CN113730536A - Heat-clearing tumor-eliminating pain-relieving plaster and preparation method thereof - Google Patents
Heat-clearing tumor-eliminating pain-relieving plaster and preparation method thereof Download PDFInfo
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- CN113730536A CN113730536A CN202111164335.3A CN202111164335A CN113730536A CN 113730536 A CN113730536 A CN 113730536A CN 202111164335 A CN202111164335 A CN 202111164335A CN 113730536 A CN113730536 A CN 113730536A
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Abstract
The invention relates to the technical field of medicines, in particular to a heat-clearing tumor-eliminating pain-relieving plaster and a preparation method thereof. The heat-clearing tumor-eliminating pain-relieving plaster can play a role in clearing heat and removing toxicity, removing blood stasis and relieving pain, and softening hardness and dissipating stagnation, is used for treating various pains caused by heat in the disease of tumors, lumps and nodules, and is particularly suitable for patients with cancer pain caused by bone metastasis. The clinical observation shows that the pain relieving effect is remarkable, the effect can be achieved even if the traditional Chinese medicine composition is repeatedly used, the drug resistance is avoided, the life quality of patients is improved, the use frequency of antibiotics and the like in the treatment period is reduced, the hospitalization cost is reduced, and the traditional Chinese medicine composition has certain economic and social values and is worthy of popularization clinically.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a heat-clearing tumor-eliminating pain-relieving plaster and a preparation method thereof.
Background
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or a similar experience to this. Cancer pain occurs in a variety of malignancies, with about 50% of cancer patients experiencing varying degrees of cancer pain and about 75% of advanced cancer patients experiencing cancer pain. Active treatment of cancer pain is one of the 4 major points in the World Health Organization (WHO) with respect to the overall planning of cancer. Modern medicine for cancer pain usually adopts a three-step pain relieving scheme for treatment, and about 40 percent of patients still have cancer pain which cannot be effectively controlled. The long-term use of the analgesic can generate drug resistance, dependence and toxic and side effects. Clinical research shows that the traditional Chinese medicine external treatment method not only has better pain relieving effect on cancer, but also has light toxic and side effects and convenient use, and also has certain tumor control effect, so that the survival quality of patients is improved, and the survival period of the patients is prolonged. At present, the application of using Wuxiang pain-relieving ointment, Xiaopi pain-relieving ointment, Chanwu gel ointment and the like to treat cancer pain in clinic has certain curative effect, but the traditional Chinese medicine composition does not specially aim at cancer pain, mostly has warm medicine property and has poor control on heat syndrome pain. At present, no corresponding Chinese medicinal ointment prescription exists, the curative effect is single, and the clinical effect is unstable.
Disclosure of Invention
In order to solve the problems, the invention provides a heat-clearing tumor-eliminating pain-relieving plaster which has the functions of clearing heat, removing toxicity, removing blood stasis, relieving pain and softening hardness to dissipate stagnation, is used for treating various pains caused by heat in the disease property of tumors, lumps and nodules, and is particularly suitable for patients with cancer pain caused by bone metastasis.
In order to achieve the purpose, the invention adopts the technical scheme that: a patch for clearing heat, eliminating tumor and relieving pain comprises the following raw materials in parts by weight: 15-20 parts of rheum officinale, 15-20 parts of golden cypress, 15-20 parts of turmeric, 15-30 parts of barbed skullcap herb, 15-20 parts of angelica dahurica, 15-30 parts of spreading hedyotis herb, 15-20 parts of trichosanthes root, 15-20 parts of coptis chinensis, 15-30 parts of hibiscus leaf, 5-10 parts of borneol, 10-15 parts of honeysuckle, 10-15 parts of weeping forsythia, 15-20 parts of frankincense, 15-20 parts of myrrh, 10-15 parts of clove, 10 parts of scorpion and 470 parts of gel plaster substrate 315.
Preferably, the feed comprises the following raw materials in parts by weight: 15 parts of rhubarb, 15 parts of phellodendron, 15 parts of turmeric, 15 parts of sculellaria barbata, 15 parts of angelica dahurica, 15 parts of oldenlandia diffusa, 15 parts of trichosanthes root, 15 parts of coptis chinensis, 15 parts of hibiscus leaf, 5 parts of borneol, 10 parts of honeysuckle, 10 parts of forsythia, 15 parts of frankincense, 15 parts of myrrh, 10 parts of clove, 10 parts of scorpion and 315 parts of gel plaster substrate.
The application also provides a preparation method of the heat-clearing tumor-eliminating pain-relieving plaster, which comprises the following steps:
step 1: preparing a fluid extract: weighing 15-30 parts of hibiscus leaf, 15-30 parts of spreading hedyotis herb, 15-30 parts of barbed skullcap herb, 10-15 parts of honeysuckle and 10-15 parts of weeping forsythia through a water extraction method, and concentrating the liquid into a fluid extract;
step 2: preparing coarse powder: weighing 15-20 parts of rhubarb, 15-20 parts of phellodendron, 15-20 parts of turmeric, 15-20 parts of angelica dahurica, 15-20 parts of trichosanthes root, 15-20 parts of coptis, 5-10 parts of borneol, 15-20 parts of frankincense, 15-20 parts of myrrh, 10-15 parts of clove and 10 parts of scorpion according to the weight part ratio, and crushing the raw materials into coarse powder;
and step 3: preparing fine powder: uniformly mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the mixture, and crushing the dried mixture into fine powder;
and 4, step 4: preparing a finished product: weighing 315-470 parts of the gel plaster matrix according to the weight part ratio, uniformly mixing the fine powder prepared in the step 3 with the gel plaster matrix, and preparing a finished product.
Preferably, the specific steps in step 1 are: weighing 15-30 parts of hibiscus leaves, 15-30 parts of spreading hedyotis herb, 15-30 parts of barbed skullcap herb, 10-15 parts of honeysuckle and 10-15 parts of weeping forsythia, adding water for extraction for 2-3 times, wherein the water addition amount is 6-10 times of the total weight of the medicinal materials, the extraction time is 1-3 hours each time, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active ingredient, namely the fluid extract.
Preferably, in the step 2, 15-20 parts of rhubarb, 15-20 parts of phellodendron bark, 15-20 parts of turmeric, 15-20 parts of angelica dahurica, 15-20 parts of trichosanthes root, 15-20 parts of coptis chinensis, 5-10 parts of borneol, 15-20 parts of frankincense, 15-20 parts of myrrh, 10-15 parts of clove and 10 parts of scorpion are weighed according to the parts by weight, and the raw materials are crushed by a crusher and sieved by a 60-80 mesh sieve to obtain coarse powder for later use.
Preferably, in step 3, the fluid extract prepared in step 1 is mixed with the coarse powder prepared in step 2, stirring is carried out for 10-30 minutes until the mixture is uniformly mixed, then the uniformly mixed mixture is dried for 5-10 minutes at 80-100 ℃ through a dryer, and then the dried mixture is crushed through a crusher and passes through a 100-mesh 150-mesh sieve, so as to obtain fine powder for later use.
Preferably, in the step 4, the mass ratio of the fine powder to the gel plaster matrix is 2:3, and the gel plaster matrix comprises sodium polyacrylate, dihydroxyaluminum glycinate, glycerol, azone and water, wherein the mass ratio of the sodium polyacrylate, the dihydroxyaluminum glycinate, the glycerol, the azone and the water is 288: 4: 660: 30: 2550.
the invention has the beneficial effects that: the heat-clearing tumor-eliminating pain-relieving plaster can play a role in clearing heat and removing toxicity, removing blood stasis and relieving pain, and softening hardness and dissipating stagnation, is used for treating various pains caused by heat in the disease of tumors, lumps and nodules, and is particularly suitable for patients with cancer pain caused by bone metastasis. The clinical observation shows that the pain relieving effect is remarkable, the effect can be achieved even if the traditional Chinese medicine composition is repeatedly used, the drug resistance is avoided, the life quality of patients is improved, the use frequency of antibiotics and the like in the treatment period is reduced, the hospitalization cost is reduced, and the traditional Chinese medicine composition has certain economic and social values and is worthy of popularization clinically.
Detailed Description
The invention relates to a heat-clearing tumor-eliminating pain-relieving plaster, which comprises the following raw materials in parts by weight: 15-20 parts of rheum officinale, 15-20 parts of golden cypress, 15-20 parts of turmeric, 15-30 parts of barbed skullcap herb, 15-20 parts of angelica dahurica, 15-30 parts of spreading hedyotis herb, 15-20 parts of trichosanthes root, 15-20 parts of coptis chinensis, 15-30 parts of hibiscus leaf, 5-10 parts of borneol, 10-15 parts of honeysuckle, 10-15 parts of weeping forsythia, 15-20 parts of frankincense, 15-20 parts of myrrh, 10-15 parts of clove, 10 parts of scorpion and 470 parts of gel plaster substrate 315.
The rhubarb is mainly used for treating: constipation due to excess heat; heat retention in the chest and fullness; dysentery due to damp-heat; jaundice; gonorrhea; edema and abdominal fullness; difficulty in urination; conjunctival congestion; swollen and sore throat; sores in the mouth and tongue; vomiting due to stomach heat; hematemesis; hemoptysis; bleeding; hematochezia; hematuria; storing blood; amenorrhea; postpartum abdominal pain due to stasis; the accumulation of symptoms; traumatic injury; carbuncles and ulcers due to heat toxin; erysipelas; scald.
Cortex Phellodendri is the dried bark of phellodendron amurense belonging to Rutaceae. Has the effects of clearing heat, eliminating dampness, purging fire, removing toxic substances, and removing bone-steaming. Can be used for treating leukorrhagia due to damp-heat, stranguria with astringency, dysentery due to damp-heat, jaundice, tinea pedis due to damp-heat, fistula, hectic fever due to yin deficiency, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, eczema, and pruritus.
Turmeric root tuber, rhizoma Curcumae Longae, has the actions of moving qi, removing blood stasis, dredging meridians and relieving pain. It can be used for treating abdominal distention and pain, shoulder pain, pain in arm, heart pain, puerperal blood pain, skin sore, tinea, menoxenia, amenorrhea, and traumatic injury. But also can extract yellow edible dye; the curcumin contained can be used as analytical chemical reagent.
The Chinese Lobelia herb, the whole herb, has the functions of clearing away heat and toxic material, promoting blood circulation to remove blood stasis, relieving swelling and pain, resisting cancer and the like. Is cold in nature and sour in taste, and the whole herb contains various vitamins, trace elements, amino acids and other components. Has the effects of cooling blood, removing toxic substances, removing blood stasis, relieving pain, relieving swelling, clearing heat and promoting diuresis.
The angelica dahurica has the functions of expelling wind-damp, promoting blood circulation, expelling pus, promoting granulation and relieving pain. Can be used for treating headache, toothache, nasosinusitis, hemorrhoid, leucorrhea with red and white discharge, carbuncle, cellulitis, pyocutaneous disease, and skin pruritus.
The herbs of Oldenlandia diffusa are bitter and bland in taste and cold in nature. The main effects are clearing away heat and toxic material, relieving pain and dissipating stagnation, and promoting urination and removing dampness. It is especially good at treating various types of inflammation. In clinical practice, the compatibility of the oldenlandia diffusa is found to be proper, which can cure various diseases. Herba Hedyotidis Diffusae, herba Clerodendranthi Spicati, herba Mesonae chinensis, herba Hedyotidis Diffusae, herba Serpentis , and herba Hedyotidis Diffusae.
The specific effects of the trichosanthes root are clearing heat and purging fire, promoting the production of body fluid to quench thirst, expelling pus and reducing swelling. The main indications are treating fever thirst, diabetes, jaundice, lung dryness hemoptysis, carbuncle and swelling and hemorrhoid flaccidity.
Huang Lian can clear heat and dry dampness, purge fire and remove toxicity. Can be used for treating damp-heat distention, fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, coma, excessive heart-fire, vexation, insomnia, hematemesis, hemorrhage, conjunctival congestion, toothache, diabetes, carbuncle, furuncle, etc.; it is used externally to treat eczema, eczema and purulent ear canal. Huang Lian (Chinese goldthread) processed with wine is good at clearing heat in upper energizer. It can be used for treating conjunctival congestion and aphtha. Jiang Huang Lian can clear stomach, harmonize stomach and stop vomiting. Can be used for treating cold and heat accumulation, damp-heat obstruction, fullness and emesis. Yu Huang Lian soothes liver, harmonizes stomach and stops vomiting. Can be used for treating liver and stomach disharmony, emesis and acid regurgitation.
Hibiscus mutabilis leaves have the curative effects of relieving swelling and expelling pus and are taken from Hibiscus mutabilis plants. The root, leaf and flower of it can be used as medicine, and has the effects of cooling blood, stopping bleeding, clearing away heat and toxic material, promoting blood circulation and relieving swelling.
Borneol can dredge orifices, dispel stagnated fire, remove nebula and improve eyesight, and relieve swelling and pain. It is indicated for wind stroke, vomiting, coma due to febrile disease, epilepsy due to convulsion, phlegm-phlegm, qi block, deafness, sore throat, aphtha, otitis media, carbuncle, swelling, hemorrhoid, nebula, and enterobiasis.
Honeysuckle has the main effects of clearing heat and removing toxicity and is mainly used for treating epidemic febrile disease, fever, heat-toxin bloody dysentery, carbuncle, cellulitis, furuncle and the like.
Fructus forsythiae and fructus forsythiae concentrated decoction have antibacterial effect in vitro, and can inhibit typhoid bacillus, paratyphoid bacillus, Escherichia coli, dysentery bacillus, diphtheria bacillus, Vibrio cholerae, staphylococcus, streptococcus, etc.
Frankincense, radix astragali, rhizoma arisaematis cum bile, rhizoma pinelliae, radix astragali, and radix astragali, radix. It is indicated for stagnation of qi and blood, pain in the heart and abdomen, carbuncle, sore, swelling and toxin, traumatic injury, dysmenorrhea, and puerperal pain due to blood stasis.
Mo Yao is indicated for stagnant pain in chest and abdomen, dysmenorrhea, amenorrhea, mass, traumatic injury, abscess, sores and ulcers, intestinal abscess, red eyes with swelling and pain. Has the effects of promoting blood circulation, relieving pain, eliminating swelling, promoting granulation, and removing blood stasis.
Flos Caryophylli has therapeutic effect on stomach cold, pain and distention, singultus, vomiting and diarrhea, arthralgia, hernia pain, halitosis, and toothache.
Quan Xie, extinguishing wind and relieving spasm, counteracting toxic pathogen and dissipating nodulation, unblocking collaterals and alleviating pain.
Preferably, the feed comprises the following raw materials in parts by weight: 15 parts of rhubarb, 15 parts of phellodendron, 15 parts of turmeric, 15 parts of sculellaria barbata, 15 parts of angelica dahurica, 15 parts of oldenlandia diffusa, 15 parts of trichosanthes root, 15 parts of coptis chinensis, 15 parts of hibiscus leaf, 5 parts of borneol, 10 parts of honeysuckle, 10 parts of forsythia, 15 parts of frankincense, 15 parts of myrrh, 10 parts of clove, 10 parts of scorpion and 315 parts of gel plaster substrate.
The application also provides a preparation method of the heat-clearing tumor-eliminating pain-relieving plaster, which comprises the following steps:
step 1: preparing a fluid extract: weighing 15-30 parts of hibiscus leaf, 15-30 parts of spreading hedyotis herb, 15-30 parts of barbed skullcap herb, 10-15 parts of honeysuckle and 10-15 parts of weeping forsythia through a water extraction method, and concentrating the liquid into a fluid extract;
step 2: preparing coarse powder: weighing 15-20 parts of rhubarb, 15-20 parts of phellodendron, 15-20 parts of turmeric, 15-20 parts of angelica dahurica, 15-20 parts of trichosanthes root, 15-20 parts of coptis, 5-10 parts of borneol, 15-20 parts of frankincense, 15-20 parts of myrrh, 10-15 parts of clove and 10 parts of scorpion according to the weight part ratio, and crushing the raw materials into coarse powder;
and step 3: preparing fine powder: uniformly mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the mixture, and crushing the dried mixture into fine powder;
and 4, step 4: preparing a finished product: weighing 315-470 parts of the gel plaster matrix according to the weight part ratio, uniformly mixing the fine powder prepared in the step 3 with the gel plaster matrix, and preparing a finished product.
Preferably, the specific steps in step 1 are: weighing 15-30 parts of hibiscus leaves, 15-30 parts of spreading hedyotis herb, 15-30 parts of barbed skullcap herb, 10-15 parts of honeysuckle and 10-15 parts of weeping forsythia, adding water for extraction for 2-3 times, wherein the water addition amount is 6-10 times of the total weight of the medicinal materials, the extraction time is 1-3 hours each time, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active ingredient, namely the fluid extract.
Preferably, in the step 2, 15-20 parts of rhubarb, 15-20 parts of phellodendron bark, 15-20 parts of turmeric, 15-20 parts of angelica dahurica, 15-20 parts of trichosanthes root, 15-20 parts of coptis chinensis, 5-10 parts of borneol, 15-20 parts of frankincense, 15-20 parts of myrrh, 10-15 parts of clove and 10 parts of scorpion are weighed according to the parts by weight, and the raw materials are crushed by a crusher and sieved by a 60-80 mesh sieve to obtain coarse powder for later use.
Preferably, in step 3, the fluid extract prepared in step 1 is mixed with the coarse powder prepared in step 2, stirring is carried out for 10-30 minutes until the mixture is uniformly mixed, then the uniformly mixed mixture is dried for 5-10 minutes at 80-100 ℃ through a dryer, and then the dried mixture is crushed through a crusher and passes through a 100-mesh 150-mesh sieve, so as to obtain fine powder for later use.
Preferably, in the step 4, the mass ratio of the fine powder to the gel plaster matrix is 2:3, and the gel plaster matrix comprises sodium polyacrylate, dihydroxyaluminum glycinate, glycerol, azone and water, wherein the mass ratio of the sodium polyacrylate, the dihydroxyaluminum glycinate, the glycerol, the azone and the water is 288: 4: 660: 30: 2550.
the present application provides specific preferred examples:
the first embodiment is as follows:
a patch for clearing heat, eliminating tumor and relieving pain comprises the following raw materials in parts by weight: 15 parts of rhubarb, 15 parts of phellodendron, 15 parts of turmeric, 15 parts of sculellaria barbata, 15 parts of angelica dahurica, 15 parts of oldenlandia diffusa, 15 parts of trichosanthes root, 15 parts of coptis chinensis, 15 parts of hibiscus leaf, 5 parts of borneol, 10 parts of honeysuckle, 10 parts of forsythia, 15 parts of frankincense, 15 parts of myrrh, 10 parts of clove, 10 parts of scorpion and 315 parts of gel plaster substrate.
Also provides a preparation method of the heat-clearing tumor-eliminating pain-relieving plaster, which comprises the following steps:
step 1: preparing a fluid extract: weighing 15 parts of hibiscus leaf, 15-30 parts of spreading hedyotis herb, 15 parts of barbed skullcap herb, 10 parts of honeysuckle and 10 parts of weeping forsythia according to the weight part ratio, adding water for extraction for 2 times, wherein the water adding amount is 6 times of the total weight of the medicinal materials, the extraction time is 1 hour each time, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active component, namely the fluid extract.
Step 2: preparing coarse powder: weighing 15 parts of rhubarb, 15 parts of phellodendron, 15 parts of turmeric, 15 parts of angelica dahurica, 15 parts of trichosanthes root, 15 parts of coptis, 5 parts of borneol, 15 parts of frankincense, 15 parts of myrrh, 10 parts of clove and 10 parts of scorpion according to the weight parts, crushing the raw materials by a crusher, and sieving the crushed raw materials by a 60-mesh sieve to obtain coarse powder for later use.
And step 3: preparing fine powder: and (3) mixing the fluid extract prepared in the step (1) with the coarse powder prepared in the step (2), stirring for 10 minutes until the mixture is uniformly mixed, drying the uniformly mixed mixture for 5 minutes at 80-100 ℃ by using a dryer, and crushing the dried mixture by using a crusher to obtain fine powder for later use, wherein the fine powder is sieved by a 100-mesh sieve.
And 4, step 4: preparing a finished product: weighing 315 parts of gel plaster matrix according to the weight part ratio, uniformly mixing the fine powder prepared in the step 3 with the gel plaster matrix, and preparing a finished product.
The second embodiment is as follows:
a patch for clearing heat, eliminating tumor and relieving pain comprises the following raw materials in parts by weight: 20 parts of rhubarb, 20 parts of phellodendron, 20 parts of turmeric, 30 parts of sculellaria barbata, 20 parts of angelica dahurica, 30 parts of oldenlandia diffusa, 20 parts of trichosanthes root, 20 parts of coptis, 30 parts of cotton rose leaf, 10 parts of borneol, 15 parts of honeysuckle, 15 parts of forsythia, 15-20 parts of frankincense, 20 parts of myrrh, 15 parts of clove, 10 parts of scorpion and 470 parts of gel plaster substrate.
Also provides a preparation method of the heat-clearing tumor-eliminating pain-relieving plaster, which comprises the following steps:
step 1: preparing a fluid extract: weighing 30 parts of hibiscus leaf, 30 parts of spreading hedyotis herb, 30 parts of barbed skullcap herb, 15 parts of honeysuckle and 15 parts of weeping forsythia according to the weight parts, adding water for extraction for 3 times, wherein the water adding amount is 10 times of the total weight of the medicinal materials, the extraction time is 3 hours each time, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active ingredient, namely the fluid extract.
Step 2: preparing coarse powder: in the step 2, 20 parts of rhubarb, 20 parts of phellodendron, 20 parts of turmeric, 20 parts of angelica dahurica, 20 parts of trichosanthes root, 20 parts of coptis, 10 parts of borneol, 20 parts of frankincense, 20 parts of myrrh, 15 parts of clove and 10 parts of scorpion are weighed according to the parts by weight, and the raw materials are crushed by a crusher and sieved by a 80-mesh sieve to obtain coarse powder for later use.
And step 3: preparing fine powder: and (3) mixing the fluid extract prepared in the step (1) with the coarse powder prepared in the step (2), stirring for 10 minutes until the fluid extract and the coarse powder are uniformly mixed, drying the uniformly mixed mixture for 5 minutes at 100 ℃ by using a dryer, and crushing the dried mixture by using a crusher to obtain fine powder for later use, wherein the fine powder is screened by a 100-mesh screen.
And 4, step 4: preparing a finished product: 470 parts of gel plaster matrix is weighed according to the weight part ratio, and the fine powder prepared in the step 3 is uniformly mixed with the gel plaster matrix to prepare a finished product.
Clinical cases
Case one: patients Jiang a certain woman, 37 years old, case number 016136, and personnel of a certain environmental protection science and technology service center, are admitted to the hospital because of 'diagnosis of more than 7 years of breast cancer, 1 year of lumbago aggravated by 2 months', and the patient finds right breast lumps in 2013 and 10 months, and then carries out right breast cancer expansion radical treatment operation, and postoperative pathology: right breast invasive ductal carcinoma, ER (+) PR (+), HER-2(-), pT3N2M0, stage III. After operation, auxiliary radiotherapy and chemotherapy and long-term endocrine therapy are carried out, and the patients with right leg pain and lumbago appear in 7 months in 2020 and do whole-body bone scanning: multiple metastases were considered in the 5 th lumbar, bilateral femur. After the bone protection and treatment of the zoledronic acid are carried out regularly, the pain is relieved. Lumbago aggravates 2 months before, pain is obvious in consciousness accompanied by burning discomfort of the waist, the oral tramadol sustained-release tablet is used for analgesia in outpatient service, serious digestive tract reactions such as malignancy and vomiting occur, then the medicine is treated by the department of the inventor, the heat-clearing, tumor-eliminating and pain-relieving patch is externally applied to the pain part of the waist after the hospital is admitted, the pain condition is obviously improved after the medicine is taken for 3 days 2 times/day and 4 hours every time, the medicine frequency is adjusted to be 1 time/day, and endocrine therapy and zoledronic acid therapy are continued.
Case two: patients Zhang, male, 58 years old, case No. 054834, 2019, 2 months patient looks up PET-CT to find right lung cancer, do puncture biopsy to suggest glandular structure, do gemcitabine + carboplatin + Terepril mab injection treatment for 7 cycles, later appear the progress of the disease, 11 months in 2019 begin with 4 microwave ablation treatments in Shenzhen city people's hospital, do reexamination in 2020, 2 months and 27 days in 2020 to suggest the progress of the disease, do right lung cancer argon helium scalpel cryoablation treatment in 2020, 22 days in 2020, 5 months and 22 days in 2020, implant 20 particles altogether. Oral aritinib capsule 8mg qd targeted therapy was started 2 weeks before. The right shoulder and back pain in nearly 1 month is admitted to the hospital and is analgetic by the oxycodone sustained release tablet 20mg PO Q12h combined with the fentanyl transdermal patch 4.2mg for external use, which is not ideal for control. Admission symptoms are as follows: shen right shoulder and back pain, NRS score of 3 points, hoarseness, no chest distress, no fever and aversion to cold, cough, yellow phlegm cough, red tongue with yellow and greasy coating, and wiry and smooth pulse. When the patient is admitted, the defecate is not smooth. After the patient is admitted, the combined heat-clearing, tumor-eliminating and pain-relieving plaster is externally used for clearing heat, dissolving stasis and relieving pain, the patient complaints pain can be obviously improved, and the amount of the pain-relieving medicine for the patient to use for a long time is considered to be not reduced temporarily.
Case three: patients who are Zhengzhi and female, aged 81 years, have case No. 050649, and in 9 months in 2019, are radiated to the right lower limb due to waist pain, and are examined for PET-CT: the right side of the sacral 1 vertebral plate is damaged by osteolytic bone, P is considered as malignant tumor, and the patient undergoes CT guided puncture biopsy and argon-helium knife cryoablation on the sacral caudal bone of 11-26 months in 2019, with postoperative pathology: metastatic invasive B cell lymphoma (sacral). Patients were admitted to the hospital for an exacerbation of pain in the right lower limb in the last 3 days. Admission symptoms are as follows: mental clarity, general spirit, easy fatigue, pain in the waist and right groin, 2 points on NRS score, pain in the right crus lateral side and right ankle, aggravation after standing and activity, 4 points on NRS score, and local burning sensation during pain attack. The oxycodone sustained release tablets 10mg Q12H are orally taken to relieve pain after admission, patients complain of less ideal pain control, the combined heat-clearing, tumor-eliminating and pain-relieving paste is externally applied to the waist and the right lower limb where pain is obvious, the pain can be obviously improved after the pain is complained for 2 days, the burning sensation is relieved, the medicine is continuously taken, and the disease condition is controlled by the next step of chemo-treatment.
In summary, the heat-clearing, tumor-eliminating and pain-relieving patch has the effects of clearing heat, removing toxicity, removing blood stasis, relieving pain, softening hardness and dissipating stagnation. Can be used for treating pain due to heat in disease caused by tumor, lump, and nodule, especially for treating cancer pain caused by bone metastasis. Clinical observation shows that the pain improvement condition is remarkable, the effect can still be achieved after the medicine is repeatedly used, the medicine can not resist the medicine, the life quality of a patient is improved, the use frequency of antibiotics and the like during treatment is reduced, the hospitalization cost is reduced, and the medicine has certain economic and social values and is worthy of popularization clinically. The patch has ideal treatment effect on various pains with local or systemic heat syndromes, especially on patients with cancer pain caused by bone metastasis caused by malignant tumor, can achieve the effects of relieving pain and clearing away heat and toxic materials after being taken, can reduce the dosage of opioid analgesics when being clinically applied properly, can also control the growth of tumor to a certain extent, and improves the survival prognosis of patients.
The above embodiments are merely illustrative of the preferred embodiments of the present invention, and not restrictive, and various changes and modifications to the technical solutions of the present invention may be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are intended to fall within the scope of the present invention defined by the appended claims.
Claims (8)
1. A heat-clearing tumor-eliminating pain-relieving plaster is characterized in that: the composite material comprises the following raw materials in parts by weight: 15-20 parts of rheum officinale, 15-20 parts of golden cypress, 15-20 parts of turmeric, 15-30 parts of barbed skullcap herb, 15-20 parts of angelica dahurica, 15-30 parts of spreading hedyotis herb, 15-20 parts of trichosanthes root, 15-20 parts of coptis chinensis, 15-30 parts of hibiscus leaf, 5-10 parts of borneol, 10-15 parts of honeysuckle, 10-15 parts of weeping forsythia, 15-20 parts of frankincense, 15-20 parts of myrrh, 10-15 parts of clove, 10 parts of scorpion and 470 parts of gel plaster substrate 315.
2. The patch for clearing heat, eliminating tumor and relieving pain according to claim 1, which is characterized in that: the composite material comprises the following raw materials in parts by weight: 15 parts of rhubarb, 15 parts of phellodendron, 15 parts of turmeric, 15 parts of sculellaria barbata, 15 parts of angelica dahurica, 15 parts of oldenlandia diffusa, 15 parts of trichosanthes root, 15 parts of coptis chinensis, 15 parts of hibiscus leaf, 5 parts of borneol, 10 parts of honeysuckle, 10 parts of forsythia, 15 parts of frankincense, 15 parts of myrrh, 10 parts of clove, 10 parts of scorpion and 315 parts of gel plaster substrate.
3. The preparation method of the heat-clearing tumor-eliminating pain-relieving plaster as claimed in claim 1, characterized in that: the method comprises the following steps:
step 1: preparing a fluid extract: weighing 15-30 parts of hibiscus leaf, 15-30 parts of spreading hedyotis herb, 15-30 parts of barbed skullcap herb, 10-15 parts of honeysuckle and 10-15 parts of weeping forsythia through a water extraction method, and concentrating the liquid into a fluid extract;
step 2: preparing coarse powder: weighing 15-20 parts of rhubarb, 15-20 parts of phellodendron, 15-20 parts of turmeric, 15-20 parts of angelica dahurica, 15-20 parts of trichosanthes root, 15-20 parts of coptis, 5-10 parts of borneol, 15-20 parts of frankincense, 15-20 parts of myrrh, 10-15 parts of clove and 10 parts of scorpion according to the weight part ratio, and crushing the raw materials into coarse powder;
and step 3: preparing fine powder: uniformly mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the mixture, and crushing the dried mixture into fine powder;
and 4, step 4: preparing a finished product: weighing 315-470 parts of the gel plaster matrix according to the weight part ratio, uniformly mixing the fine powder prepared in the step 3 with the gel plaster matrix, and preparing a finished product.
4. The preparation method of the heat-clearing tumor-eliminating pain-relieving plaster according to claim 3, which is characterized in that: the specific steps in the step 1 are as follows: weighing 15-30 parts of hibiscus leaves, 15-30 parts of spreading hedyotis herb, 15-30 parts of barbed skullcap herb, 10-15 parts of honeysuckle and 10-15 parts of weeping forsythia, adding water for extraction for 2-3 times, wherein the water addition amount is 6-10 times of the total weight of the raw materials, the extraction time is 1-3 hours each time, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active ingredient, namely the fluid extract.
5. The preparation method of the heat-clearing tumor-eliminating pain-relieving plaster according to claim 3, which is characterized in that: in the step 2, 15-20 parts of rhubarb, 15-20 parts of phellodendron, 15-20 parts of turmeric, 15-20 parts of angelica dahurica, 15-20 parts of trichosanthes root, 15-20 parts of coptis root, 5-10 parts of borneol, 15-20 parts of frankincense, 15-20 parts of myrrh, 10-15 parts of clove and 10 parts of scorpion are weighed according to the parts by weight, and the raw materials are crushed by a crusher and sieved by a 60-80 mesh sieve to obtain coarse powder for later use.
6. The preparation method of the heat-clearing tumor-eliminating pain-relieving plaster according to claim 3, which is characterized in that: and 3, mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the uniformly mixed mixture at 80-100 ℃ by using a dryer, crushing the dried mixture by using a crusher, and sieving the crushed mixture by using a sieve of 100 meshes and 150 meshes to obtain fine powder for later use.
7. The preparation method of the heat-clearing, tumor-eliminating and pain-relieving patch according to claim 6 is characterized in that: mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, stirring for 10-30 minutes until the mixture is uniformly mixed, and drying the uniformly mixed mixture for 20-30 minutes at 80-100 ℃ by a dryer.
8. The preparation method of the heat-clearing tumor-eliminating pain-relieving plaster according to claim 3, which is characterized in that: in the step 4, the mass ratio of the fine powder to the gel plaster matrix is 2:3, and the gel plaster matrix comprises sodium polyacrylate, dihydroxyaluminum glycinate, glycerol, azone and water, wherein the mass ratio of the sodium polyacrylate, the dihydroxyaluminum glycinate, the glycerol, the azone and the water is 288: 4: 660: 30: 2550.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623455A (en) * | 2015-02-27 | 2015-05-20 | 曹兰 | External application plaster for treating skeletal metastatic cancer pain and preparation method of external application plaster |
| CN105213513A (en) * | 2015-10-08 | 2016-01-06 | 广西德坤瑶药业有限公司 | A kind of tumour eliminating and analgesic plaster and preparation method thereof |
| CN105853921A (en) * | 2016-05-11 | 2016-08-17 | 长兴县中医院 | External medicine for treating bone metastatic cancer pain and preparation method thereof |
-
2021
- 2021-09-30 CN CN202111164335.3A patent/CN113730536A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623455A (en) * | 2015-02-27 | 2015-05-20 | 曹兰 | External application plaster for treating skeletal metastatic cancer pain and preparation method of external application plaster |
| CN105213513A (en) * | 2015-10-08 | 2016-01-06 | 广西德坤瑶药业有限公司 | A kind of tumour eliminating and analgesic plaster and preparation method thereof |
| CN105853921A (en) * | 2016-05-11 | 2016-08-17 | 长兴县中医院 | External medicine for treating bone metastatic cancer pain and preparation method thereof |
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Application publication date: 20211203 |