CN113842432A

CN113842432A - External ointment for conditioning skin allergy and pruritus and preparation method

Info

Publication number: CN113842432A
Application number: CN202111296708.2A
Authority: CN
Inventors: 郭继磊; 刘涛
Original assignee: Beijing Taichu Institute Of Traditional Chinese Medicine
Current assignee: Beijing Taichu Institute Of Traditional Chinese Medicine
Priority date: 2021-11-03
Filing date: 2021-11-03
Publication date: 2021-12-28

Abstract

The invention provides an external ointment for conditioning skin allergy and pruritus and a preparation method thereof, wherein the external ointment comprises the following steps: mixing Coptidis rhizoma extract, cortex Phellodendri extract, radix Sophorae Flavescentis extract, cortex Dictamni Radicis extract, Kochiae fructus extract, rhizoma Polygonati extract, indigo naturalis extract, flos Lonicerae extract, fructus forsythiae extract, and Glycyrrhrizae radix extract. Pulverizing Mentholum, Camphora, Borax, and Borneolum Syntheticum, grinding into 140 mesh, mixing with the above powder, adding oleum Caryophylli, oleum Camphora, and vaseline, blending, homogenizing, and packaging. Is developed according to the traditional Chinese medicine theory and combining the modern medicine research result and the clinical experience of the traditional Chinese medicine. The selected components are pure Chinese herbal medicines, the compatibility is scientific and reasonable, the external administration is realized, the externally applied ointment directly acts on an affected part, the stimulation of an oral preparation to the liver and the kidney of the stomach and the intestine is avoided, the side effect of the medicine is reduced, the treatment course is short, the effect is quick, the cost is low, the use is convenient, and no toxic or side effect exists.

Description

External ointment for conditioning skin allergy and pruritus and preparation method

Technical Field

The invention discloses an external ointment for conditioning skin allergy and pruritus and a preparation method thereof.

Background

Eczema, dermatitis, urticaria, skin allergic diseases, psoriasis and the like are caused by the fact that channels and collaterals are blocked due to exogenous wind evil, endogenous damp toxin and pathogenic toxin, so that nutrient-defensive disharmony and qi and blood stagnation cause heat toxin to be accumulated in skin; eczema, dermatitis, urticaria, skin allergic diseases, psoriasis and the like, and the clinical manifestations are that red and swollen pimples, pruritus and pain appear on the body and the skin of four limbs, the pruritus aggravates pain and uneasiness during the attack of diseases, and nasal obstruction, watery nasal discharge, dizziness, headache, poor mental state and the like can also appear clinically; the traditional Chinese medicine theory considers that the diseases in human body and the skin toxin are caused, such as urticaria; the traditional Chinese medicine composition can relieve clinical symptoms by conditioning the common patients with chlorpheniramine, terfeladine, dexamethasone acetate, clobetasol propionate, prednisone acetate, cortisone acetate, beclomethasone propionate and other medicines, has a certain curative effect, usually treats symptoms and root causes, is easy to relapse, brings a lot of side effects to the patients after long-term use, and can cause skin atrophy, telangiectasia, pigmentation, osteoporosis and other symptoms and secondary infection after long-term use. Bringing great pain to the patient. Compared with western medicines, the traditional Chinese medicine has smaller side effect and becomes the preferred medicine.

Disclosure of Invention

The invention provides an externally-applied ointment for conditioning skin allergy pruritus, which is used for conditioning eczema, dermatitis, urticaria, skin allergy pruritus, psoriasis and other symptoms and root causes and has the effect of treating both symptoms and root causes.
	The invention discloses an external ointment for conditioning skin allergy pruritus, which is prepared from the following raw materials in percentage by weight:
7-10% of coptis extract, 8-9% of phellodendron extract, 6-7% of sophora flavescens extract, 5-6% of cortex dictamni extract, 5-6% of fructus kochiae extract, 6-7% of rhizoma polygonati extract, 6-7% of camphor, 2-3% of borax, 4-5% of indigo naturalis extract, and the like, 3-4% of borneol, 8-9% of honeysuckle extract, 6-7% of forsythia extract, 6-7% of licorice extract, 8-9% of menthol, 4-5% of clove oil, 5-6% of camphor oil and 6-7% of vaseline.
	The invention discloses an external ointment for conditioning skin allergic pruritus, which is prepared from the following raw materials in an optimal ratio:
8% of coptis extract, 8% of phellodendron extract, 6% of sophora flavescens extract, 5% of cortex dictamni extract, 5% of fructus kochiae extract, 6% of rhizoma polygonati extract, 6% of camphor, 3% of borax, 4% of indigo naturalis extract, 3% of borneol, 8% of honeysuckle extract and 8% of forsythia extract Extract 6% and licorice extract6 percent of menthol, 8 percent of clove oil, 6 percent of camphor oil and 7 percent of vaseline.
	The invention provides a preparation method of an ointment for conditioning skin allergy and pruritus, which comprises the following steps:
mixing Coptidis rhizoma extract, cortex Phellodendri extract, radix Sophorae Flavescentis extract, cortex Dictamni Radicis extract, Kochiae fructus extract, rhizoma Polygonati extract, indigo naturalis extract, flos Lonicerae extract, fructus forsythiae extract, and Glycyrrhrizae radix extract. Mixing with Mentholum and Camphora Pulverizing Borneolum, Borax and Borneolum, grinding into 140 mesh, mixing with the above materials, adding oleum Caryophylli, oleum Camphora and vaseline, mixing, homogenizing, packaging, and packaging.
	The usage and dosage are as follows: the ointment is externally used for cleaning the affected part, and a proper amount of ointment is taken and smeared on the affected part for 2-3 times per day.
Conditioning function: promoting blood circulation, removing blood stasis, clearing heat, cooling blood, dispelling pathogenic wind, eliminating dampness, relieving itching, and resisting allergy.
	Indications are as follows: skin pruritus, urticaria, eczema, dermatitis, psoriasis, various skin allergies and the like.
The pharmacological drug effect of the invention is explained as follows:
	the Coptidis rhizoma extract and cortex Phellodendri extract are used for dispelling pathogenic wind and cold, dredging orifice and eliminating pathogenic factor, and treating nasal obstruction and watery nasal discharge caused by pathogenic wind and cold; radix Sophorae Flavescentis extract, cortex Dictamni Radicis extract, and has effects of inducing sweat, relieving exterior syndrome, dispelling pathogenic wind, removing dampness, and clearing head and eyes for treating damp-heat due to pathogenic wind-cold Eczema and pruritus caused by the eczema; the camphor, the borneol, the honeysuckle extract and the forsythia extract have the functions of promoting blood circulation and removing blood stasis, clearing heat and purging fire and cooling blood, and the broom cypress fruit extract and the polygonatum extract break blood and remove blood stasis and condition scabies, eczema and pruritus Symptoms of the disease; the licorice extract has the functions of clearing away heat and toxic materials and resisting allergy; external use of borax for clearing away heat and toxic materialDetumescence, clearing heat and purging fire, cooling blood and removing toxicity; indigo naturalis extract is used for treating heat toxin, speckle, hematemesis, etc.; treating pyocutaneous disease and mumps by external application; the camphor oil has the functions of healing wound, Deodorizing and the like; clove oil, for scrofula, is used as a stone-removing ointment, which is fragrant and strong and acts directly through meridians and collaterals, pungent and pungent to dissipate nodulation and stagnate ears. The menthol has the effects of diminishing inflammation, relieving pain, relieving itching, promoting blood circulation, relieving edema and the like; the medicines are compatible with each other and have synergistic effect, mutually reinforcing and mutually keeping the effect of promoting blood circulation by removing blood stasis, relieving pain and promoting tissue regeneration and resisting allergy, and relieving the pain of allergic pruritus.
The positive effects of the present invention are further illustrated in combination with clinical trials as follows:
	firstly, diagnosis standard:
allergic diseases such as psoriasis are caused by the obstruction of meridians caused by exogenous wind evil, endogenous damp toxin and pathogenic toxin, so that the nutrient-defensive qi is not harmonized, qi and blood are stagnated, and heat toxin is accumulated in the skin; allergic rhinitis, ultraviolet burn, pollen allergy, etc.
	Selecting according to clinical manifestations: red, swollen, pimple, itching and pain, white psoriasis appear on the skin of the body and the limbs; nasal obstruction, nasal discharge, lacrimation, dizziness, etc.
Secondly, the medication method comprises the following steps: applying on affected surface for 3 times daily;
	the therapeutic effect judgment standard is as follows:
and (3) curing: after the medicine is applied, the skin surface symptoms disappear, and the body surface returns to normal.
	The method has the following advantages: after the medicine is applied, the symptoms on the surface of the skin gradually reduce or disappear.
And (4) invalidation: after application to the skin surfaceThe symptoms are relieved, and the sign change is not obvious.
	The invention is used for clinically conditioning 100 patients with anaphylaxis caused by wind-heat damp toxin type, 85 patients are cured, 98 patients are effective, and 2 patients are ineffective; other unknown reasons cause skin allergy, pruritus patients 100, fully recover 86 cases, effective 96 cases, no And 4 cases.
The invention has the positive effects that:
	is developed according to the traditional Chinese medicine theory and combining the modern medicine research result and the clinical experience of the traditional Chinese medicine. The selected medicines are pure Chinese herbal medicines, are scientifically matched and externally administered, directly act on an affected part, have quick action and avoid oral preparation The preparation has the advantages of reduced pain, short treatment course, low cost, and convenient administration. Rapid disappearance of clinical symptoms, obvious curative effect, convenient and safe use and no toxic or side effect.
Detailed Description
	Example 1:
weighing 8% of coptis extract, 8% of phellodendron extract, 6% of sophora flavescens extract, 5% of cortex dictamni extract, 5% of fructus kochiae extract, 6% of rhizoma polygonati extract, 4% of indigo naturalis extract, 8% of honeysuckle extract and 8% of forsythia extract according to weight percentage Mixing extract 6% and Glycyrrhrizae radix extract 6%. 3 percent of borneol, 8 percent of menthol, 6 percent of camphor and 3 percent of borax, grinding the mixture into 140 meshes, mixing the mixture with the former, adding 5 percent of clove oil, 6 percent of camphor oil and 7 percent of vaseline, blending the mixture, homogenizing the mixture on a machine, filling and boxing, and (4) finishing.

Passing through the following dictionaryType cases further show the opsonizing effect of the drug of the invention:
	case 1
Zhanga male, age 56, eczema: the whole body is extremely itchy, the affected part is red in sheet shape, and western medicines are used for a long time, so that the side effects are large, the disease is easy to recur, and the disease is not effective after long-term medical treatment. Conditioning: firstly, the affected part is cleaned, and then the ointment of the invention is smeared on the affected part three times a day The disease condition is obviously relieved after the continuous administration for seven days, the systemic pruritus and the flaky erythema are basically subsided after 20 days, the systemic eczema is completely subsided after three months, the systemic toxicity is continuously removed after the continuous application of the medicine, the skin surface is smooth, the color is the same as the surrounding, and no toxicity exists after 6 months of healing And (5) relapse.
	Case 2
The medicine is taken by a certain queen woman, 41 years old, urticaria and anti-allergy western medicines, is relieved to some extent, is temporarily effective and rebounds after a while; conditioning: the affected part is cleaned by clean water, and then the ointment is smeared on the affected part, and the clinical symptoms of the ointment are achieved after the ointment is applied for 3 days three times a day The medicine is obviously relieved, the clinical symptoms are completely disappeared after the medicine is continuously taken for 40 days, the disease is cured, and the disease does not rebound after 6 months of cure.
	Case 3
Zhangyinji, age 62, symptoms: after the dermatitis is treated for 10 years by using various traditional Chinese medicines and western medicines and hormone for conditioning, the symptoms are aggravated after failing to relieve, the red skin is aggravated after a long time, the skin is scratched and scratched day and night, and the pain is not great. Conditioning: the affected part is firstly cleaned and dried by clear water The ointment is applied to the affected part three times a day, the medicine is continuously applied, the disease condition is obviously relieved for more than ten days, the general pruritus and the flaky prurigo are relieved in fifteen days, all the symptoms are relieved, and the smooth scar of the whole body is full when the scar is basically subsided for three months After withdrawal, the medicine is applied continuously and the whole body is detoxified. The product is not itchy after one week, and after one month of use, the area where skin turns black is reduced, three areasAfter month, the symptoms disappeared, followed one year later without recurrence.

Claims

1. The externally-applied ointment for conditioning skin allergy and pruritus is characterized by being prepared from the following medicines in percentage by weight:

7-10% of coptis extract, 8-9% of phellodendron extract, 6-7% of sophora flavescens extract, 5-6% of cortex dictamni extract, 5-6% of fructus kochiae extract, 6-7% of rhizoma polygonati extract, 6-7% of camphor, 2-3% of borax, 4-5% of indigo naturalis extract, 3-4% of borneol, 8-9% of honeysuckle extract, 6-7% of fructus forsythiae extract, 6-7% of liquorice extract, 8-9% of menthol, 4-5% of clove oil, 5-6% of camphor oil and 6-7% of vaseline.

2. The external ointment for conditioning allergic skin pruritus according to claim 1, which is prepared from the following medicines in percentage by weight:

8% of coptis extract, 8% of phellodendron extract, 6% of sophora flavescens extract, 5% of cortex dictamni extract, 5% of fructus kochiae extract, 6% of rhizoma polygonati extract, 6% of camphor, 3% of borax, 4% of indigo naturalis extract, 3% of borneol, 8% of honeysuckle extract, 6% of fructus forsythiae extract, 6% of liquorice extract, 8% of menthol, 5% of clove oil, 6% of camphor oil and 7% of vaseline.

3. The method for preparing the external ointment for conditioning the allergic pruritus of the skin according to claim 1 or 2, which comprises the following steps:

mixing Coptidis rhizoma extract, cortex Phellodendri extract, radix Sophorae Flavescentis extract, cortex Dictamni Radicis extract, Kochiae fructus extract, rhizoma Polygonati extract, indigo naturalis extract, flos Lonicerae extract, fructus forsythiae extract, and Glycyrrhrizae radix extract. Pulverizing Mentholum, Camphora, Borax, and Borneolum Syntheticum, grinding into 140 mesh, mixing with the above materials, adding oleum Caryophylli, oleum Camphora, and vaseline, mixing, homogenizing, packaging, and packaging.