer block 3502, the top of the charging ram 3401 is preferably V-shaped groove;
Vertical transport component 3500, with endless apron 3501 and the transfer block being arranged on the conveyer belt 3501
3502, the endless apron 3501 can be described under the driving of power device 3300 together with 3502 shuttling movement of transfer block
Transfer block 3502 has the holding tank 35021 of side opening, as shown in Figure 3-4, the central axes of the holding tank 35021 and horizontal plane
Angle be 65 ° -70 °, such as 65 °, 67 °, 70 ° (slot generally inclined), the bottom surface of the holding tank 35021 and side
Angle is 50 ° -60 °, such as 50 °, 55 °, 60 °, (also having angle between the bottom surface and side of holding tank 35021), circulation conveying
Side with 3501 has baffle (on the left of Fig. 3-4), prevents reaction cup 900 from skidding off from holding tank 35021;
Cup assembly 3600 out are arranged on the bracket component 3200, side plate 3601 including two sides and are located at side plate
Sole piece 3602 among 3601, it is described go out cup assembly 3600 on the cup out correspond into rim of a cup on the vertical transport component 3500
Place, is formed with out cup channel between side plate 3601 and sole piece 3602, the change in shape of the sole piece 3602 make to obtain glass channel from
It is followed successively by the first tilting section 36021, the second tilting section 36022, vertical section 36023 into rim of a cup to cup mouth, as in Figure 3-5,
The central axes of bottom surface of first tilting section and the angle of horizontal plane are 65 ° -70 ° such as 65 °, 67 °, 70 °, first inclination
The bottom surface of section 36021 and the angle of vertical side are 50 ° -60 ° such as 50 °, 55 °, 60 °, second tilting section 36022 with it is perpendicular
Straight side is vertical and is 70-80 ° with the angle of horizontal plane, such as 70 °, 75 °, 80 °, on the side plate 3601 of the vertical section two sides
Guide protrusions 36011 are formed, guide protrusions 36011 block the two sides of reaction cup 900, make reaction cup 900 in vertical mode
It falls;The top into rim of a cup on the cup assembly 3600 out is provided with into cup baffle 3603,3600 side of cup assembly out
It is additionally provided with the backward channel 3101 for returning to reaction cup 900 in discharging barrel 3100, reaction cup 900 is made by backward channel 3101
It can fall back in discharging barrel 3100, prevent reaction cup from falling in other regions;The bottom edge into cup baffle 3603 and described the
The bottom surface of one tilting section it is parallel, and the bottom edge into cup baffle 3603 at a distance from the bottom surface of first tilting section than anti-
Answer the big 4-5mm of the height of cup;The top surface into cup baffle 3603 is inclined-plane, and the bottom surface with first tilting section 36021
In parallel;The cup assembly 3600 out further includes the closed plate in the closing cup channel out, the bottom edge of the closed plate and the water
The distance between transmission surface (hereinafter transmission belt top surface) of flat conveying assembly 3700 is greater than 900 overhead height of reaction cup and is less than
900 total height of reaction cup is arranged this height, by stirring for closed plate bottom edge, can will upside down 900 quilt of reaction cup fallen
It stirs, overturns reaction cup 900, so that reaction cup 900 be enable to fall with correct posture.Closed plate is preferably transparent modeling
Flitch allows operator to check in time in the event of a failure in order to observe the state of reaction cup 900 in glass channel.
Horizontal feed component 3700, for accepting the reaction cup 900 dropped out from the cup mouth in cup channel out, horizontal feed group
Part 3700 drives and two parallel transmission belts of movement including horizontal feed motor 3702 with by horizontal feed motor 3702
3701, reaction cup 900 is transported to analyzer by going out behind cup channel to fall between two transmission belts 3701, and by transmission belt 3701
It is internal.
The full-automatic reason cup feed mechanism of above-described embodiment passes through to the transfer block 3502 and out synthesis in cup channel through testing
Consider and specially designed, using the matching relationship of angle, under the synergy of power device and gravity, is made mixed and disorderly anti-
Answer cup since discharging barrel 3100 finally from horizontal feed component 3700, so that when running continuously, just occurring within average 24 hours
As soon as secondary card cup situation, and automatically managing shown in Fig. 4-1 needs people to clear up a secondary card cup for cup feed mechanism average every 2 hours, it can
It is greatly improved by property.
-- emergency treatment device 4, as shown in Fig. 4-1 and 4-2, comprising: the sample room of analyzer front opening is installed vertically on sample
Support plate 412 on this room bottom plate 411 is arranged in the sliding rail 413 of 412 side of support plate, is slidably arranged on the sliding rail
Sample plane 414, one or more blind holes for accommodating sample tubes are provided in the sample plane 414, sample plane 414 is in outer masterpiece
When being slided with lower along sliding rail, blind hole can be made to be located at outside analyzer plus sample tube position and taking inside analyzer
Sample converts between position;
As shown in Fig. 4-1, the independent emergency treatment sampling hole corresponding to sample position is provided on the workbench at the top of analyzer
421;
Rotating arm driving motor can drive the rotation arm body to rotate the independence so that on sampling probe Alignment stage
Emergency treatment sampling hole 421.
As shown in the Fig. 4-2, rear and front end is separately installed with blocking sample plane 414 and skids off sliding rail on sample room's bottom plate
413 the first limited block 415 and the second limited block 416.
-- reaction tray device 5 reacts disc mechanism 5100, including cylinder 5110, the circle being rotatably arranged in cylinder 5110
Disk 5120, isometrical on disk 5120 to be placed with a circle reaction cup receiving hole 5121, reaction cup 900 can be placed in reaction cup receiving hole
In 5121, the distance of two neighboring reaction cup receiving hole 5121 is the half of 900 width of reaction cup to 2/3 on disk 5120;
Driving mechanism 5200, for driving disk 5120 to rotate;
The front end of manipulator crawl position is arranged in uniform shaking mechanism, identical as uniform shaking mechanism hereinafter;
Feed mechanism 5400 and cutting agency 5500 are located at 5110 side of cylinder, feed mechanism 5400 and cutting agency
5500 structure is identical, but is oppositely arranged, and includes rack 5420, and electromagnetic driver 5410 is hingedly arranged at rack 5420
On oscillating deck 5430, there are two parallel yokes 5431, oscillating deck 5430 also to make to put by spring for setting on oscillating deck 5430
Movable plate 5430 abuts against the telescopic rod of electromagnetic driver 5410 always, and after electromagnetic driver 5410 is powered, telescopic rod stretches out, and pushes
Oscillating deck 5430 is swung, and after electromagnetic driver 5410 powers off, telescopic rod is retracted;
Heating mechanism is located in cylinder 5110 and is located on 5,120 4 peripheral wall of disk, for heating reaction cup, preferably silicon
Glue heater.
-- cleaning device 6, including cleaning disc mechanism, imbibition mechanism for filling liquid and uniform shaking mechanism 63;
Cleaning disc mechanism includes:
Cylinder 61 has circular reaction cup run channel 611;
Disk 62 is rotatably arranged in cylinder 61, isometrical on disk 62 to be placed with a circle reaction cup receiving hole, reaction cup
900 can be placed in reaction cup receiving hole;
Several magnetic pole groups, setting, which is sequentially arranged in cylinder 61 along 900 traffic direction of reaction cup, (has 6 in such as Fig. 6-1
Magnetic pole group, two pole pairs are one group), each magnetic pole group is made of the pole pair for being located at several 611 two sides of reaction cup run channel,
Each magnetic pole group at least has there are two the pole pair for being located at 611 two sides of reaction cup run channel, each pole pair in each magnetic pole group
In magnet pole orientation it is identical, the pole orientation of two neighboring pole pair is opposite, and (such as pole pair pole orientation is followed successively by N-
S, N-S, S-N, S-N;N-S, N-S, S-N, S-N;N-S, N-S, S-N, S-N;N-S, N-S, S-N, S-N;N-S, N-S, S-N, S-
N;N-S, N-S, S-N, S-N), the pole pair of the last one magnetic pole group setting height gradually decreases, the latter pole pair with it is previous
A pole pair is compared to height decline 5-8mm;
Uniform shaking mechanism 63 is located between two magnetic pole groups as shown in Fig. 6-4, comprising: lifting actuator, lifter plate are fixed
Actuator 6310 is shaken up in 61 bottom of cylinder, by shaft coupling and the rocking bar 6311 that shakes up actuator 6310 and connect, setting exists
The eccentric cup 6330 at 6311 top of rocking bar, the elastic piece 6321 for extending into 62 top of disk being fixed on cylinder 61, elastic piece
It is provided on 6321 for covering the lid wheel 6322 at 900 top of reaction cup, 6322 bottoms of lid wheel, which have, can extend into reaction cup 900
In circle wheel, the central axes of eccentric cup 6330 are not conllinear with the central axes of rocking bar 6311, the central axes of eccentric cup 6330 and rocking bar
The distance of 6311 central axes is that the 1/4-1/5 of 900 width of reaction cup (is 1cm than 900 width of reaction cup, then distance is 2-
2.5mm, otherwise the liquid in reaction cup 900 can be overflowed because shaking amplitude is big), when being shaken up to reaction cup 900, lifting
Actuator drives lifter plate to rise, and shakes up actuator 6310, rocking bar 6311, eccentric cup 6330 and rises with lifter plate, eccentric cup
Reaction cup 900 is jacked up (so that reaction cup 900 is not limited by reaction cup receiving hole 6121) by 6330, the top of reaction cup 900
The lid wheel 6322 of elastic piece 6321 is resisted, reaction cup 900 is fixed, and is shaken up the starting of actuator 6310 later, is passed through eccentric cup
6330 shake reaction cup 900, shake up liquid in reaction cup 900, and 6322 bottoms of lid wheel have silastic-layer, when shaking up, remove
The last one shakes up shaking up actuator 6310 first and make reaction cup 900 to a direction with 40-50 rpms outside driving mechanism
Speed rotate 10-15s, backward other direction rotates 3-5s with 20-30 rpms of speed, makes it possible to when least
It is interior to obtain best cleaning effect, the last one shake up outside driving mechanism shake up actuator 6310 first and make reaction cup 900 to
One direction rotates 13-20s with 20-30 rpms of speed;
All magnets are neodymium ferro-boron magnet.
The eccentric cup 6330 of uniform shaking mechanism 63 before the last one magnetic pole group has magnetism, and magnetic pole is located at top and bottom ends.
It is last that the imbibition injection needle 64 of imbibition mechanism for filling liquid can extend into each magnetic pole group when needing imbibition and fluid injection
In reaction cup 900 on the corresponding position of one pole pair, after imbibition and fluid injection, then imbibition injection needle 64 is taken out, removed
Outside last root imbibition injection needle 64, remaining imbibition injection needle 64 all has the function of imbibition and fluid injection, last root imbibition
Injection needle 64 only has the function of imbibition.
The analyzer disc type cleaning device of the present embodiment, by the pole pair for being located at several 611 two sides of reaction cup run channel
Attract the magnetic bead in reaction cup 900, is located at magnetic bead on 900 front and rear wall of reaction cup, so that is made is inserted into reaction cup 900
The magnetic bead in reaction cup 900 is not will suck it away when imbibition 64 imbibition of injection needle.Meanwhile by the variation of the pole each pole pair N-S so that
Magnetic bead in the gap reaction cup 900 of imbibition moves, and further comes into full contact with magnetic bead with cleaning solution, washes off nonadherent
In the reagent of magnetic bead surfaces.
-- Sample Dilution device 7, comprising:
Mounting plate 74;
Purge chamber 71 is fixed on mounting plate 74, has the first cavity 711, has on the roof of first cavity 711
Dilution inlet offers cleaning solution liquid outlet on the bottom wall of first cavity 711;
Cleaning pipe 73 protrudes into the first cavity 711;
Cleaning pipe driving mechanism is arranged on mounting plate 74, drives cleaning pipe 73 along its axial-movement to adjust cleaning pipe
73 protrude into the amount of protruding into of the first cavity 711;
Rotating electric machine 75;
Diluted cup 72 is arranged in the first cavity 711, can rotate under the rotating electric machine 75 driving, and revolving
Diluted cup can be cleaned the alignment of pipe 73 when going to special angle;
It is extend into again after also there is the second cavity 712, the cleaning pipe 73 to pass through the second cavity 712 in the purge chamber 71
In first cavity 711, inlet and outlet are provided in the cavity wall of second cavity 712, are used for 73 side wall of cleaning pipe
Cleaning solution crystallization, prevent from moving up and down brought ring wear under cleaning pipe 73, and then avoid the generation of leakage;
The cleaning pipe 73 is respectively provided with sealing ring, anti-leak-stopping at the cavity wall for passing through the first cavity 711 and the second cavity 712
The generation at night.
As shown in Fig. 7-1, the diluted cup 72 is two be oppositely arranged, can be under the driving of rotating electric machine 75, with two
The upward mode of diluted cup alternate open rotates.This setting can two diluted cups rotate it is fixed after, dilution to opening upwards
Sample is added in cup and dilution is diluted, while the diluted cup that Open Side Down is cleaned, to currently dilute process
It finishes, carries out dilute next time before, by controlling rotating electric machine two diluted cup positions can be exchanged, it is available at this time to have cleaned
The diluted cup crossed continues to dilute work, and there are the diluted cups of raffinate after last time dilution, can clean to it.
It is provided with baffle among described two diluted cups 72, the cleaning solution that this setting can avoid in the cleaning process of lower section is splashed into
In the sample being currently diluted, test result is influenced.
The central axes of first cavity 711 and the second cavity 712 are conllinear and arrangement, the cleaning pipe 73 are also vertical vertically
Arrangement.As deformation, cleaning pipe 73 can also be extend into the first cavity 711 with other angle arrangements, such as side, at this time
The position of second cavity 712 follows the setting position of cleaning pipe 73 to do corresponding change, as long as cleaning pipe 73 can be in diluted cup
It is directed at diluted cup when rotating to special angle, the mode being vertically arranged is optimal selection.
The bottom wall of first cavity 711 is obliquely installed, and the liquid outlet is located at minimum point, is conducive to the row of cleaning solution
Out.
It is also provided with water inlet on the side chamber wall of first cavity 711, clear water is passed through by the water inlet, to clear
Wash the first cavity 711.
Cleaning pipe driving mechanism includes cleaning pipe driving motor 76, and the guide rail on mounting plate 74 is arranged in, clear for installing
It washes pipe 73 and the sliding block on guide rail is set, cleaning pipe driving motor 76 drives the sliding block to move on the guide rail, makes clear
The movement routine for washing pipe 73 is more stable reliable, to enter or exit purge chamber 71.
As shown in Fig. 7-1 and Fig. 7-2, the purge chamber 71, cleaning pipe 73 are mounted on 74 side of mounting plate, the rotation
Rotating motor 75, cleaning pipe driving motor 76 are mounted on 74 other side of mounting plate, damage rotation to prevent 71 leakage of purge chamber
Motor 75 and cleaning pipe driving motor 76, while the height of overall mechanism can be reduced.
In use, sample and dilution can be added into diluted cup 72 by the inlet at 711 top of the first cavity,
It is finished to currently dilute process, can be under the driving of rotating electric machine 75, Open Side Down for the diluted cup for making there are raffinate after dilution, so
Cleaning pipe is driven to be moved upward in diluted cup by cleaning pipe driving mechanism afterwards, cleaning solution is sprayed from cleaning pipe, to dilution
Room is cleaned, and cleaning finishes i.e. controllable cleaning pipe and moves down, and exits diluted cup.Purge chamber 71 of the invention includes first
Cavity 711 and the second cavity 712, first cavity 711 are mainly used for containing waste liquid caused by cleaning diluted cup, the first chamber
Body 711 is additionally provided with water inlet, can irregularly clean according to the actual situation to the first cavity 711, second cavity 712
Inlet and outlet are provided in cavity wall, the cleaning solution crystallization on 73 side wall of cleaning pipe prevents under cleaning pipe 73 up and down
Ring wear brought by mobile, and then avoid the generation of leakage.
-- shine measuring device 8, as shown in Fig. 8-1 and 8-2, comprising: measuring chamber 81, top opening, inside, which has, to be accommodated
The accommodating chamber of reaction cup, top are additionally provided with guide rail 812, and side has photon via hole, is equipped with switch cover actuator 814;
Top cover 82 is slidably arranged on the guide rail 812 at 81 top of measuring chamber, can be in the drive of switch cover actuator 814
It is moved under dynamic along guide rail 812, to change between the position that closed measurement chamber 81 is open and the position that opening measuring chamber 81 is open,
It is additionally provided with reagent on top cover 82, pipe 821 is added, when top cover 82 is in the position of the opening of closed measurement chamber 81, by adding to reagent
Entering the injection liquid of pipe 821 can flow into the reaction cup of accommodating chamber, convenient for the dropwise addition of various reactants, luminous agent, switch cover
The specific kind of drive that actuator 814 drives top cover 82 to move are as follows: the cunning parallel with guide rail 812 is provided at the top of measuring chamber 81
Rail 816 is provided with the sliding block 815 directly connecting with the drive rod of switch cover actuator 814, one end of top cover 82 on sliding rail 816
It is connect with sliding block 815, this layout type can make the top of top cover 82 without other components, enable manipulator, various liquid lines
Enough there are enough spaces to be arranged;
Photon counter 83 (photomultiplier tube) is arranged at 81 photon via hole of measuring chamber, tries for acquiring in reaction cup
Photon caused by agent is luminous;
Shutter structure, as shown in Fig. 8-3 or 8-4, be arranged between photon counter 83 and measuring chamber 81, can close or
Person opens photon via hole, including the rotary drive 841 being installed on mounting plate 840, the baffle 842 with through-hole 8421, and gear
Sliding slot 8411 is also formed on plate 842, is driven for rotation the driving of part 841 and is rotated, trundle 8422 is arranged in sliding slot 8411,
When trundle 8422 rotates, by the cooperation with sliding slot 8411, move horizontally baffle 842, to make logical on baffle 842
Hole 8421 is overlapped (baffle 842 does not block photon) or dislocation with photon via hole (baffle 842 blocks photon).
By the design of shutter structure, before opening top cover 82, baffle 842 is driven to move by rotary drive 841, from
And through-hole 8421 and photon via hole on baffle 842 is made to misplace, the camera lens of photon counter 83 can be sheltered from, exterior light is prevented
Line injects photon counter 83, guarantees the service life and precision of photon counter.After top cover 2 is closed, passing through rotation driving
Part 841 drives baffle 842 to move, to make the through-hole 8421 on baffle 842 be overlapped with photon via hole, in this way, photon counter
The luminous quantity of substance in reaction cup can be acquired.
As further improving, also settable sensor, for incuding whether photon via hole is blocked by baffle 842,
Position sensor is such as set whether to incude baffle 842 positioned at the position for blocking photon via hole, once baffle 842 is not located at and blocks
When the position of photon via hole, then switch cover actuator 814 is prevented to open measuring chamber 81, to prevent photon counter 83 external
Light is irradiated to and is damaged.Photoelectric sensor 8401 such as is installed in 840 side of mounting plate, the through-hole on baffle 842
8421 be pulled to photon via hole dislocation position when, then sense photoelectric sensor 8401, at this point, switch cover actuator
814 can just activate to open top cover 82.
In order to facilitate manipulator to the hands free operation of reaction cup, enable reaction cup automatically into measuring chamber, this implementation
Example further includes stripper, and stripper includes a pair of of the yoke 822 arranged in parallel being arranged on 82 side of top cover, top cover 82
When in the position for opening the opening of measuring chamber 81, yoke 822 is located above accommodating chamber.This is designed as the machinery for adapting to specific structure
Hand and do, this specific structure manipulator has a discharging blocking arm, and discharging blocking arm overlaps yoke 822, and manipulator continues decentralization
So that mechanical finger abandons reaction cup.Position sensor 85 (photoelectric sensor transmitting terminal) is arranged in 81 top of measuring chamber, top cover
82 are equipped with baffle corresponding with transmitting terminal.When top cover 82, which is closed, to be completed, transmitting terminal can sense baffle, so as to control
System part sends the signal that top cover 82 is turned off, thus the operation of shutdown switch lid actuator 814, or continue other related dynamic
Make.
-- material collecting barrel 9 is set to analyzer bottom, for storing used reaction cup.
The chemical illumination immunity analysis instrument of the present embodiment, comprising: agent formulation device, sample conveying device manage cup automatically
Device, emergency treatment device, reaction tray device, cleaning device, Sample Dilution device, shine measuring device, and material collecting barrel and takes manipulator
Sample needle is moved between each device by manipulator and sampling probe, is transmitted reaction cup and liquid, is realized entire immunoassay mistake
The automatic operation of journey improves full-automatic degree.
Taking the above-mentioned ideal embodiment according to the present invention as inspiration, through the above description, relevant staff is complete
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention
Property range is not limited to the contents of the specification, it is necessary to which the technical scope thereof is determined according to the scope of the claim.
Claims (6)
1. a kind of chemical illumination immunity analysis instrument characterized by comprising agent formulation device (1), sample conveying device (2),
Automatic reason cup device (3), emergency treatment device (4), reaction tray device (5), cleaning device (6), Sample Dilution device (7) shine and survey
It measures device (8), material collecting barrel (9), manipulator and sampling probe;
Sampling probe draw and conveying liquid can sample conveying device (2), emergency treatment device (4) and Sample Dilution device (7) it
Between swing;
Manipulator can grasp and convey reaction cup, and reaction cup is made to move to reaction tray device (5) from automatic reason cup device (3),
Cleaning device (6) are moved to from reaction tray device (5), luminous measuring device (8) are moved to from cleaning device (6), from luminous survey
Amount device (8) moves to material collecting barrel (9);
Agent formulation device (1), for providing water purification and configuring cleaning solution supplying cleaning device (6) and Sample Dilution device (7);
Sample conveying device (2), for sample to be tested to be transported to sample position, sampling probe can be by sample after reaching sample position
In this absorption and the reaction cup being filled into reaction tray device (5);
Automatic reason cup device (3), for reaction cup to be transported to discharge position in reaction cup with vertical state, manipulator can be from anti-
Discharge position on cup is answered to pick up reaction cup and be placed into reaction tray device (5);
Material collecting barrel (9), is set to analyzer bottom, for storing used reaction cup;
Sample conveying device (2) includes:
Conveying mechanism (2100), the bottom plate including being divided into upper plate and lower plate, be mounted on two on upper plate it is parallel upper
Expect guide rail (2101) and blanking guide rail (2102), the two parallel feeding transmission belts (2103) and blanking for being exposed to upper plate pass
Defeated band (2104), is equipped with driving wheel between upper plate and lower plate, feeding transmission belt (2103) and blanking transmission belt (2104) are each
It is arranged on a pair of of driving wheel, feeding transmission belt (2103) and blanking transmission belt (2104) are driven by power device and drive sample rack
(1000) it is moved respectively along loading guide (2101) and blanking guide rail (2102);
Baffle (2300) is located at the bottom plate one end of conveying mechanism (2100), has recessing groove (2301), barcode scanning slot (2302), allows
Position hole (2303), barcode scanning slot (2302) is to allow barcode scanning light to pass through;
Pushing mechanism (2400) moves sample rack (1000) along baffle (2300), packet for pushing sample rack (1000)
Include: the first pushing motor (2402), the first pushing motor (2402) drive pushing plate (2401) to move along baffle (2300), thus
It pushes sample rack (1000);
Blocking mechanism (2200), setting is in loading guide (2101) end, including stops driving part (2201), is arranged at upper bottom
The blocking guide rail (2203) in board bottom portion, what is be arranged on guide rail (2203) is blocked driving part (2201) driving and leads along blocking
Rail (2203) moves and blocking sliding block (2202) close or far from baffle (2300), stops before being provided on sliding block (2202)
Block (2211) and backstop (2212), can accommodate a sample rack between positive stop (2211) and backstop (2212)
(1000), positive stop (2211) and backstop (2212) all have the raised position for protruding from upper plate and non-bulging in upper plate
Decline state, one side of the positive stop (2211) far from baffle (2300) is inclined-plane, and backstop (2212) is close to baffle (2300)
One side be inclined-plane so that sample rack (1000) pass through positive stop (2211) when, positive stop (2211) can be depressed, it is preceding
When block (2211) and backstop (2212) and blocking sliding block (2202) move together, backstop (2212) is depressed by upper plate,
Positive stop (2211) pushes sample rack (1000) against firmly baffle (2300);
Cutting agency (2500), including pushing motor (2501) and promotion guide rail (2503), for baffle (2300) end will to be located at
The sample rack (1000) at end is shifted on blanking guide rail (2102), to make sample rack (1000) can be by blanking transmission belt (2104)
It drives, pushing motor (2501) drive rocker mechanism (2504) is to make push plate (2502) to do reciprocal fortune along promotion guide rail (2503)
Dynamic, push plate (2502) can pass through relief hole (2303) to push the sample rack (1000) for being located at baffle (2300) side;
Automatically managing cup device (3) includes,
Bracket component (3200);
Discharging barrel (3100) is arranged on bracket component (3200), and upper end has opening, along the vertical direction cross section from top to bottom
It is gradually reduced, has partition among discharging barrel (3100), discharging barrel (3100) is divided into two parts;
Cup assembly (3400) are pushed away, has from discharging barrel (3100) bottom and protrudes into the charging ram (3401) in discharging barrel (3100), energy
It is enough to move reciprocatingly under the driving of power device (3300), reaction cup (900) is pushed away when charging ram (3401) moves reciprocatingly
To the holding tank (35021) of transfer block (3502), the top of charging ram (3401) is V-shaped groove;
Vertical transport component (3500), with endless apron (3501) and the transfer block being arranged on conveyer belt (3501)
(3502), endless apron (3501) can under the driving of power device (3300) together with transfer block (3502) shuttling movement,
Transfer block (3502) has the holding tank (35021) of side opening, and the central axes of holding tank (35021) and the angle of horizontal plane are
65 ° -70 °, the bottom surface of holding tank (35021) and the angle of side are 55 ° -60 °;
Cup assembly (3600) out are arranged on bracket component (3200), side plate (3601) including two sides and are located at side plate
(3601) intermediate sole piece (3602), corresponding on cup assembly (3600) into rim of a cup goes out cup on vertical transport component (3500) out
Place, is formed with out cup channel, the change in shape of sole piece (3602) makes to obtain a glass channel between side plate (3601) and sole piece (3602)
The first tilting section (36021), the second tilting section (36022), vertical section (36023) are followed successively by from into rim of a cup to cup mouth, first
The central axes of the bottom surface of tilting section and the angle of horizontal plane are 65 ° -70 °, the bottom surface of the first tilting section (36021) and vertical side
The angle in face is 50 ° -60 °, and vertical with the vertical side and angle with horizontal plane of the second tilting section (36022) is 70-80 °,
It is formed guide protrusions (36011) on the side plate (3601) of vertical section two sides, guide protrusions (6011) block reaction cup (900)
Two sides;The top into rim of a cup on cup assembly (3600) is provided with into cup baffle (3603) out, and cup assembly (3600) side is also out
It is provided with the backward channel (3101) for returning to reaction cup (900) in discharging barrel (3100);Into cup baffle (3603) bottom edge with
The bottom surface of first tilting section it is parallel, and into the bottom edge of cup baffle at a distance from the bottom surface of the first tilting section than the height of reaction cup
Big 4-5mm;It is inclined-plane into the top surface of cup baffle (3603), and parallel with the bottom surface of the first tilting section (36021);Cup assembly out
It (3600) further include the closed plate for closing out cup channel, the bottom edge of closed plate and the distance between the transmission surface of horizontal feed component
Greater than reaction cup (900) overhead height and it is less than reaction cup (900) total height.
2. chemical illumination immunity analysis instrument according to claim 1, which is characterized in that emergency treatment device (4), comprising: analysis
The sample room of instrument front opening, the support plate (412) being installed vertically on sample room's bottom plate (411) are arranged in support plate (412)
The sliding rail (413) of side, the sample plane (414) being slidably arranged on sliding rail, sample plane are provided with one or more on (414)
Accommodating the blind hole of sample tube can be such that blind hole is located at outside analyzer when sample plane (414) is slided along sliding rail under external force
Portion plus sample tube position and sample position inside analyzer between convert;
The independent emergency treatment sampling hole (421) corresponding to sample position is provided on workbench at the top of analyzer;
Rotating arm driving motor can drive rotation arm body rotation so that the independent emergency treatment on sampling probe Alignment stage samples
Hole (421);
Rear and front end is separately installed with the first limited block for stopping sample plane (414) to skid off sliding rail (413) on sample room's bottom plate
(415) and the second limited block (416).
3. chemical illumination immunity analysis instrument according to claim 1, which is characterized in that reaction tray device (5) includes reacting
Disc mechanism (5100), including cylinder (5110), the disk (5120) being rotatably arranged in cylinder (5110), on disk (5120)
Isometrical to be placed with a circle reaction cup receiving hole (5121), reaction cup (900) can be placed in reaction cup receiving hole (5121), disk
(5120) distance of two neighboring reaction cup receiving hole (5121) is the half of reaction cup (900) width to 2/3 on;
Driving mechanism (5200), for driving disk (5120) to rotate;
Uniform shaking mechanism is arranged in the front end of manipulator crawl position, is located between two magnetic pole groups, comprising: lifting actuator, lifting
Plate, be fixed on cylinder (6110) bottom shakes up actuator (6310), by shaft coupling with shake up what actuator (6310) was connect
Rocking bar (6311), the eccentric cup (6330) being arranged at the top of rocking bar (6311), is fixed on cylinder (6110) and extend into disk
(6120) elastic piece (6321) at the top of is provided with for covering the lid wheel at the top of reaction cup (900) on elastic piece (6321)
(6322), lid wheel (6322) bottom have can extend into reaction cup (900) circle wheel, the central axes of eccentric cup (6330) with shake
The central axes of bar (6311) are not conllinear, and the central axes of eccentric cup (6330) are reaction cup at a distance from the central axes of rocking bar (6311)
(900) 1/4-1/5 of width, when shaking up to reaction cup (900), lifting actuator driving lifter plate is risen, and shakes up driving
Part (6310), rocking bar (6311), eccentric cup (6330) are risen with lifter plate, and eccentric cup (6330) jacks up reaction cup (900), instead
The lid wheel (6322) that elastic piece (6321) is resisted at the top of cup (900) is answered, reaction cup (900) is fixed again, shakes up driving later
Part (6310) starting shakes reaction cup (900) by eccentric cup (6330), shakes up reaction cup (900) interior liquid;
Feed mechanism (5400) and cutting agency (5500) are located at cylinder (5110) side, feed mechanism (5400) and blanking machine
The structure of structure (5500) is identical, but is oppositely arranged, and includes rack (5420), and electromagnetic driver (5410) is hingedly arranged at
Oscillating deck (5430) in rack (5420), there are two parallel yoke (5431), oscillating decks for setting on oscillating deck (5430)
(5430) also oscillating deck (5430) is made to abut against the telescopic rods of electromagnetic driver (5410), electromagnetic driver always by spring
(5410) after by electricity, telescopic rod stretches out, and oscillating deck (5430) is pushed to swing, after electromagnetic driver (5410) power-off, telescopic rod contracting
It returns;
Heating mechanism is located in cylinder (5110) and is located on (5120) four peripheral wall of disk, for heating reaction cup.
4. chemical illumination immunity analysis instrument according to claim 1, which is characterized in that cleaning device (6), clear dishwashers
Structure, imbibition mechanism for filling liquid and uniform shaking mechanism (63);
Cleaning disc mechanism includes:
Cylinder (61) has circular reaction cup run channel (611);
Disk (62) is rotatably arranged in cylinder (61), isometrical on disk (62) to be placed with a circle reaction cup receiving hole, instead
Answer cup (900) that can be placed in reaction cup receiving hole;
Several magnetic pole groups, setting are sequentially arranged in cylinder (61) along reaction cup (900) traffic direction, and each magnetic pole group has position
Pole pair in several reaction cup run channel (11) two sides is constituted, and each magnetic pole group at least have that there are two positioned at reaction cup run channel
(611) pole orientation of the pole pair of two sides, the magnet in each magnetic pole group in each pole pair is identical, two neighboring pole pair
Pole orientation on the contrary, the pole pair setting height of the last one magnetic pole group gradually decreases, the latter pole pair and previous magnetic
Extremely to compared to height decline 5-8mm;
Uniform shaking mechanism (63) is located between two magnetic pole groups, comprising: lifting actuator, lifter plate are fixed on cylinder (6110) bottom
Portion shakes up actuator (6310), by shaft coupling and the rocking bar (6311) for shaking up actuator (6310) and connecting, is arranged in rocking bar
(6311) the eccentric cup (6330) at the top of, the elastic piece extending at the top of disk (6120) being fixed on cylinder (6110)
(6321), it is provided on elastic piece (6321) for covering the lid wheel (6322) at the top of reaction cup (900), lid wheel (6322) bottom
With the circle wheel that can extend into reaction cup (900), the central axes of eccentric cup (6330) and the central axes of rocking bar (6311) are not total
Line, the central axes of eccentric cup (6330) are the 1/4-1/5 of reaction cup (900) width at a distance from the central axes of rocking bar (6311),
When being shaken up to reaction cup (900), lifting actuator driving lifter plate rise, shake up actuator (6310), rocking bar (6311),
Eccentric cup (6330) is risen with lifter plate, and eccentric cup (6330) jacks up reaction cup (900), and reaction cup resists at the top of (900)
The lid wheel (6322) of elastic piece (6321), reaction cup (900) are fixed again, actuator (6310) starting are shaken up later, by inclined
Heart cup (6330) shakes reaction cup (900), shakes up reaction cup (900) interior liquid;
The imbibition injection needle (64) of imbibition mechanism for filling liquid can be extend into when needing imbibition and fluid injection each magnetic pole group last
In reaction cup (900) on the corresponding position of a pole pair, after imbibition and fluid injection, then imbibition injection needle (64) are taken out,
In addition to last root imbibition injection needle (64), remaining imbibition injection needle (64) all has the function of imbibition and fluid injection, last
Root imbibition injection needle (64) only has the function of imbibition.
5. chemical illumination immunity analysis instrument according to claim 1, which is characterized in that Sample Dilution device (7), comprising:
Mounting plate (74);
Purge chamber (71) is fixed on mounting plate (74), is had the first cavity (711), is had on the roof of the first cavity (711)
Dilution inlet offers cleaning solution liquid outlet on the bottom wall of the first cavity (711);
Cleaning pipe (73) protrudes into the first cavity (711);
Cleaning pipe driving mechanism is arranged on mounting plate (74), drives cleaning pipe (73) along its axial-movement to adjust cleaning pipe
(73) amount of protruding into of the first cavity (711) is protruded into;
Rotating electric machine (75);
Diluted cup (72), setting can rotate in the first cavity (711) in the case where rotating electric machine (75) drive, and rotate
Diluted cup can be cleaned pipe (73) and be aligned when to special angle;
Also there are the second cavity (712) in purge chamber (1), cleaning pipe (73) extend into first after passing through the second cavity (712) again
In cavity (711), inlet and outlet are provided in the cavity wall of the second cavity (712);
Cleaning pipe (73) is respectively provided with sealing ring at the cavity wall for passing through the first cavity (711) and the second cavity (712).
6. chemical illumination immunity analysis instrument according to claim 1, which is characterized in that luminous measuring device (8) packet
Include: measuring chamber (81), top opening, inside have the accommodating chamber for accommodating reaction cup, and top is additionally provided with guide rail (812), side
With photon via hole, switch cover actuator (814) are installed;
Top cover (82) is slidably arranged on the guide rail (812) at the top of measuring chamber (81), can be in switch cover actuator (814)
Driving under along guide rail (812) move, with the position that closed measurement chamber (81) be open and open measuring chamber (81) be open position
Change between setting, reagent is additionally provided on top cover (82), pipe (821) is added, top cover (82) is in closed measurement chamber (81) opening
When position, it can be flowed into the reaction cup of accommodating chamber by the way that pipe (821) injection liquid is added to reagent;
Photon counter (83) is arranged at measuring chamber (81) photon via hole, luminous produced for acquiring reagent in reaction cup
Photon;
Shutter structure is arranged between photon counter (83) and measuring chamber (81), can be closed or opened photon via hole, wraps
The rotary drive (841) being installed on mounting plate (840) is included, the baffle (842) with through-hole (8421), on baffle (842)
It also forms sliding slot (8411), rotary drive (841) drives and rotates trundle (8422) setting in sliding slot (8411), passes
When dynamic pin (8422) rotation, by the cooperation with sliding slot (8411), move horizontally baffle (842), to make baffle (842)
On through-hole (8421) be overlapped or misplace with photon via hole.
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CN201710507018.4A CN107356773B (en) | 2017-06-28 | 2017-06-28 | A kind of chemical illumination immunity analysis instrument |
PCT/CN2017/106254 WO2019000707A1 (en) | 2017-06-28 | 2017-10-16 | Chemiluminescence immunoassay analyser |
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CN201710507018.4A CN107356773B (en) | 2017-06-28 | 2017-06-28 | A kind of chemical illumination immunity analysis instrument |
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CN107356773B true CN107356773B (en) | 2019-07-30 |
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