CN113651873B - 肽组合物和使用方法 - Google Patents

肽组合物和使用方法

Info

Publication number
CN113651873B
CN113651873B CN202110665678.1A CN202110665678A CN113651873B CN 113651873 B CN113651873 B CN 113651873B CN 202110665678 A CN202110665678 A CN 202110665678A CN 113651873 B CN113651873 B CN 113651873B
Authority
CN
China
Prior art keywords
compound
retinal
pharmaceutical composition
composition
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202110665678.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN113651873A (zh
Inventor
C.G.贝西尔利
A.J.布里奇斯
J.K.弗雷施利
W.A.亨克
L.L.约翰逊
F.X.史密斯
E.西尔万
D.N.扎克斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan Ann Arbor
ONL Therapeutics Inc
Original Assignee
University of Michigan Ann Arbor
ONL Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan Ann Arbor, ONL Therapeutics Inc filed Critical University of Michigan Ann Arbor
Publication of CN113651873A publication Critical patent/CN113651873A/zh
Application granted granted Critical
Publication of CN113651873B publication Critical patent/CN113651873B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CN202110665678.1A 2015-05-01 2016-04-29 肽组合物和使用方法 Active CN113651873B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562155711P 2015-05-01 2015-05-01
US62/155,711 2015-05-01
PCT/US2016/030098 WO2016178993A1 (en) 2015-05-01 2016-04-29 Peptide compositions and methods of use
CN201680038258.8A CN107708416B (zh) 2015-05-01 2016-04-29 肽组合物和使用方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680038258.8A Division CN107708416B (zh) 2015-05-01 2016-04-29 肽组合物和使用方法

Publications (2)

Publication Number Publication Date
CN113651873A CN113651873A (zh) 2021-11-16
CN113651873B true CN113651873B (zh) 2025-09-02

Family

ID=57217771

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202110665678.1A Active CN113651873B (zh) 2015-05-01 2016-04-29 肽组合物和使用方法
CN201680038258.8A Active CN107708416B (zh) 2015-05-01 2016-04-29 肽组合物和使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201680038258.8A Active CN107708416B (zh) 2015-05-01 2016-04-29 肽组合物和使用方法

Country Status (21)

Country Link
US (5) US10508134B2 (https=)
EP (3) EP3997981A1 (https=)
JP (2) JP6884755B2 (https=)
KR (2) KR20240046280A (https=)
CN (2) CN113651873B (https=)
AU (1) AU2016258837B2 (https=)
CA (1) CA2984154A1 (https=)
CY (1) CY1124911T1 (https=)
DK (1) DK3288379T3 (https=)
EA (2) EA202090184A3 (https=)
ES (1) ES2906173T3 (https=)
HR (1) HRP20220138T1 (https=)
HU (1) HUE057883T2 (https=)
LT (1) LT3288379T (https=)
MX (1) MX387317B (https=)
PL (1) PL3288379T3 (https=)
PT (1) PT3288379T (https=)
RS (1) RS62866B1 (https=)
SI (1) SI3288379T1 (https=)
SM (1) SMT202200069T1 (https=)
WO (1) WO2016178993A1 (https=)

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LT3288379T (lt) 2015-05-01 2022-02-25 Onl Therapeutics, Inc. Peptidų kompozicijos ir naudojimo būdai
WO2019183246A1 (en) * 2018-03-20 2019-09-26 Onl Therapeutics, Inc. Compositions and methods of fas inhibition
EP3810082A1 (en) * 2018-06-19 2021-04-28 Cella Therapeutics, LLC Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a cnp compound, an npr-b compound, a tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension
WO2021127052A1 (en) * 2019-12-18 2021-06-24 Cella Therapeutics, Llc DRUG DELIVERY SYSTEMS COMPRISING A NEUROTROPHIC AGENT, AN APOPTOSIS SIGNALING FRAGMENT INHIBITOR (FAS) OR FAS LIGAND (FASL) INHIBITOR, A TUMOR NECROSIS FACTOR-α (TNF-α) OR TNF RECEPTOR INHIBITOR, A MITOCHONDRIAL PEPTIDE, AN OLIGONUCLEOTIDE, A CHEMOKINE INHIBITOR, OR A CYSTEINE-ASPARTIC PROTEASE INHIBITOR
EP4355349A4 (en) * 2021-06-15 2025-04-16 ONL Therapeutics, Inc. Methods and compositions for treating eye diseases and disorders
AU2022311780A1 (en) * 2021-07-13 2024-02-08 Onl Therapeutics, Inc. Methods and compositions for improving visual function in ocular diseases and disorders
WO2023129766A1 (en) * 2021-12-27 2023-07-06 Onl Therapeutics, Inc. Sfasl for inhibiting rpe cell death and associated disorders
EP4565596A1 (en) * 2022-08-05 2025-06-11 ONL Therapeutics, Inc. Peptide compositions and methods of use
US20260062449A1 (en) * 2022-08-05 2026-03-05 Onl Therapeutics, Inc. Peptide compositions and methods of use
EP4698204A1 (en) * 2023-04-19 2026-02-25 ONL Therapeutics, Inc. Methods and compositions for treating rnfl thinning

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CN107708416A (zh) * 2015-05-01 2018-02-16 Onl医疗股份有限公司 肽组合物和使用方法

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EP3810082A1 (en) 2018-06-19 2021-04-28 Cella Therapeutics, LLC Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a cnp compound, an npr-b compound, a tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension

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Also Published As

Publication number Publication date
US20210094985A1 (en) 2021-04-01
SMT202200069T1 (it) 2022-03-21
EA202090184A2 (ru) 2020-05-31
HRP20220138T1 (hr) 2022-05-27
BR112017023479A2 (pt) 2018-07-24
WO2016178993A1 (en) 2016-11-10
CN107708416B (zh) 2021-06-29
US10508134B2 (en) 2019-12-17
DK3288379T3 (da) 2022-02-07
EP3288379A1 (en) 2018-03-07
EP4623925A3 (en) 2026-02-11
JP6884755B2 (ja) 2021-06-09
JP2018514590A (ja) 2018-06-07
US20230287052A1 (en) 2023-09-14
US20250346631A1 (en) 2025-11-13
US10829518B2 (en) 2020-11-10
US20180291062A1 (en) 2018-10-11
US12258425B2 (en) 2025-03-25
PL3288379T3 (pl) 2022-03-07
KR20240046280A (ko) 2024-04-08
EP3997981A1 (en) 2022-05-18
CN113651873A (zh) 2021-11-16
RS62866B1 (sr) 2022-02-28
CY1124911T1 (el) 2023-01-05
US20200123201A1 (en) 2020-04-23
HK1251979A1 (zh) 2019-05-10
JP2021120400A (ja) 2021-08-19
MX2017014075A (es) 2018-07-06
EA035293B1 (ru) 2020-05-26
AU2016258837A1 (en) 2017-11-09
CA2984154A1 (en) 2016-11-10
HUE057883T2 (hu) 2022-06-28
KR102652804B1 (ko) 2024-04-01
LT3288379T (lt) 2022-02-25
KR20170140383A (ko) 2017-12-20
SI3288379T1 (sl) 2022-06-30
PT3288379T (pt) 2022-02-08
EP3288379B1 (en) 2021-11-03
MX387317B (es) 2025-03-18
ES2906173T3 (es) 2022-04-13
US11597749B2 (en) 2023-03-07
EA201792399A1 (ru) 2018-05-31
EP3288379A4 (en) 2018-10-24
CN107708416A (zh) 2018-02-16
EP4623925A2 (en) 2025-10-01
EA202090184A3 (ru) 2020-07-31
AU2016258837B2 (en) 2020-12-03

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