CN113663023A - A Ganoderma composition for treating hypertension and its preparation method - Google Patents
A Ganoderma composition for treating hypertension and its preparation method Download PDFInfo
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Abstract
The invention provides a lucid ganoderma composition for treating hypertension and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The ganoderma lucidum composition mainly comprises the following raw materials in parts by weight: 6-10 parts of ganoderma lucidum spore oil, 10-15 parts of lily, 5-7 parts of cassia seed and 6-9 parts of parasitic loranthus. The Ganoderma composition has good effects of nourishing body and invigorating primordial qi, and can be used for treating and preventing hypertension. The lily, the cassia seed and the parasitic loranthus are used for enhancing the treatment effect of hypertension, have the effects of improving sleep, inhibiting bacteria and improving immunity, and have better curative effects on the clinical symptoms of dizziness, insomnia, dreaminess, soreness and weakness of waist and knees and the like caused by the hypertension. In addition, the preparation method of the ganoderma lucidum composition not only can enable the dissolution effect of the effective components to be better, but also has the advantages of shorter preparation period and higher cost performance.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a ganoderma lucidum composition for treating hypertension and a preparation method thereof.
Background
Hypertension (hypertension) is a clinical syndrome characterized by an increase in systemic arterial blood pressure (systolic pressure and/or diastolic pressure) (systolic pressure not less than 140 mm hg, diastolic pressure not less than 90 mm hg), which may be accompanied by functional or organic damage to organs such as heart, brain, kidney, etc. Hypertension is the most common chronic disease and also the most major risk factor for cardiovascular and cerebrovascular diseases. The blood pressure of a normal person fluctuates within a certain range along with the changes of internal and external environments. In the whole population, the blood pressure level gradually increases with age, the systolic pressure is more obvious, but the diastolic pressure shows a descending trend after the age of 50, and the pulse pressure is increased. The causes of hypertension include genetic factors, mental and environmental factors, age factors, lifestyle factors, drug influences, and disease influences, and for example, diseases such as obesity, diabetes, thyroid disease, and renal artery stenosis all cause hypertension to various degrees.
Disclosure of Invention
The invention aims to provide a ganoderma lucidum composition for treating hypertension, which can effectively treat hypertension.
Another object of the present invention is to provide a method for preparing a ganoderma lucidum composition for treating hypertension, which can prepare the ganoderma lucidum composition in a simple and convenient manner, with a short manufacturing cost and period and a high cost performance.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the invention provides a ganoderma lucidum composition for treating hypertension, which comprises the following raw materials in parts by weight: 6-10 parts of ganoderma lucidum spore oil, 10-15 parts of lily, 5-7 parts of cassia seed and 6-9 parts of parasitic loranthus.
On the other hand, the invention provides a preparation method of a ganoderma lucidum composition for treating hypertension, which mainly comprises the following steps:
decocting semen Cassiae and herba Taxilli in water to obtain medicinal liquid and residue; pulverizing Bulbus Lilii, mixing with the residue, and mixing with gel matrix or Mel to obtain paste; concentrating the medicinal liquid to obtain water extract; mixing the paste, water extract and Ganoderma spore oil to obtain mixture, drying for the first time, making into pill, kneading into pill, and drying for the second time to obtain Ganoderma composition.
The ganoderma lucidum composition for treating hypertension and the preparation method thereof provided by the embodiment of the invention at least have the following beneficial effects:
the invention provides a lucid ganoderma composition for treating hypertension, which comprises the following raw materials in parts by weight: 6-10 parts of ganoderma lucidum spore oil, 10-15 parts of lily, 5-7 parts of cassia seed and 6-9 parts of parasitic loranthus. The ganoderma lucidum composition takes ganoderma lucidum spore oil as a main nourishing raw material, so that the effect of tonifying primordial qi is achieved, on one hand, the body is nourished, and on the other hand, the good effect of treating and preventing hypertension is achieved. The lily, the cassia seed and the parasitic loranthus are used as auxiliary raw materials, the treatment effect of the ganoderma lucidum composition on hypertension is enhanced, the effects of improving sleep, inhibiting bacteria and improving immunity are achieved, and the ganoderma lucidum composition has a good improvement effect on clinical symptoms such as dizziness, insomnia and dreaminess, soreness and weakness of waist and knees and the like caused by hypertension. Therefore, the ganoderma lucidum composition is suitable for various types of hypertension and is suitable for wide crowds.
On the other hand, the invention provides a preparation method of the ganoderma lucidum composition for treating hypertension, which not only can enable the dissolution effect of the active ingredients to be better, but also has the advantages of shorter preparation period and higher cost performance.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The invention provides a lucid ganoderma composition for treating hypertension, which mainly comprises the following raw materials in parts by weight: 6-10 parts of ganoderma lucidum spore oil, 10-15 parts of lily, 5-7 parts of cassia seed and 6-9 parts of parasitic loranthus. The effects of the raw materials are as follows:
ganoderma lucidum spore oil: the Ganoderma spore oil is oily lipid extracted from wall-broken Ganoderma spore by supercritical carbon dioxide fluid extraction technology, and integrates multiple active ingredients of Ganoderma spore. The main chemical components of ganoderma lucidum spores are protein, amino acid, glycopeptide, vitamin, sterol, triterpene, alkaloid, fatty acid, lactone, inorganic ion and the like, wherein the amino acid comprises essential amino acid of organism such as isoleucine, valine, methionine, phenylalanine and the like, and the vitamin, polysaccharide, oligosaccharide, alkaloid and inorganic element are closely related to the health of human beings and the prevention and treatment of diseases. Thus, ganoderma lucidum spore oil is a material having a beneficial effect on the body. Because the ganoderma lucidum spore oil is rich in triterpenes with better biological activity, the ganoderma lucidum spores can inhibit the release of cell histamine, thereby achieving the effects of reducing blood pressure and blood fat. In addition, ganoderma lucidum also has the functions of better regulating cardiovascular system and improving body immunity.
Lily: has sweet taste and cold nature, and has effects of nourishing yin, moistening lung, clearing heart fire and tranquilizing mind, and can be used for treating yin deficiency, dryness of the shell, cough, hemoptysis, vexation, pavor, insomnia, dreaminess, and absentmindedness. It is worth mentioning here that lily has a better effect in conditioning yin deficiency and yang excess, so as to achieve the effect of treating yin deficiency and yang excess type hypertension. In addition, when the lily is used as one of the raw materials of the composition, the sleep quality of a hypertensive can be improved, and the health recovery is facilitated.
Cassia seed: sweet, bitter, slightly salty and cold in nature, enters liver and large intestine channels, has the effects of clearing liver and improving vision and relaxing bowel, and is mainly used for treating diseases such as conjunctival congestion, pain and astringency, photophobia, lacrimation, headache, dizziness, dim eyesight, constipation and the like. The cassia seed contains chrysophanol, cassia seed essence, cassia glycoside and other chemical components as well as sterol, fatty acid, protein and trace elements essential for human body, and has high blood pressure lowering, blood fat reducing and constipation relieving effects. In addition, the cassia seed also has the functions of enhancing immunity, inhibiting bacteria, promoting gastric secretion and the like, so that the ganoderma lucidum composition has a better using effect. The cassia seed has good effect on deficiency yang hyperactivity type hypertension.
Parasitic loranthus: bitter and sweet in taste, neutral in nature, entering liver and kidney meridians, has the effects of dispelling wind-damp, nourishing liver and kidney, strengthening tendons and bones and calming fetus yuan, and is mainly used for treating diseases such as rheumatic arthralgia, soreness and weakness of waist and knees, weakness of muscles and bones, dizziness and the like. Therefore, the loranthus parasiticus has good effects of nourishing liver and kidney, has good relieving and treating effects on the kidney qi deficiency type hypertension, and meanwhile, the cassia seed can also effectively treat symptoms such as dizziness, soreness and weakness of waist and knees and the like caused by the hypertension. In addition, the parasitic loranthus has better effects of promoting blood circulation and diuresis, and further achieves the effect of reducing blood pressure through diuresis.
In conclusion, the ganoderma lucidum composition takes ganoderma lucidum spore oil as a main nourishing raw material, so that the effect of tonifying primordial qi is achieved, on one hand, the body is nourished, and on the other hand, the good effect of treating and preventing hypertension is achieved. The lily, the cassia seed and the parasitic loranthus are used as auxiliary raw materials, the treatment effect of the ganoderma lucidum composition on hypertension is enhanced, the effects of improving sleep, inhibiting bacteria and improving immunity are achieved, and the ganoderma lucidum composition has a good improvement effect on clinical symptoms such as dizziness, insomnia and dreaminess, soreness and weakness of waist and knees and the like caused by hypertension. Therefore, the ganoderma lucidum composition is suitable for various types of hypertension and is suitable for wide crowds.
In the invention, the composition also comprises the following raw materials in parts by weight: 1-2 parts of cogongrass rhizome, 0.8-1.2 parts of white radish and 2-4 parts of perilla seed. The effects of the raw materials are as follows:
cogongrass rhizome: sweet taste and cold nature, entering lung, stomach and bladder channels, has the effects of cooling blood, stopping bleeding, clearing heat, inducing diuresis and the like, and is mainly used for treating blood-heat hematemesis, epistaxis, hematuria, fever polydipsia, lung-heat cough, stomach-heat vomiting, damp-heat jaundice, edema oliguria, stranguria with heat, pain and the like. The cogongrass rhizome prepared by the method has a good diuretic effect, so that the cogongrass rhizome has a good treatment effect on hypertension, and meanwhile, the cogongrass rhizome has a good antibacterial and hemostatic effect, so that when the cogongrass rhizome is used as one of raw materials of the ganoderma lucidum composition, the cogongrass rhizome can be used for cooperating with cassia seed to further achieve a good antibacterial and anti-inflammatory effect.
White radish: sweet and pungent in taste, cool in nature, and entering liver, stomach, lung and large intestine channels, has effects of clearing heat, promoting fluid production, cooling blood, stopping bleeding, descending qi, relieving epigastric distention, promoting digestion, resolving stagnation, promoting appetite, invigorating spleen, guiding qi downward, eliminating phlegm, etc., and is mainly used for treating dyspepsia, anorexia, emesis, acid regurgitation, etc. Therefore, when the white radish is used as one of the raw materials of the lucid ganoderma composition, the stomach diseases of patients can be effectively relieved. In addition, the white radish has better diuretic effect, can improve the state of a patient, can reduce the hypertension of the patient by diuresis, and has better treatment effect.
Perilla seed: pungent and warm in flavor, entering lung and large intestine meridians, has the effects of lowering qi, eliminating phlegm, relieving asthma and moistening intestine, and is mainly used for treating phlegm stagnation and adverse qi, cough and asthma, intestinal dryness and constipation, and the like. Therefore, the perilla seed has a good effect on symptoms such as asthma caused by hypertension. In addition, the perilla seeds can accelerate blood flow and reduce the generation of cholesterol, thereby achieving the effects of reducing blood pressure and blood fat.
In conclusion, the cogongrass rhizome, the white radish and the perilla seed have good diuretic effect, so that the concentration of sodium ions in a patient body is reduced, the contraction force of the smooth muscle of the arteriolar wall of the patient is reduced, the blood vessels are dilated, the blood pressure of the patient is reduced, the cardiac output is inconvenient, and the effect is good. Furthermore, the cogongrass rhizome, the white radish and the perilla seed which are used as the raw materials of the lucid ganoderma composition have good effects on stomach diseases of patients at the same time, so that the effect of conditioning bodies is achieved.
In the invention, the composition also comprises 0.5 to 1 weight part of ricepaper pith, 0.5 to 1 weight part of bruised ginger and 1 to 3 weight parts of cassia twig. The effects of the raw materials are as follows:
ricepaperplant pith: sweet and light taste, slightly cold nature, entering lung and stomach channels, has the effects of clearing and promoting diuresis and promoting lactation, and is mainly used for treating stranguria, unsmooth urination, edema, jaundice, damp-warm disease, scanty and brownish urine and other diseases. It should be noted that medulla Tetrapanacis has the effects of dredging channels and promoting blood circulation, and can avoid complications such as thrombosis caused by hypertension. Meanwhile, the ricepaperplant pith has the effects of promoting blood circulation and blood circulation, has a good diuretic effect, and has good effects of reducing blood pressure and blood fat.
Ginger worm: pungent, salty and neutral in flavor, enter liver, lung and stomach meridians, have the effects of dispelling wind, relieving spasm, resolving phlegm and resolving masses, and are mainly used for treating diseases such as wind stroke aphonia, epilepsy, headache, laryngeal wind, pharyngitis, scrofula tuberculosis, urticaria and erysipelas. In addition, the ginger worms have the effects of activating collaterals and clearing channels, and dispelling wind and removing arthralgia, so that the ginger worm not only has the effect of preventing complicated thrombotic diseases, but also can further relieve and treat headache and thoracic obstruction, and has a good using effect.
Cassia twig: it is pungent and sweet in flavor, warm in nature, and has effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels and collaterals, supporting yang, regulating qi, and calming Chong and descending qi, and can be used for treating wind-cold type common cold, abdominal psychroalgia, blood cold amenorrhea, arthralgia, phlegm and fluid retention, edema and cardiopalmus. In addition, the effects of warming channels and activating collaterals, activating yang and inducing diuresis of cassia twig can prevent and treat vascular diseases caused by hypertension.
In conclusion, the ricepaperplant pith, the bruised ginger and the cassia twig all have good effects of activating blood and dredging channels, and when the raw materials are used as the raw materials of the ganoderma lucidum composition, the ganoderma lucidum composition can effectively prevent and treat vascular diseases, blood vessel dissimilarity and other symptoms, so that the ganoderma lucidum composition has good curative effects on unsmooth blood vessels, unsmooth channels and collaterals and the like caused by hypertension.
The invention provides a preparation method of a ganoderma lucidum composition for treating hypertension, which comprises the following preparation steps:
decocting semen Cassiae and herba Taxilli in water to obtain medicinal liquid and residue; pulverizing Bulbus Lilii, mixing with the residue, and mixing with gel matrix or Mel to obtain paste; concentrating the medicinal liquid to obtain water extract; mixing the paste, water extract and Ganoderma spore oil to obtain mixture, drying for the first time, making into pill, kneading, and drying for the second time to obtain the composition.
In detail, the cassia seed and the parasitic loranthus are decocted by adding water, and the mass ratio of the water to the medicine is 2:1, so that the volume of the decoction is small, and the cost of concentration and preparation is lower. Meanwhile, water can fully dissolve the effective components in the medicine into water, the effective components cannot be saturated in the water, and the extraction effect is good.
Decocting semen Cassiae and herba Taxilli in water for 8-12 min, maintaining the temperature for 5-10 min, and filtering to obtain medicinal liquid. After decoction, a large amount of active ingredients can be dissolved out from the cassia seeds and the parasitic loranthus in the decoction process, but when the decoction time is long, the active ingredients are easy to damage under the high-temperature condition, the curative effect is poor, and when the decoction time is short, the dissolution amount of the active ingredients is small, and the curative effect is poor. After decoction, the effective components on the outer wall of the raw materials can be dissolved into the decoction more completely by keeping the temperature, so that the composition has better drug effect. When the holding time is short, the content of the effective components in the composition is relatively low, and when the holding time is long, the curative effect of the composition cannot be increased, and the time cost is high.
It should be noted here that the ultrasound is performed during the heat preservation process, and the frequency of the ultrasound is 35KHz to 45 KHz. In the heat preservation process, the dissolution rate of the effective components on the cell walls of the raw materials into water is low, so that the dissolution rate of the effective components on the cell walls into the water can be high by carrying out ultrasonic treatment, and the preparation period is short.
Grinding the residue and Bulbus Lilii before mixing, wherein the grinding pressure is 0.3-0.5 MPa, and the grinding time is 20-30 min. Under the pressure, the medicine dregs can be ground into powder, on one hand, the medicine dregs are convenient for stomach absorption and digestion, and the effective components are promoted to play a role, on the other hand, the fineness of the medicine dregs can be finer, so that the composition is finer and smoother, and the taking effect is better.
It should be noted that when the lily is pulverized, the particle size of the lily is less than 0.5mm, so that the lily and the medicine residue are better mixed, and the lily and the medicine residue are easy to absorb, so that the composition has a better curative effect.
The gel matrix or the honey and the medicine residue have the mass ratio of (7-8):1, the gel matrix and the honey can make the medicine residue in a viscous state, and the medicine residue can be used as a thickening agent, and can also be used as a filling agent to make the size of the pill larger, thereby being convenient for taking, reducing the smell and the bitter taste of the medicine and reducing the difficulty of taking. In addition, the gel matrix and the pill can be adhered to the mucous membrane of the stomach after being taken, so that the digestive absorption capacity of the stomach is enhanced.
It should be noted that the gel matrix can be selected from food-grade materials such as gelatin and xanthan gum, and glycerol can be added during mixing.
It is also noted herein that honey has a better protective effect on the stomach, so that the composition does not cause damage to the stomach and is better administered.
Homogenizing in the mixing process of the paste, the ganoderma spore oil and the water extract, wherein the homogenizing pressure is 0.2MPa-0.25 MPa. The homogeneity can make the lotion and the water extract mix more evenly to make lotion and water extract distribute evenly, avoid appearing the inhomogeneous condition of the drug effect of composition, the not good condition of quality.
After the first drying, the water content of the mixture is 20% -25%, and after the second drying, the water content of the composition is less than 5%. After the first drying, the water content of the mixture is 20% -25%, the pelleting and pill rolling processes can be easier to carry out, the pelleting difficulty is reduced, the pill making period is shortened, and the time cost is lower. After the second drying, the water content of the composition is less than 5%, and at the moment, the composition has better preservation effect and longer preservation period.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The present embodiment aims to provide a ganoderma lucidum composition for treating hypertension, which comprises the following raw materials:
8kg of ganoderma lucidum spore oil, 13kg of lily, 6kg of cassia seed and 8kg of parasitic loranthus.
The preparation method of the composition comprises the following steps:
decocting semen Cassiae and herba Taxilli with water (the mass ratio of water to medicine is 2:1) to obtain medicinal liquid and residue; grinding the residue under 0.4MPa for 25min, pulverizing Bulbus Lilii to particle size of less than 0.5mm, mixing with ground residue, and mixing with gel matrix at a mass ratio of 7.5:1 to obtain paste; concentrating the medicinal liquid 15 times to obtain water extract; mixing the paste, water extract and Ganoderma spore oil, homogenizing under 0.22MPa to obtain mixture, drying for the first time (drying temperature of 60-80 deg.C, drying time of 1h-3h), making into pill, kneading, and drying for the second time (drying temperature of 120-130 deg.C, drying time of 4h-6h) to obtain the composition.
Example 2
The present embodiment aims to provide a ganoderma lucidum composition for treating hypertension, which comprises the following raw materials:
6kg of ganoderma lucidum spore oil, 10kg of lily, 5kg of cassia seed, 6kg of parasitic loranthus, 1kg of cogongrass rhizome, 0.8kg of white radish and 2kg of perilla seed.
The preparation method of the composition comprises the following steps:
decocting semen Cassiae and herba Taxilli with water (the mass ratio of water to medicine is 2:1) to obtain medicinal liquid and residue; grinding the residue under 0.3MPa for 20min, pulverizing Bulbus Lilii to particle size of less than 0.5mm, mixing with ground residue, and mixing with gel matrix at a mass ratio of 7:1 to obtain paste; concentrating the medicinal liquid 16 times to obtain water extract; mixing the paste, water extract and Ganoderma spore oil, homogenizing under 0.20MPa to obtain mixture, drying for the first time (drying temperature of 60-80 deg.C, drying time of 1h-3h), making into pill, kneading, and drying for the second time (drying temperature of 120-130 deg.C, drying time of 4h-6h) to obtain the composition.
Example 3
The present embodiment aims to provide a ganoderma lucidum composition for treating hypertension, which comprises the following raw materials:
10kg of ganoderma lucidum spore oil, 15kg of lily, 7kg of cassia seed, 9kg of parasitic loranthus, 2kg of cogongrass rhizome, 1.2kg of white radish, 4kg of perilla fruit, 1kg of ricepaper pith, 1kg of ginger worm and 3kg of cassia twig.
The preparation method of the composition comprises the following steps:
decocting semen Cassiae and herba Taxilli with water (the mass ratio of water to medicine is 2:1) to obtain medicinal liquid and residue; grinding the residue under 0.5MPa for 20min, pulverizing Bulbus Lilii to particle size of less than 0.5mm, mixing with ground residue, and mixing with Mel at a mass ratio of 8:1 to obtain paste; concentrating the medicinal liquid by 14 times to obtain water extract; mixing the paste, water extract and Ganoderma spore oil, homogenizing under 0.25MPa to obtain mixture, drying for the first time (drying temperature of 60-80 deg.C, drying time of 1h-3h), making into pill, kneading, and drying for the second time (drying temperature of 120-130 deg.C, drying time of 4h-6h) to obtain the composition.
Example 4
The present embodiment aims to provide a ganoderma lucidum composition for treating hypertension, which comprises the following raw materials:
7kg of ganoderma lucidum spore oil, 11kg of lily, 5.5kg of cassia seed, 6.5kg of loranthus parasiticus, 1.5kg of cogongrass rhizome, 0.9kg of white radish, 2.5kg of perilla fruit, 0.5kg of ricepaper pith, 0.5kg of euglena and 1kg of cassia twig.
The preparation method of the composition comprises the following steps:
decocting semen Cassiae and herba Taxilli with water (the mass ratio of water to medicine is 2:1) to obtain medicinal liquid and residue; grinding the residue under 0.35MPa for 20min, pulverizing Bulbus Lilii to particle size of less than 0.5mm, mixing with ground residue, and mixing with Mel at a mass ratio of 7:1 to obtain paste; concentrating the medicinal liquid 15 times to obtain water extract; mixing the paste, water extract and Ganoderma spore oil, homogenizing under 0.23MPa to obtain mixture, drying for the first time (drying temperature of 60-80 deg.C, drying time of 1h-3h), making into pill, kneading, and drying for the second time (drying temperature of 120-130 deg.C, drying time of 4h-6h) to obtain the composition.
Example 5
The present embodiment aims to provide a ganoderma lucidum composition for treating hypertension, which comprises the following raw materials:
9kg of ganoderma lucidum spore oil, 14kg of lily, 6.5kg of cassia seed, 8.5kg of loranthus parasiticus, 1.8kg of cogongrass rhizome, 1.1kg of white radish, 3.5kg of perilla fruit, 0.8kg of ricepaper pith, 0.8kg of euglena and 2.5kg of cassia twig.
The preparation method of the composition comprises the following steps:
decocting semen Cassiae and herba Taxilli with water (the mass ratio of water to medicine is 2:1) to obtain medicinal liquid and residue; grinding the residue under 0.45MPa for 28min, pulverizing Bulbus Lilii to particle size of less than 0.5mm, mixing with ground residue, and mixing with Mel at a mass ratio of 8:1 to obtain paste; concentrating the medicinal liquid 15 times to obtain water extract; mixing the paste, water extract and Ganoderma spore oil, homogenizing under 0.24MPa to obtain mixture, drying for the first time (drying temperature of 60-80 deg.C, drying time of 1h-3h), making into pill, kneading, and drying for the second time (drying temperature of 120-130 deg.C, drying time of 4h-6h) to obtain the composition.
Effect example 1
The products prepared in examples 1-5 were subjected to stability tests, the results of which are shown in Table 1. The test method is as follows:
the products prepared in examples 1-5 were stored for 120 days at 10 deg.C, 30 deg.C and 60 deg.C, respectively, and at a relative humidity of 75% -85%.
TABLE 1 test results
As can be seen from the above table, the products prepared in examples 1 to 5 have good stability, do not have mildewing performance in high temperature and high humidity environments, and have high stability due to the good antibacterial effect of the raw materials themselves. Moreover, the prepared product has light medicinal flavor, is suitable for taking and has good effect.
Effect example 2
100 volunteers were collected, patients aged 46-65 years, mean age (58.21 + -2.31) years, body mass index of 21kg/m2-25 kg/m2The average body mass index is (23.36 +/-1.58) kg/m2The disease course is 5 years to 9 years, and the average is (8.14 +/-1.43) years. Inclusion and exclusion criteria were as follows:
selecting a standard: 1) has the syndrome of blood stasis and qi stagnation, and the main symptoms are headache, dizziness and soft knee; the secondary symptoms are insomnia, palpitation and amnesia; 2) not participating in other related studies within three months; 3) oral antihypertensives for controlling blood pressure.
Exclusion criteria: 1) slow and acute diseases such as severe center of gravity, lung, liver and the like are combined; 2) patients with combined malignant tumors or severe infections; 3) renal failure or organic lesions.
The taking method comprises the following steps: the volunteers were divided into 4 groups according to the disease conditions, namely, the group of example 1, the group of example 2, the group of example 4 and the group of example 5, and 1g to 1.5g of the product was orally taken respectively for 1 time per day and 3 months continuously, and the curative effect is shown in table 2.
The treatment effect is determined as follows:
the effect is shown: a decrease in diastolic (systolic) pressure of greater than 20mm Hg and blood pressure that has fallen to a normal level, or has not reached a normal state but has fallen to a value greater than 20mm Hg;
the method has the following advantages: the diastolic (systolic) pressure drop is greater than 10mm Hg and the blood pressure has been normal, or has not reached normal but has dropped to 10-19 mm Hg;
and (4) invalidation: both diastolic and systolic pressures do not meet the above objectives. The total effective rate is the effective rate plus the significant efficiency.
TABLE 2 therapeutic results
As can be seen from the above table, the product prepared by the invention has good treatment effect on hypertension and can effectively control blood pressure. The reason why the treatment effect of the group of example 3 is better is that the raw materials are more added in the preparation process of example 3, so that the effect is better.
To sum up, the invention provides a ganoderma lucidum composition for treating hypertension, which comprises the following raw materials in parts by weight: 6-10 parts of ganoderma lucidum spore oil, 10-15 parts of lily, 5-7 parts of cassia seed and 6-9 parts of parasitic loranthus. The ganoderma lucidum composition takes ganoderma lucidum spore oil as a main nourishing raw material, so that the effect of tonifying primordial qi is achieved, on one hand, the body is nourished, and on the other hand, the good effect of treating and preventing hypertension is achieved. The lily, the cassia seed and the parasitic loranthus are used as auxiliary raw materials, the treatment effect of the ganoderma lucidum composition on hypertension is enhanced, the effects of improving sleep, inhibiting bacteria and improving immunity are achieved, and the ganoderma lucidum composition has a good improvement effect on clinical symptoms such as dizziness, insomnia and dreaminess, soreness and weakness of waist and knees and the like caused by hypertension. Therefore, the ganoderma lucidum composition is suitable for various types of hypertension and is suitable for wide crowds.
On the other hand, the invention provides a preparation method of the ganoderma lucidum composition for treating hypertension, which not only can enable the dissolution effect of the active ingredients to be better, but also has the advantages of shorter preparation period and higher cost performance.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. The ganoderma lucidum composition for treating hypertension is characterized by comprising the following raw materials in parts by weight: 6-10 parts of ganoderma lucidum spore oil, 10-15 parts of lily, 5-7 parts of cassia seed and 6-9 parts of parasitic loranthus.
2. The ganoderma lucidum composition for treating hypertension according to claim 1, further comprising the following raw materials in parts by weight: 1-2 parts of cogongrass rhizome, 0.8-1.2 parts of white radish and 2-4 parts of perilla seed.
3. The ganoderma lucidum composition for treating hypertension according to claim 2, comprising 0.5-1 parts by weight of ricepaper pith, 0.5-1 parts by weight of euglena officinalis and 1-3 parts by weight of cinnamomum cassia twig.
4. A method for preparing the ganoderma lucidum composition for treating hypertension according to any one of claims 1 to 3, comprising the steps of:
decocting semen Cassiae and herba Taxilli in water to obtain medicinal liquid and residue; pulverizing Bulbus Lilii, mixing with the residue, and mixing with gel matrix or Mel to obtain paste; concentrating the medicinal liquid to obtain water extract; mixing the paste, the water extract and the ganoderma lucidum spore oil to obtain a mixture, drying for the first time, and then making pills, rolling the pills and drying for the second time to obtain the ganoderma lucidum composition.
5. The preparation method according to claim 4, wherein the decoction time is 8min-12min, the decoction is kept for 5min-10min, and the decoction is filtered to obtain the liquid medicine.
6. The method according to claim 5, wherein ultrasound is performed during the incubation, and the frequency of the ultrasound is 35KHz to 45 KHz.
7. The preparation method according to claim 4, wherein the residue is ground before being mixed with the lily, the grinding pressure is 0.3MPa to 0.5MPa, and the grinding time is 20min to 30 min.
8. The preparation method of claim 4, wherein the mass ratio of the gel matrix or honey to the medicine residue is (7-8): 1.
9. The method according to claim 4, wherein the homogenization is performed during the mixing of the ointment, the ganoderma lucidum spore oil and the water extract, and the pressure of the homogenization is 0.2MPa to 0.25 MPa.
10. The preparation method according to claim 4, wherein the water content of the mixture is 20% to 25% after the first drying, and the water content of the Ganoderma composition is less than 5% after the second drying.
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