CN113767089B - 伐度司他中间体的制造方法 - Google Patents

伐度司他中间体的制造方法 Download PDF

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Publication number
CN113767089B
CN113767089B CN202080031146.6A CN202080031146A CN113767089B CN 113767089 B CN113767089 B CN 113767089B CN 202080031146 A CN202080031146 A CN 202080031146A CN 113767089 B CN113767089 B CN 113767089B
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reaction
mol
formula
compound
reactor
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CN113767089A (zh
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町田康士
安河内宏昭
西山章
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Kaneka Corp
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Kaneka Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
CN202080031146.6A 2019-04-26 2020-03-05 伐度司他中间体的制造方法 Active CN113767089B (zh)

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JP2019-086759 2019-04-26
JP2019086759 2019-04-26
PCT/JP2020/009453 WO2020217733A1 (ja) 2019-04-26 2020-03-05 Ｖａｄａｄｕｓｔａｔ中間体の製造方法

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CN113767089A CN113767089A (zh) 2021-12-07
CN113767089B true CN113767089B (zh) 2024-06-11

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US (1) US12134600B2 (https=)
JP (1) JP7470106B2 (https=)
CN (1) CN113767089B (https=)
WO (1) WO2020217733A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021117767A1 (ja) * 2019-12-10 2021-06-17 田辺三菱製薬株式会社 含窒素ヘテロアリールカルボキサミド酢酸誘導体の製造方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1107144A (zh) * 1993-11-02 1995-08-23 赫彻斯特股份公司 取代的杂环羧酰胺酯，它们的制备及它们作为药物的用途
CN101506149A (zh) * 2006-06-26 2009-08-12 宝洁公司 脯氨酰羟化酶抑制剂及使用方法
WO2011143419A1 (en) * 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Pyrazines useful as inhibitors of atr kinase
CN103717575A (zh) * 2011-06-06 2014-04-09 阿克比治疗有限公司 用于制备[(3-羟基吡啶-2-羰基)氨基]链烷酸、酯和酰胺的方法
CN105837502A (zh) * 2016-04-05 2016-08-10 湖南欧亚生物有限公司 一种Vadadustat的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021117767A1 (ja) * 2019-12-10 2021-06-17 田辺三菱製薬株式会社 含窒素ヘテロアリールカルボキサミド酢酸誘導体の製造方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1107144A (zh) * 1993-11-02 1995-08-23 赫彻斯特股份公司 取代的杂环羧酰胺酯，它们的制备及它们作为药物的用途
CN101506149A (zh) * 2006-06-26 2009-08-12 宝洁公司 脯氨酰羟化酶抑制剂及使用方法
WO2011143419A1 (en) * 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Pyrazines useful as inhibitors of atr kinase
CN103717575A (zh) * 2011-06-06 2014-04-09 阿克比治疗有限公司 用于制备[(3-羟基吡啶-2-羰基)氨基]链烷酸、酯和酰胺的方法
CN105837502A (zh) * 2016-04-05 2016-08-10 湖南欧亚生物有限公司 一种Vadadustat的合成方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Palladium-catalyzed aminocarbonylation of heteroaryl halides using di-tert-butylphosphinoferrocene;Bo Qu，等;《Tetrahedron Letters》;第50卷;6126–6129 *

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WO2020217733A1 (ja) 2020-10-29
US12134600B2 (en) 2024-11-05
JP7470106B2 (ja) 2024-04-17
US20220204451A1 (en) 2022-06-30
JPWO2020217733A1 (https=) 2020-10-29
CN113767089A (zh) 2021-12-07

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