CN113693987A

CN113693987A - Traditional Chinese medicine composition with moisturizing effect and extract and application thereof

Info

Publication number: CN113693987A
Application number: CN202111088493.5A
Authority: CN
Inventors: 陈赫予; 陈克
Original assignee: Individual
Current assignee: Chen Heyu
Priority date: 2021-09-16
Filing date: 2021-09-16
Publication date: 2021-11-26

Abstract

The invention discloses a traditional Chinese medicine composition with a moisturizing effect, and an extract and application thereof. The peucedanum root, the common cnidium fruit, the epimedium herb, the polygala root, the largehead atractylodes rhizome and the liquorice are combined together according to monarch, minister, assistant and guide compatibility to obtain the extract, and the extract can be prepared into a product with the skin moisturizing effect, can relieve and moisturize the skin, improve the moisture value of the skin, improve the skin barrier function, reduce the water loss through the epidermis, solve or improve the problems of dry skin, chap, desquamation, peeling, sensitivity, dark skin color, premature aging and the like, and keep the skin in a good state of comfort, moisturization, softness and smoothness.

Description

Traditional Chinese medicine composition with moisturizing effect and extract and application thereof

Technical Field

The invention relates to the technical field of extraction and application of a traditional Chinese medicine composition for moisturizing skin, and particularly relates to a traditional Chinese medicine composition with a moisturizing effect, and an extract and application thereof.

Background

Moisturization refers to the moisturizing of the skin. It plays a fundamental role in the overall state of the skin, and when the moisture content of the epidermis is sufficient, the skin feels comfortable, moist, soft and smooth, and the subsequent skin care steps are facilitated, so that the moisture retention is also the basis for the efficacy of other cosmetics. However, the skin moisturizing ability is reduced due to the following reasons: 1. impaired skin barrier function; 2. is in a dry environment for a long time; 3. genetic or age factors. The reduction of the moisture retention capacity causes a series of problems of skin moisture content reduction, dryness, desquamation, peeling, sensitivity, dark skin color, premature aging and the like. With the improvement of the national living standard, people pay more and more attention to the safety and efficacy of moisturizing products, and plant moisturizing components are natural and organic in source and have remarkable moisturizing effect, so that the moisturizing product is a new current skin-care trend.

At present, a plurality of types of moisturizing products are available in the market, a common moisturizing method is to directly moisturize or seal and moisturize skin by using oily components with high proportion, and the method generally has the problems of short moisturizing effect or easy pore blockage, acne generation and the like caused by heavy skin burden; the common plant raw materials have the technical problems of complex extraction process, high cost and poor cooperativity, and the application and development of the plant moisturizing product are hindered.

Disclosure of Invention

In order to solve the problems of the prior art, the invention provides a traditional Chinese medicine composition with moisturizing effect and an extract and application thereof, the adopted traditional Chinese medicine composition is selected from natural plants, a preferable combination of monarch, minister, assistant and guide compatibility is obtained through a large number of experiments, the extract can be directly used, or according to different product types, a proper amount of pure water, various water phase raw materials, oil phase raw materials, powder raw materials, stabilizing agents, preservatives and other ingredients are added into the extract to prepare a corresponding product, the product can relax and moisturize the skin, improve the moisture value of the skin, improve the barrier function of the skin, reduce the water loss through the epidermis, solve or improve the problems of skin dryness, chapping, desquamation, peeling, sensitivity, dark skin color, premature aging and the like, and ensure that the skin keeps a good state of comfort, moisturization, softness and smoothness.

The technical scheme adopted by the invention is as follows:

a traditional Chinese medicine composition with a moisturizing effect comprises the following components in parts by weight: 5-50 parts of radix peucedani, 5-50 parts of fructus cnidii, 3-30 parts of herba epimedii, 5-50 parts of polygala tenuifolia, 5-50 parts of rhizoma atractylodis macrocephalae and 5-50 parts of liquorice.

An extract of a traditional Chinese medicine composition is prepared by adding 15-20 times of pure water by weight into the traditional Chinese medicine composition, soaking the traditional Chinese medicine composition in a decocting machine for 2-4 hours, extracting the mixture for 1-1.5 hours by micro-boiling, standing the mixture for 4-6 hours, filtering supernatant liquid of the mixture, and concentrating the filtrate to about 700 parts by mass of solution under the environment of vacuum negative pressure of-0.07 to-0.1 MPa and 45-55 ℃.

The application of the extract of a traditional Chinese medicine composition is to directly use the extract or add a proper amount of pure water, various aqueous phase raw materials, oil phase raw materials, powder raw materials, stabilizing agents, preservatives and other ingredients into the extract according to different product types to prepare corresponding moisturizing cosmetics, medicines and dressings.

The invention selects six traditional Chinese medicines of radix peucedani, common cnidium fruit, epimedium herb, thinleaf milkwort root-bark, largehead atractylodes rhizome and liquoric root to be compatible according to the monarch, minister, assistant and guide formula, thereby effectively playing the moisture-preserving effect. The brief introduction of the medicinal materials is as follows:

peucedanum praeruptorum (Peucedanum praeruptorum) is described as follows according to the book 253 of the plant materials for cosmetics compiled in New edition, edited by Wang Jian Xin Shu, 1 st edition in 2020: the radix Peucedani extract has good moisture keeping effect in conductance measurement and moisture absorption test, and can be used as humectant of cosmetic by increasing skin water content by 40% when applied at 0.01%.

The cnidium fruit has the following effects according to the first 315 pages of the national pharmacopoeia 2015 edition, which is compiled by the national pharmacopoeia committee of 6 months 1 st edition of 2015 by the pharmaceutical science and technology publishing company: dry dampness and dispel wind, kill parasites and relieve itching. According to pages 334 of "cosmetic plant material universities" edited by wang Jian Xin dynasty, 6 th edition, 2012 of Chinese textile Press, there are the following records: tests such as moisture absorption of cnidium officinale extract show that it has good moisture absorption and retention properties, and can be used as skin care product for preventing and treating dry skin.

Epimedium herb is described in the book of plant materials for cosmetics compiled by Wangjian Xin Shu (handbook of plant materials for cosmetics compiled by Wang Jian Xin, 1 st edition, 2020, chemical industry Press, as follows: the water extract of herba Epimedii 0.01% can increase water content of horny layer by more than 2 times when applied, and can be used as skin humectant.

Polygala tenuifolia according to the book "cosmetic plant material universities" page 457 compiled by Wang Jian Xin Suo 6 month 1 edition 2012 of Chinese textile Press: the polygala root extract has strong inhibition effect on degradation of hyaluronic acid. This also means that the inhibition of hyaluronic acid improves the water-holding capacity of the skin layer, and is suitable for use in moisture-retaining cosmetics.

The atractylodes macrocephala koidz has the following effects according to 104 pages of the national pharmacopoeia 2015 edition, which is compiled by the national pharmacopoeia committee of 6 months 1 edition 2015 of the pharmaceutical scientific publishing company: invigorate spleen, replenish qi, dry dampness, induce diuresis, and check sweating. According to the book of plant materials for cosmetics compiled in New edition, 243, edited by Wang Jian Xin Suo, 1 st edition, 2020, of chemical industry Press, the following are mentioned: the water extract of rhizoma Atractylodis Macrocephalae has good water retention effect. The water-retaining ability of the low humidity 20% environment and the humidity of 43% were measured by weighing in a constant temperature humidity chamber and compared with glycerin. Tests show that the water holding capacity of the water extract of the white atractylodes rhizome is better than that of glycerol after a long time at low humidity, and the water extract can be used as a moisturizing agent.

Licorice root, according to the Chinese pharmacopoeia 2015, published by the national pharmacopoeia committee of 1 st edition of 6 months in 2015, the first 87 pages of which have the following effects: clearing away heat and toxic materials, relieving spasm and pain, and harmonizing the other drugs.

The technical scheme provided by the invention has the beneficial effects that:

in order to achieve the purpose of skin moisturizing, the peucedanum root, the common cnidium fruit, the epimedium herb, the polygala root, the largehead atractylodes rhizome and the liquorice are combined together according to monarch, minister, assistant and guide compatibility to obtain extracts of the peucedanum root, the common cnidium fruit, the epimedium herb, the polygala root, the largehead atractylodes rhizome and the liquorice, products with skin moisturizing effects can be prepared, the skin can be relaxed and moisturized, the moisture value of the skin is improved, the barrier function of the skin is improved, the water loss of the skin is reduced through epidermis, the problems of skin dryness, skin chapping, desquamation, peeling, sensitivity, dark skin color, premature aging and the like are solved or improved, and the skin is kept in a good state of comfort, moisturizing, softness and smoothness. The extract of the traditional Chinese medicine composition has wide application range, is safe and effective, can be used for a long time, has good compatibility with most cosmetic raw materials, has simple process when being added into cosmetics, and is suitable for industrial production.

Drawings

FIG. 1 shows a control of skin moisture changes over 30 days;

FIG. 2 shows a control of the change in epidermal water loss in skin over 30 days;

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the following detailed description is further provided in conjunction with the embodiments.

Example 1: preparation of Chinese medicinal extract of the invention

Preparing a traditional Chinese medicine extract: weighing 5g of radix peucedani, 5g of fructus cnidii, 30g of herba epimedii, 50g of polygala tenuifolia, 50g of rhizoma atractylodis macrocephalae and 50g of liquorice, washing, bagging, putting into a decocting machine, adding 15 times of pure water according to the weight of the traditional Chinese medicine composition, soaking for 4h, then extracting for 1.5h by micro-boiling, standing for 6h, taking supernatant, filtering by using a 1-micron plate frame, taking filtrate, and concentrating to about 700g of solution under the vacuum negative pressure of-0.07 to-0.1 MPa and at the temperature of 45-55 ℃ to obtain the traditional Chinese medicine extract.

Example 2: preparation of Chinese medicinal extract of the invention

Preparing a traditional Chinese medicine extract: weighing 50g of radix peucedani, 50g of fructus cnidii, 3g of herba epimedii, 10g of polygala tenuifolia, 10g of rhizoma atractylodis macrocephalae and 10g of liquorice, washing, bagging, putting into a decocting machine, adding 18 times of pure water according to the weight of the traditional Chinese medicine composition, soaking for 3h, then extracting for 1h by micro-boiling, standing for 4h, taking supernatant, filtering by using a 1-micron plate frame to obtain filtrate, and concentrating to about 700g of solution under the vacuum negative pressure of-0.07 to-0.1 MPa at the temperature of 45-55 ℃ to obtain the traditional Chinese medicine extract.

Example 3: preparation of Chinese medicinal extract of the invention

Preparing a traditional Chinese medicine extract: weighing 25g of radix peucedani, 20g of fructus cnidii, 10g of herba epimedii, 25g of polygala tenuifolia, 25g of rhizoma atractylodis macrocephalae and 20g of liquorice, washing, bagging, putting into a decocting machine, adding 20 times of pure water according to the weight of the traditional Chinese medicine composition, soaking for 2h, then extracting for 1h by micro-boiling, standing for 4h, taking supernatant, filtering by using a 1-micron plate frame to obtain filtrate, and concentrating to about 700g of solution under the vacuum negative pressure of-0.07 to-0.1 MPa at the temperature of 45-55 ℃ to obtain the traditional Chinese medicine extract.

Example 4: is the application of the traditional Chinese medicine extract in moisturizing and skin-care water.

The formula of moisturizing lotion containing 30wt% of the herbal extract prepared in example 1 is shown in table 1:

TABLE 1

The components of the formulation of table 1 were prepared according to the following process:

(1) weighing the components according to the component names and the weight in the table, and putting the components into a stirring pot;

(2) mixing the 5 components in the phase A, heating to 95-100 ℃, preserving heat for 30min, and stirring until the components are completely dissolved;

(3) adding phase B, stirring until all components are uniformly mixed and completely dissolved, cooling to below 45 ℃, and discharging.

Example 5: is the application of the traditional Chinese medicine extract in the moisturizing and skin-moistening milk.

The formula of moisturizing lotion containing 30wt% of the herbal extract prepared in example 3 is shown in table 2:

TABLE 2

The components of the formulation of table 2 were prepared according to the following process:

(1) weighing the components according to the component names and the weight in the table;

(2) mixing the phase A components, heating to 80-85 ℃, dissolving and uniformly stirring;

(3) mixing and stirring the components of the phase B until the components are completely dissolved, and heating to 80-85 ℃;

(4) adding phase B into phase A, homogenizing in a vacuum emulsifying pot at 2500rmp for 8min, vacuum-defoaming, stirring, cooling to below 45 deg.C, and discharging.

Moisture retention effect experiment of Chinese medicine extract

Selecting 20 dry skin testers, wherein the testers are 20-50 years old and 50% of male and female proportion respectively. The test site of the test person was required not to use cosmetics or external drugs 7 days before the test. Two 5X 5cm each are scribed on the inner forearm of the subject²The square test area of the size was tested by applying a test sample amount of about 0.2g to the right arm as a test area and the corresponding symmetric area of the left arm as a blank control, and simultaneously performing skin moisture content and trans-epidermal moisture loss (TEWL) tests. After the test is finished, the tested person needs to use the test sample once in the morning and at night every day, the right arm is smeared with the sample, and the left arm is smeared with the reference substance. The use was continued for 30 days and the subjects were asked to return visits on

days

5, 10, 15, 20, 25, 30 of the trial.

1: measurement of skin moisture content: the electrochemical method is mainly used for measuring the water content by adopting a capacitance method, the capacitance method is used for measuring the water content of the human skin horny layer based on the obvious difference of dielectric constants of water and other substances, the measured capacitance values of the skin are different according to the difference of the water content of the skin horny layer, and the parameters can represent the water content of the skin. The moisture retention efficacy of the product is evaluated by measuring the change of the water content of the stratum corneum through measuring the change of the capacitance of the stratum corneum of the skin before and after the product is used, and the method is one of the common methods for evaluating the efficacy of the moisture retention cosmetics.

The experimental method comprises the following steps: the moisture content of each test site was measured using a Corneometer CM825 tester and repeated 5 times, respectively, to obtain an average value. The results of the experiment are shown in FIG. 1. As can be seen from FIG. 1, the skin moisture value of the blank control sample is slightly increased but has no obvious variation trend, and the skin moisture value is improved by about 6% after the blank control sample is used for 30 days, which indicates that the skin moisture value of the blank control sample is not obviously improved; compared with a blank control sample, the traditional Chinese medicine extract prepared in the example 1 can obviously improve the skin moisture value, and the skin moisture value is increased continuously along with the time, and the skin moisture value is improved by about 37% after the traditional Chinese medicine extract is used for 30 days, so that the traditional Chinese medicine extract prepared in the example 1 has a good moisturizing effect.

2: determination of epidermal Water loss (TEWL)

The determination method comprises the following steps: according to Fick's Fick's law of diffusion, under the condition of stipulated humiture, through measuring unit time, unit cross-sectional area, near the water vapor partial pressure gradient on the epidermis (within about 1 cm), obtain the value of TEWL of water loss through the epidermis. The lower the TEWL value of the skin, the less transepidermal water loss per unit time and per unit cross-sectional area, indicating better barrier function of the skin and, conversely, worse. A relatively stable testing environment is formed on the surface of the skin by using a cylindrical cavity measuring probe, and the moisture content evaporated through the epidermis is measured by two groups of sensors, so that the moisture loss condition of the surface of the skin is measured, and the moisturizing effect of the cosmetics on the surface of the skin can be evaluated.

The experimental method comprises the following steps: the TEWL values for the trans-epidermal water loss were measured using a Tewameter TM 300 skin water loss test probe.

The experimental result is shown in fig. 2, and it can be seen from fig. 2 that the TEWL slightly decreases but the decrease trend is not obvious when the blank control sample is used, and the TEWL decreases by about 9% when the blank control sample is used for 30 days, which indicates that the skin barrier function is not obviously improved when the blank control sample is used; compared with a blank control sample, the traditional Chinese medicine extract prepared in the example 3 can obviously reduce the TEWL with an obvious reduction trend, and the TEWL is reduced by about 33% after the traditional Chinese medicine extract is used for 30 days, so that the barrier function of the skin is obviously enhanced by using the traditional Chinese medicine extract prepared in the example 3, and the traditional Chinese medicine extract prepared in the example 3 of the invention is proved to have stronger moisturizing capability.

The test and the result of the moisturizing lotion prepared in example 4 and the moisturizing lotion prepared in example 5 of the present invention are as follows:

the experimental method comprises the following steps: 30 volunteers are selected, the age is 20-50 years, and the proportion of male and female is 50% respectively.

The use method comprises the following steps: after the face is cleaned every day, a tested person coats a sample on the face skin, the sample needs to be used once in the morning and at night every day, the average change of the moisture value of the skin and the average change of the moisture loss of the skin through the epidermis are measured after the sample is continuously used for 30 days, the moisture content of the skin is increased, the moisture loss of the skin through the epidermis is reduced, and the moisturizing effect is good, otherwise, the moisturizing effect of the skin is poor. Statistics as shown in table3, showing:

item	Mean change in skin moisture value	Average change of water loss of skin through epidermis
			Example 4 moisturizing lotion	Increase by 39 percent	Reduce by 45 percent
Example 5 moisturizing lotion	The improvement is 43 percent	The reduction is 47 percent

TABLE 3

The experimental results are as follows: the moisture content of the skin was increased by 39% on average and the transepidermal water loss of the skin was decreased by 45% on average by applying the moisturizing lotion of example 4 to the face, the moisture content of the skin was increased by 43% on average and the transepidermal water loss of the skin was decreased by 47% on average by applying the moisturizing lotion of example 5 to the face. The two samples have obvious moisturizing effect, and no adverse reaction phenomena such as allergy, irritation and the like occur in the use process of the two samples.

In the above embodiments, the traditional Chinese medicine composition is a crude medicinal material or a traditional Chinese medicine decoction piece, the traditional Chinese medicine composition with the moisturizing effect and the extract and the application thereof in the embodiments include the application of the extract of the traditional Chinese medicine composition in the preparation of cosmetics, medicines, medical devices and disinfection products with the moisturizing effect.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. A traditional Chinese medicine composition with a moisturizing effect comprises the following components in parts by weight: 5-50 parts of radix peucedani, 5-50 parts of fructus cnidii, 3-30 parts of herba epimedii, 10-50 parts of polygala tenuifolia, 10-50 parts of rhizoma atractylodis macrocephalae and 10-50 parts of liquorice.

2. The traditional Chinese medicine composition with moisturizing effect as claimed in claim 1, wherein the components specifically comprise: 5 parts of radix peucedani, 5 parts of fructus cnidii, 30 parts of herba epimedii, 50 parts of polygala tenuifolia, 50 parts of rhizoma atractylodis macrocephalae and 50 parts of liquorice.

3. The traditional Chinese medicine composition with moisturizing effect as claimed in claim 1, wherein the components specifically comprise: 50 parts of radix peucedani, 50 parts of fructus cnidii, 3 parts of herba epimedii, 10 parts of polygala tenuifolia, 10 parts of rhizoma atractylodis macrocephalae and 10 parts of liquorice.

4. The traditional Chinese medicine composition with moisturizing effect as claimed in claim 1, wherein the components specifically comprise: 25 parts of radix peucedani, 20 parts of fructus cnidii, 10 parts of herba epimedii, 25 parts of polygala tenuifolia, 25 parts of rhizoma atractylodis macrocephalae and 20 parts of liquorice.

5. An extract of the traditional Chinese medicine composition as claimed in any one of claims 1 to 4, which is prepared by adding pure water 15-20 times the weight of the traditional Chinese medicine composition by mass, soaking in a decocting machine for 2-4 h, slightly boiling for extraction for 1-1.5 h, standing for 4-6 h, filtering the supernatant, and concentrating to about 700 parts by mass of solution under vacuum negative pressure of-0.07 to-0.1 MPa at 45-55 ℃.

6. The application of the extract of the traditional Chinese medicine composition with the moisturizing effect in the preparation of cosmetics with the moisturizing effect according to claim 5 is characterized in that the extract is directly used, or according to different product types, a proper amount of pure water, water phase raw materials, oil phase raw materials, powder raw materials, stabilizing agents, preservatives and the like are added into the extract to prepare corresponding moisturizing cosmetics, medicines and dressings.