CN104644802A - Medicine for treating cervical cancer and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating cervical cancer. The method comprises the following steps: preparing American cockroaches, salvia chinensis, clethra loosestrife herbs, Changium smyrnioides, phellinus pini, mume flowers and hairyvein agrimonia herbs and buds in parts by weight and making into 50-mesh powder; adding 85% ethanol according to feed liquid rate of 1:9; performing reflux extraction for three times (2 hours each time); mixing reflux liquid; concentrating an extract with the relative density of 1.28-1.32 (38 DEG C); drying in vacuum and preparing into 200-mesh powder; b, selecting maltose and venenum bufonis in parts by weight and preparing into 300-mesh powder; uniformly mixing with the powder obtained in the step a. Through a lot of experiments, traditional Chinese medicinal materials with different medicine properties are selected and matched scientifically; a special preparation method is adopted, the medicines are used together, so that a synergic effect is prominent, and the medicine has functions of activating blood circulation, stopping pain, and detoxifying and eliminating the swelling, and has an obvious inhibition effect on the cervical cancer.

Description

A kind of medicine for cervical cancer and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of medicine for cervical cancer and preparation method thereof.

Background technology

Cervical cancer is modal gynecologic malignant tumor.The cancer in situ age occurred frequently is 30 ~ 35 years old, and infiltrating carcinoma is 45 ~ 55 years old, and its morbidity in recent years has the trend of rejuvenation.The generally application of nearly cervical cytology examination decades, makes cervical cancer and precancerous lesion be able to early discovery and treatment, and the M & M of cervical cancer is existing obviously to decline.

Many employings surgical operation Combined with Radiotherapy chemotherapeutic treatment when Therapeutic cancer and malignant tumor at present.Though operation can remove primary lesion, when cancerous cell has had the transfer diffused to beyond original site, excision just can not be relied on separately to reach the object for the treatment of, fundamentally can not stop regeneration and the transfer of cancerous cell; Though radiotherapy, chemotherapy can kill cancerous cell, but because malignant tumor and normal structure organ or adjacent tissue form a complicated entity jointly, while treatment, normal tissue cell is suffered damage, bring out the intestines and stomach reaction, bone marrow depression and Liver and kidney impairment of cardiac function, make patient body weaker, be difficult to further treatment.Conventional chemical drugs Therapeutic Method is difficult to stop cancer cell metastasis and have very large toxic and side effects, and this is at present to the subject matter existed in the treatment of cancer.

Treatment by Chinese herbs cancer is an effective approach, and Chinese Traditional Medicine becomes the focus of antitumor research gradually to the therapeutical effect of tumor, and achieves comparatively much progress.The Therapeutic cancer that develops into of theory of Chinese medical science lays the foundation, and compound of Chinese medicine malignant tumor has unique advantage.Had the report of many treatment by Chinese herbs cancers in prior art, but the Ji Li of application treatment by Chinese herbs cancer is different, effect of drugs is also different, but reach the same goal by different routes, have certain effect to the treatment of cancer, this just illustrates in traditional Chinese medical herbal treatment cancer, should have wide excavation space.

Summary of the invention

The object of this invention is to provide a kind of medicine for cervical cancer.Treatment for cervical cancer provides a kind of effective medicine newly.

The present invention is used for the medicine of cervical cancer; Be made up of the raw material of following parts by weight: periplaneta americana 12 ~ 14 parts, Herba Salviae Chinensis 30 ~ 33 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 21 ~ 23 parts, Radix Changii 15 ~ 17 parts, maltose 6 ~ 9 parts, phellin uspini 26 ~ 28 parts, FLOS MUME spend 10 ~ 12 parts, Herba Agrimoniae 8 ~ 10 parts, Venenum Bufonis 1 ~ 1.2 part.

As optimization, this is used for the medicine of cervical cancer; Be made up of the raw material of following parts by weight: periplaneta americana 13 parts, Herba Salviae Chinensis 31 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 22 parts, Radix Changii 16 parts, maltose 8 parts, phellin uspini 27 parts, FLOS MUME spend 11 parts, Herba Agrimoniae 9 parts, Venenum Bufonis 1.1 parts.

Prepare this method for cervical cancer medicine, comprise the following steps:

A, the periplaneta americana of getting described parts by weight, Herba Salviae Chinensis, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), Radix Changii, phellin uspini, FLOS MUME flower, Herba Agrimoniae, make 50 object powder; By solid-liquid ratio 1:9, add 85% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (38 DEG C); Then vacuum drying, makes 200 object powder;

B, the maltose getting described parts by weight, Venenum Bufonis make 300 object powder; Then with the powder mix homogeneously in step a.According to 0.36 gram one, incapsulate.Daily three times, each 2.

Effective ingredient in invention comprises: periplaneta americana salty in the mouth cold in nature, have acid, have dissipating blood stasis, removing food stagnancy, removing toxic substances, diuretic, the function such as detumescence.Cure mainly infantile malnutrition, tonsillitis, health enclosed mass, carbuncle skin ulcer swell and ache and Scolopendra, venom etc.

Herba Salviae Chinensis promoting blood circulation and stopping pain, clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Cure mainly dysmenorrhea due to blood stasis, leucorrhea with red and white discharge, bones and muscles pain, various tumor, jaundice dysentery; External treatment facial paralysis, mastitis, carbuncle, scrofula.

Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.For menoxenia, leucorrhea, infantile malnutrition, rheumatic arthritis, traumatic injury, mastitis, venom.

Radix Changii lung heat clearing, reduces phlegm, suppressing the hyperactive liver, stomach function regulating, removing toxic substances.Control phlegm-fire cough dyspnea, dizzy, vomiting, order also, leucorrhea, furunculosis skin infection.

Maltose invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, nourishing the lung to arrest cough.Cure mainly weakness of the spleen and stomach, dry cough, xeropulmonary cough.

Phellin uspini be used for various cancer, esophageal carcinoma, gastric cancer, colon cancer, pulmonary carcinoma, breast carcinoma, uterus carcinoma etc., can improve the symptom of patient, as increase appetite and body weight, ease the pain, sometimes visual tumors reduce, ascites pleural fluid reduce.The cellular immune function of patient can be significantly improved, extend the life cycle of tumor patient, obviously improve life quality.

FLOS MUME the flowers are in blossom strongly fragrant and in, reduce phlegm, removing toxic substances.For gloomy vexed, stomachache due to hyperactive liver-QI attacking the stomach, globus hystericus, scrofula sore.

Herba Agrimoniae stops blooding, stomach invigorating.Control spitting of blood, spit blood, hematuria, has blood in stool, dysentery, bleeding not during menses, and impairment caused by overstrain takes off power, carbuncle, traumatic injury, wound hemorrhage.

Venenum Bufonis detoxifies, detumescence, heart tonifying, pain relieving; Control furuncle, carbuncle, carbuncle on the back, scrofula, chronic osteomyelitis, laryngopharynx swelling and pain, infantile malnutrition, heart failure, wind, carious pain.

The present invention is screened by great many of experiments, and adopt the Chinese crude drug of different properties, carried out scientific compatibility, have employed special preparation method, above all medicines share, and synergy is given prominence to, and have effect of promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling; Obvious inhibitory action is had to Cervical Tumor.

Pertinent clinical data is as follows:

Basic document: object of study chooses Internal Medicine-Oncology recurrent or advanced cervical cancer totally 53 examples, 33-70 years old ages, the median age 49 years old.

Person's condition is: 1. all person patients all turn out to be squamous carcinoma of the cervix, adenocarcinoma or adenosquamous carcinoma through pathological biopsy, has lost surgical engine meeting.2. there is the outer internal organs of pelvic cavity, lymph metastasis or occurred tumor recurrence in pelvic cavity after treatment first in patient.3. not pregnant, without brain metastes, there is measurable tumor focus.4. estimate life cycle >=2 months, ECOG scoring≤2 points.5. treat in first 4 weeks and do not accept chemotherapy, radiotherapy or operative treatment.6. the heart, liver and normal renal function, hemopoietic function of bone marrow is without obvious damage (leukocyte >=3.0xlO9/L, neutrophil cell >=1.5xlO9/L, platelet >=lOOxlO9/L).

Therapeutic scheme: adopt inventive embodiments 1 Chinese medicine, daily three times, each 2; Within 15 days, be a cycle, 4 cycle post-evaluation curative effects.

Evaluation criterion: therapeutic evaluation is with reference to " solid tumor the standard of curative effect evaluation (RECIST) ", be divided into complete incidence graph (CR), partial rcsponse (PR), stable disease (SD) and progression of disease (PD), be wherein effectively judged to be CR and PR sum.

Statistical method: adopt SPSS 17.0 software kit to carry out data statistic analysis.Means of subsistence statistical analysis adopts Kaplan-Meier method, and P<0.05 is that difference has statistical significance.

Curative effect is added up: 53 routine patients all can Estimating curative effect.Wherein CR13 example, PR34 example, SD3 example, PD3 example; Total effective rate is 88.68% (47/53).

Detailed description of the invention

The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.

Embodiment 1:a, get periplaneta americana 13 grams, Herba Salviae Chinensis 31 grams, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 22 grams, Radix Changii 16 grams, phellin uspini 27 grams, FLOS MUME spend 11 grams, Herba Agrimoniae 9 grams, makes 50 object powder; By solid-liquid ratio 1:9, add 85% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (38 DEG C); Then vacuum drying, makes 200 object powder;

B, get maltose 8 grams, Venenum Bufonis 1.1 restrains into 300 object powder; Then with the powder mix homogeneously in step a.According to 0.36 gram one, incapsulate.Daily three times, each 2.

Embodiment 2:a, get periplaneta americana 12 grams, Herba Salviae Chinensis 30 grams, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 21 grams, Radix Changii 15 grams, phellin uspini 26 grams, FLOS MUME spend 10 grams, Herba Agrimoniae 8 grams, makes 50 object powder; By solid-liquid ratio 1:9, add 85% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (38 DEG C); Then vacuum drying, makes 200 object powder;

B, get maltose 6 grams, Venenum Bufonis 1 restrains into 300 object powder; Then with the powder mix homogeneously in step a.According to 0.36 gram one, incapsulate.Daily three times, each 2.

Embodiment 3:a, get periplaneta americana 14 grams, Herba Salviae Chinensis 33 grams, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 23 grams, Radix Changii 17 grams, phellin uspini 28 grams, FLOS MUME spend 12 grams, Herba Agrimoniae 10 grams, makes 50 object powder; By solid-liquid ratio 1:9, add 85% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (38 DEG C); Then vacuum drying, makes 200 object powder;

B, get maltose 9 grams, Venenum Bufonis 1.2 restrains into 300 object powder; Then with the powder mix homogeneously in step a.According to 0.36 gram one, incapsulate.Daily three times, each 2.

Claims (3)

1. the medicine for cervical cancer; It is characterized in that being made up of the raw material of following parts by weight:

Periplaneta americana 12 ~ 14 parts, Herba Salviae Chinensis 30 ~ 33 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 21 ~ 23 parts, Radix Changii 15 ~ 17 parts, maltose 6 ~ 9 parts, phellin uspini 26 ~ 28 parts, FLOS MUME spend 10 ~ 12 parts, Herba Agrimoniae 8 ~ 10 parts, Venenum Bufonis 1 ~ 1.2 point.

2. the medicine for cervical cancer according to claim 1; It is characterized in that being made up of the raw material of following parts by weight: periplaneta americana 13 parts, Herba Salviae Chinensis 31 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 22 parts, Radix Changii 16 parts, maltose 8 parts, phellin uspini 27 parts, FLOS MUME spend 11 parts, Herba Agrimoniae 9 parts, Venenum Bufonis 1.1 parts.

3. prepare the method for cervical cancer medicine described in claim 1, it is characterized in that comprising the following steps:

A, the periplaneta americana of getting described parts by weight, Herba Salviae Chinensis, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), Radix Changii, phellin uspini, FLOS MUME flower, Herba Agrimoniae, make 50 object powder; By solid-liquid ratio 1:9, add 85% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (38 DEG C); Then vacuum drying, makes 200 object powder;

B, the maltose getting described parts by weight, Venenum Bufonis make 300 object powder; Then with the powder mix homogeneously in step a.