CN210401445U

CN210401445U - Sample analyzer

Info

Publication number: CN210401445U
Application number: CN201920922003.9U
Authority: CN
Inventors: 胡力坚
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2019-06-18
Filing date: 2019-06-18
Publication date: 2020-04-24
Anticipated expiration: 2029-06-18

Abstract

The utility model provides a sample analyzer, include: a sample rack comprising a plurality of sample container securing apertures for receiving sample containers loadable with a sample; a carrying device configured to be movable in a vertical direction; a sampling device having a sampling needle configured to be movably inserted into a sample container in a sampling position on the sample rack in the vertical direction so as to suck a sample in the sample container; a detection device configured to detect a sample drawn by the sampling device; a sample transport device configured to transport the sample rack so that the sample containers on the sample rack can pass through the blending position and the sampling position in sequence; wherein, handling device and sampling device are adjacent and the interval sets up for sampling device does not interfere handling device along vertical direction's motion. Through the utility model discloses can realize improving sample analyzer's detection speed.

Description

Sample analyzer

Technical Field

The utility model relates to a sample analysis field particularly relates to a sample analyzer.

Background

Among the sample analysis appearance that possesses autoinjection function at present, including handling device and sampling device, be used for carrying and sampling the sample to the sample container respectively, because handling device and the adjacent setting of sampling device to handling device and sampling device have overlap region in the space, especially on vertical direction, lead to sampling device and handling device can't independently function, must some serial action, have restricted the measuring speed of analysis appearance.

There is therefore a need for improvements to current sample analyzers to address this problem.

SUMMERY OF THE UTILITY MODEL

The utility model provides a sample analyzer, sample analyzer includes:

a sample rack comprising a plurality of sample container securing apertures for receiving sample containers loadable with a sample;

a handling device configured to be movable in a vertical direction to handle a sample container in a blending position on the sample rack out of its sample container holding aperture for blending and back into its sample container holding aperture after blending;

a sampling device having a sampling needle configured to be movable in the vertical direction into a sample container in a sampling position on the sample rack to aspirate a sample in the sample container;

a detection device configured to detect a sample aspirated by the sampling device;

a sample transport device configured to transport the sample rack so that sample containers on the sample rack can pass through the blending location and the sampling location in sequence;

wherein the handling device and the sampling device are arranged adjacently and at intervals so that the sampling device does not interfere with the movement of the handling device in the vertical direction.

Optionally, the handling device and the sampling needle are configured to be horizontally movable back and forth along a first direction perpendicular to the vertical direction, and the handling device and the sampling needle are arranged adjacently and at a distance such that the handling device and the sampling needle can be horizontally moved back and forth along the first direction without interfering with each other.

Optionally, the handling device and the sampling device are spaced apart in a second direction perpendicular to the vertical direction and the first direction.

Optionally, the sampling device is arranged corresponding to the sampling position, and the carrying device is arranged corresponding to the blending position.

Optionally, the blending position and the sampling position are adjacently arranged, so that the carrying device and the sampling device can simultaneously and respectively carry and sample adjacent sample containers on the sample rack at the blending position and the sampling position;

or the distance of at least one sample container fixing hole is arranged between the blending position and the sampling position, so that the carrying device and the sampling device can carry and sample the sample containers on the sample rack, which are positioned at the blending position and the sampling position and are spaced by the at least one sample container fixing hole, respectively.

Optionally, the sampling device comprises: the sampling device comprises a horizontal bracket and a vertical bracket, wherein the horizontal bracket is arranged along the first direction, the vertical bracket is movably arranged on one side of the horizontal bracket close to the carrying device along the first direction, the sampling needle is arranged on the vertical bracket, so that the vertical bracket can drive the sampling needle to move along the first direction, and the vertical bracket is constructed in a way that the vertical bracket does not interfere with the movement of the carrying device along the vertical direction.

Optionally, the sampling device further comprises:

the horizontal guide rods extend along the first direction and are fixed at two ends of the horizontal support, and the vertical support can be movably sleeved on the horizontal guide rods along the first direction;

the first driving assembly is fixed on one side of the horizontal bracket, which is far away from the vertical bracket, and is used for driving the vertical bracket and the sampling needle arranged on the vertical bracket to move along a horizontal guide rod;

the vertical guide rail extends along the vertical direction and is fixedly arranged on the vertical bracket, and the sampling needle is arranged on the vertical guide rail;

and the second driving assembly is fixed on the vertical bracket and is used for driving the sampling needle to move along the vertical guide rail.

Optionally, the second drive assembly is disposed above the vertical support and adjacent to the horizontal support such that it does not interfere with movement of the handling device in a vertical direction.

Optionally, the sampling device further comprises:

a sampling needle connection line connected to the sampling needle for providing pressure to the sampling needle and/or for transporting a sample drawn by the sampling needle;

the sampling needle connecting pipeline fixing part is fixedly arranged on the vertical bracket and is used for fixing the sampling needle connecting pipeline;

wherein the sampling needle connection pipe and the sampling needle connection pipe fixing member are arranged so as not to interfere with the movement of the carrying device in the vertical direction.

Optionally, the sampling device further comprises a receiving portion for receiving the sampling needle connecting line and a cable for receiving the sampling device, the receiving portion being fixedly connected to the vertical support and disposed below the horizontal support so as not to interfere with the movement of the carrying device in the vertical direction.

Alternatively, the housing portion is configured as a tank chain having one end fixed and the other end movable in the first direction along with the vertical stand.

Optionally, the carrying device comprises a gripping mechanism and a first driving mechanism, the gripping mechanism is used for gripping the sample container, and the first driving mechanism is used for driving the gripping mechanism to move along the vertical direction.

Optionally, the carrying device further comprises a second driving mechanism for driving the gripping mechanism to move along the first direction; and/or the carrying device further comprises a third driving mechanism for driving the clamping mechanism to rotate so as to uniformly mix the samples in the sample containers clamped by the clamping mechanism.

Optionally, the sample analyzer includes a blending device, and the carrying device can carry the sample container located at the blending position on the sample rack out of the sample container fixing hole of the sample container to be placed in the blending device, so that the blending device can blend the sample in the sample container.

Optionally, the detection apparatus comprises a cell sorter counting module for sorting and counting particles in the sample aspirated by the sampling apparatus and a CRP detection module for detecting a CRP concentration of the sample aspirated by the sampling apparatus.

Optionally, the CRP detection module comprises:

a reaction cell provided with a reaction site for supplying a sample and a reagent;

a photometer arranged to illuminate the analyte in the sample with light in order to obtain the absorbance of the analyte over different time periods.

According to the utility model discloses an in the sample analysis appearance, handling device is constructed to follow vertical direction motion, sampling device has the sampling needle, the sampling needle is constructed to follow vertical direction motion stretches into in the sample container that is in the sampling position on the sample frame, and handling device with the adjacent and interval setting of sampling device makes sampling device does not interfere handling device follows vertical direction's motion, through the improvement can improve sample analysis appearance's detection speed.

Drawings

The following drawings of the present invention are used herein as part of the present invention for understanding the present invention. There are shown in the drawings, embodiments and descriptions of the invention, which are used to explain the principles of the invention.

In the drawings:

FIG. 1 shows a schematic diagram of a sample analyzer with autosampling function;

FIG. 2 shows a schematic perspective view of the sample analyzer of FIG. 1;

FIG. 3 shows a schematic perspective view of a sample rack;

fig. 4 to 6 are schematic structural views of a handling device in a sample analyzer at different viewing angles;

FIGS. 7 and 8 are schematic perspective views of a sampling device in a sample analyzer;

FIG. 9 is a schematic diagram showing the relative position of a handling device and a sampling device in a sample analyzer;

FIG. 10 shows a top view of a handling device in relation to a sampling device in a sample analyzer;

FIG. 11 illustrates a front view of a handling device in relation to a sampling device in a sample analyzer;

FIG. 12 is a schematic diagram showing the positional relationship between the location of the kneading and sampling positions in a sample analyzer;

FIG. 13 is a schematic diagram showing the time required for homogenization and sampling in the sample analyzer of FIG. 12;

fig. 14 is a schematic diagram showing a positional relationship between a kneading position and a sampling position in a sample analyzer according to an example of the present invention;

fig. 15 and 16 are schematic perspective views of a sampling device in a sample analyzer according to an example of the present invention;

fig. 17 is a plan view showing a relative positional relationship between a carrying device and a sampling device in a sample analyzer according to an example of the present invention;

fig. 18 is a front view showing a relative positional relationship between a carrying device and a sampling device in a sample analyzer according to an example of the present invention.

Detailed Description

In order to provide a thorough understanding of the present invention, detailed steps and structures will be provided in the following description in order to explain the technical solution provided by the present invention. The preferred embodiments of the present invention are described in detail below, however, other embodiments of the present invention are possible in addition to these detailed descriptions.

Fig. 1 is a sample analyzer with an autosampling function, and the sample analyzer 1 includes a sampling device 12 for pipetting a sample at a sampling position and a carrying device 11 for gripping and carrying a sample container at a kneading position before pipetting the sample to knead the sample, as shown in fig. 2.

The conveying device 11 is disposed corresponding to the mixing position of the sample analyzer 1, and the sampling device 12 is disposed corresponding to the sampling position of the sample analyzer 1.

A sample rack of the type to which the sample analyzer 1 is applied is shown in fig. 3, and the sample rack 80 is provided with a plurality of sample container holding holes 801 for holding sample containers 90. The handling device 11 of the sample analyzer 1 grips the sample container 90 from the sample container holding hole 801 of the sample rack 80 that is routed to the mixing position of the sample analyzer 1, so as to mix the sample in the sample container 90. The sampling device 12 of the sample analyzer 1 aspirates a sample from the sample container 90 held in the sample container holding hole 801 of the sample rack 80 by the sampling position of the sample analyzer 1.

The positional relationship between the sampling position and the mixing position of the sample analyzer 1 corresponds to the positional relationship between the sample container fixing holes 801 of the sample rack 80. Such as sample

container holding holes

801a and 801b of the sample rack 80 being adjacent, sample

container holding holes

801a and 801c being separated by 1 (i.e., separated by 1 sample container holding hole 801b), sample

container holding holes

801a and 801d being separated by 2 (i.e., separated by 2 sample

container holding holes

801b and 801c), and so on. Accordingly, when the sample container fixing hole 801a of the sample rack 80 moves to correspond to the sampling position of the sample analyzer 1, the sample container fixing hole 801b of the sample rack 80 at this time just corresponds to the kneading position of the sample analyzer 1, and is defined as the sampling position being adjacent to the kneading position; when the sample container fixing hole 801a of the sample rack 80 moves to correspond to the sampling position of the sample analyzer 1, the sample container fixing hole 801c of the sample rack 80 corresponds to the blending position of the sample analyzer 1, and the interval between the sampling position and the blending position is defined as 1 bit; when the sample container fixing hole 801a of the sample rack 80 moves to correspond to the sampling position of the sample analyzer 1, the sample container fixing hole 801d of the sample rack 80 corresponds to the blending position of the sample analyzer 1, and the interval between the sampling position and the blending position is defined as 2 bits; and so on.

The adjacent and spaced sampling positions to the kneading position are explained and illustrated with reference to the above unless otherwise specified.

As shown in fig. 4 to 6, the handling device 11 of the sample analyzer 1 shown in fig. 1 and 2 may include: the device comprises a clamping jaw 1101, a first support 1111, a second support 1112, a third support 1113, motors 1121-1123, vertical guide rails 1131-1132, annular synchronous toothed belts 1141-1143 wound on a synchronous wheel and a rotating shaft 1151. The motors 1121-1123 are preferably stepping motors.

The first support 1111 is used to fix the motor 1121 and the vertical guide 1131, and the first support 1111 is fixed to a front plate (not shown) of the sample analyzer 1 by screws. The vertical guide 1131 is disposed along the Z1 and Z2 directions, and the second support 1112 is connected to the slider of the vertical guide 1131 to be slidable along the Z1 or Z2 direction. The second support frame 1112 is used for fixing the motor 1122 and a vertical guide 1132, the vertical guide 1132 is arranged along the directions of Y1 and Y2, and the third support frame 1113 is connected with a slider of the vertical guide 1132 so as to be capable of sliding along the directions of Y1 or Y2. The third support 1113 is used for fixing the motor 1123, and the rotating shaft 1151 is fixed on the third support 1113 in a rotating connection manner, and the rotating shaft 1151 can rotate along the direction of R1 or R2. The clamping jaws 1101 are fixedly connected to the rotation shaft 1151 and can rotate along the rotation shaft 1151 in the direction of R1 or R2, in which case the clamping jaws 1101 of the handling device 11 can rotate under the driving of the fixing motor 1123 after gripping the sample container, so as to mix the sample in the sample container, especially the venous blood sample. Wherein, the Z1-Z2 direction is a vertical direction perpendicular to a horizontal plane, and the Y1-Y2 direction is a horizontal direction perpendicular to the vertical direction.

The annular timing cog belt 1141 is driven by the rotation of the motor 1121 to rotate under the guidance of two timing wheels. The second supporting frame 1112 is connected to the annular synchronous toothed belt 1141, and the second supporting frame 1112 can drive the clamping jaw 1101 to move along the direction Z1 or Z2 under the driving of the motor 1121.

The ring-shaped timing belt 1142 is driven by the rotation of the motor 1122 to rotate under the guidance of two timing wheels. The third support 1113 is connected to the endless timing belt 1142, and the third support 1113 can drive the clamping jaw 1101 to move along the direction Y1 or Y2 under the driving of the motor 1122.

The annular synchronous toothed belt 1143 is driven by the rotation of the motor 1123 to rotate under the guidance of two synchronous wheels. The rotating shaft 1151 drives the clamping jaw 1101 to rotate along the direction of R1 or R2 under the driving of the motor 1123.

As shown in fig. 7 and 8, the sampling device 12 of the sample analyzer 1 shown in fig. 1 and 2 may include: a horizontal bracket 1201,

motors

1202 and 1222, synchronizing

wheels

1203 and 1204, a ring-shaped synchronizing toothed belt 1205 wound on the synchronizing

wheels

1203 and 1204, and a horizontal guide rod 1206 arranged along the directions of Y1 and Y2; the device comprises a vertical support 1221, vertical guide rods 1223 arranged along the directions Z1 and Z2, a lead screw 1224 arranged in parallel with the vertical guide rods 1223, a nut 1225 sleeved on the lead screw 1224, a sampling needle fixing component 1226, a sampling needle 1227, a sampling needle cleaning swab 1228, a sampling needle connecting pipeline 1229, a sampling needle connecting pipeline fixing part 1330 and a tank chain 1231. With

motors

1202 and 1222 preferably being stepper motors.

The horizontal bracket 1201 is used to fix the motor 1202 and the horizontal guide 1206. The vertical bracket 1221 is used to fix the motor 1222 and the vertical guide rod 1223. The vertical bracket 1221 is sleeved on the horizontal guide rod 1206 and is connected with the annular synchronous toothed belt 1205 through a connecting piece. The endless timing belt 1205 is rotationally driven by a motor 1202, and is guided by two timing

wheels

1203 and 1204. The vertical support 1221 can be moved in the Y1 or Y2 direction by the motor 1202.

The sampling needle 1227 is fixed on the sampling needle fixing part 1226, the sampling needle fixing part 1226 is sleeved on the vertical guide rod 1223 and the lead screw 1224, the nut 1225 is clamped in a clamping groove formed in the sampling needle fixing part 1226, and relative rotation is not generated between the nut 1225 and the sampling needle fixing part 1226. The lead screw 1224 is connected to the motor 1222 via a screw, and the motor 1222 can rotate the lead screw 1224 and drive the sampling needle fixing member 1226 to carry the sampling needle 1227 to move in the Z1 or Z2 direction.

The sampling needle cleaning swab 1228 is clamped on the vertical support 1221, and the sampling needle 1227 passes through a through hole in the middle of the sampling needle cleaning swab 1228. When the motor 1222 drives the sampling needle fixing member 1226 to carry the sampling needle 1227 in the Z1 or Z2 direction, the sampling needle 1227 moves relative to the sampling needle cleaning swab 1228. The sampling needle cleaning swab 1228 is used to clean the sampling needle 1227 of the sample remaining on the outer wall of the sampling needle 1227 after the completion of aspiration of the sample from the sample container.

As shown in fig. 8, the sampling needle connecting line 1229 is connected to the sampling needle 1227, and the sample suctioned by the sampling needle 1227 is transported along the sampling needle connecting line 1229. The sampling needle connecting line fixing member 1330 is fixedly connected to the vertical support 1221, and is configured to fix the sampling needle connecting line 1229. The tank chain 1231 is used for laying a connecting line of the sampling needle connecting pipeline 1229 and the motor 1222.

Fig. 9 to 11 show relative positional relationships between the transport device 11 and the sampling device 12 on the sample analyzer 1. The sample analyzer 1 sets the kneading position P1 and the sampling position P2 adjacent to each other as shown in fig. 12.

The structure and layout of such sampling means 12 and handling means 11 of the sample analyzer 1 have inherent drawbacks: as can be seen from the top view of fig. 10 and the front view of fig. 11, the moving mechanisms of the handling device 11 and the sampling device 12 have a partial overlapping area in space, and when the sampling needle 1227 of the sampling device 12 is located in the area a, the movement of the clamping jaw 1101 of the handling device 11 along the directions Z1 and Z2 is safe; when the sampling needle 1227 of the sampling device 12 is located in the B region, the movement of the gripping jaw 1101 of the carrying device 11 in the Z1 and Z2 directions interferes with the sampling device 12. In order not to interfere, the jaw 1101 must wait until the sampling needle 1227 returns to region a before it can be actuated, which results in the actuation of the sampling needle 1227 and the jaw 1101 being partially in series.

Assuming that it takes T1 for the sample to be mixed, the time taken for the sampling needle 1227 to sample, aliquote, or pipette the reagent in the B region of fig. 10 is T2, the time taken for the sample to advance 1 position is T3, and the time taken for the sample to reach the sampling position P2 until the final instrument outputs its measurement result is T4.

As explained with reference to fig. 12 and 13, when the sample a reaches the sampling position P2, the sample B simultaneously reaches the kneading position P1. The sampling device 12 samples and divides the sample a, and the jaw 1101 cannot mix the sample B during the time period T2 where the sampling needle 1227 remains in the area B of fig. 10. Only after the needle 1227 moves to area a of fig. 10 can the jaw 1101 initiate the mixing of sample B and take time T1, after which the sampler transports sample B to the sampling position P2 and time T3, while sample C reaches the mixing position P1. Thereafter, the sampling device 12 samples and divides the sample B. Similarly, neither jaw 1101 can mix the sample C during the time period T2 when the sampling needle 1227 remains in the area B of fig. 10.

When the sample batch test is carried out, the maximum detection test speed of the analyzer is as follows in consideration of measurement superposition:

in the above formula, the unit of T1 to T3 is s.

In fig. 13, a _ T1, B _ T1, C _ T1, and D _ T1 are respectively blending times of the sample A, B, C, D, a _ T2, B _ T2, C _ T2, and D _ T2 are respectively sampling times of the sample A, B, C, D, a _ T3, B _ T3, C _ T3, and D _ T3 are respectively times when the sample A, B, C, D advances by one bit, and a _ T4, B _ T4, C _ T4, and D _ T4 are respectively detection times of the sample A, B, C, D.

It can be seen that the time at T2 at which the sampling needle 1227 remains in the region B of fig. 10 is a factor that limits the speed of the analyzer measurement, since the motion of the sampling needle 1227 and the motion of the jaws 1101 are performed in partial series.

In order to solve the above problem, the present invention provides a sample analyzer, as shown in fig. 15 to 18, comprising:

a sample rack 80, said sample rack 80 comprising a plurality of sample container holding apertures 801 for receiving sample loadable sample containers 90;

a handling device 11, said handling device 11 being configured to be movable in a vertical direction Z in order to handle a sample container 90 in a blending position P1 on said sample rack 80 out of its sample container holding hole 801 for blending and back into its sample container holding hole 801 after blending;

a sampling device 22, said sampling device 22 having a sampling needle 2227 configured to be movably inserted into a sample container fixing hole 801 at a sampling position P2 on said sample rack 80 along said vertical direction Z so as to suck a sample in the sample container;

a detection device (not shown) configured to detect the sample aspirated by the sampling device 22;

a sample transport device (not shown) configured to transport the sample rack 80 so that the sample containers 90 on the sample rack 80 can pass the homogenization position P1 and the sampling position P2 in sequence;

wherein the handling device 11 and the sampling device 22 are arranged adjacently and at an interval such that the sampling device 22 does not interfere with the movement of the handling device 11 in the vertical direction Z.

Sample analyzer because handling device 11 with sampling device 22 is adjacent and the interval sets up, can not take place to overlap in the space of vertical direction, consequently can be simultaneously respectively right be in on the sample frame mixing position P1 with the corresponding sample container of sampling position P2 carries and samples and transports.

Alternatively, the carrying device 11 and the sampling needle 2227 are configured to be horizontally movable back and forth along a first direction Y perpendicular to the vertical direction, and the carrying device 11 and the sampling device 22 are disposed adjacent to each other and at intervals so that the carrying device 11 and the sampling needle 2227 can be horizontally movable back and forth along the first direction Y without interfering with each other.

Further, the carrying device 11 and the sampling device 22 are provided at intervals in a second direction X perpendicular to the vertical direction Z and the first direction Y.

Wherein, according to the utility model discloses a sample analyzer's working process can be for: the respective sample containers 90 on the sample rack 80 are first transported by a sample transport device (not shown) to a mixing position P1 and a sampling position P2 provided in the sample analyzer, where, for example, the sample containers in the sample container holding holes 801b are transported to a sampling position P2, at which time the sample containers in the sample container holding holes 801c are in the mixing position P1. Then, the sampling device 22 drives the sampling needle 2227 to move horizontally along the first direction Y1 to above the sample container corresponding to the sampling position P2, then the sampling needle 2227 moves downward along the vertical direction Z2 to enter the sample container loaded with the sample to be sampled and suck the sample to be sampled, after the sample to be sampled is sucked, the sampling needle 2227 moves upward along the vertical direction Z1 to leave the sample container, and then the sampling device 22 drives the sampling needle 2227 to move horizontally along the first direction Y2 to the detection device and discharge the sucked sample to be sampled into the detection device to detect the sample. While the sampling device 22 performs the sampling operation on the sample container corresponding to the sampling position P2, the transport device 11 transports the sample container in the sample container fixing hole 801c at the mixing position P1 on the sample rack 80, and performs the mixing operation. For example, during the transportation process, the height of the transportation device 11 corresponds to the height of the sample container at the blending position P1, the transportation device 11 moves horizontally along the first direction Y1 until contacting the corresponding sample container, the sample container is pushed into the transportation device 11 by the forward force of the transportation device 11, so that the transportation device 11 grips the sample container, and then the transportation device 11 moves the gripped sample container upwards along the vertical direction Z1 to leave the sample rack and shake and blend the sample container or transport the sample container to another blending device for blending. After the sampling operation of the sampling device 22 on the sample containers in the sample container fixing holes 801b and the blending operation of the transporting device 11 on the sample containers in the sample container fixing holes 801c are completed, the sample rack 80 is moved by a distance of one sample container fixing hole by a sample transporting device (not shown) so that the sample containers in the sample container fixing holes 801c are transported to the sampling position P2, at which time the sample containers in the sample container fixing holes 801d are at the blending position P1, and then the sampling operation on the sample containers in the sample container fixing holes 801c and the blending operation on the sample containers in the sample container fixing holes 801d are simultaneously performed by the sampling device 22 and the transporting device 11, respectively, until all the sample containers on the sample rack 80 are tested.

The sample analyzer of the present invention will be further described with reference to fig. 14 to 18.

Note that, in the present invention, the vertical direction is a direction perpendicular to the horizontal plane, and is an up-down direction, for example, a Z direction, such as directions Z1 and Z2 shown in fig. 15, 16, and 18. The first direction is a direction of a travel locus of the sampling device between the sampling position and the detecting device in a horizontal plane or a direction perpendicular to an extending direction of a sample rack transported to the sample analyzer in a horizontal direction, and is a front-back direction, for example, a Y direction, such as Y1, Y2 directions shown in fig. 15 to 17; the second direction is a direction perpendicular to the vertical direction and the first direction on a horizontal plane, is parallel to an extending direction of the sample rack transported to the sample analyzer, and is a left-right direction, for example, an X direction, such as X1 and X2 directions shown in fig. 17 and 18.

In an example of the present invention, the sampling device 22 corresponds to the sampling position P2, and the carrying device 11 corresponds to the blending position P1.

In an example of the present invention, in the sample analyzer, the blending position P1 and the sampling position P2 are not adjacently disposed, but are spaced apart by a distance of at least one sample container fixing hole, so that the distance between the carrying device and the sampling device in the second direction, i.e., the X direction, is increased to ensure that the carrying device and the sampling device do not interfere with each other as shown in fig. 10 and 11 when moving in the Z direction, and therefore the carrying device and the sampling device can carry and sample the sample container on the sample rack at least one sample container fixing hole spaced apart by the blending position and the sampling position, respectively.

In a specific embodiment, the structures of the handling device 11 and the sampling device 22 of the sample analyzer can be explained and illustrated with reference to fig. 1 to 11, and are not repeated herein.

In one example, as shown in fig. 14, the kneading position P1 and the sampling position P2 are set at a distance of one sample container fixing hole apart, so that the carrying device and the sampling device operate independently in the Z direction without interference.

It should be noted that, after setting up mixing position and sampling position interval, handling device and sampling device are not only in vertical direction Z orientation mutually noninterfere promptly, and it is also mutually noninterfere in the X direction of horizontal plane and Y direction, in the embodiment of the utility model discloses an under the condition of explanation and explanation not to the contrary, handling device and sampling device do not all take place to interfere in X direction and Y direction, along X direction and Y direction promptly, handling device and sampling device can not take place to overlap in the space.

The sample analyzer of the present invention will be described in detail with reference to fig. 14. As shown in fig. 14, after the blending position P1 and the sampling position P2 of the sample analyzer are designed to be non-adjacent, such as 1 bit apart, when the sample a reaches the sampling position P2, the sample C reaches the blending position P1, the sample B is located between the sampling position P2 and the blending position P1, and the sample B has been blended.

Since the kneading position P1 and the sampling position P2 are not adjacent to each other, the movement mechanisms of the sampling device 22 and the handling device 11 do not interfere with each other, and for example, the movement of the sampling needle 2227 and the movement of the holding jaw 1101 may be independent of each other.

While sampling needle 2227 is sampling sample a, jaws 1101 may simultaneously mix sample C. Generally, the sampling time of the sampling needle is less than or equal to the mixing time of the clamping jaw. When sample C is completely mixed and sample a is completely sampled, the sample injector (i.e., sample transport device) may deliver sample B to sampling location P2. At this time, the shortest time interval from the collection of the sample a by the sampling needle 2227 to the collection of the sample B is T1+ T3, then the highest detection speed of the analyzer can be achieved:

in this embodiment, the time interval from completion of the kneading at the kneading position P1 to movement to the sampling position P2 for the sample B with the sample rack full of samples is T1+2 × T3, where T1 is the elapsed time for the sample B to finish kneading at the sample C located at the kneading position P1 between the sampling position P2 and the kneading position P1, and 2 × T3 is the elapsed time for the sample B to be fed 2 times from the kneading position P1 to the sampling position P2. The sample B can be collected after being mixed uniformly by T1+2 XT 3, and blood cells in the sample B are at risk of re-sedimentation at the time of T1+2 XT 3. If the time of T1+2 × T3 is too long, the measurement result is affected, and if the time of T1+2 × T3 is short enough, the result is not affected much. In this case, T1 and T3 can be designed appropriately so that the sample that has been mixed and is waiting for sampling runs as little risk of re-settling as possible.

Of course, in another embodiment of the present invention, the blending position P1 and the sampling position P2 may be adjacent to each other. In this embodiment, the structure of the sample analyzer is further improved, wherein various structures, arrangements, and related explanations and explanations of the sample analyzer in the above-described embodiment can be incorporated into this embodiment without contradiction.

As can be seen from the top view of fig. 10 and the front view of fig. 11, the components that interfere with the movement of the handling device 11, in particular the clamping jaw 1101, in the direction Z1 include: a motor 1222 of the sampling device 12, a vertical support 1221, a sampling needle connecting pipeline 1229, a sampling needle connecting pipeline fixing part 1330, and a tank chain 1231.

The modified sample analyzer, and more particularly the sampling device and handling device, will now be described in detail with reference to fig. 15 to 18.

As shown in fig. 15 and 16, the sampling device 22 includes: a horizontal support 2201 disposed in the first direction, i.e., Y1-Y2, and a vertical support 2221 disposed in the vertical direction, i.e., Z1-Z2. Wherein the vertical support 2221 is movably disposed on the horizontal support 2201 along the first direction, i.e., Y1-Y2, so that the vertical support 2221 is reciprocally moved on the horizontal support along the first direction, i.e., Y1-Y2, to achieve sampling and discharging the sampling into a testing device for analysis.

Alternatively, the vertical stand 2221 is disposed near one side of the carrier device 11 and configured such that the vertical stand 2221 does not interfere with the movement of the carrier device 11 in the vertical direction Z1-Z2, as shown in fig. 17, and the vertical stand 2221 is disposed adjacent to the carrier device 11.

The sampling device 22 may further include a horizontal guide 2206 disposed along the first direction, i.e., Y1-Y2, wherein the horizontal guide 2206 may be disposed at a middle lower portion of the horizontal support 2201, for example, at a bottom portion of the horizontal support 2201, as shown in fig. 15. Two ends of the horizontal guide rod 2206 are respectively fixed at two ends of the horizontal support 2201. The vertical bracket 2221 is movably fitted over the horizontal guide bar in the first direction.

Optionally, the sampling device 22 further includes a first driving component 2202 for driving the vertical support 2221 with the sampling needle 2227 disposed thereon to move along a horizontal guide rod 2206, wherein the first driving component 2202 is fixed on the horizontal support, for example, on a side of the horizontal support 2201 facing away from the vertical support 2221 and on an end of the horizontal support 2201 away from a sampling position P2, as shown in fig. 15.

Wherein the first driving assembly 2202 includes a motor, such as a stepper motor, but not limited to this example.

It should be noted that the components 2201 to 2206 of the horizontal driving mechanism of the sampling device 22 have substantially the same structure as the components 1201 to 1206 of the horizontal driving mechanism of the sampling device 12, and are not described again.

Further, the sampling device 22 further includes a vertical guide 2223 arranged along the vertical direction, i.e., the direction Z1-Z2, a lead screw 2224 arranged parallel to the vertical guide 2223, and a nut 2225 sleeved on the lead screw 2224. Wherein the vertical guide 2223 is fixedly arranged on the vertical bracket.

Wherein the sampling needle 2227 is disposed on the vertical support 2221 so that the vertical support 2221 can drive the sampling needle 2227 to move in the first direction, and the vertical support is configured so that the vertical support does not interfere with the movement of the carrying device in the vertical direction.

Specifically, the sampling device 22 further includes a sampling needle fixing part 2226, a sampling needle washing swab 2228, a sampling needle connecting line 2229, a sampling needle connecting line fixing part 1330, and a housing part 2231.

The sampling needle 2227 is fixed to the sampling needle fixing part 2226, the sampling needle fixing part 2226 is fixed to the slider of the vertical guide rail 2223, the lead screw 2224 passes through a hole formed in the sampling needle fixing part 2226, the nut 2225 is clamped in a slot formed in the sampling needle fixing part 2226, and relative rotation is not generated between the nut 2225 and the sampling needle fixing part 2226.

The sampling device 22 further includes a second driving assembly 2222 fixed to the vertical bracket, wherein the lead screw 2224 is connected to the second driving assembly 2222 through a screw, and the second driving assembly 2222 can drive the lead screw 2224 to rotate and drive the sampling needle fixing member 2226 with the sampling needle 2227 to move along the Z1 or Z2 direction.

The second driving unit 2222 is disposed above the vertical support 2221 and close to the horizontal support 2201 so that it does not interfere with the movement of the carrying device 21 in the vertical direction. The second driving assembly 2222 includes a motor, such as a stepping motor, etc., but is not limited to this example.

In one example, the size of the second driving assembly 2222 is reduced so that the second driving assembly 2222 does not interfere with the handling device 11, for example, there is no overlap in the directions X, Y and Z. The size of the second driving unit 2222 in the X direction can be reduced, or the second driving unit 2222 can be moved in the X direction away from the conveying device 21, so that the conveying device 11 and the second driving unit 2222 are spaced apart from each other, and no interference occurs during operation.

Further, a sampling needle cleaning swab 2228 is secured to the upright support 2221, and a sampling needle 2227 is passed through a central aperture in the sampling needle cleaning swab 2228. When the sampling needle moves along the vertical direction, the sampling needle moves relative to the sampling needle cleaning swab.

As shown in fig. 16, one end of the sampling needle connecting line 2229 is connected to the sampling needle 2227, the other end of the sampling needle connecting line 2229 is connected to a pressure source (not shown), and the sampling needle connecting line 2229 can be used to provide pressure to the sampling needle 2227, that is: when the sampling needle 2227 performs a sample sucking operation, the sampling needle connecting pipeline 2229 provides negative pressure for the sampling needle 2227 so that the sampling needle sucks a sample; after the sampling needle 2227 is moved to the reaction cell of the detection device in the Y2 direction, the sampling needle 2227 is supplied with positive pressure by the sampling needle connecting line 2229, and the sample is discharged by the positive pressure by the sampling needle 2227, but it is also possible to directly suck the sample from the sampling needle to the reaction cell of the detection device by the negative pressure directly by the sampling needle connecting line 2229. The sampling needle connecting line fixing member 2330 is fixedly connected to the vertical holder 2221 for fixing the sampling needle connecting line 2229.

Wherein the sampling needle connecting line 2229 and the sampling needle connecting line fixing member 2330 are arranged so as not to interfere with the movement of the carrying device in the vertical direction.

Specifically, in an example, the blending position P1 and the sampling position P2 of the sample analyzer are adjacent to each other, and the distance between the sampling needle 2227 of the sampling device 22 and the clamping jaw 1101 of the handling device 11 is the same as the distance between the sampling needle 1227 of the sampling device 12 and the clamping jaw 1101 of the handling device 11 shown in fig. 10 and 11, so that in order to avoid interference between the sampling device 22 and the handling device 11, the position of the sampling needle connecting pipeline 2229 needs to be changed, that is, the sampling needle connecting pipeline 2229 is arranged on the side, away from the handling device 11, of the vertical support 2221, as shown in fig. 16.

Likewise, the position of the sampling needle connecting line fixing member 2330 may be changed, and the connecting line fixing member 2330 is disposed at a side of the vertical support 2221 away from the carrying device 11, as shown in fig. 16.

By shifting the sampling needle connecting line 2229 and connecting line fixing 2330 to the side of the vertical rack remote from the handling device, the spacing between the sampling device 22 and the handling device 11 is increased, avoiding overlap or interference in the vertical direction.

Further, in addition to moving the sampling needle connecting line 2229 and the connecting line holder 2330, the above-described effects can be achieved by reducing the size of the sampling needle connecting line 2229 and the connecting line holder 2330, or reducing the size of the sampling needle connecting line 2229 and the connecting line holder 2330 while moving the sampling needle connecting line 2229 and the connecting line holder 2330.

Further, the housing 2231 is configured to receive the sampling needle connecting line 2229 and a cable that houses the sampling device 22, such as a connecting line for laying the sampling needle connecting line 2229 and the second drive assembly 2222. Wherein the receiving portion is fixedly connected with the vertical support and disposed below the horizontal support 2201 so that it does not interfere with the movement of the carrying device in the vertical direction.

Specifically, in order to prevent the storage section 2231 from interfering with the conveying device, the distance between the storage section 2231 and the horizontal support is reduced, for example, the X-direction distance between the storage section 2231 and the conveying device is made larger than the X-direction distance between the vertical support and the conveying device, so that the storage section 2231 does not protrude to one side of the conveying device to interfere with the conveying device.

In an example of the present invention, the storage section 2231 is constructed as a tank chain having one end fixed and the other end movable along the first direction along the vertical support.

Alternatively, the tank chain is disposed substantially parallel to the horizontal support, and one end of the tank chain is fixed to the horizontal support 2201 and the other end is connected to the vertical support 2221 so as to be movable in the first direction Y1-Y2 with the vertical support 2221.

In the present invention, after reducing and/or moving the position of some components in the sampling device, as can be seen from the top view of fig. 17 and the front view of fig. 18, there is no overlapping area in the space between the moving mechanism of the handling device 11 and the sampling device 22, and the distance d is kept between the clamping jaw 1101 of the handling device 11 and the sampling device 22 in the directions X1 and X2, so that the actions of the clamping jaw 1101 of the handling device 11 and the sampling needle 2227 of the sampling device 22 can be independent of each other.

In other words, when sample a reaches the sampling position P2, sample B simultaneously reaches the blend position P1. While sampling needle 2227 is sampling sample a, jaws 1101 may simultaneously mix sample B. Generally, the sampling time of the sampling needle is less than or equal to the mixing time of the clamping jaw. When sample B is done blending, sample a is done sampling, and the sampler may deliver sample B to sampling location P2. Then the shortest time interval from the collection of sample a by sampling needle 2227 to the collection of sample B is T1+ T3, then the highest detection speed for this sample analyzer can be achieved:

through the improvement, sampling device and handling device mutual interference's problem has been solved to sample analyzer for sampling needle and clamping jaw action can go on in parallel, eliminate sample B and wait for the time T2 that could carry out the mixing after sample A samples, consequently according to the utility model discloses a this kind of sampling device of sample analyzer and handling device's structure and overall arrangement can make this sample analyzer obtain higher detection speed.

It should be noted that the structure of the carrying device according to the present invention is substantially the same as that of the carrying device 11, and the description thereof is omitted.

In addition, in another example, the sample analyzer includes a blending device (not shown), and the carrying device can carry the sample container in the blending position on the sample rack out of the sample container fixing hole of the sample rack and place the sample container in the blending device so as to blend the sample in the sample container. Preferably, the blending device can blend the peripheral blood sample, and the carrying device can be used for carrying the sample container and can also blend the venous blood sample.

Optionally, the detection apparatus comprises a cell sorter counting module (not shown) for sorting and counting particles in the sample aspirated by the sampling apparatus and a CRP detection module (not shown) for detecting a CRP concentration of the sample aspirated by the sampling apparatus.

Wherein the CRP detection module may comprise:

According to the utility model discloses an in the sample analysis appearance, handling device is constructed to follow vertical direction motion, sampling device has the sampling needle, the sampling needle is constructed to follow vertical direction motion stretches into in the sample container that is in the sampling position on the sample frame, and handling device with the adjacent and interval setting of sampling device makes sampling device does not interfere handling device is along vertical direction's motion, through the improvement can improve sample analysis appearance's detection speed.

Technical terms used in the embodiments of the present invention are only used to illustrate specific embodiments and are not intended to limit the present invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. Further, the use of "including" and/or "comprising" in the specification is intended to specify the presence of stated features, integers, steps, operations, elements, and/or components, but does not preclude the presence or addition of one or more other features, integers, steps, operations, elements, and/or components.

The corresponding structures, materials, acts, and equivalents of all means or step plus function elements in the claims below, if any, are intended to include any structure, material, or act for performing the function in combination with other claimed elements as specifically claimed. The description of the present invention has been presented for purposes of illustration and description, but is not intended to be exhaustive or limited to the invention in the form disclosed. Various modifications and alterations will become apparent to those skilled in the art without departing from the scope and spirit of this invention. The embodiments described in this application are intended to better explain the principles and the practical application of the invention and to enable others skilled in the art to understand the invention.

The flow chart described in the present invention is merely an example, and various modifications and changes can be made to the drawings or the steps in the present invention without departing from the spirit of the present invention. For instance, the steps may be performed in a differing order, or steps may be added, deleted or modified. It will be understood by those skilled in the art that all or part of the above-described embodiments may be implemented and equivalents may be made thereto without departing from the scope of the invention as defined in the claims.

Claims

1. A sample analyzer, comprising:

2. The sample analyzer of claim 1, wherein the handling device and the sampling needle are configured to be horizontally movable back and forth along a first direction perpendicular to the vertical direction, and the handling device and the sampling needle are disposed adjacent to and spaced apart from each other such that the handling device and the sampling needle are horizontally movable back and forth along the first direction without interfering with each other.

3. The sample analyzer of claim 2 wherein the handling device and the sampling device are spaced apart along a second direction perpendicular to the vertical direction and the first direction.

4. The sample analyzer of any one of claims 1 to 3, wherein the sampling device is disposed in correspondence with the sampling position, and the handling device is disposed in correspondence with the blending position.

5. The sample analyzer of claim 4, wherein the blending position and the sampling position are disposed adjacent to each other, such that the handling device and the sampling device can simultaneously and respectively handle and sample adjacent sample containers on the sample rack at the blending position and the sampling position;

or the distance of at least one sample container fixing hole is arranged between the blending position and the sampling position, so that the carrying device and the sampling device can carry and sample the sample containers which are positioned at the blending position and the sampling position on the sample rack at the same time.

6. The sample analyzer of claim 2, wherein the sampling device includes a horizontal rack disposed along the first direction and a vertical rack disposed along a vertical direction, the vertical rack being movably disposed along the first direction on a side of the horizontal rack adjacent to the handling device, and the sampling needle is disposed on the vertical rack such that the vertical rack can bring the sampling needle to move along the first direction, the vertical rack being configured such that it does not interfere with the movement of the handling device along the vertical direction.

7. The sample analyzer of claim 6, wherein the sampling device further comprises:

8. The sample analyzer of claim 7 wherein the second drive assembly is disposed above the vertical support and proximate to the horizontal support such that it does not interfere with movement of the handling device in a vertical direction.

9. The sample analyzer of claim 8, wherein the sampling device further comprises:

10. The sample analyzer as claimed in claim 6, wherein the sampling device further comprises a receiving portion for receiving the sampling needle connection line and a cable receiving the sampling device, the receiving portion being fixedly connected to the vertical rack and disposed below the horizontal rack so as not to interfere with movement of the carrying device in the vertical direction.

11. The sample analyzer of claim 10 wherein the receptacle is configured as a tank chain having one end fixed and the other end movable with the vertical support in the first direction.

12. The sample analyzer as claimed in claim 11, wherein the carrying means comprises a gripping mechanism for gripping the sample container and a first driving mechanism for driving the gripping mechanism to move in a vertical direction.

13. The sample analyzer of claim 12, wherein the handling device further comprises a second driving mechanism for driving the grasping mechanism to move in the first direction; and/or the carrying device further comprises a third driving mechanism for driving the clamping mechanism to rotate so as to uniformly mix the samples in the sample containers clamped by the clamping mechanism.

14. The sample analyzer of claim 12 or 13, wherein the sample analyzer comprises a blending device, and the carrying device can carry the sample container in the blending position on the sample rack out of the sample container fixing hole of the sample container to be placed in the blending device, so that the blending device can blend the sample in the sample container.

15. The sample analyzer of claim 14, wherein the detection device comprises a cell sorter counting module to sort and count particles in the sample drawn by the sampling device and a CRP detection module to detect a CRP concentration of the sample drawn by the sampling device.

16. The sample analyzer of claim 15, wherein the CRP detection module comprises: