CN113825834A - 使用rna引导的核酸内切酶进行dna构建体整合的改进工艺 - Google Patents
使用rna引导的核酸内切酶进行dna构建体整合的改进工艺 Download PDFInfo
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| WO2022015956A1 (en) | 2020-07-15 | 2022-01-20 | Sorrento Therapeutics, Inc. | Improved process for dna integration using rna-guided endonucleases |
| EP4214318A1 (en) * | 2020-09-18 | 2023-07-26 | Vor Biopharma Inc. | Compositions and methods for cd7 modification |
| EP4320234A2 (en) * | 2021-04-07 | 2024-02-14 | Astrazeneca AB | Compositions and methods for site-specific modification |
| EP4370676A2 (en) * | 2021-06-18 | 2024-05-22 | Artisan Development Labs, Inc. | Compositions and methods for targeting, editing or modifying human genes |
| WO2023097236A1 (en) * | 2021-11-24 | 2023-06-01 | The Rockefeller University | Compositions and methods for generating immunoglobulin knock-in mice |
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| WO2016057951A2 (en) * | 2014-10-09 | 2016-04-14 | Life Technologies Corporation | Crispr oligonucleotides and gene editing |
| WO2016182959A1 (en) * | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
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| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5489677A (en) | 1990-07-27 | 1996-02-06 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms |
| US6555674B2 (en) | 2000-08-09 | 2003-04-29 | Nsgene A/S | JeT promoter |
| DE202013012241U1 (de) | 2012-05-25 | 2016-01-18 | Emmanuelle Charpentier | Zusammensetzungen für die durch RNA gesteuerte Modifikation einer Ziel-DNA und für die durch RNA gesteuerte Modulation der Transkription |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| AU2014361834B2 (en) | 2013-12-12 | 2020-10-22 | Massachusetts Institute Of Technology | CRISPR-Cas systems and methods for altering expression of gene products, structural information and inducible modular Cas enzymes |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| GB2569733B (en) | 2016-09-30 | 2022-09-14 | Univ California | RNA-guided nucleic acid modifying enzymes and methods of use thereof |
| WO2019173837A1 (en) | 2018-03-09 | 2019-09-12 | Sorrento Therapeutics, Inc. | Dimeric antigen receptors (dar) |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2016057951A2 (en) * | 2014-10-09 | 2016-04-14 | Life Technologies Corporation | Crispr oligonucleotides and gene editing |
| WO2016182959A1 (en) * | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
Non-Patent Citations (2)
| Title |
|---|
| JUSTIN S. ANTONY等: ""Gene correction of HBB mutations in CD34+ hematopoietic stem cells using Cas9 mRNA and ssODN donors", MOLECULAR AND CELLULAR PEDIATRICS, vol. 5, no. 1, pages 1 - 2 * |
| XIAOYUN DAI等: "One-step generation of modular CAR-T cells with AAV–Cpf1", NATURE METHODS, vol. 16, pages 251 - 252 * |
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| AU2020239050A1 (en) | 2021-11-04 |
| JP2022524435A (ja) | 2022-05-02 |
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