CN113711052B - 自动分析装置 - Google Patents
自动分析装置 Download PDFInfo
- Publication number
- CN113711052B CN113711052B CN202080028798.4A CN202080028798A CN113711052B CN 113711052 B CN113711052 B CN 113711052B CN 202080028798 A CN202080028798 A CN 202080028798A CN 113711052 B CN113711052 B CN 113711052B
- Authority
- CN
- China
- Prior art keywords
- reagent
- pipe
- temperature
- heat
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004458 analytical method Methods 0.000 title claims description 17
- 239000007788 liquid Substances 0.000 claims abstract description 102
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 67
- 238000007885 magnetic separation Methods 0.000 claims abstract description 27
- 238000006243 chemical reaction Methods 0.000 claims description 56
- 238000003756 stirring Methods 0.000 claims description 16
- 238000012546 transfer Methods 0.000 claims description 13
- 238000007599 discharging Methods 0.000 claims description 6
- 238000007664 blowing Methods 0.000 claims description 4
- 239000006148 magnetic separator Substances 0.000 abstract description 7
- 238000012545 processing Methods 0.000 description 21
- 238000006467 substitution reaction Methods 0.000 description 20
- 239000000126 substance Substances 0.000 description 10
- 238000000926 separation method Methods 0.000 description 7
- 238000003556 assay Methods 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 230000007723 transport mechanism Effects 0.000 description 6
- 238000002372 labelling Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000009833 condensation Methods 0.000 description 4
- 230000005494 condensation Effects 0.000 description 4
- 239000006249 magnetic particle Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000011810 insulating material Substances 0.000 description 2
- 238000003760 magnetic stirring Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28D—HEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS, IN WHICH THE HEAT-EXCHANGE MEDIA DO NOT COME INTO DIRECT CONTACT
- F28D1/00—Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium is a large body of fluid, e.g. domestic or motor car radiators
- F28D1/02—Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium is a large body of fluid, e.g. domestic or motor car radiators with heat-exchange conduits immersed in the body of fluid
- F28D1/04—Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium is a large body of fluid, e.g. domestic or motor car radiators with heat-exchange conduits immersed in the body of fluid with tubular conduits
- F28D1/047—Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium is a large body of fluid, e.g. domestic or motor car radiators with heat-exchange conduits immersed in the body of fluid with tubular conduits the conduits being bent, e.g. in a serpentine or zig-zag
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1888—Pipettes or dispensers with temperature control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F28—HEAT EXCHANGE IN GENERAL
- F28D—HEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS, IN WHICH THE HEAT-EXCHANGE MEDIA DO NOT COME INTO DIRECT CONTACT
- F28D21/00—Heat-exchange apparatus not covered by any of the groups F28D1/00 - F28D20/00
- F28D2021/0019—Other heat exchangers for particular applications; Heat exchange systems not otherwise provided for
- F28D2021/005—Other heat exchangers for particular applications; Heat exchange systems not otherwise provided for for medical applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00386—Holding samples at elevated temperature (incubation) using fluid heat transfer medium
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00425—Heating or cooling means associated with pipettes or the like, e.g. for supplying sample/reagent at given temperature
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00534—Mixing by a special element, e.g. stirrer
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Thermal Sciences (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019093649 | 2019-05-17 | ||
| JP2019-093649 | 2019-05-17 | ||
| PCT/JP2020/007329 WO2020235162A1 (fr) | 2019-05-17 | 2020-02-25 | Automate d'analyse |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113711052A CN113711052A (zh) | 2021-11-26 |
| CN113711052B true CN113711052B (zh) | 2024-05-24 |
Family
ID=73458601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080028798.4A Active CN113711052B (zh) | 2019-05-17 | 2020-02-25 | 自动分析装置 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220187285A1 (fr) |
| EP (2) | EP4342584A2 (fr) |
| JP (1) | JP7139525B2 (fr) |
| CN (1) | CN113711052B (fr) |
| WO (1) | WO2020235162A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4202445A1 (fr) * | 2016-12-13 | 2023-06-28 | Hitachi High-Tech Corporation | Analyseur automatique |
| US20230213543A1 (en) * | 2021-12-31 | 2023-07-06 | Instrumentation Laboratory Company | Systems and methods for probe tip heating |
| JP2024030088A (ja) * | 2022-08-23 | 2024-03-07 | 株式会社日立ハイテク | 自動分析装置 |
| WO2024075383A1 (fr) * | 2022-10-06 | 2024-04-11 | 株式会社日立ハイテク | Dispositif d'analyse automatisé et procédé de fonctionnement d'un dispositif d'analyse automatisé |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5360886A (en) * | 1985-02-27 | 1986-09-04 | Fisher Scientific Company | Temperature controlled multi-cuvette analysis system |
| JP2000097951A (ja) * | 1999-11-01 | 2000-04-07 | Olympus Optical Co Ltd | 分注装置 |
| WO2002040874A1 (fr) * | 2000-11-16 | 2002-05-23 | California Institute Of Technology | Appareil et procedes pour effectuer des dosages et des criblages a haut rendement |
| EP2145949A1 (fr) * | 2007-04-06 | 2010-01-20 | Universal Bio Research Co., Ltd. | Dispositif et procédé de régulation de la température |
| JP2011036773A (ja) * | 2009-08-10 | 2011-02-24 | Hitachi Ltd | 反応装置及び反応プラント |
| CN102375346A (zh) * | 2010-08-06 | 2012-03-14 | 株式会社日立高新技术 | 液晶曝光装置 |
| WO2017193989A1 (fr) * | 2016-05-12 | 2017-11-16 | 利多(香港)有限公司 | Dispositif de chauffage de liquide destiné à être utilisé dans un analyseur |
| WO2018163990A1 (fr) * | 2017-03-06 | 2018-09-13 | コニカミノルタ株式会社 | Système de régulation de température |
| WO2019087482A1 (fr) * | 2017-11-02 | 2019-05-09 | 株式会社日立ハイテクノロジーズ | Dispositif d'analyse automatique |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6023725Y2 (ja) * | 1977-11-10 | 1985-07-15 | 株式会社島津製作所 | 試薬分注装置 |
| JPH0634688Y2 (ja) * | 1992-06-11 | 1994-09-07 | 株式会社ニッテク | 試薬用ピペット装置 |
| JP3127660B2 (ja) * | 1993-04-15 | 2001-01-29 | 松下電器産業株式会社 | 自動蛍光検出装置 |
| JP2781790B2 (ja) * | 1996-09-25 | 1998-07-30 | 照明 伊藤 | 検体分取分注装置 |
| WO2012112622A2 (fr) | 2011-02-14 | 2012-08-23 | The Board Of Trustees Of The Leland Stanford Jr. University | Appareil, systèmes, et procédés de réalisation d'une chirurgie laparoscopique |
| JP5798603B2 (ja) * | 2013-09-24 | 2015-10-21 | 株式会社フジクラ | 筐体内に光ファイバを具備する機器、支持部材、及び支持方法 |
| CN103992938B (zh) * | 2014-05-19 | 2016-05-25 | 苏州东胜兴业科学仪器有限公司 | 基因扩增装置 |
| JP6300760B2 (ja) | 2015-06-19 | 2018-03-28 | 株式会社ユニバーサルエンターテインメント | 遊技媒体取扱装置及び遊技システム |
| JP6442378B2 (ja) * | 2015-07-23 | 2018-12-19 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
-
2020
- 2020-02-25 US US17/594,557 patent/US20220187285A1/en active Pending
- 2020-02-25 CN CN202080028798.4A patent/CN113711052B/zh active Active
- 2020-02-25 JP JP2021520053A patent/JP7139525B2/ja active Active
- 2020-02-25 WO PCT/JP2020/007329 patent/WO2020235162A1/fr active Application Filing
- 2020-02-25 EP EP24150098.2A patent/EP4342584A2/fr active Pending
- 2020-02-25 EP EP20808285.9A patent/EP3971578A4/fr active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5360886A (en) * | 1985-02-27 | 1986-09-04 | Fisher Scientific Company | Temperature controlled multi-cuvette analysis system |
| JP2000097951A (ja) * | 1999-11-01 | 2000-04-07 | Olympus Optical Co Ltd | 分注装置 |
| WO2002040874A1 (fr) * | 2000-11-16 | 2002-05-23 | California Institute Of Technology | Appareil et procedes pour effectuer des dosages et des criblages a haut rendement |
| EP2145949A1 (fr) * | 2007-04-06 | 2010-01-20 | Universal Bio Research Co., Ltd. | Dispositif et procédé de régulation de la température |
| JP2011036773A (ja) * | 2009-08-10 | 2011-02-24 | Hitachi Ltd | 反応装置及び反応プラント |
| CN102375346A (zh) * | 2010-08-06 | 2012-03-14 | 株式会社日立高新技术 | 液晶曝光装置 |
| WO2017193989A1 (fr) * | 2016-05-12 | 2017-11-16 | 利多(香港)有限公司 | Dispositif de chauffage de liquide destiné à être utilisé dans un analyseur |
| WO2018163990A1 (fr) * | 2017-03-06 | 2018-09-13 | コニカミノルタ株式会社 | Système de régulation de température |
| WO2019087482A1 (fr) * | 2017-11-02 | 2019-05-09 | 株式会社日立ハイテクノロジーズ | Dispositif d'analyse automatique |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4342584A2 (fr) | 2024-03-27 |
| CN113711052A (zh) | 2021-11-26 |
| JP7139525B2 (ja) | 2022-09-20 |
| US20220187285A1 (en) | 2022-06-16 |
| EP3971578A1 (fr) | 2022-03-23 |
| EP3971578A4 (fr) | 2023-09-06 |
| WO2020235162A1 (fr) | 2020-11-26 |
| JPWO2020235162A1 (fr) | 2020-11-26 |
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|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant |