CN113663002A - 一种治疗尖锐湿疣的中药组合物及其制备方法 - Google Patents
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Abstract
本发明属于中医药技术领域，公开了一种治疗尖锐湿疣的中药组合物及其制备方法。以大黄清热泻火，凉血解毒；樟脑疥癣瘙痒、疮疡湿烂；虎杖痈肿疮毒；苦参湿疹湿疮，皮肤瘙痒；蛇床子抗病原微生物作用；白鲜皮湿热疮毒，湿疹；黄丹拔毒生肌，杀虫止痒；五倍子收湿敛疮，对金黄色葡萄球菌、链球菌、肺炎球菌、伤寒、副伤寒、痢疾、炭疽、白喉、绿脓等杆菌均有抑制作用；地肤子利尿通淋，清热利湿，止痒的功效。黄柏清热燥湿，泻火解毒，除骨蒸的功效。具有宣散风热、清解血毒的功效；还具备抗病原微生物、清热解毒抑菌杀灭病毒，软坚散结，拔毒生肌。制备方法简单，便于制备，便于保存，便于使用。
Description
技术领域
本发明属于中医药技术领域，具体涉及一种治疗尖锐湿疣的中药组合物及其制备方法。
背景技术
目前市面上治疗尖锐湿疣的方法，包括辅食要激光多种手术治疗，甚至化疗，但给这些方法给病人造成的副作用非常大，而且费用高治愈率低等缺陷。
发明内容
为了解决现有技术存在的上述问题，本发明目的在于提供一种治疗尖锐湿疣的中药组合物及其制备方法。
本发明所采用的技术方案为：一种治疗尖锐湿疣的中药组合物，所述组合物主要由以下质量份数的原料制备得到：
大黄10-30份，樟脑5-15份，虎杖15-45份，苦参10-30份，蛇床子15-45份，白鲜皮10-30份，黄丹10-30份，五倍子20-60份，地肤子15-45份和黄柏5-15份。
大黄，中药名。为蓼科大黄属植物掌叶大黄Rheum palmatum L.、唐古特大黄R.tanguticumMaxim.exBalf.或药用大黄R.officinaleBaill.的根及根茎。具有泻下攻积，清热泻火，凉血解毒，逐瘀通经的功效。主治积滞便秘，血热吐衄，目赤咽肿，热毒疮疡，烧烫伤，瘀血诸证，湿热痢疾、黄疸、淋证。味苦，性寒；归脾、胃、大肠、肝经。化学成分：主要为蒽醌衍生物，主要包括蒽醌苷和双蒽醌苷。双蒽醌苷中有番泻苷A、B、C、D、E、F；游离型的苷元有大黄酸、大黄酚、大黄素、芦荟大黄素、大黄素甲醚等。另含鞣质类物质、有机酸和雌激素样物质等。药理作用：1、对消化系统的作用：大黄有泻下作用，大黄蒽醌苷是其产生泻下作用的主要成分。对胃、十二指肠以及肝损伤有保护作用，并能促进胆汁和胰腺的分泌。2、对血液系统的作用：大黄对微循环具有双向调节作用，既能止血，又能活血，还可降血脂。3、抗病原微生物作用：大黄蒽醌对金黄色葡萄球菌、肺炎链球菌、白喉杆菌、大肠杆菌等，均有不同程度的抑制作用。此外，大黄对某些真菌、阿米巴原虫、阴道滴虫和血吸虫等均有一定的抑制作用。4、对心血管系统的作用：大黄小剂量有强心作用，大剂量则表现为抑制作用。大黄酊剂可使兔耳血管扩张，使正常大鼠血压下降。5、对免疫功能的作用：大黄对免疫功能有增强作用，能促进人T淋巴细胞转化，提高肝炎患者血内巨噬细胞的吞噬功能。大黄蒽醌类衍生物对机体免疫功能也有一定的抑制作用。6、此外，大黄尚有一定的降低尿素氮、利尿、抗炎、解热、抗肿瘤、抗衰老、抗生育等作用。毒理作用：小鼠腹腔注射掌叶大黄醇提取物40g(生药)/kg，大鼠灌服煎剂30g/kg，72h内未见异常表现和死亡，小鼠口服掌叶大黄煎剂LD50153.5±4.5g/kg。
樟脑，中药名。为樟科樟属植物樟Cinnamomumcamphora(L.)Presl.的枝、干、叶及根部，经提炼制成的颗粒状物结晶。具有除湿杀虫，温散止痛，开窍辟秽的功效。主治痧胀腹痛、吐泻、神昏、疥癣瘙痒、疮疡湿烂、寒湿脚气、牙痛、跌打伤痛等。味辛，性热；归心、脾经。化学成分：为一种双环萜酮(C10H16O)物质。药理作用：1、局部作用：樟脑涂于皮肤有温和的刺激及防腐作用，还有轻度的局部麻醉作用。2、对中枢神经系统的作用：具有兴奋中枢神经系统的作用。3、对循环系统的作用：樟脑制剂曾一度广泛应用为强心药，但各家报告结果很不一致，迄今无定论。4、此外，樟脑口服有驱风作用以及轻微的祛痰作用。
虎杖，中药名。为蓼科蓼属植物虎杖Polygonumcuspidatum Sieb.et Zucc.的干燥根茎和根。具有利湿退黄，清热解毒，散瘀止痛，化痰止咳的功效。主治湿热黄疸、淋浊、带下、水火烫伤、痈肿疮毒、毒蛇咬伤、经闭、癥瘕、跌打损伤、风湿痹痛、肺热咳嗽等。味微苦，性微寒；归肝、胆、肺经。化学成分：含虎杖苷、黄酮类、大黄素、大黄素甲醚、白藜芦醇、多糖。药理作用：1、抗病原微生物的作用：虎杖煎剂、虎杖苷及白藜芦醇对金黄色葡萄球菌、白色葡萄球菌、卡他球菌、甲型或乙型链球菌、大肠杆菌、变形杆菌、绿脓杆菌、伤寒杆菌、福氏痢疾杆菌等有抑制作用。虎杖水煎液对多种病毒也有抑制作用。2、对呼吸系统的影响：虎杖有镇咳作用，虎杖煎剂还能明显对抗组织胺引起的豚鼠离体气管的收缩。3、对心血管系统的影响：虎杖煎剂有降压、减慢心率、加强心肌收缩力、保护心脏、抑制血小板聚集、改善血液流变学、改善微循环、升高白细胞及血小板、抗休克的作用。4、对中枢系统的影响：虎杖有镇静、镇痛的作用。5、此外，虎杖还有止血、抗肿瘤、降血糖、降血脂、抗炎、抗氧化的作用。毒理作用：在虎杖蒽醌衍生物的小鼠最大耐受量实验中，小鼠口服9g/kg。1星期无死亡。大黄素、白藜芦醇甙对小鼠腹腑注射的LD50分别为249.5±34.3mg/kg和1000.0±57.3mg/kg。
苦参，中药名。为豆科槐属植物苦参SophoraflavescensAit.的干燥根。具有清热燥湿，杀虫，利尿的功效。主治湿热泻痢，便血，黄疸，湿热带下，阴肿阴痒，湿疹湿疮，皮肤瘙痒，疥癣，湿热小便不利。味苦，性寒；归心、肝、胃、大肠经。化学成分：本品含苦参碱、氧化苦参碱、异苦参碱、槐果碱、异槐果碱、槐胺碱、氧化槐果碱等生物碱，此外还含苦醇C、苦醇G、异苦参酮、苦参醇、新苦参醇等黄酮类化合物。药理作用：本品对心脏有明显的抑制作用，可使心率减慢，心肌收缩力减弱，心输出量减少；苦参、苦参碱、苦参黄酮均有抗心律失常作用；苦参注射液对抗乌头碱所致的心律失常，作用较快而持久，并有降压作用；其煎剂对结核杆菌、痢疾杆菌、金黄色葡萄球菌、大肠杆菌均有抑制作用，对多种皮肤真菌也有抑制作用。还有利尿、抗炎、抗过敏、镇静、平喘、祛痰、升高白细胞、抗肿瘤等作用。
蛇床子，中药名。为伞形科蛇床属植物蛇床Cnidiummonnieri(L.)Cuss.的果实。具有温肾壮阳，燥湿杀虫，祛风止痒的功效。主治阴部湿痒，湿疹，疥癣；寒湿带下，湿痹腰痛；肾虚阳痿，宫冷不孕等。味辛，苦，性温；归脾，肾经。化学成分：果实含挥发油1.3％，已从油中分出27个成分。还含香豆精类等成分，如蛇床明素、花椒毒素等。药理作用：1、对循环系统作用：有抗心律失常、降压作用。2、对呼吸系统作用：有平喘、祛痰、扩张支气管作用。3、抗病原微生物作用：对耐药性金黄色葡萄球菌、绿脓杄菌及皮肤癣菌、滴虫有抑制作用。4、对免疫系统作用：具有增强免疫功能、抗变态反应作用。5、对神经系统作用：有镇痛、局麻、改善脑功能、促进记忆作用。6、此外，蛇床子还有抗骨质疏松、抗炎、抗诱变、性激素样等作用。毒理作用：蛇床子总香豆精小鼠口服LD50为2.44±0.05g/kg。100％蛇床子提取液20m/kg腹腔注射，注药后30min内小鼠活动减少，呈现镇静作用，观察48h未见小鼠死亡、兔眼角膜实验中，未见结膜红肿、充血。
白鲜皮，中药名。为芸香科白鲜属植物白鲜DictamnusdasycarpusTurcz.的干燥根皮。具有清热燥湿，祛风解毒的功效。主治湿热疮毒，湿疹，疥癣，湿热黄疸，风湿热痹。味苦，性寒；归脾、胃、膀胱经。化学成分：本品含白鲜碱、白鲜内酯、胡芦巴碱、胆碱、谷甾醇、白鲜脑交酯、稗皮酮、黄柏酮、黄柏酮酸等。药理作用：本品水浸剂对堇色毛癣菌、同心性毛癣菌、许兰氏黄癣菌、奥杜盎氏小芽孢癣菌、铁锈色小芽孢癣菌、羊毛状小芽孢癣菌、腹股沟表皮癣菌、星形奴卡氏菌等多种致病性真菌有不同程度的抑制作用，并有解热作用；白鲜碱对家兔和豚鼠子宫平滑肌有强力的收缩作用，小剂量白鲜碱对离体蛙心有兴奋作用，对离体兔耳血管有明显的收缩作用；本品挥发油在体外有抗癌作用。
黄丹，将纯铅放在铁锅中加热，炒动，利用空气使之氧化，待冷后放入石臼中研成粉末。用水漂洗，将粗细粉末分开，漂出之细粉，再经氧化24小时，研成细粉过筛即得。生用或炒用。性味归经：药材为橙红色或橙黄色粉末，光泽黯淡，不透明。以色橙红，细腻光滑，无粗粒，见水不成疙瘩者为佳。辛，微寒，有毒。归心、入脾、肝经。功效：外用：拔毒生肌，杀虫止痒；内服：坠痰镇惊，攻毒截疟。临床：用于疮疡多脓。本品主要外用于散剂及膏药中，能与植物油化合，为制膏药的基础剂，有较好的解毒收敛作用。如经验方红油膏，即用本品配合九一丹(熟石膏九钱、升丹一钱)，调入油膏内，有防腐生肌作用，可治溃疡不敛。
五倍子，中药名。为漆树科盐肤木属植物盐肤木Rhuschinensis Mill.、青麸杨Rhuspotaninii Maxim.或红麸杨RhuspunjabensisStew.var.sinica(Diels)Rehd.etWils.叶上的虫瘿，主要由五倍子蚜Melaphischinensis(Bell)Baker寄生而形成。具有敛肺降火，止咳止汗，涩肠止泻，固精止遗，收敛止血，收湿敛疮的功效。主治咳嗽，咯血，自汗，盗汗，久泻，久痢，遗精，滑精，崩漏，便血痔血，湿疮，肿毒。味酸、涩，性寒；归肺、大肠、肾经。化学成分：本品主含没食子鞣质60％-70％、没食子酸2％-4％以及树脂、脂肪、蜡质、淀粉等。药理作用：没食子酸对蛋白质有沉淀作用，与皮肤、黏膜的溃疡面接触后，其组织蛋白质即被凝固，形成一层被膜而呈收敛作用；腺细胞的蛋白质被凝固引起分泌抑制，产生黏膜干燥；神经末梢蛋白质的沉淀，可呈微弱的局部麻醉现象。与若干金属、生物碱苷类形成不溶解化合物，因而用作解毒剂。对小肠有收敛作用，可减轻肠道炎症，止腹泻。此外，对金黄色葡萄球菌、链球菌、肺炎球菌、伤寒、副伤寒、痢疾、炭疽、白喉、绿脓等杆菌均有抑制作用。
地肤子，中药名。为藜科地肤属植物地肤Kochiascoparia(L.)Schrad的成熟果实。具有利尿通淋，清热利湿，止痒的功效。主治淋证，阴痒带下，风疹，湿疹。味辛、苦，性寒；归肾、膀胱经。化学成分：本品含三萜皂苷、脂肪油、维生素A类物质。药理作用：本品水浸剂对许兰氏黄癣菌、奥杜盎氏小芽孢癣菌、铁锈色小芽孢癣菌等多种皮肤真菌，均有不同程度的抑制作用。地肤子水提物有抑制单核巨噬系统的吞噬功能及迟发型超敏反应(DTH)。
黄柏，中药名。为芸香科黄檗属植物黄皮树PhellodendronchinenseSchneid.的干燥树皮。具有清热燥湿，泻火解毒，除骨蒸的功效。主治湿热带下，热淋涩痛，湿热泻痢，黄疸，湿热脚气，痿证，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹瘙痒。味苦，性寒；归肾、膀胱、大肠经。化学成分：黄柏树皮含有小檗碱、黄柏碱、木兰花碱、药根碱、掌叶防己碱等多种生物碱，并含黄柏内酯、黄柏酮、黄柏酮酸及7-脱氢豆甾醇、β-谷甾醇、菜油甾醇等；黄皮树树皮含小檗碱、木兰花碱、黄柏碱、掌叶防己碱等多种生物碱及内酯、甾醇等。药理作用：本品具有与黄连相似的抗病原微生物作用，对痢疾杆菌、伤寒杆菌、结核杆菌、金黄色葡萄球菌、溶血性链球菌等多种致病细菌均有抑制作用；对某些皮肤真菌、钩端螺旋体、乙肝表面抗原也有抑制作用；所含药根碱具有与小檗碱相似的正性肌力和抗心律失常作用；黄柏提取物有降压、抗溃疡、镇静、肌松、降血糖及促进小鼠抗体生成等作用。
作为优选地，所述组合物主要由以下质量份数的原料制备得到：
大黄14-26份，樟脑7-13份，虎杖21-40份，苦参14-26份，蛇床子21-40份，白鲜皮14-26份，黄丹14-26份，五倍子28-52份，地肤子21-40份和黄柏7-13份。
作为优选地，所述组合物主要由以下质量份数的原料制备得到：
大黄20份，樟脑10份，虎杖30份，苦参20份，蛇床子30份，白鲜皮20份，黄丹20份，五倍子40份，地肤子30份和黄柏10份。
一种治疗尖锐湿疣的中药组合物的制备方法，所述方法包括按照相应比例选取大黄、樟脑、虎杖、苦参、蛇床子、白鲜皮、黄丹、五倍子、地肤子和黄柏分别粉碎后、混合、加入溶剂混匀，获得成品。
作为优选地，所述大黄、樟脑、虎杖、苦参、蛇床子、白鲜皮、黄丹、五倍子、地肤子和黄柏分别粉碎，粒径均过500-2000目。
作为优选地，所述大黄、樟脑、虎杖、苦参、蛇床子、白鲜皮、黄丹、五倍子、地肤子和黄柏分别粉碎，粒径均过1000-1500目。
作为优选地，所述溶剂为酒。
作为优选地，所述溶剂中含有乙醇的质量份数为38-60wt％。
作为优选地，所述大黄、樟脑、虎杖、苦参、蛇床子、白鲜皮、黄丹、五倍子、地肤子和黄柏的总质量与溶剂的质量比为1：3-5。
作为优选地，所述成品为外用制剂。
本发明的有益效果为：
本发明提供了一种治疗尖锐湿疣的中药组合物，该组合物是以大黄，味苦，性寒；归脾、胃、大肠、肝经；泻下攻积，清热泻火，凉血解毒，逐瘀通经；樟脑，味辛，性热；归心、脾经；主治痧胀腹痛、吐泻、神昏、疥癣瘙痒、疮疡湿烂、寒湿脚气、牙痛、跌打伤痛；虎杖，味微苦，性微寒；归肝、胆、肺经；主治湿热黄疸、淋浊、带下、水火烫伤、痈肿疮毒、毒蛇咬伤、经闭、癥瘕、跌打损伤、风湿痹痛、肺热咳嗽等；苦参，味苦，性寒；归心、肝、胃、大肠经主治湿热泻痢，便血，黄疸，湿热带下，阴肿阴痒，湿疹湿疮，皮肤瘙痒，疥癣，湿热小便不利，还有利尿、抗炎、抗过敏、镇静、平喘、祛痰、升高白细胞、抗肿瘤等作用。蛇床子，味辛，苦，性温；归脾，肾经；主治阴部湿痒，湿疹，疥癣；寒湿带下，湿痹腰痛；肾虚阳痿，宫冷不孕等。抗病原微生物作用、抗骨质疏松、抗炎、抗诱变、性激素样等作用。白鲜皮，味苦，性寒；归脾、胃、膀胱经；主治湿热疮毒，湿疹，疥癣，湿热黄疸，风湿热痹。黄丹，归心、入脾、肝经。功效：外用：拔毒生肌，杀虫止痒。五倍子，味酸、涩，性寒；归肺、大肠、肾经；敛肺降火，止咳止汗，涩肠止泻，固精止遗，收敛止血，收湿敛疮的功效。此外，对金黄色葡萄球菌、链球菌、肺炎球菌、伤寒、副伤寒、痢疾、炭疽、白喉、绿脓等杆菌均有抑制作用。地肤子，味辛、苦，性寒；归肾、膀胱经；利尿通淋，清热利湿，止痒的功效。黄柏，味苦，性寒；归肾、膀胱、大肠经；清热燥湿，泻火解毒，除骨蒸的功效。
该组合物不仅具有宣散风热、清解血毒的功效；还具备抗病原微生物、清热解毒抑菌杀灭病毒，软坚散结，拔毒生肌。
该组合物的制备方法简单，便于制备，便于保存，便于使用。
具体实施方式
下面结合具体实施例对本发明做进一步阐释。本领域技术人员将会理解，下列所描述的实施例是本发明一部分实施例，而不是全部的实施例，仅用于说明本发明，而不应视为限制本发明的范围。所用试剂均为可以通过市售购买获得的常规产品。
实施例1：
一种治疗尖锐湿疣的中药组合物的制备方法，所述方法包括按照相应比例选取大黄100克、樟脑50克、虎杖150克、苦参100克、蛇床子150克、白鲜皮100克、黄丹100克、五倍子200克、地肤子150克和黄柏50克分别粉碎后过500目滤筛、混合、加入38wt％乙醇3450克混匀，获得成品。
实施例2：
一种治疗尖锐湿疣的中药组合物的制备方法，所述方法包括按照相应比例选取大黄300克、樟脑150克、虎杖450克、苦参300克、蛇床子450克、白鲜皮300克、黄丹300克、五倍子600克、地肤子450克和黄柏150克分别粉碎后过2000目滤筛、混合、加入60wt％乙醇17250克混匀，获得成品。
实施例3：
一种治疗尖锐湿疣的中药组合物的制备方法，所述方法包括按照相应比例选取大黄140克、樟脑70克、虎杖210克、苦参140克、蛇床子210克、白鲜皮140克、黄丹140克、五倍子280克、地肤子210克和黄柏70克分别粉碎后过1000目滤筛、混合、加入38wt％乙醇4830克混匀，获得成品。
实施例4：
一种治疗尖锐湿疣的中药组合物的制备方法，所述方法包括按照相应比例选取大黄260克、樟脑130克、虎杖400克、苦参260克、蛇床子400克、白鲜皮260克、黄丹260克、五倍子520克、地肤子400克和黄柏130克分别粉碎后过1500目滤筛、混合、加入60wt％乙醇9060克混匀，获得成品。
实施例5：
一种治疗尖锐湿疣的中药组合物的制备方法，所述方法包括按照相应比例选取大黄200克、樟脑100克、虎杖300克、苦参200克、蛇床子300克、白鲜皮200克、黄丹200克、五倍子400克、地肤子300克和黄柏100克分别粉碎后过1500目滤筛、混合、加入38wt％乙醇6900克混匀，获得成品。
使用方式：成品为外用制剂。每日在任意一个疣体上涂抹3至5遍，3个小时换一次药。一般一个疗程是1-3个月。
使用在长有疣体的身体部位；例如阴茎、股沟、皮肤、阴道内、性器官等、生殖器，肛门周围等性接触部位的皮肤黏膜处。
禁忌：治疗期间，不能过性生活。
临床病例：
患者一：男、76岁，高血压史、2007年11月初诊，冠状沟系带处、HPV感染米粒状尖锐湿疣一年多。
治疗方式：用药外涂，一日4、5次。连续用药至2008年3月，复诊。
治疗结果：疣体全部脱落。之后坚持用药一年防复发，随后两年没有复发。
患者二：男、40岁，2021年1月患生殖尖锐湿疣一年半，经冷冻激光治疗后复发，来时疣体较多。
治疗方式：用药外涂，一日4、5次，治疗4个月。
治疗结果：五一复诊，疣体消失。
患者三：男、51岁，患病一年，阴茎冠状沟系带HPV感染，之前在网上买了腐蚀药。
治疗方式：用药外涂，一日4、5次，用药6月复诊。
治疗结果：疣体完全消失，至今未复发。
患者四：女、35岁，外阴感染HPV，尖锐湿疣，患病多年，经过4次激光手术，再次复发。
治疗方式：2018年8月就诊，用药外涂，一日4、5次，三月后。
治疗结果：疣体完全消失，至今未复发。
本发明不局限于上述可选的实施方式，任何人在本发明的启示下都可得出其他各种形式的产品，均属于本发明的保护范围。上述具体实施方式不应理解成对本发明的保护范围的限制，本领域的普通技术人员应当理解，在不背离本发明的范围下，可对前述各实施例所记载的技术方案进行修改，或对其中部分或者全部技术特征进行等同替换，与此同时这些修改或者替换，并不会使相应的技术方案的本质脱离本发明各实施例技术方案的范围。
Claims (10)
1.一种治疗尖锐湿疣的中药组合物，其特征在于，所述组合物主要由以下质量份数的原料制备得到：
大黄10-30份，樟脑5-15份，虎杖15-45份，苦参10-30份，蛇床子15-45份，白鲜皮10-30份，黄丹10-30份，五倍子20-60份，地肤子15-45份和黄柏5-15份。
2.根据权利要求1所述的一种治疗尖锐湿疣的中药组合物，其特征在于，所述组合物主要由以下质量份数的原料制备得到：
大黄14-26份，樟脑7-13份，虎杖21-40份，苦参14-26份，蛇床子21-40份，白鲜皮14-26份，黄丹14-26份，五倍子28-52份，地肤子21-40份和黄柏7-13份。
3.根据权利要求2所述的一种治疗尖锐湿疣的中药组合物，其特征在于，所述组合物主要由以下质量份数的原料制备得到：
大黄20份，樟脑10份，虎杖30份，苦参20份，蛇床子30份，白鲜皮20份，黄丹20份，五倍子40份，地肤子30份和黄柏10份。
4.一种如权利要求1-3任一所述的治疗尖锐湿疣的中药组合物的制备方法，其特征在于，所述方法包括按照相应比例选取大黄、樟脑、虎杖、苦参、蛇床子、白鲜皮、黄丹、五倍子、地肤子和黄柏分别粉碎后、混合、加入溶剂混匀，获得成品。
5.根据权利要求4所述的一种治疗尖锐湿疣的中药组合物的制备方法，其特征在于，所述大黄、樟脑、虎杖、苦参、蛇床子、白鲜皮、黄丹、五倍子、地肤子和黄柏分别粉碎，粒径均过500-2000目。
6.根据权利要求5所述的一种治疗尖锐湿疣的中药组合物的制备方法，其特征在于，所述大黄、樟脑、虎杖、苦参、蛇床子、白鲜皮、黄丹、五倍子、地肤子和黄柏分别粉碎，粒径均过1000-1500目。
7.根据权利要求4所述的一种治疗尖锐湿疣的中药组合物的制备方法，其特征在于，所述溶剂为酒。
8.根据权利要求7所述的一种治疗尖锐湿疣的中药组合物的制备方法，其特征在于，所述溶剂中含有乙醇的质量份数为38-60wt％。
9.根据权利要求4所述的一种治疗尖锐湿疣的中药组合物的制备方法，其特征在于，所述大黄、樟脑、虎杖、苦参、蛇床子、白鲜皮、黄丹、五倍子、地肤子和黄柏的总质量与溶剂的质量比为1：3-5。
10.根据权利要求4所述的一种治疗尖锐湿疣的中药组合物的制备方法，其特征在于，所述成品为外用制剂。
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568194A (zh) * | 2017-09-29 | 2019-04-05 | 俞有芳 | 一种苦参洗浴液及制备方法 |
| CN113116974A (zh) * | 2021-04-22 | 2021-07-16 | 河北大国工匠工程科技有限公司 | 一种瘙痒用冰水及其使用方法 |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568194A (zh) * | 2017-09-29 | 2019-04-05 | 俞有芳 | 一种苦参洗浴液及制备方法 |
| CN113116974A (zh) * | 2021-04-22 | 2021-07-16 | 河北大国工匠工程科技有限公司 | 一种瘙痒用冰水及其使用方法 |
Non-Patent Citations (1)
| Title |
|---|
| 彭旭东: "自拟中药方内服外洗加肛肠治疗仪治疗肛门尖锐湿疣", 《四川中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118252887A (zh) * | 2023-09-28 | 2024-06-28 | 袁树明 | 一种治疗皮肤病的制剂及其制备方法 |
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