CN104623455A - External application plaster for treating skeletal metastatic cancer pain and preparation method of external application plaster - Google Patents
External application plaster for treating skeletal metastatic cancer pain and preparation method of external application plaster Download PDFInfo
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Abstract
The invention relates to an external application traditional Chinese medicine for relieving pain and particularly relates to an external application plaster for treating skeletal metastatic cancer pain and a preparation method of the external application plaster, wherein the external application plaster has effects on relieving and treating the skeletal metastatic pain of cancer patients. The external application plaster is prepared by reasonably blending common traditional Chinese medicines such as unprocessed radix aconiti, ephedra, asarum, raw rhubarb, peach kernels, rhizoma sparganii, olibanum and myrrh. The external application plaster is rapid in taking effects and few in side effects when being used for relieving pain, is economic and practical, is capable of reducing the economic burdens of cancer patients, and is particularly good in adaptability for middle and advanced cancer patients.
Description
Technical field
The present invention relates to ointment prepared by a kind of Chinese prescription, especially by sticking region of interest, there is for cancer patient Bone tumour pain externally applied ointment of the treatment metastatic pain of alleviation and therapeutical effect and preparation method thereof.
Background technology
Cancer bone metastasis pain is more common middle and terminal cancer patient, the painful and more difficult control of symptom.Effective pain management, is even more important for the life quality improving middle and terminal cancer patient.Show according to preliminary survey: in general hospital and Cancer Hospital, each phase cancer patient accounts for more than 40% with pain person in various degree, in middle and terminal cancer patient in Bone tumour pain patients pain ratio up to 50-60%, and the cancer pain patient of about 24% is treated accordingly, wherein, severe pain accounts for about 20%.Cancer pain can from psychology, physiology, spirit and society many-sided quality of life affecting patient.The existing Therapeutic Method for cancer patient Bone tumour pain mainly divides oral, injection two kinds, application third order convergence principle, some patients's pain can be effectively controlled, but the side effect that analgesic drug product is correlated with affects again diet and the daily life of patient conversely.Moreover also having quite a few end-stage patients, oral and injection does not all reach pain relieving promising result.Externally applied ointment is the external therapy of motherland's medical science, the reason of external treatment and the reason for the treatment of by oral administration of medicines, the medicine of external treatment and the medicine for the treatment of by oral administration of medicines.When the Transdermal absorption of externally used paste acts on the diseases such as treatment meridians, be generally subsides position mainly with human meridian point.The plaster being affixed on body surface excites nerve tip, and by reflection, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, reach reducing swelling and alleviating pain, the effect of antiinflammatory.Medicine reaches subcutaneous tissue at acupuncture point place by Cutaneous permeation simultaneously, produces the relative potence of drug level in local, thus plays stronger pharmacological action, and to wound, dermatosis, the treatment of non-cancer lesion, all has the local actions such as anticorrosion anti-inflammatory analgetic.
In addition, the medicine that some zest is strong, strong stimulation, by neural reflex, can regulate human body function enhancing antibody to be formed, and improves body immunity.Meanwhile, after medicine break-through skin and mucosa, enter body circulation through blood vessel or lymphatic vessel, systemic medication effect can be produced, reach the object of disease therapy.
Summary of the invention
The object of the invention be to provide a kind of economical and practical, lasting medicine, side effect little, not only reducing swelling and alleviating pain can also improve externally applied ointment of the treatment metastatic pain of the immunity of patient and preparation method thereof.
For achieving the above object, the present invention adopts following technical scheme:
A kind of externally applied ointment for the treatment of metastatic pain of the present invention, is made up of the composition of following weight portion:
Radix Aconiti 8-10, Herba Ephedrae 3-6, Herba Asari 8-10, Radix Et Rhizoma Rhei 5-8, Rhizoma Sparganii 5-8, Olibanum 6-8, Myrrha 6-9, Semen Persicae 6-10, Semen Momordicae 6-10, Borneolum Syntheticum 8-10, Sanguis Draxonis 4-6, Flos Lonicerae 6-12, Rhizoma Corydalis 7-8, Oletum Trogopterori 6-9, Camphora 4-6; Cortex Cinnamomi 4-6.
The preparation method of the externally applied ointment of above-mentioned treatment metastatic pain, following steps are made:
A) liquid component is prepared; By the Radix Aconiti of above-mentioned weight portion, Herba Asari, Herba Ephedrae, Rhizoma Sparganii mixed grinding powdering, immersing 200-300 weight portion concentration is in the ethanol of 75%, soaks 15 days under natural temperature; It is in the ethanol of 75% that the Borneolum Syntheticum of above-mentioned weight portion immerses 150-200 weight portion concentration, soaks 15 days under natural temperature; Get above-mentioned two kinds of soaks to filter respectively, removing filtering residue, obtains two kinds of filtrates, by two kinds of filtrate mix homogeneously, obtains liquid component;
B) mastic composition is prepared; By the Radix Et Rhizoma Rhei of above-mentioned weight portion, Olibanum, Myrrha, Semen Persicae, Semen Momordicae, Flos Lonicerae, Rhizoma Corydalis, Oletum Trogopterori mixing is cataclasm, fried withered with putting in pot with the vegetable oil of 120-180 weight portion, cross and filter filtering residue and obtain mastic filtrate, mastic filtrate being concentrated refining to dripping into pearl, receiving cream and obtaining concentrated mastic; The Sanguis Draxonis of above-mentioned weight portion, Cortex Cinnamomi are broken into fine powder, this fine powder and Camphora are added in concentrated mastic and stirs evenly, obtain ointment composition;
C) product synthesis; Above-mentioned ointment composition is spread upon on base material, adopts aerosol apparatus to be sprayed onto on ointment composition by aforesaid liquid composition, be the externally applied ointment of described treatment cancer pain.。
Radix Aconiti: be the parent root of ranunculaceae plant Ka Shi Aconitum carmichjaelii Debx. AconitumcarmichaeliDebx..Another name: E Erhua, the ornamental work of iron, the five poisonous creatures: scorpion, viper, centipede, house lizard, toad.Pungent, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.Cure mainly: expelling wind and removing dampness, antalgic.Be usually used in anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type have a pain.Can be used for disease such as treatment anemofrigid-damp arthralgia, arthralgia etc.Take orally after the general process of preparing Chinese medicine.
Herba Ephedrae: another name: Ephedra sinica, magnificent Herba Ephedrae.For the dry herb stem of Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf, epheday intermedia Ephedra intermedia Schrenk et C. A. Mey. or ephedra equisetina Ephedra equisetina Bge., dry.It is the wind-cold-dispersing medicinal in Chinese medicine.Abnormal smells from the patient: pungent, micro-hardship, temperature.Return lung, urinary bladder channel.Cure mainly: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chestly to breath with cough, edema due to wind pathogen edema; Bronchial asthma.
Herba Asari: have another name called magnificent Herba Asari, little Xin, few pungent, careless Herba Asari of basin etc., belong to Aristolochiales, Aristolochiaceae perennial herb.Cure mainly: dispel the wind, cold expelling, row water, has one's ideas straightened out.Control air-cooled headache, toothache, rheumatic arthralgia.Herba Asari can outer dispersing wind and cold, again can in dispel YIN-cold, pain relieving simultaneously, antitussive effect are better.
Radix Et Rhizoma Rhei: the i.e. decoction pieces of primary crude drug Radix Et Rhizoma Rhei.Radix Et Rhizoma Rhei is the medical herbs that " Chinese Pharmacopoeia " includes, and medicinal source is the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim.ex Balf. or Rheum officinale Rheum officinale Baill..Major function is stasis removing, relieving constipation by purgation, stagnates for Gastrointestinal excess heat, constipation.
Rhizoma Sparganii: be Sparganiaceae plant rhizoma scirpi Sparganium stoloni erum, the dry tuber of Buch.-Ham..For lump in the abdomen mass in the abdomen, dysmenorrhea, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain.
Olibanum: real name smokes land, the smoked Lu Xiang of another name, horse hair perfume, nipple are fragrant, collapse perfume etc., is the resin that olive subject plant Boswellia carterii Boswellia carterii Birdw. and congener Boswellia bhaurdajiana Birdw. bark ooze out.Cure mainly: regulating qi and activating blood, analgesic therapy, chase after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Myrrha: have another name called myrrh, bright Myrrha, Myrrha, raw bright Myrrha etc.For olive subject plant Herba Violae tree or the dry resin of Ha Didingshu.Cure mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.There is the effect such as promoting blood circulation and stopping pain, detumescence and promoting granulation.Be a kind ofly to invigorate blood circulation, blood stasis dispelling, pain relieving, stomach invigorating Chinese medicine.
Semen Persicae: be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Gather after fruit maturation, removing sarcocarp and nucleocapsid, take out seed, dry.There is blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, effect of relieving cough and asthma.For amenorrhea dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.
Semen Momordicae: another name vomiting nut, glutinous meal fruit, mouse draw Fructus Benincasae etc.Perennial herbaceous stem rattan wood, the tuberous root that tool expands.Nature and flavor: bitter, micro-sweet, cool; Poisonous, return liver, spleen, stomach warp.Cure mainly: mass dissipating and swelling eliminating, counteracting toxic substances treats skin ulcer.For sore swollen toxin, acute mastitis, scrofula, anal fistula, chronic eczema, tinea alba.
Borneolum Syntheticum: have another name called sheet brain, Fructus Citri tangerinae sheet, Blumeae preparatum Tabellae, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing etc. is through steam distillation and recrystallization and obtaining by Compositae Herba Blumeae Balsamiferae stem and leaf or canella Borneolum Syntheticum Camphor tree branch and leaf.Also useful Oleum Terebinthinae obtains through a series of chemical method technique.It can be used for excess syndrome of stroke coma, for conjunctival congestion and swelling pain, sore throat aphtha, to swell and ache for skin infection, does not hold back after bursting.
Sanguis Draxonis: another name black horse Lin exhausts, wooden Sanguis Draxonis.Medical material Ji Yuan: the resin in babassu Sanguis Draxonis fruit and rattan.There is promoting blood circulation to remove blood stasis, analgesic therapy, effect of hemostasia and promoting granulation.Current domestic Dragon Blood mostly is Liliaceae Dracaena cochinchinensis or dracaena cambodiana Pierre resin.
Flos Lonicerae: have another name called Radix Ophiopogonis.Medical material Flos Lonicerae is Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or is with the flower just opened.Flos Lonicerae sweet in the mouth cold in nature, has effect of heat-clearing and toxic substances removing, removing heat from bloodization silt, cure mainly affection due to external wind and heat, pestilence from the beginning of, skin infection furunculosis, red and swollen heat pain, passing stool with blood and pus etc.
Rhizoma Corydalis: Papaveraceae, Corydalis perennial herb, another name: Rhizoma Corydalis, corydalis tuber, rhizoma corydalis, Rhizoma Corydalis.Cure mainly: invigorate blood circulation, dissipating blood stasis, regulate the flow of vital energy, pain relieving.Control all pains of trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.
Oletum Trogopterori: have another name called medicine basis, cold number worm excrement, Oletum Trogopterori etc.Be divided into Oletum Trogopterori rice, Oletum Trogopterori block two kinds.The dry feces of Oletum Trogopterori rice and trogopterus xanthipes Milne-Edwards, Oletum Trogopterori block is that the mixture of its feces and urine presss from both sides to condense with the drying of a small amount of sandstone and forms.Abnormal smells from the patient is sweet, temperature.Return liver and gall warp.Cure mainly: promoting blood circulation to remove blood stasis, parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.
Camphora: Camphora is the branch of canella Camphor tree, dry, leaf and root, through refining obtained crystalline particulate.There is orifice opening, qi stagnation removing, ward off foul, killing parasites for relieving itching, reducing swelling and alleviating pain effect, cure mainly the symptoms such as scabies pruritus, traumatic pain, toothache.
Cortex Cinnamomi: be the dry bark of canella Cortex Cinnamomi Cinnamomum cassia Presl.There is benefit fire supporing yang, guiding fire to origin, dispersing cold for relieving pain, effect of promoting the flow of QI-blood by warming the meridian.For sexual impotence cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, upward floating of YANG in deficiency condition, dizzy conjunctival congestion, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, and colic of cold type is suffered from abdominal pain, dysmenorrhea amenorrhea.
Modern medicine thinks that cancer pain generation dominant mechanism is because cancerous tissue directly oppresses adjacent tissue or nerve, causes ischemia and the necrosis of respective organization; Cancerous cell can transfer to its adjacent tissue, can cause pathologisch Bruch; Cancerous cell invades profit to lymphoid tissue, can produce inflammation and some chemical algogenic substances comprise: 5-hydroxy tryptamine, prostaglandin, Kallidin I etc.; Cancerous cell invades blood vessel or internal organs, and arterial thrombosis or internal organs can be caused to block, and the symptom of congestion and swelling appears in vein, can stimulate the neural sensor of blood vessel parietal layer, pleura wall and internal organs peplos simultaneously and cause the generation of pain.
Research shows, the pain caused by Bone tumour cancer is mainly because the changes in excitability of Primary Sensory Neuron that triggers of cancer metastasis, and spinal nerves chemical change, cell remodeling are the material bases forming its behavior hyperalgesia.
Bone tumour cancer causes the abnormal factor increased of Primary Sensory Neuron irritability from two aspects: one is the excessive activation of osteoclast; Two is the factors such as tumor cell secretion tumor necrosis factor, il-1 (IL-1), endothelin-1 (ET-1).Malignant cell can secrete prostaglandin (PGs), cytokine, epidermal growth factor (EGF), transforming growth factor (TGF) and platelet derived growth because of (PDGF) etc., has many materials can excited primary afferent neuron in them.Have the macrophage of 20%-30% to produce tumor necrosis factor and IL-1 etc. in addition in tumor tissues, the two also all can excited primary afferent neuron.Separately there are some researches show that exogenous ET-1 can produce the behavior symptom of acute pain, the appearance that pathologic tenderness is abnormal can be strengthened, thus promote the generation of inflammatory pain.
Analgesia plaster by reducing the inflammatory mediator in peripheral tissues, can reduce the impulsion that nociceptor produces, thus reduces the release of afferent nerve fiber tip nocuity mediator.This illustrates that analgesia ointment can reduce inflammatory reaction, has significant antiinflammatory action.Illustrate that analgesia ointment can reduce posterior horn of spinal cord immunoreactive positive neurons to the nociceptive inputs imported into, thus suppress the unlatching of pain sensation valve to ease the pain.
Chinese medicine thinks that the pathogenesis of cancer pain is qi depression to blood stasis, expectorant coagulates, blockage of main and collateral channels and pain, evil Sheng is weakened body resistance, essence and blood not flourish and pain, therefore Therapeutic Principle is that QI and blood regulating is with logical pain relieving, this patent analgesia plaster is by Radix Aconiti, Herba Asari, Olibanum, Rhizoma Sparganii, Borneolum Syntheticum, the Chinese medicine compositions such as Radix Et Rhizoma Rhei, with Radix Aconiti in we, Herba Asari is monarch drug, promoting the flow of QI in the collateral by warming the meridian narcotic analgesic, modern pharmacology also confirms Radix Aconiti, Herba Asari has anti-inflammatory and antalgic anesthesia nerve and waits effect, there is good analgesic effect, Olibanum, Rhizoma Sparganii, Myrrha three medicine is combined into minister, blood-activating and qi-promoting removing obstruction in the collateral to relieve pain, with the effect of principal drug assistance, assistant is with Rhizoma Corydalis, Semen Momordicae, Oletum Trogopterori, Semen Persicae, Sanguis Draxonis eliminating stagnation is sensible, blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain, this medical instrument has the merit of searching and picking meridians, be widely used in treatment cancer pain, utilize Camphora, the pungent perfume (or spice) of Borneolum Syntheticum is walked to alter and is had one's ideas straightened out, change addiction pain relieving, and the transdermal characteristic of medicine can be increased, there is again certain antitumor action, as making medicine, strengthen drug effect, all medicines share and pass through local penetration, the defeated cloth effect of meridians, play through focus.The double effects of adjustment local and whole body, adopting with pain is the external of fine jade Chinese medicinal ointment, there is the direct effect of medicine on the one hand, on the other hand by the conduction of meridians, make medicine can play whole body therapeutic effect, improve the threshold of pain, regulate neurohumoral systems function, thus strengthen the analgesic effect of Chinese medicine, alleviate the pain syndrome caused by cancer, extend the life cycle of patient, Topical administration, after skin absorbs, the efficacy of a drug is gone directly disease institute, pain relieving is effective rapidly, can avoid orally absorbing through digestive tract the too many levels deactivation that runs into and some medicines take some toxic and side effects brought orally.
Above-mentioned various Chinese medicine ingredients organically combines by the medicine for external use of this treatment cancer pain, give full play to the pharmacological action of various Chinese medicine, there is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, warming YANG pain relieving, effect of dispersing swelling and dissipating binds, by the combination of spray and Chinese medicinal ointment, both the advantage that the pain relieving of spray is fast had been remained, again by plaster extend drug effect, the plaster of external by the tip that excites nerve, by reflection, blood vessel dilating, promote local blood circulation, improve surrounding tissue nutrition, reach reducing swelling and alleviating pain, the effect of antiinflammatory, serves effect for the treatment of both the principal and secondary aspects of a disease.Its pain relieving instant effect, side effect are little, and economical and practical, and alleviate the financial burden of cancer patient, special centering patients with advanced cancer adaptability is good.
Detailed description of the invention
Embodiment 1:
Standby medicine: according to following parts by weight for medicine: Radix Aconiti 8 grams, 3 grams, Herba Ephedrae, Herba Asari 8 grams, Radix Et Rhizoma Rhei 5 grams, Rhizoma Sparganii 5 grams, Olibanum 6 grams, Myrrha 6 grams, 6 grams, Semen Persicae, Semen Momordicae 6 grams, Borneolum Syntheticum 8 grams, Sanguis Draxonis 4 grams, Flos Lonicerae 6 grams, Rhizoma Corydalis 7 grams, Oletum Trogopterori 6 grams, Camphora 4 grams; Cortex Cinnamomi 4 grams.
Make, make in accordance with the following steps:
A) liquid component is prepared; By the Radix Aconiti of above-mentioned weight portion, Herba Asari, Herba Ephedrae, Rhizoma Sparganii mixed grinding powdering, immersing 200-300 weight portion concentration is in the ethanol of 75%, soaks 15 days under natural temperature; It is in the ethanol of 75% that the Borneolum Syntheticum of above-mentioned weight portion immerses 150-200 weight portion concentration, soaks 15 days under natural temperature; Get above-mentioned two kinds of soaks to filter respectively, removing filtering residue, obtains two kinds of filtrates, by two kinds of filtrate mix homogeneously, obtains liquid component;
B) mastic composition is prepared; By the Radix Et Rhizoma Rhei of above-mentioned weight portion, Olibanum, Myrrha, Semen Persicae, Semen Momordicae, Flos Lonicerae, Rhizoma Corydalis, Oletum Trogopterori mixing is cataclasm, fried withered with putting in pot with the vegetable oil of 120-180 gram, cross and filter filtering residue and obtain mastic filtrate, mastic filtrate being concentrated refining to dripping into pearl, receiving cream and obtaining concentrated mastic; The Sanguis Draxonis of above-mentioned weight portion, Cortex Cinnamomi are broken into fine powder, this fine powder and Camphora are added in concentrated mastic and stirs evenly, obtain ointment composition;
C) product synthesis; Above-mentioned ointment composition is spread upon on base material, adopts aerosol apparatus to be sprayed onto on ointment composition by aforesaid liquid composition, be the externally applied ointment of described treatment cancer pain.Each dosage of forcing on can be grasped flexibly according to the thickness of the size of base material area and ointment.Smearing ointment thickness is large, and then duration of efficacy is long, otherwise the thinner then duration of efficacy of smearing ointment is short.
Use: the skin flat position above-mentioned external plaster being spread on the nearly pain of patient 72 hours is a medication cycle.
The routine cancer pain patient of Stochastic choice 50, age is between 55 years old-65 years old, be divided into 2 groups at random, A group: 25 examples adopt medicine for external use of the present invention to stick, B group: 25 examples adopt the externally-used pain-relieving of certain brand to paste treatment, clinical observation shows: A group 25 routine cancer pain patient is after application plaster of the present invention, within 8-10 minute, patient pain can obviously alleviate or disappear, medication still has 19 routine patient feels pain to alleviate after 3 days, 3 routine patient pain start to recover degree in the past, 3 routine patient pain disappear, medication after 6 days 13 patients still feels pain alleviate, degree before 12 patient pain recover, 0 routine patient feels pain disappears, its effective percentage of 3 days is 88%, effective percentage after 6 days is: 52%.The routine patient of B group 25 is after the externally-used pain-relieving patch of certain brand of application, within many 5-10 minute after sticking externally-used pain-relieving medicine, there is pain relief in various degree or disappearance in patient, in use after 3 days, still have 15 patient feels pain to alleviate, 3 patient pain disappear, and 7 patient pain return to former degree, 3 patient feels pain are only had to alleviate than before after 6 days in use, all the other 22 patient feels pain are identical with before use or increase the weight of, and its 3 days effective percentage are: within 60%, 6 days, effective percentage is: 12%.
Conclusion: externally applied ointment of the present invention in quick-acting antalgesic with conventional externally-used pain-relieving subsides in difference little, but in long-term efficacy, there is the feature of more lasting better efficacy, be worthy of popularization.
Embodiment 2:
Standby medicine: Radix Aconiti 10, Herba Ephedrae 6, Herba Asari 10, Radix Et Rhizoma Rhei 8, Rhizoma Sparganii 8, Olibanum 8, Myrrha 9, Semen Persicae 10, Semen Momordicae 10, Borneolum Syntheticum 10, Sanguis Draxonis 6, Flos Lonicerae 12, Rhizoma Corydalis 8, Oletum Trogopterori 9, Camphora 6; Cortex Cinnamomi 6.
Make, with embodiment 1.
According to patient body situation and age gap distance, the parts by weight of mentioned component can suitably adjust within the specific limits, and its scope is as follows: Radix Aconiti 8-10, Herba Ephedrae 3-6, Herba Asari 8-10, Radix Et Rhizoma Rhei 5-8, Rhizoma Sparganii 5-8, Olibanum 6-8, Myrrha 6-9, Semen Persicae 6-10, Semen Momordicae 6-10, Borneolum Syntheticum 8-10, Sanguis Draxonis 4-6, Flos Lonicerae 6-12, Rhizoma Corydalis 7-8, Oletum Trogopterori 6-9, Camphora 4-6; Cortex Cinnamomi 4-6.
Claims (2)
1. treat an externally applied ointment for metastatic pain, it is characterized in that being made up of the composition of following weight portion:
Radix Aconiti 8-10, Herba Ephedrae 3-6, Herba Asari 8-10, Radix Et Rhizoma Rhei 5-8, Rhizoma Sparganii 5-8, Olibanum 6-8, Myrrha 6-9, Semen Persicae 6-10, Semen Momordicae 6-10, Borneolum Syntheticum 8-10, Sanguis Draxonis 4-6, Flos Lonicerae 6-12, Rhizoma Corydalis 7-8, Oletum Trogopterori 6-9, Camphora 4-6; Cortex Cinnamomi 4-6.
2. a kind of preparation method for the treatment of the externally applied ointment of metastatic pain as claimed in claim 1, is characterized in that being made up of following steps:
A) liquid component is prepared; By the Radix Aconiti of above-mentioned weight portion, Herba Asari, Herba Ephedrae, Rhizoma Sparganii mixed grinding powdering, immersing 200-300 weight portion concentration is in the ethanol of 75%, soaks 15 days under natural temperature; It is in the ethanol of 75% that the Borneolum Syntheticum of above-mentioned weight portion immerses 150-200 weight portion concentration, soaks 15 days under natural temperature; Get above-mentioned two kinds of soaks to filter respectively, removing filtering residue, obtains two kinds of filtrates, by two kinds of filtrate mix homogeneously, obtains liquid component;
B) mastic composition is prepared; By the Radix Et Rhizoma Rhei of above-mentioned weight portion, Olibanum, Myrrha, Semen Persicae, Semen Momordicae, Flos Lonicerae, Rhizoma Corydalis, Oletum Trogopterori mixing is cataclasm, fried withered with putting in pot with the vegetable oil of 120-180 weight portion, cross and filter filtering residue and obtain mastic filtrate, mastic filtrate being concentrated refining to dripping into pearl, receiving cream and obtaining concentrated mastic; The Sanguis Draxonis of above-mentioned weight portion, Cortex Cinnamomi are broken into fine powder, this fine powder and Camphora are added in concentrated mastic and stirs evenly, obtain ointment composition;
C) product synthesis; Above-mentioned ointment composition is spread upon on base material, adopts aerosol apparatus to be sprayed onto on ointment composition by aforesaid liquid composition, be the externally applied ointment of described treatment cancer pain.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853921A (en) * | 2016-05-11 | 2016-08-17 | 长兴县中医院 | External-use drug for treating osseous metastasis cancer pain and preparation method of external-use drug |
| CN108567964A (en) * | 2018-07-06 | 2018-09-25 | 昆明市中医医院 | Tumour eliminating and analgesic cream |
| CN113730536A (en) * | 2021-09-30 | 2021-12-03 | 冯高飞 | Heat-clearing tumor-eliminating pain-relieving plaster and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050117013A (en) * | 2004-06-09 | 2005-12-14 | 남기혜 | Extract extracted from a typha latifolia's stem as an inhibitor of histamine release, interleukin-6 secretion and/or secretion of reactive oxygen species by neutrophil |
| CN101422531A (en) * | 2007-10-29 | 2009-05-06 | 严现坤 | Wind-expelling pain-assuaging paste capable of treating lumbar intervertebral disc protrusion |
| CN101732665A (en) * | 2009-12-31 | 2010-06-16 | 程江平 | Externally applied Chinese medicinal spray for pain relieving of cancers and preparation method thereof |
-
2015
- 2015-02-27 CN CN201510089451.1A patent/CN104623455A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050117013A (en) * | 2004-06-09 | 2005-12-14 | 남기혜 | Extract extracted from a typha latifolia's stem as an inhibitor of histamine release, interleukin-6 secretion and/or secretion of reactive oxygen species by neutrophil |
| CN101422531A (en) * | 2007-10-29 | 2009-05-06 | 严现坤 | Wind-expelling pain-assuaging paste capable of treating lumbar intervertebral disc protrusion |
| CN101732665A (en) * | 2009-12-31 | 2010-06-16 | 程江平 | Externally applied Chinese medicinal spray for pain relieving of cancers and preparation method thereof |
Non-Patent Citations (5)
| Title |
|---|
| 刘召苓等: "中药涂搽配合放射治疗癌性骨转移疼痛疗效观察", 《中国中医急症》 * |
| 彭成: "《有毒中药附子、川乌、草乌的安全性评价与应用》", 31 August 2014, 四川科学技术出版社 * |
| 徐阳等: "消瘤止痛膏联合唑来膦酸治疗恶性肿瘤骨转移引起疼痛的疗效分析", 《中国当代医药》 * |
| 李新年: "跌打止痛膏治疗软组织损伤疗效观察", 《河南中医学院学报》 * |
| 马军等: "《中国临床肿瘤学教育专辑》", 31 October 2009, 中国协和医科大学出版社 * |
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| CN105853921A (en) * | 2016-05-11 | 2016-08-17 | 长兴县中医院 | External-use drug for treating osseous metastasis cancer pain and preparation method of external-use drug |
| CN108567964A (en) * | 2018-07-06 | 2018-09-25 | 昆明市中医医院 | Tumour eliminating and analgesic cream |
| CN113730536A (en) * | 2021-09-30 | 2021-12-03 | 冯高飞 | Heat-clearing tumor-eliminating pain-relieving plaster and preparation method thereof |
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