CN104306632A - An antitumor medicine and a preparing method thereof - Google Patents
An antitumor medicine and a preparing method thereof Download PDFInfo
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- CN104306632A CN104306632A CN201410501829.XA CN201410501829A CN104306632A CN 104306632 A CN104306632 A CN 104306632A CN 201410501829 A CN201410501829 A CN 201410501829A CN 104306632 A CN104306632 A CN 104306632A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
An antitumor medicine and a preparing method thereof are disclosed. The antitumor medicine is prepared from following raw materials by weight: 60 parts of coprinus atramentarius, 13 parts of yam rhizome, 16 parts of maca, 12 parts of serrate rabdosia herb, 16 parts of cassia twig, 9 parts of konjak, 1 part of dried body of scorpion and 12 parts of hyaluronic acid. The preparing method includes following steps of: a) weighing the coprinus atramentarius and the maca, preparing into powder having a size of 100 meshes, adding water the weight of which is 10 times of the weight of the powder, decocting for 4 times with decoction in each time being performed for 3 h, combining decoction liquids, concentrating until the relative density is 1.15-1.20, and drying under vacuum to obtain an extract product A; b) weighing the yam rhizome, the serrate rabdosia herb and the cassia twig, preparing into powder having a size of 100 meshes, adding ethanol having a concentration of 95% with the weight of the ethanol being 12 times of the weight of the powder, performing reflux extraction for 3 times with reflux extraction in each time being performed for 2 h, combining extraction liquids, concentrating until the relative density is 1.15-1.20, and drying under vacuum to obtain an extract product B; and c) preparing the dried body of scorpion, the konjak and the hyaluronic acid into powder having a size of more than 500 meshes, and uniformly mixing the powder with the extract product A and the extract product B.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of antitumor drug and preparation method thereof.
Background technology
Along with social development, the raising gradually of industrialization degree, environment goes from bad to worse, and rhythm of life is accelerated in addition, and the pressure that people bear continues to increase, and dietary habit, lifestyle change etc., and the sickness rate of tumor all can be caused to continue to raise.Therefore, the control of tumor has become the social problem of relation mankind future destiny, and antitumor research becomes in current life sciences and medical research to be rich in challenges and far reaching field.
Many employings surgical operation Combined with Radiotherapy chemotherapeutic treatment when Therapeutic cancer and malignant tumor at present.Though operation can remove primary lesion, when cancerous cell has had the transfer diffused to beyond original site, excision just can not be relied on separately to reach the object for the treatment of, fundamentally can not stop regeneration and the transfer of cancerous cell; Though radiotherapy, chemotherapy can kill cancerous cell, but because malignant tumor and normal structure organ or adjacent tissue form a complicated entity jointly, while treatment, normal tissue cell is suffered damage, bring out the intestines and stomach reaction, bone marrow depression and Liver and kidney impairment of cardiac function, make patient body weaker, be difficult to further treatment.Conventional chemical drugs Therapeutic Method is difficult to stop cancer cell metastasis and have very large toxic and side effects, and this is at present to the subject matter existed in the treatment of cancer.
Treatment by Chinese herbs cancer is an effective approach, and Chinese Traditional Medicine becomes the focus of antitumor research gradually to the therapeutical effect of tumor, and achieves comparatively much progress.The Therapeutic cancer that develops into of theory of Chinese medical science lays the foundation, and compound of Chinese medicine malignant tumor has unique advantage.Had the report of many treatment by Chinese herbs cancers in prior art, but the Ji Li of application treatment by Chinese herbs cancer is different, effect of drugs is also different, but reach the same goal by different routes, have certain effect to the treatment of cancer, this just illustrates in traditional Chinese medical herbal treatment cancer, should have wide excavation space.
Summary of the invention
The object of this invention is to provide a kind of antitumor drug and preparation method thereof.Treatment for tumor provides a kind of effective medicine newly.
Antitumor drug of the present invention is made up of the raw material of following parts by weight: ink-cap (Coprinus atramentartius) 52 ~ 68 parts of, Rhizoma Dioscoreae Septemlobae 13 ~ 14 parts, Maca 16 ~ 18 parts, Herba Rabdosiae Lophanthoidis 12 ~ 15 parts, Ramulus Cinnamomi 15 ~ 18 parts, Rhizoma amorphophalli 8 ~ 10 parts, Scorpio 1 ~ 2 part, hyaluronic acid 9 ~ 12 parts.
As optimization, this antitumor drug; Raw material by following parts by weight: ink-cap (Coprinus atramentartius) 60 parts of, Rhizoma Dioscoreae Septemlobae 13 parts, Maca 16 parts, Herba Rabdosiae Lophanthoidis 12 parts, Ramulus Cinnamomi 16 parts, Rhizoma amorphophalli 9 parts, Scorpio 1 part, hyaluronic acid 12 parts are made.
Prepare the method for this antitumor drug, comprise the following steps:
A, the ink-cap (Coprinus atramentartius) getting affiliated weight fraction, Maca make 100 order powder; Then add the water of 10 times of weight, decoct 4 times, each 3 hours, collecting decoction, being concentrated into relative density is 1.15 ~ 1.20, and namely vacuum drying obtains extract A;
B, get affiliated weight fraction Rhizoma Dioscoreae Septemlobae, Herba Rabdosiae Lophanthoidis, Ramulus Cinnamomi makes 100 order powder, add the ethanol of 12 times of weight concentrations 95%, reflux, extract, 3 times, each 2 hours, merge extractive liquid, being concentrated into relative density is 1.15 ~ 1.20, and namely vacuum drying obtains extract B;
C, the Rhizoma amorphophalli of described parts by weight, Scorpio, hyaluronic acid are made the above powder of 500 order; Same extract A, extract B mix homogeneously.
Effective ingredient in invention comprises: ink-cap (Coprinus atramentartius) (Classification system: Coprinus atramentarius (Bull.:Fr) Fr) beneficial the intestines and stomach, phlegm-eliminiating and qi-regulating, removing toxic substances, and detumescence, can be aid digestion, eliminates the phlegm, and controls innominate toxic swelling and other carbuncle sore.
Scorpio (Classification system Scorpionidae) has " spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., antiinflammatory counteracting toxic substances, removing obstruction in the collateral to relieve pain " function; Cure mainly diseases such as " infantile convulsion, tic spasm, dermatosis, cardiovascular and cerebrovascular disease, inflammation, hepatitis B, tumors ".
Rhizoma Dioscoreae Septemlobae (Classification system Dioscorea tokoro Makino) dispels the wind, dampness removing; Dispelling the wind and dampness pathogens insensitive impediment, lumbocrural pain, dysuria, stranguria with turbid discharge, seminal emission, damp and hot sore.
Maca (Classification system multiple access with collision avoidance) is containing the ferrum of higher amount, and protein, aminoacid, mineral zinc etc. can help firm immune system, promotes body premunition, to resisting fatigue, improves Anemia.
Rhizoma amorphophalli (Classification system Amorphophallus rivieri) is cold in nature, pungent, poisonous; Can blood circulation promoting and blood stasis dispelling, removing toxic substances and promoting subsidence of swelling, wide intestinal relieving constipation, resolving phlegm and softening hard masses; Cure mainly the disease such as blood pressure lowering, blood sugar lowering, scrofula sucutaneous nodule, damage congestive edema, constipation stomachache, laryngopharynx swelling and pain, gingival swelling and pain.
Herba Rabdosiae Lophanthoidis (Classification system Rabdosia serra (Maxim.) Hara) clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis.Control acute hepatitis, acute cholecystitis, dysentery, enteritis, the difficulty in urination, traumatic injury congestive edema.
Ramulus Cinnamomi (Classification system CassiaTwig) has effect of complement sun, promoting blood circulation, warming the spleen and stomach, normal with invigorating the liver and kidney medicine, fill blood medicine compatibility, treatment insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, have and significantly ease pain and the effect of anti-cancer and cancer-preventing.
The macromolecule mucopolysaccharide of hyaluronic acid (Hyaluronic acid) to be a kind of by D-N-acetylglucosamine and D-Glucose aldehydic acid be construction unit.
The present invention is screened by great many of experiments, adopts the Chinese crude drug of different properties, has carried out scientific compatibility, have employed special preparation method, above all medicines share, and to opposing tumor, improve autoimmune ability, the growth of anticancer, especially has good effect to cervical cancer.
Pertinent clinical data is as follows:
Basic document: object of study chooses Internal Medicine-Oncology recurrent or advanced cervical cancer totally 32 examples, 31-68 years old ages, the median age 45 years old.
Person's condition is: 1. all person patients all turn out to be squamous carcinoma of the cervix, adenocarcinoma or adenosquamous carcinoma through pathological biopsy, has lost surgical engine meeting.2. there is the outer internal organs of pelvic cavity, lymph metastasis or occurred tumor recurrence in pelvic cavity after treatment first in patient.3. not pregnant, without brain metastes, there is measurable tumor focus.4. estimate life cycle >=2 months, ECOG scoring≤2 points.5. treat in first 4 weeks and do not accept chemotherapy, radiotherapy or operative treatment.6. the heart, liver and normal renal function, hemopoietic function of bone marrow is without obvious damage (leukocyte >=3.0xlO9/L, neutrophil cell >=1.5xlO9/L, platelet >=lOOxlO9/L).
Therapeutic scheme: adopt inventive embodiments 1 Chinese medicine, daily three times, each 10; Within 21 days, be a cycle, 8 cycle post-evaluation curative effects.
Evaluation criterion: therapeutic evaluation is with reference to " solid tumor the standard of curative effect evaluation (RECIST) ", be divided into complete incidence graph (CR), partial rcsponse (PR), stable disease (SD) and progression of disease (PD), be wherein effectively judged to be CR and PR sum.
Statistical method: adopt SPSS 17.0 software kit to carry out data statistic analysis.Means of subsistence statistical analysis adopts Kaplan-Meier method, and P<0.05 is that difference has statistical significance.
Curative effect is added up: 32 routine patients all can Estimating curative effect.Wherein CR 6 example, PR22 example, SD 2 example, PD2 example; Total effective rate is 87.5% (28/32).
Detailed description of the invention
The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.
Embodiment 1:
A, get ink-cap (Coprinus atramentartius) 35 grams, Maca 16 grams, make 100 order powder, then mix homogeneously respectively; Add the water of 10 times of weight, decoct 4 times, each 3 hours, collecting decoction, being concentrated into relative density is 1.15 ~ 1.20, and namely vacuum drying obtains extract A;
100 order powder, then mix homogeneously restrained into by b, Qu Rhizoma Dioscoreae Septemlobae 13 grams, Herba Rabdosiae Lophanthoidis 12 grams, Ramulus Cinnamomi 26; Add the ethanol of 12 times of weight concentrations 95%, reflux, extract, 3 times, each 2 hours, merge extractive liquid, being concentrated into relative density is 1.15 ~ 1.20, and namely vacuum drying obtains extract B;
C, get Rhizoma amorphophalli 9 grams, Scorpio 1 gram, hyaluronic acid 12 restrain into the above powder of 300 order; Same extract A, extract B mix homogeneously.According to 0.2 gram one, incapsulate.
Embodiment 2:
A, get ink-cap (Coprinus atramentartius) 32 grams, Maca 16 grams, make 100 order powder, then mix homogeneously respectively; Add the water of 10 times of weight, decoct 4 times, each 3 hours, collecting decoction, being concentrated into relative density is 1.15 ~ 1.20, and namely vacuum drying obtains extract A;
100 order powder, then mix homogeneously restrained into by b, Qu Rhizoma Dioscoreae Septemlobae 13 grams, Herba Rabdosiae Lophanthoidis 12 grams, Ramulus Cinnamomi 25; Add the ethanol of 12 times of weight concentrations 95%, reflux, extract, 3 times, each 2 hours, merge extractive liquid, being concentrated into relative density is 1.15 ~ 1.20, and namely vacuum drying obtains extract B;
C, get Rhizoma amorphophalli 8 grams, Scorpio 1 gram, hyaluronic acid 9 restrain into the above powder of 300 order; Same extract A, extract B mix homogeneously.According to 0.2 gram one, incapsulate.
Embodiment 3:
A, get ink-cap (Coprinus atramentartius) 38 grams, Maca 18 grams, make 100 order powder, then mix homogeneously respectively; Add the water of 10 times of weight, decoct 4 times, each 3 hours, collecting decoction, being concentrated into relative density is 1.15 ~ 1.20, and namely vacuum drying obtains extract A;
100 order powder, then mix homogeneously restrained into by b, Qu Rhizoma Dioscoreae Septemlobae 14 grams, Herba Rabdosiae Lophanthoidis 15 grams, Ramulus Cinnamomi 28; Add the ethanol of 12 times of weight concentrations 95%, reflux, extract, 3 times, each 2 hours, merge extractive liquid, being concentrated into relative density is 1.15 ~ 1.20, and namely vacuum drying obtains extract B;
C, get Rhizoma amorphophalli 10 grams, Scorpio 2 grams, hyaluronic acid 12 restrain into the above powder of 300 order; Same extract A, extract B mix homogeneously.According to 0.2 gram one, incapsulate.
Claims (3)
1. antitumor drug and preparation method thereof; It is characterized in that by the raw material of following parts by weight: ink-cap (Coprinus atramentartius) 32 ~ 38 parts of, Rhizoma Dioscoreae Septemlobae 13 ~ 14 parts, Maca 16 ~ 18 parts, Herba Rabdosiae Lophanthoidis 12 ~ 15 parts, Ramulus Cinnamomi 25 ~ 28 parts, Rhizoma amorphophalli 8 ~ 10 parts, Scorpio 1 ~ 2 part, hyaluronic acid 9 ~ 12 parts are made.
2. antitumor drug according to claim 1; It is characterized in that by the raw material of following parts by weight: ink-cap (Coprinus atramentartius) 35 parts of, Rhizoma Dioscoreae Septemlobae 13 parts, Maca 16 parts, Herba Rabdosiae Lophanthoidis 12 parts, Ramulus Cinnamomi 26 parts, Rhizoma amorphophalli 9 parts, Scorpio 1 part, hyaluronic acid 12 parts are made.
3. prepare a method for antitumor drug described in claim 1, it is characterized in that comprising the following steps:
A, the ink-cap (Coprinus atramentartius) getting described weight fraction, Maca make 100 order powder; Then add the water of 10 times of weight, decoct 4 times, each 3 hours, collecting decoction, being concentrated into relative density is 1.15 ~ 1.20, and namely vacuum drying obtains extract A;
B, get described weight fraction Rhizoma Dioscoreae Septemlobae, Herba Rabdosiae Lophanthoidis, Ramulus Cinnamomi makes 100 order powder, add the ethanol of 12 times of weight concentrations 95%, reflux, extract, 3 times, each 2 hours, merge extractive liquid, being concentrated into relative density is 1.15 ~ 1.20, and namely vacuum drying obtains extract B;
C, the Rhizoma amorphophalli of described parts by weight, Scorpio, hyaluronic acid are made the above powder of 300 order; Same extract A, extract B mix homogeneously.
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| CN201410501829.XA CN104306632A (en) | 2014-09-27 | 2014-09-27 | An antitumor medicine and a preparing method thereof |
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| CN201410501829.XA CN104306632A (en) | 2014-09-27 | 2014-09-27 | An antitumor medicine and a preparing method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958473A (en) * | 2015-06-29 | 2015-10-07 | 济南正骐生物科技有限公司 | Anti-neoplastic drug composition and preparation method thereof |
| WO2017031658A1 (en) * | 2015-08-24 | 2017-03-02 | 济南正骐生物科技有限公司 | Anti-neoplastic medicine composition and preparation method therefor |
| CN108079197A (en) * | 2018-01-18 | 2018-05-29 | 张涉应 | A kind of anti-tumor drug and preparation method |
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| CN103656041A (en) * | 2013-12-11 | 2014-03-26 | 张晨 | Traditional Chinese medicine for treating cervical cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2007295906A (en) * | 2006-04-27 | 2007-11-15 | Kenko No Eki:Kk | Devil's tongue powder |
| CN103656041A (en) * | 2013-12-11 | 2014-03-26 | 张晨 | Traditional Chinese medicine for treating cervical cancer |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958473A (en) * | 2015-06-29 | 2015-10-07 | 济南正骐生物科技有限公司 | Anti-neoplastic drug composition and preparation method thereof |
| WO2017031658A1 (en) * | 2015-08-24 | 2017-03-02 | 济南正骐生物科技有限公司 | Anti-neoplastic medicine composition and preparation method therefor |
| CN108079197A (en) * | 2018-01-18 | 2018-05-29 | 张涉应 | A kind of anti-tumor drug and preparation method |
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