CN113786350A - Essence emulsion composition with speckle-lightening and brightening effects and preparation method thereof - Google Patents
Essence emulsion composition with speckle-lightening and brightening effects and preparation method thereof Download PDFInfo
- Publication number
- CN113786350A CN113786350A CN202111126726.6A CN202111126726A CN113786350A CN 113786350 A CN113786350 A CN 113786350A CN 202111126726 A CN202111126726 A CN 202111126726A CN 113786350 A CN113786350 A CN 113786350A
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- CN
- China
- Prior art keywords
- lightening
- spot
- brightening
- essence
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000000694 effects Effects 0.000 title claims abstract description 41
- 238000005282 brightening Methods 0.000 title claims abstract description 40
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- 239000000839 emulsion Substances 0.000 title claims description 8
- 238000000855 fermentation Methods 0.000 claims abstract description 46
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
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- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 2
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- 240000007817 Olea europaea Species 0.000 claims description 2
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- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims description 2
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention discloses an essence milk composition with the effects of lightening spots and brightening and a preparation method thereof. The essence milk comprises the following raw material components: 0.5-30% of spot-lightening and brightening functional components and 70-99.5% of cosmetic auxiliary material matrix. The components with the speckle-lightening and brightening effects comprise: undecylenoyl phenylalanine, lactobacillus fermentation lysate, porphyra umbilicalis extract, lentil seed extract; the cosmetic auxiliary material matrix comprises: emollient, emulsifier, filler, thickener, antiseptic, pH regulator, daily essence and deionized water. The essential milk composition with the spot-lightening effect can inhibit the generation of melanin, reduce the deposition of the melanin, increase the metabolism of epidermis, promote the regeneration of skin, improve the dark yellow and dark skin, prevent or reduce future spots and spots in formation, achieve the effects of homogenizing skin color, brightening skin and improving the human complexion image by compounding the components.
Description
Technical Field
The invention relates to a skin care product and a preparation method thereof, belongs to the technical field of daily chemicals, and particularly relates to an essence emulsion composition with the effects of lightening spots and brightening and a preparation method thereof.
Background
The beauty of beautiful and clean skin and tender skin is the desire of every beauty lovers for sleep. However, the color stains on the face are extremely annoying over time and under the influence of environmental factors, and a lot of time and energy are needed to remove the color stains and to do preventive work. How to effectively improve the color spots and dark skin on the face and make people look more lifelike and lively is a very concern for many people.
Skin problems such as mottle, dullness, etc. are mostly attributable to two aspects: local pigmentation of the skin and slow metabolism of the skin. The spots on the skin of people are mostly caused by local melanin deposition on the skin, melanin is generated after melanocytes are stimulated by ultraviolet irradiation and the like, and the skin is blackened after the melanocytes are transferred to a horny layer, but the melanin is gradually shed along with old cells due to the metabolic action of the horny layer of the skin.
However, with the increase of age, or the pressure of life and work, the stimulation of external environment, etc., the metabolism speed of skin keratinocytes is reduced, when melanin cannot be timely shed off, melanin can be accumulated on the skin to form color spots, and when the skin keratinocytes are slowly renewed, old cells on the skin are accumulated, the skin can also be dull and dull, the color spots are more obvious, and people can look very tired and non-active.
In light of the problems encountered in the present state of the art, it would be desirable to provide a composition that simultaneously radically improves the mottling problem and dullness problem of human skin, and scientifically selects and organically combines each component, and is expected to provide synergistic effects in lightening mottles, evening skin color, and the like.
Disclosure of Invention
The invention aims to provide a essence milk composition with the effects of lightening spots and brightening, which can improve the effects of dullness and dull skin and pigmentation and is greatly favored by consumers.
The invention also aims to provide a preparation method of the essence milk composition with the speckle-lightening and brightening effects.
In order to achieve the purpose, the invention adopts the following technical scheme:
the essence milk composition with the effects of lightening spots and brightening comprises the following components in percentage by weight:
0.5-30% of spot-fading and brightening functional components, which comprise: undecylenoyl phenylalanine, lactobacillus fermentation lysate, porphyra umbilicalis extract, lentil seed extract;
70-99.5% of a cosmetic adjuvant matrix comprising: emollient, emulsifier, filler, thickener, antiseptic, pH regulator, daily essence and deionized water.
Further, the speckle-lightening and brightness-improving functional component comprises the following components in proportion by total weight of the composition:
0.05-6% of undecylenoyl phenylalanine, 0.1-6% of lactobacillus fermentation lysate, 0.1-6% of Porphyra umbilicalis extract, and 0.2-4.5% of lentil seed extract.
Preferably, the spot-fading and brightness-improving functional component comprises the following components in proportion by total weight of the composition:
0.1-5% of undecylenoyl phenylalanine, 0.1-5.5% of lactobacillus fermentation lysate, 1-4.5% of laver umbilicus extract, and 0.5-4.5% of lentil seed extract.
Further, the cosmetic auxiliary material matrix consists of the following components:
3.0-27.0% of an emollient; 3-22.0% of emulsifier; 0.1-11.0% of a filler; 0.1-13.0% of a thickening agent; 0.1-8.0% of preservative; 0.01-0.7% of pH regulator; 0.01-0.7% of daily essence; the balance being deionized water.
Preferably, the cosmetic adjuvant matrix consists of:
6.0-10.0% of an emollient; 3-10.0% of emulsifier; 2-8% of a filler; 2-9% of a thickening agent; 0.5-2.0% of preservative; 0.07-0.6% of pH regulator; 0.05-0.5% of daily essence; the balance being deionized water.
Further, the spot-fading and brightening functional components comprise the following components in percentage by mass based on the total weight of the composition:
undecylenoyl phenylalanine: lactic acid bacteria fermentation lysate: the laver extract of umbilicus shape: lentil seed extract 1: (0.5-2): (0.4-1.6): (0.5 to 1).
Further, the extraction method of the laver umbilicus extract comprises the following steps:
1) cleaning and drying the laver umbilicus, and grinding for later use;
2) putting the ground powder into propylene glycol according to a material-liquid ratio of 1: (5-10) soaking for 5-15 hours after mixing;
3) carrying out ultrasonic treatment on the soak solution, wherein the ultrasonic temperature is 30-50 ℃; the ultrasonic treatment time is 20-60 min; the ultrasonic power is 300-800W;
4) filtering the liquid after ultrasonic treatment, continuously performing ultrasonic extraction and filtration on filter residues according to the step 3), mixing the filtrates obtained in the two steps, and concentrating under reduced pressure to obtain the laver umbiliciformis extract.
Further, the extraction method of the fenugreek seed extract comprises the following steps:
1) cleaning lentil seeds and then placing the lentil seeds in a vacuum drying box for drying for later use;
2) taking the dried lentil seeds, and carrying out reflux degreasing on the lentil seeds for 4 to 8 hours by using ethanol at the temperature of 60 ℃;
3) filtering the liquid in the step 2), collecting residues, draining the solvent under reduced pressure, and then adding a solvent into the mixture in a ratio of 1: (5-10) continuing to add 80% ethanol, carrying out ultrasonic treatment for 2 times, combining the filtrates obtained in the two times, concentrating, and then adding a solvent with a volume ratio of 1: (4-8) precipitating with 95% ethanol;
4) standing for 24h, vacuum filtering, further washing, purifying, and drying to obtain lentil seed extract.
Further, the method for preparing the lactobacillus fermentation lysate comprises the following steps:
1) mixing the lactobacillus strains in a proportion of 1: (5-10) carrying out expanding culture in a seed culture medium according to the volume ratio;
2) mixing the lactobacillus expanded and cultured in the step 1) in a ratio of 1: (5-10) inoculating the mixture to a fermentation culture medium based on a constant-temperature shaking table for fermentation to obtain a fermentation liquid; the fermentation temperature is 37 ℃, the rotating speed of a shaking table is 50-200r/min, and the fermentation time is 5-12 h;
3) carrying out ultrasonic treatment on the fermentation liquor obtained in the step 2) for 10-30min by using a cell ultrasonic crusher, centrifuging at the centrifugal rotation speed of 10000r/min, and taking supernate to remove filter residues;
4) sterilizing the supernatant obtained in the step 3) at high temperature of 95 ℃ for 10-30min to obtain the lactobacillus fermentation lysate.
Further, the emollient is selected from one or more of squalane, avocado oil, shea butter, cetyl esters, jojoba oil, glycerol, butylene glycol, propylene glycol, glycerol, dimethicone, hexyldecanol, dimethiconol, isopropyl palmitate, phytosterols, capric triglyceride, lauryl alcohol, hydrogenated polyisobutene, rapeseed oil, polydecene, soybean oil, grapeseed oil, isononyl isononanoate, ethylhexyl isononanoate, isohexadecane, isopropyl myristate, behenyl alcohol;
the emulsifier is selected from one or more of behenyl alcohol polyether-25, sucrose stearate, sorbitan olive oleate, polysorbate-20, laureth-23, polysorbate-80, potassium dodecyl phosphate, lecithin, poloxamer 407, glyceryl stearate, and ceteareth-25;
the filler is selected from one or more of diatomite, mica powder, aluminum octyl starch succinate, boron nitride, kaolin and talcum powder;
the thickening agent is selected from one or more of carboxymethyl cellulose, xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, ammonium acryloyldimethyl taurate/VP copolymer, aminomethyl propanol, polyacrylamide, sodium polyacrylate, gum arabic, carbomer, agar, sodium hyaluronate, starch, gelatin, pectin and carrageenan;
the preservative is selected from one or more of phenoxyethanol, ethylhexyl glycerol, caprylyl glycol, chlorphenesin, propylene glycol and sodium benzoate;
the pH regulator is one or more of arginine and lactic acid.
The preparation method of the essence milk composition with the speckle-lightening and brightening effects comprises the following steps:
1) wetting and completely dispersing the thickening agent in water to obtain a mixed solution;
2) adding spot-lightening and brightening functional components, an emollient, a filler, a preservative and a pH regulator into the mixed solution obtained in the step 1), heating to 65 ℃, and homogenizing at 3000r/min for 3 minutes to completely disperse the components;
3) adding an emulsifier and a daily essence into the step 2), homogenizing at 3000r/min for 3 minutes to completely emulsify the mixture, and heating to 65 ℃ to obtain the essence emulsion composition with the effects of lightening spots and brightening.
A cosmetic comprises the essence milk composition with the speckle-lightening and brightening effects prepared by the preparation method.
Specifically, the essence milk composition with the spot-lightening and brightening effects is a skin care product, is mainly used for essence milk, and can be in a solvent dispersion or suspension mode, an emulsified particle mode or a polymer coating mode.
By means of the technical scheme, the invention has the following beneficial effects:
1) the innovative spot-lightening and brightening functional components mainly comprise: undecylenoyl phenylalanine, lactobacillus fermentation lysate, laver umbilicalis extract, lentil seed extract. The four functional components are compounded at the same time, so that the generation of melanin can be inhibited, the deposition of the melanin is reduced, the metabolism of epidermis is increased, the regeneration of skin is promoted, the dark yellow and dim skin is improved, future spots and spots in formation are prevented or reduced, and the purposes of homogenizing the skin color, brightening the skin and improving the energy and spirit of people are achieved.
2) The invention discloses innovative spot-lightening efficacy components, and simultaneously solves the problem of spot formation from the source by compounding and using, the undecylenoyl phenylalanine can effectively inhibit the generation of melanin, and the lactobacillus fermentation lysate, the navy laver extract and the lentil seed extract can accelerate the renewal and repair of the skin, so that the skin becomes finer, softer, rich in luster and dark yellow to improve the skin.
Drawings
FIG. 1 is a plaque lightening ingredient efficacy test;
FIG. 2 is a graph of skin tone patch density change rate after 56 days using the serum dairy product of example 1;
fig. 3 is a graph of the uniform rate of change of skin tone after 56 days using the serum dairy product of example 1;
FIG. 4 is a graph of the rate of change of stain visibility after 56 days using the serum dairy product of example 1;
fig. 5 shows the results of the synergy test.
Detailed Description
The invention discloses an essence milk composition with the effects of lightening spots and brightening and a preparation method thereof. The essential milk composition mainly comprises the components for lightening spots: undecylenoyl phenylalanine, lactobacillus fermentation lysate, laver umbilicus extract, lentil seed extract, which has effects of inhibiting melanin production and enhancing stratum corneum metabolism. Through the preferred combination and efficacy test, the most preferred composition ratio is found to achieve synergistic efficacy in improving skin stains, dullness and the like.
Wherein, the undecylenoyl phenylalanine is a melanocyte stimulating hormone (alpha-MSH) receptor antagonist, controls the combination of the antagonist on melanin generating factors, can effectively inhibit the activity of the tyrosinase, reduces the generation of melanin from the source, thereby reducing the deposition of skin pigment, improving color spots, brightening the color of the skin, and simultaneously can prevent or reduce future color spots and color spots in formation.
The lactobacillus fermentation lysate promotes the growth and renewal of the skin, improves the quality of the skin, maintains and repairs the barrier function of the skin, promotes the cell binding force and promotes the exfoliation of the keratin. Because the stratum corneum cells have a 28-day metabolic cycle, melanin generated in the skin cannot be always deposited on the surface of the skin and gradually falls off along with the metabolism of the stratum corneum, and the lactobacillus fermentation lysate can effectively promote the desquamation process and remove old and accumulated keratinocytes.
The main functions of the laver extract are to make the epidermis soft and bright, improve the skin darkness caused by dry skin, supplement lipid for the skin, repair the epidermis, rebuild the skin lipid film and reduce the water loss. In addition, the Porphyra umbilicalis extract can promote the penetration of other components into the skin due to its high permeability. The laver extract can not only improve the moisture of skin, but also improve the metabolism of skin.
The lentil seed extract has the main functions of restoring the normal keratinization process of the skin, stimulating the replacement of stratum corneum cells, preventing the hardening of peripheral tissues, shrinking large pores, improving the texture of the skin, enabling the skin to look smoother and finer, enabling the skin to be more uniform in color and enabling the skin to be more shiny.
The present invention is illustrated by the following examples, which are provided for the purpose of further illustration only and are not intended to limit the scope of the present invention. Other insubstantial modifications and adaptations of the present invention can be made without departing from the scope of the present invention.
Unless otherwise specified, the following percentages (%) are mass percentages. All the raw material components of the invention are commercial products.
Examples 1 to 3
The essential milk composition with the effects of lightening spots and brightening the skin comprises the following raw material components in percentage by weight as shown in table 1.
TABLE 1 raw material component ratios (% by mass) of examples 1 to 3
The preparation process of the essential milk composition with spot-lightening function of the embodiment 1 comprises the following steps:
1) extracting the laver umbilicalis extract:
cleaning and drying 20g of umbilicus laver, and grinding for later use; putting the ground powder into propylene glycol according to a material-liquid ratio of 1: 5, soaking for 12 hours after mixing; carrying out ultrasonic treatment on the soak solution, wherein the ultrasonic temperature is 30 ℃; the ultrasonic treatment time is 30 min; the ultrasonic power is 500W; filtering the liquid after ultrasonic treatment, continuously performing ultrasonic extraction and filtration on filter residues, mixing the filtrates obtained in the two steps, and concentrating under reduced pressure to obtain the laver umbiliciformis extract.
Extracting the fenugreek seed extract:
cleaning 12g lentil seeds, and drying in a vacuum drying oven for later use; taking the dried lentil seeds, and carrying out reflux degreasing on the lentil seeds for 5 hours by using ethanol at the temperature of 60 ℃; the liquid was filtered, the residue collected and the solvent was drained under reduced pressure and the residue was washed with 1: 8, continuously adding 80% ethanol, carrying out ultrasonic treatment for 2 times, combining the filtrates obtained in the two times, concentrating, and then adding a solvent with a volume ratio of 1: 6, precipitating by 95% ethanol; standing for 24h, and performing suction filtration; and further washing, purifying and drying the substances obtained by suction filtration to obtain the lentil seed extract.
Preparation of lactic acid bacteria fermentation lysate:
mixing the lactobacillus strains in a proportion of 1: 8, carrying out expanding culture in a seed culture medium according to the volume ratio; expanding cultured lactobacillus according to the proportion of 1: 8, inoculating the mixture to a constant-temperature shaking table for fermentation to obtain fermentation liquor; the fermentation temperature is 37 ℃, the rotating speed of a shaking table is 120r/min, and the fermentation time is 10 h; subjecting the obtained fermentation liquor to ultrasonic treatment for 20min by using a cell ultrasonic crusher, centrifuging at a centrifugal rotation speed of 10000r/min, and taking supernate to remove filter residue; and (3) sterilizing the obtained supernatant at high temperature of 95 ℃ for 20min to obtain the lactobacillus fermentation lysate.
2) Wetting and completely dispersing the thickening agent in water to obtain a mixed solution;
3) adding 1 part of undecylenoyl phenylalanine to the mixed solution in the step 2); 1 part of a lactic acid bacteria fermentation lysate; 1.5 parts of a laver umbilicus extract; 1 part lentil seed extract;
4) adding an emollient, a filler, a preservative and a pH regulator into the mixed solution obtained in the step 3), heating to 65 ℃, and homogenizing at 3000r/min for 3 minutes to completely disperse the mixed solution;
5) adding an emulsifier and a daily essence into the step 4), homogenizing at 3000r/min for 3 minutes to completely emulsify the mixture, and heating to 65 ℃ to obtain the essence emulsion composition with the effects of lightening spots and brightening.
The preparation process of the essential milk composition with spot-lightening function of the embodiment 2 comprises the following steps:
1) extracting the laver umbilicalis extract:
cleaning and drying 40g of the laver umbilicus, and grinding for later use; putting the ground powder into propylene glycol according to a material-liquid ratio of 1: 10, and soaking for 15 hours; carrying out ultrasonic treatment on the soak solution, wherein the ultrasonic temperature is 40 ℃; the ultrasonic treatment time is 60 min; the ultrasonic power is 800W; filtering the liquid after ultrasonic treatment, continuously performing ultrasonic extraction and filtration on filter residues, mixing the filtrates obtained in the two steps, and concentrating under reduced pressure to obtain the laver umbiliciformis extract.
Extracting the fenugreek seed extract:
cleaning 36g lentil seeds, and drying in a vacuum drying oven for later use; taking the dried lentil seeds, and carrying out reflux degreasing on the lentil seeds for 8 hours by using ethanol at the temperature of 60 ℃; the liquid was filtered, the residue collected and the solvent was drained under reduced pressure and the residue was washed with 1: 10, continuously adding 80% ethanol, carrying out ultrasonic treatment for 2 times, combining the filtrates obtained in the two times, concentrating, and then adding a solvent with the volume ratio of 1: 8 in 95% ethanol. Standing for 24h, and performing suction filtration; and further washing, purifying and drying the substances obtained by suction filtration to obtain the lentil seed extract.
Preparation of lactic acid bacteria fermentation lysate:
mixing the lactobacillus strains in a proportion of 1: 10 volume ratio in the seed culture medium for expanding culture; expanding cultured lactobacillus according to the proportion of 1: inoculating the mixture with the volume ratio of 10 into a constant-temperature shaking table for fermentation to obtain fermentation liquor; the fermentation temperature is 37 ℃, the rotating speed of a shaking table is 150r/min, and the fermentation time is 12 h; subjecting the obtained fermentation liquor to ultrasonic treatment for 30min by using a cell ultrasonic crusher, centrifuging at a centrifugal rotation speed of 10000r/min, and taking supernate to remove filter residue; and (3) sterilizing the obtained supernatant at high temperature of 95 ℃ for 30min to obtain the lactobacillus fermentation lysate.
2) Wetting and completely dispersing the thickening agent in water to obtain a mixed solution;
3) adding 2 parts of undecylenoyl phenylalanine to the mixed solution of the step 2); 3 parts of a lactic acid bacteria fermentation lysate; 3 parts of a laver umbilicus extract; 2 parts lentil seed extract;
4) adding an emollient, a filler, a preservative and a pH regulator into the mixed solution obtained in the step 3), heating to 65 ℃, and homogenizing at 3000r/min for 3 minutes to completely disperse the mixed solution;
5) adding an emulsifier and a daily essence into the step 4), homogenizing at 3000r/min for 3 minutes to completely emulsify the mixture, and heating to 65 ℃ to obtain the essence emulsion composition with the effects of lightening spots and brightening.
The preparation process of the essential milk composition with spot-lightening function of the embodiment 3 comprises the following steps:
1) extracting the laver umbilicalis extract:
cleaning and drying 12g of laver umbilicus, and grinding for later use; putting the ground powder into propylene glycol according to a material-liquid ratio of 1: 6, soaking for 8 hours after mixing; carrying out ultrasonic treatment on the soak solution, wherein the ultrasonic temperature is 30 ℃; the ultrasonic treatment time is 20 min; the ultrasonic power is 400W; filtering the liquid after ultrasonic treatment, continuously performing ultrasonic extraction and filtration on filter residues, mixing the filtrates obtained in the two steps, and concentrating under reduced pressure to obtain the laver umbiliciformis extract.
Extracting the fenugreek seed extract:
cleaning 10g lentil seeds, and drying in a vacuum drying oven for later use; taking the dried lentil seeds, and carrying out reflux degreasing on the lentil seeds for 4 hours by using ethanol at the temperature of 60 ℃; the liquid was filtered, the residue collected and the solvent was drained under reduced pressure and the residue was washed with 1: 9, adding 80% ethanol, carrying out ultrasonic treatment for 2 times, combining the filtrates obtained in the two times, concentrating, and then adding a solvent with a volume ratio of 1: 4 by 95% ethanol precipitation. Standing for 24h, and performing suction filtration; and further washing, purifying and drying the substances obtained by suction filtration to obtain the lentil seed extract.
Preparation of lactic acid bacteria fermentation lysate:
mixing the lactobacillus strains in a proportion of 1: 5, carrying out expanding culture in a seed culture medium according to the volume ratio; expanding cultured lactobacillus according to the proportion of 1: 5 is inoculated to a constant-temperature shaking table for fermentation to obtain fermentation liquor; the fermentation temperature is 37 ℃, the rotating speed of a shaking table is 100r/min, and the fermentation time is 8 h; subjecting the obtained fermentation liquor to ultrasonic treatment for 10min by using a cell ultrasonic crusher, centrifuging at a centrifugal rotation speed of 10000r/min, and taking supernate to remove filter residue; and (3) sterilizing the obtained supernatant at high temperature of 95 ℃ for 10min to obtain the lactobacillus fermentation lysate.
2) Wetting and completely dispersing the thickening agent in water to obtain a mixed solution;
3) adding 1.2 parts of undecylenoyl phenylalanine to the mixture in step 2); 1.8 parts of a lactic acid bacteria fermentation lysate; 1.8 parts of a laver umbilicus extract; 1.2 parts lentil seed extract; (ii) a
4) Adding an emollient, a filler, a preservative and a pH regulator into the mixed solution obtained in the step 3), heating to 65 ℃, and homogenizing at 3000r/min for 3 minutes to completely disperse the mixed solution;
5) adding an emulsifier and a daily essence into the step 4), homogenizing at 3000r/min for 3 minutes to completely emulsify the mixture, and heating to 65 ℃ to obtain the essence emulsion composition with the effects of lightening spots and brightening.
Test example for Effect verification
1. Safety test
Test samples: example 1;
the test method comprises the following steps: and (4) testing the safety by adopting a third-party detection mechanism. The selection area is not more than 50mm2And a suitable patch device having a depth of about 1mm, wherein about 0.02 to about 0.025ml (g) of the test substance is applied to the patch device in a closed patch test. The patch tester is attached to the curved side of the forearm of the subject, the subject is removed 24h later, the skin reaction is observed 0.5h, 24h and 48h after removal, and the result is recorded according to the skin reaction grading standard in the technical regulation for cosmetic safety 2015.
TABLE 2 Patch test results
Remarking: grading standard of skin reaction;
level 0: negative reaction;
level 1: carrying out suspicious reaction; only faint erythema;
and 2, stage: weak positive reaction (erythema reaction); erythema, infiltration, edema, and possibly papules;
and 3, level: strong positive reaction (herpes reaction); erythema, infiltration, edema, pimples, herpes; the reaction may be beyond the test area;
4, level: very strong response (fusional herpes response); erythema, severe infiltration, edema, fusional herpes, and response beyond the test area.
As can be seen from table 2 above, the prepared essence milk showed no irritation and passed safety.
2. Stability test
Test samples: example 1;
the test method comprises the following steps: and (5) observing the appearance color, viscosity and pH value for three months according to internal control standard.
Table 3 stability test results
| Time | 45℃ | 40℃ | 37℃ | 25℃ | 5℃ | -15℃ | CYCLE | Illumination of light |
| 1W | √ | √ | √ | √ | √ | √ | √ | √ |
| 2W | √ | √ | √ | √ | √ | √ | √ | √ |
| 3W | √ | √ | √ | √ | √ | √ | √ | √ |
| 4W | √ | √ | √ | √ | √ | √ | √ | √ |
| 2M | √ | √ | √ | √ | √ | √ | √ | √ |
| 3M | √ | √ | √ | √ | √ | √ | √ | √ |
From the above table 3, the prepared essence milk has no significant changes in color, viscosity and pH value within three months under high and low temperature or illumination conditions, which indicates that the essence milk has better stability.
3. Efficacy test of lightening ingredient
Test samples: the spot-lightening efficacy-enhancing composition of example 1 (1% undecylenoyl phenylalanine, 1% lactic acid bacteria fermentation lysate, 1.5% porphyra umbilicalis extract, 1% lentil seed extract).
The test method comprises the following steps: 60 volunteers were divided into two groups, a sample group and a control group (2% ascorbyl glucoside) were applied to the whole face 2 times a day for 84 days. The change in the melanin particle content of the skin before and after the use of the sample was measured.
And (3) testing results: as shown in figure 1, the pigmentation of the pigmented spots of the volunteers is effectively improved, and the content of melanin is effectively reduced by 13% by using the spot-lightening component on the 84 th day, which indicates that the prepared spot-lightening efficacy composition can remarkably reduce the melanin deposition of the pigmented spots and achieve the effect of lightening the pigmented spots.
4. Evaluation of lightening effect of essence milk
Test samples: example 1; the control group was without the test product.
The test method comprises the following steps: the samples were used twice daily, morning and evening, and tried for 8 weeks. Randomly selecting one side part to be coated with a proper amount of test samples, using no test sample as a control at the other side, using the test samples once in the morning and at night, and using the sunscreen product to coat the whole face every morning without replacing the used part in the midway of the experiment.
The results were tested at the following 4 time periods, respectively:
before use of the sample (D0), after use of the sample for 14 days (D14), after use of the sample for 28 days (D28) and after use of the sample for 56 days (D56).
The detection items are as follows: clinical evaluation by dermatologist.
Evaluation criteria:
1) density of color spots: according to Asian human skin aging spectrum, grade 0-7;
2) degree of color spot visibility: score 0 indicates many visible spots, score 9 indicates no spots on the skin;
3) uniform skin color: score 0 indicates inconsistent skin color, mottle, inconsistent color, different pigmentation of skin color, score 9 indicates consistent skin color, uniform and harmonious color.
As shown in fig. 2-4 and tables 4-6, which are clinical evaluation results of dermatologists, clinical evaluation analysis of target sites of subjects after using the samples for 56 days can obtain that the average value of the stain density clinical scores in the sample areas is significantly reduced by 15.02%; the mean value of the clinical scores of the skin color evenness of the sample area is remarkably increased by 34.55%; the mean clinical score for the extent of stain visualization in the sample area was significantly increased by 34.86%. The invention is demonstrated to have good ability to improve skin stains and even skin tone.
TABLE 4 rate of change of density of color spots
| Time | After 14 days of use | After 28 days of use | After 56 days of use |
| Sample (I) | -6.26％ | -9.39％ | -15.02％ |
| Control | -0.79％ | -0.62％ | -5.19％ |
TABLE 5 Uniform Rate of Change of skin color
| Time | After 14 days of use | After 28 days of use | After 56 days of use |
| Sample (I) | 18.18％ | 27.27％ | 34.55％ |
| Control | 4.46％ | 10.71％ | 16.07％ |
TABLE 6 rate of change of color spot visibility
| Time | After 14 days of use | After 28 days of use | After 56 days of use |
| Sample (I) | 21.10％ | 27.52％ | 34.86％ |
| Control | 5.31％ | 9.73％ | 17.70％ |
5. Synergistic experiment of spot-lightening composition
An essence milk composition for lightening spots and brightening the eyes is prepared into essence milk, and the raw material components of the essence milk comprise the following components in percentage by weight as shown in the following tables 7-8.
TABLE 7 proportion of the components of the essence milk for lightening spots in comparative examples 1 to 7 (unit: mass%)
TABLE 8 proportioning of the components of the spot-lightening essence milks of comparative examples 8 to 14 (unit: mass%)
The preparation process of the spot-lightening essence milk of the comparative example is the same as that of the example 1.
The effect of example 1 and comparative examples 1 to 14 of the synergistic effect test of the spot-lightening composition (spot-lightening effect) was verified, and the test procedure and results were as follows:
1. the tester: 150 healthy women (25-45 years old) divided into 15 groups of 10 persons each; each group used the same formulation.
2. Test area: a face;
3. use of: twice a day in the morning and evening for 8 weeks
4. Testing an instrument:
CR400 for detecting skin color
5. Testing indexes are as follows: measuring the change in color lightness (. DELTA.L)*)：ΔL*＝[L*(after 8 weeks of testing of the control or example products) -L*(before starting the test)]-[L*(blank product tested for 8 weeks) -L*(before starting the test)]
6. The test effects are shown in table 9 below.
TABLE 9 test group Effect
As can be seen from the results of fig. 5 and table 9, example 1 has the best spot-fading ability as compared with comparative examples 1 to 14. This demonstrates that the selected composition has synergistic speckle-reducing ability, which not only can inhibit the generation of melanin from the source, but also can promote the metabolism and renewal of epidermis to prevent the accumulation of melanin, and make the skin fine, soft and glossy.
Meanwhile, the invention does not generate any stimulation to human skin, has wide use population, can effectively improve the problems of skin color spots, dullness and the like when being prepared and applied to the essential milk, and is a product with higher cost performance.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.
Claims (10)
1. The essence milk composition with the effects of lightening spots and brightening is characterized by comprising the following components in parts by weight:
0.5-30% of spot-fading and brightening functional components, which comprise: 0.05-6% of undecylenoyl phenylalanine, 0.1-6% of lactobacillus fermentation lysate, 0.1-6% of laver umbilicus extract, and 0.2-4.5% of lentil seed extract;
70-99.5% of a cosmetic adjuvant matrix comprising: emollient, emulsifier, filler, thickener, antiseptic, pH regulator, daily essence and deionized water.
2. The essence milk composition with the spot-fading and brightening effects as claimed in claim 1, wherein the spot-fading and brightening effects component comprises the following components in proportion by total weight of the composition:
0.1-5% of undecylenoyl phenylalanine, 0.1-5.5% of lactobacillus fermentation lysate, 1-4.5% of laver umbilicus extract, and 0.5-4.5% of lentil seed extract.
3. The essential milk composition with the spot-lightening and brightening effects as claimed in claim 1, wherein the cosmetic adjuvant base is composed of the following components by weight of the total composition:
3.0-27.0% of an emollient; 3-22.0% of emulsifier; 0.1-11.0% of a filler; 0.1-13.0% of a thickening agent; 0.1-8.0% of preservative; 0.01-0.7% of pH regulator; 0.01-0.7% of daily essence; the balance being deionized water.
4. The essential milk composition with the spot-lightening and brightening effects as claimed in claim 1, wherein the cosmetic adjuvant base is composed of the following components by weight of the total composition:
6.0-10.0% of an emollient; 3-10.0% of emulsifier; 1-8% of a filler; 2-9% of a thickening agent; 0.5-2.0% of preservative; 0.07-0.6% of pH regulator; 0.05-0.5% of daily essence; the balance being deionized water.
5. The essence milk composition with the spot-fading and brightening effects as claimed in claim 1, wherein the spot-fading and brightening effects comprise the following components in parts by mass:
undecylenoyl phenylalanine: lactic acid bacteria fermentation lysate: the laver extract of umbilicus shape: lentil seed extract 1: (0.5-2): (0.4-1.6): (0.5 to 1).
6. The essence milk composition with the spot-fading and brightening effects as claimed in claim 5, wherein the extraction method of the laver umbilicalis extract comprises the following steps:
1) cleaning and drying the laver umbilicus, and grinding for later use;
2) putting the ground powder into propylene glycol according to a material-liquid ratio of 1: (5-10) soaking for 5-15 hours after mixing;
3) carrying out ultrasonic treatment on the soak solution, wherein the ultrasonic temperature is 30-50 ℃; the ultrasonic treatment time is 20-60 min; the ultrasonic power is 300-800W;
4) filtering the liquid after ultrasonic treatment, continuously performing ultrasonic extraction and filtration on filter residues according to the step 3), mixing the filtrates obtained in the two steps, and concentrating under reduced pressure to obtain the laver umbiliciformis extract.
7. The essence milk composition with spot-lightening and brightening effects as claimed in claim 5, wherein the extraction method of the extract of fenugreek seeds comprises the following steps:
1) cleaning lentil seeds and then placing the lentil seeds in a vacuum drying box for drying for later use;
2) taking the dried lentil seeds, and carrying out reflux degreasing on the lentil seeds for 4 to 8 hours by using ethanol at the temperature of 60 ℃;
3) filtering the liquid in the step 2), collecting residues, draining the solvent under reduced pressure, and then performing filtration on the residues in a ratio of 1: (5-10) continuing to add 80% ethanol, carrying out ultrasonic treatment for 2 times, combining the filtrates obtained in the two times, concentrating, and then adding a solvent with a volume ratio of 1: (4-8) precipitating with 95% ethanol;
4) standing for 24h, vacuum filtering, washing, purifying, and drying to obtain lentil seed extract.
8. The essence milk composition with spot-lightening efficacy according to any one of claims 1 to 5, characterized in that:
the emollient is selected from one or more of squalane, avocado oil, shea butter, cetyl ester, jojoba oil, glycerol, butylene glycol, propylene glycol, glycerol, polydimethylsiloxane, hexyldecanol, dimethiconol, isopropyl palmitate, phytosterol, capric triglyceride, lauryl alcohol, hydrogenated polyisobutene, rapeseed oil, polydecene, soybean oil, grape seed oil, isononyl isononanoate, ethylhexyl isononanoate, isohexadecane, isopropyl myristate, and behenyl alcohol;
the emulsifier is selected from one or more of behenyl alcohol polyether-25, sucrose stearate, sorbitan olive oleate, polysorbate-20, laureth-23, polysorbate-80, potassium dodecyl phosphate, lecithin, poloxamer 407, glyceryl stearate, and ceteareth-25;
the filler is selected from one or more of diatomite, mica powder, aluminum octyl starch succinate, boron nitride, kaolin and talcum powder;
the thickening agent is selected from one or more of carboxymethyl cellulose, xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, ammonium acryloyldimethyl taurate/VP copolymer, aminomethyl propanol, polyacrylamide, sodium polyacrylate, gum arabic, carbomer, agar, sodium hyaluronate, starch, gelatin, pectin and carrageenan;
the preservative is selected from one or more of phenoxyethanol, ethylhexyl glycerol, caprylyl glycol, chlorphenesin, propylene glycol and sodium benzoate;
the pH regulator is one or more of arginine and lactic acid.
9. The method for preparing the essence milk composition having the spot-lightening and brightening effects of any one of claims 1 to 8, characterized in that: the method comprises the following steps:
1) wetting and completely dispersing the thickening agent in water to obtain a mixed solution;
2) adding spot-lightening and brightening functional components, an emollient, a filler, a preservative and a pH regulator into the mixed solution obtained in the step 1), heating to 65 ℃, and homogenizing at 3000r/min for 3 minutes to completely disperse the components;
3) adding an emulsifier and a daily essence into the step 2), homogenizing at 3000r/min for 3 minutes to completely emulsify the mixture, and heating to 65 ℃ to obtain the essence emulsion composition with the effects of lightening spots and brightening.
10. A cosmetic characterized by: the cosmetic comprises the essence milk composition with the spot-lightening and brightening effects prepared by the preparation method of claim 9;
the cosmetic is in the form of a solvent dispersion or suspension, or in the form of emulsified particles, or in the form of a polymer coating.
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| CN104644511A (en) * | 2015-03-10 | 2015-05-27 | 广州市白云联佳精细化工厂 | Sunscreen cosmetic composition and method for preparing seaweed sunscreen components of composition |
| CN106727149A (en) * | 2017-01-04 | 2017-05-31 | 广州聚澜健康产业研究院有限公司 | A kind of gentle makeup remover of compacting |
| CN112263524A (en) * | 2020-11-27 | 2021-01-26 | 湖北省麦诗特生物科技有限公司 | Cosmetic composition with multiple skin care effects and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104644511A (en) * | 2015-03-10 | 2015-05-27 | 广州市白云联佳精细化工厂 | Sunscreen cosmetic composition and method for preparing seaweed sunscreen components of composition |
| CN106727149A (en) * | 2017-01-04 | 2017-05-31 | 广州聚澜健康产业研究院有限公司 | A kind of gentle makeup remover of compacting |
| CN112263524A (en) * | 2020-11-27 | 2021-01-26 | 湖北省麦诗特生物科技有限公司 | Cosmetic composition with multiple skin care effects and preparation method thereof |
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