CN113616420B - 抑菌铜基合金功能性复合敷料 - Google Patents
抑菌铜基合金功能性复合敷料 Download PDFInfo
- Publication number
- CN113616420B CN113616420B CN202110900550.9A CN202110900550A CN113616420B CN 113616420 B CN113616420 B CN 113616420B CN 202110900550 A CN202110900550 A CN 202110900550A CN 113616420 B CN113616420 B CN 113616420B
- Authority
- CN
- China
- Prior art keywords
- copper
- based alloy
- functional composite
- wound surface
- dressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000010949 copper Substances 0.000 title claims abstract description 74
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 title claims abstract description 70
- 229910052802 copper Inorganic materials 0.000 title claims abstract description 70
- 229910045601 alloy Inorganic materials 0.000 title claims abstract description 68
- 239000000956 alloy Substances 0.000 title claims abstract description 68
- 239000002131 composite material Substances 0.000 title claims abstract description 50
- 230000000844 anti-bacterial effect Effects 0.000 title abstract description 25
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 26
- 229910052742 iron Inorganic materials 0.000 claims description 20
- 230000003385 bacteriostatic effect Effects 0.000 claims description 19
- 238000002156 mixing Methods 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 15
- 238000005516 engineering process Methods 0.000 claims description 13
- 238000010146 3D printing Methods 0.000 claims description 9
- 229920000642 polymer Polymers 0.000 claims description 9
- 238000009987 spinning Methods 0.000 claims description 9
- 238000002844 melting Methods 0.000 claims description 7
- 230000008018 melting Effects 0.000 claims description 7
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 6
- GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 claims description 6
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 6
- 239000004626 polylactic acid Substances 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 5
- 239000008273 gelatin Substances 0.000 claims description 5
- 229920000159 gelatin Polymers 0.000 claims description 5
- 235000019322 gelatine Nutrition 0.000 claims description 5
- 235000011852 gelatine desserts Nutrition 0.000 claims description 5
- 229920002674 hyaluronan Polymers 0.000 claims description 5
- 229960003160 hyaluronic acid Drugs 0.000 claims description 5
- PXMNMQRDXWABCY-UHFFFAOYSA-N 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol Chemical compound C1=NC=NN1CC(O)(C(C)(C)C)CCC1=CC=C(Cl)C=C1 PXMNMQRDXWABCY-UHFFFAOYSA-N 0.000 claims description 3
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 claims description 3
- 239000005751 Copper oxide Substances 0.000 claims description 3
- 239000005839 Tebuconazole Substances 0.000 claims description 3
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 claims description 3
- 229910000431 copper oxide Inorganic materials 0.000 claims description 3
- 125000004774 dichlorofluoromethyl group Chemical group FC(Cl)(Cl)* 0.000 claims description 3
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 3
- 239000004088 foaming agent Substances 0.000 claims description 3
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 3
- 229920005906 polyester polyol Polymers 0.000 claims description 3
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000011787 zinc oxide Substances 0.000 claims description 3
- 229910000166 zirconium phosphate Inorganic materials 0.000 claims description 3
- LEHFSLREWWMLPU-UHFFFAOYSA-B zirconium(4+);tetraphosphate Chemical compound [Zr+4].[Zr+4].[Zr+4].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LEHFSLREWWMLPU-UHFFFAOYSA-B 0.000 claims description 3
- 230000035876 healing Effects 0.000 abstract description 11
- 206010061218 Inflammation Diseases 0.000 abstract description 8
- 241000894006 Bacteria Species 0.000 abstract description 6
- 230000012010 growth Effects 0.000 abstract description 6
- 230000009471 action Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 230000028327 secretion Effects 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 206010063560 Excessive granulation tissue Diseases 0.000 abstract description 3
- 230000008859 change Effects 0.000 abstract description 3
- 238000005265 energy consumption Methods 0.000 abstract description 3
- 210000001126 granulation tissue Anatomy 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 230000004089 microcirculation Effects 0.000 abstract description 3
- 210000004204 blood vessel Anatomy 0.000 abstract description 2
- 239000012567 medical material Substances 0.000 abstract description 2
- 238000004321 preservation Methods 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- 206010052428 Wound Diseases 0.000 description 58
- 208000027418 Wounds and injury Diseases 0.000 description 58
- 238000000034 method Methods 0.000 description 13
- 239000000243 solution Substances 0.000 description 10
- 230000001684 chronic effect Effects 0.000 description 7
- 238000001514 detection method Methods 0.000 description 7
- 239000004814 polyurethane Substances 0.000 description 5
- 229910000640 Fe alloy Inorganic materials 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 231100000263 cytotoxicity test Toxicity 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 230000002045 lasting effect Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229920002635 polyurethane Polymers 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 229920002749 Bacterial cellulose Polymers 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 3
- 206010041925 Staphylococcal infections Diseases 0.000 description 3
- 239000005016 bacterial cellulose Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 210000004969 inflammatory cell Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 3
- 210000003632 microfilament Anatomy 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 241000222173 Candida parapsilosis Species 0.000 description 2
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 2
- 102000002151 Microfilament Proteins Human genes 0.000 description 2
- 108010040897 Microfilament Proteins Proteins 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229940055022 candida parapsilosis Drugs 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 229960003085 meticillin Drugs 0.000 description 2
- 231100000956 nontoxicity Toxicity 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229910017827 Cu—Fe Inorganic materials 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 208000008960 Diabetic foot Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 238000003723 Smelting Methods 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 238000012925 biological evaluation Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- IYRDVAUFQZOLSB-UHFFFAOYSA-N copper iron Chemical compound [Fe].[Cu] IYRDVAUFQZOLSB-UHFFFAOYSA-N 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 239000013039 cover film Substances 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 238000001523 electrospinning Methods 0.000 description 1
- 238000010041 electrostatic spinning Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000002169 hydrotherapy Methods 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 201000003130 ventricular septal defect Diseases 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0206—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
- A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
- B22F10/20—Direct sintering or melting
- B22F10/28—Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F5/00—Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product
- B22F5/10—Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product of articles with cavities or holes, not otherwise provided for in the preceding subgroups
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C9/00—Alloys based on copper
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/16—Materials with shape-memory or superelastic properties
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/25—Process efficiency
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Manufacturing & Machinery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Mechanical Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plasma & Fusion (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
本发明涉及医用材料技术领域，公开了抑菌铜基合金功能性复合敷料，由功能性复合海绵和铜基合金生物支架组成。本发明具有抑菌抗炎、形变记忆、便携可控、促愈保湿、防粘安全等多种功效，搭载中空负压引流装置使用，可使得本发明在负压增大的作用下紧实地贴覆于创面表面，通过功能性复合海绵的虹吸作用充分引流出深部的分泌物，同时铜基合金可充分发挥抑菌抗炎、促血管生长的作用；本发明极大促进了深、浅部肉芽组织的生长，充分有效地引流了创面深部的分泌物，改善了创面局部的微循环，高效持续地抗炎抑菌，可有效避免敷料与创面粘连；本发明设备投资少，产品流程短，可快速实现工业化规模生产，能耗更低，具有更强的市场竞争力。
Description
技术领域
本发明涉及医用材料技术领域，具体涉及抑菌铜基合金功能性复合敷料。
背景技术
随着生活方式的改变，慢性难愈性创面逐年增加，如：糖尿病足、压疮、慢性血管性溃疡及严重创伤等发病率不断上升，导致慢性难愈性创面成为临床治疗的难点和负担，此类患者对创面敷料的使用频率及需求十分紧张。针对各类创面修复再生，临床的治疗手段仍旧离不开创面敷料，随着科学技术的发展，新型功能性创面敷料逐渐普及，这些新型功能性创面敷料包括：金属离子抗菌敷料、生物活性敷料、人工皮肤等，这些敷料大多已经在国外开始应用或者即将投入使用，国内的功能性敷料也开始缓慢应用，但是由于研发技术有限、功能单一、造价成本高，导致国内功能性创面敷料的应用范围较为局限。目前虽然研究了较多的创面敷料，但是大多新型创面敷料在抑菌抗炎、抑制瘢痕等方面或多或少存在一些缺陷和不足，在一定程度上限制了其应用范围。专利CN103480027A“一种细菌纤维素复合壳聚糖纤维湿性敷料的制备方法”利用从多种微生物中提取的细菌纤维素复合壳聚糖电纺丝溶液作为创面敷料，起到了维持创面湿润和有效抑菌的效用，但其中的细菌纤维素的提取工艺较复杂且来源有限，尚不能达到大型规模化生产，也导致成本偏高，难以广泛应用到临床实际中。
创面封闭式负压引流技术已广泛应用于我国临床的创伤修复中，其原理主要是通过充分引流创面局部的渗出液及异常分泌物，给予创面一个负压微环境以促进局部的微循环，从而达到快速促进创面愈合的目的。创面封闭式负压引流治疗体系主要包括负压吸引机、引流管、海绵敷料、医用封闭半透膜、负压吸引连接盘、引流物收集器皿等，目前针对其中各环节的创新研发层出不穷，特别是针对海绵敷料的研究，由于它在整个创面封闭式负压引流中既是直接与创面接触的介质，也是负压吸引装置发挥虹吸作用的媒介，起到了决定性作用。目前常用的医用海绵敷料材料中有效的抑菌抗炎成分主要为：壳聚糖、海藻酸盐、纳米金属离子等，其中有效成分的作用持续时长有限且制作工艺繁杂。因此，从技术及功能上作出全面地改进才能使功能性海绵创面敷料实现质的突破，才能从实际上真正改善慢性创面的疗效，为广大患者带来福音。
发明内容
基于以上问题，本发明提供抑菌铜基合金功能性复合敷料，本发明功能多样、抑菌效率高、可有效避免敷料创面粘连，还具有持久抑菌、抗炎促愈、绿色环保、安全无害的特点，本发明设备投资少，产品流程短，可快速实现工业化规模生产，能耗更低，具有更强的市场竞争力。
为解决以上技术问题，本发明提供了以下技术方案：
抑菌铜基合金功能性复合敷料，由功能性复合海绵和铜基合金生物支架组成，所述功能性复合海绵为PU海绵，包括如下质量份数的化学成分：聚酯多元醇100份，甲苯二异氰酸酯100份，发泡剂50份，灭菌纯水700份，氧化铜1份，磷酸锆1份，氧化锌1份，1,2-苯并异噻唑-3-酮1份，二甲胺基/N,N-二甲基-N-苯基-(N-氟二氯甲硫基)-磺酰胺1份，N-苯并咪唑-2-基氨基甲酸甲酯1份，戊唑醇1份，2-[(二氯氟甲基)-硫]-1H-异吲哚-1,3-(2H)-二酮1份，聚丙烯酸钠2份；所述铜基合金生物支架由多种铜基合金粉末混合预热堆放后经选择性激光熔化3D打印技术制成，所述铜基合金生物支架为50μm铜基合金微丝网络生物支架。
进一步的，所述铜基合金粉末包括Cu-20wt％Fe和Cu-10wt％Fe中的任意一种，Cu-20wt％Fe中纯铁与电解铜的质量配比为2:3，Cu-10wt％Fe中纯铁与电解铜的质量配比为1:4。
进一步的，所述功能性复合海绵与创面接触的一面涂覆有高分子聚合物混纺或纺丝溶液。
进一步的，所述高分子聚合物混纺或纺丝溶液包括如下质量的成分中的任意一种：1.5g聚乳酸，2.5g左旋聚乳酸，5.5g透明质酸，4.5g明胶。
进一步的，所述铜基合金生物支架包含不同直径的孔，孔径大小为70～150μm。
与现有技术相比，本发明的有益效果是：本发明具有抑菌抗炎、形变记忆、便携可控、促愈保湿、防粘安全等多种功效，搭载中空负压引流装置使用，可使得本发明在负压增大的作用下紧实地贴覆于创面表面，通过功能性复合海绵的虹吸作用充分引流出深部的分泌物，同时铜基合金可充分发挥抑菌抗炎、促血管生长的作用；本发明将具有形变记忆能力的功能性复合海绵和具备高效持久抑菌功效的铜基合金生物支架结合，极大促进了深、浅部肉芽组织的生长，充分有效地引流了创面深部的分泌物，改善了创面局部的微循环，高效持续地抗炎抑菌，可有效避免敷料与创面粘连；本发明设备投资少，产品流程短，可快速实现工业化规模生产，能耗更低，具有更强的市场竞争力。
附图说明
图1为本发明的实施例2应用于大鼠创面组织学结果图；
图2为本发明的实施例3应用于大鼠创面组织学结果图；
图3为本发明的实施例2和实施例3的抑菌铜基合金功能性复合敷料的杀菌试验结果对比图；
图4为本发明的实施例2和实施例3的抑菌铜基合金功能性复合敷料的细胞毒性试验结果图。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚明白，下面结合实施例和附图，对本发明作进一步的详细说明，本发明的示意性实施方式及其说明仅用于解释本发明，并不作为对本发明的限定。
实施例1：
本实施例提供抑菌铜基合金功能性复合敷料，由具有形变记忆能力的功能性复合海绵和具备高效持久抑菌功效的铜基合金生物支架组成，所述功能性复合海绵为聚氨酯(PU)海绵，包括如下质量份数的化学成分：聚酯多元醇100份，甲苯二异氰酸酯100份，发泡剂50份，灭菌纯水700份，氧化铜1份，磷酸锆1份，氧化锌1份，1,2-苯并异噻唑-3-酮1份，二甲胺基/N,N-二甲基-N-苯基-(N-氟二氯甲硫基)-磺酰胺1份，N-苯并咪唑-2-基氨基甲酸甲酯1份，戊唑醇1份，2-[(二氯氟甲基)-硫]-1H-异吲哚-1,3-(2H)-二酮1份，聚丙烯酸钠2份，上述成分共同混合发泡后形成PU海绵。本实施例的功能性复合海绵与创面接触的一面涂覆有高分子聚合物混纺或纺丝溶液，本实施例采用静电纺丝技术将高分子聚合物混纺或纺丝溶液喷涂覆盖于功能性复合海绵底部而成。本实施例的高分子聚合物混纺或纺丝溶液包括如下质量的成分中的任意一种：1.5g聚乳酸，2.5g左旋聚乳酸，5.5g透明质酸，4.5g明胶。
上述铜基合金生物支架由多种铜基合金粉末混合预热堆放后经选择性激光熔化3D打印技术制成，铜基合金生物支架为50μm铜基合金微丝网络生物支架，本实施例的铜基合金粉末包括Cu-20wt％Fe和Cu-10wt％Fe中的任意一种，Cu-20wt％Fe中纯铁与电解铜的质量配比为2:3，Cu-10wt％Fe中纯铁与电解铜的质量配比为1:4。
本实施例的铜基合金粉末的制备方法如下：利用真空气体保护熔炼技术和氩气保护下的在线退火工艺制得铜基合金粉末，在线退火工艺为公开号为CN110814305A、题目为一种Cu-Fe复合材料双熔体混合铸造装备与工艺的专利中的技术，其中双熔体混合铸造法的工艺参数为：纯铜熔体温度为1300℃，铜铁母合金熔体温度为1600℃，混合腔温度为1300℃，结晶器冷却水流量为2000L/h。
本实施例的铜基合金生物支架的制备方法如下：首先将预生产的铜基合金微丝网络生物支架的三维结构图输入3D打印设备的电脑系统，将铜基合金粉末预热堆放，然后使用3D打印设备的刮平棍子将表面的粉末均匀铺平，高能电子束在3D打印设备电脑系统的控制下根据支架三维结构图的分层信息进行选择性融化后凝固，这样完成一层的打印生产后再进行下一层的融化，最后去除多余的粉末后形成最终需要的空间结构的铜基合金微丝网络生物支架，生产的支架具有不同直径的孔，孔径大小为70～150μm。
本实施例的抑菌铜基合金功能性复合敷料需搭载中空负压引流装置使用，本实施例的中空负压引流装置为公开号为CN106730097A、题目为一种用于创面清创循环水疗的交替中空负压引流治疗系统的中空负压引流治疗体系。当仪器感知负压值超过有效愈合阈值时，可智能性反馈信息至引流装置，通过高导、耐蚀的铜基合金生物支架微丝传导至功能性复合海绵，功能性复合海绵回弹在创面局部形成一中空负压环境以便于表面的肉芽组织生长及血运灌流，使慢性难愈性创面能够更快、更好、更有效地愈合。
本实施例的抑菌铜基合金功能性复合敷料搭配中空负压引流装置使用可保证创面微环境的平衡稳态，利于各类创面愈合及组织再生，它的搭载针对性地解决了慢性难愈性创面局部乏氧的难题，可以为慢性难愈性创面交互式局部间歇供氧。本实施例的技术方案填补了目前临床负压引流治疗方式的疗效盲区，通过结合新型功能性生物材料的特性可以为当前功能性创面敷料的研发提供崭新的方向，使广大创面患者群体从实际中获益。
本实施例的功能性复合海绵与铜基合金生物支架通过3D打印技术生成后，在铜基合金生物支架的框架中进行功能性复合海绵的发泡，从而使二者嵌合在一起，铜基合金微丝可以穿插在海绵的孔隙中，进而形成了抑菌铜基合金功能性复合敷料。
本实施例的功能性复合海绵结合铜基合金生物支架，显著地增大了铜基合金生物支架与创面中的细菌接触的比表面积，可发挥持久高效的抑菌作用，并且其所用的原料成本大大减少；另外由于所加工的铜基合金生物支架具有高强超弹、耐蚀高导、形变记忆、柔软顺滑的性能，可以很好地与PU海绵融合且与人体皮肤接触时无任何异物感和不适感，二者结合后搭载中空负压引流装置，充分地解决了目前临床上VSD治疗中敷料与创面粘连、创面表面肉芽生长有限、创面局部感染、易漏气阻塞等缺陷，另外这种局部的中空环境可更智能个性化地调节负压值大小，对于创面的愈合、创面组织的再生修复十分有利，可以显著减少创面愈合后瘢痕增生的问题。
实施例2：
本实施例的功能性复合海绵的配方及制作方式与实施例1相同，本实施例的高分子聚合物混纺或纺丝溶液为明胶，明胶的质量为4.5g。本实施例用于制备铜基合金生物支架的铜基合金粉末为Cu-20wt％Fe，是通过Cu-20wt％Fe合金粉末混合预热堆放后经选择性激光熔化3D打印技术制成Cu-20wt％Fe合金微丝(直径50μm)网络生物支架，生产的支架的孔隙直径为70μm。
将本实施例制备的抑菌铜基合金功能性复合敷料按照“JISZ2801-2000《抗菌加工制品－抗菌性试验方法和抗菌效果》、GB/T2591-2003《抗菌塑料抗菌性能实验方法和抗菌效果》”等相关标准规定进行抗菌性能检测，其中抑菌率的计算公式为：抑菌率(％)＝[(空白组菌落数-实验组菌落数)/空白组菌落数]×100％。
实验方法：稀释平板法，具体实验步骤如下：培养基选用水解酪蛋白(MH)琼脂，pH为7.2-7.4，琼脂厚度为4mm，分别取ATCC25923、ATCC27853、ATCC22019、MRSA四种菌种液(浓度1.5×106CFU/mL)依次滴加到空白对照和本实施例中的抑菌铜基合金功能性复合敷料上，用灭菌镊子将覆盖膜分别覆在各个样品上，使菌液均匀接触样品，置于灭菌平皿中，放在恒温培养箱中37℃、相对湿度90％以上条件下培养24h；取出已培养24h的样品，分别加入10mL洗脱液，反复清洗样品及覆盖膜，充分摇匀后，分别取0.05mL滴加到营养琼脂培养基，每个样品做三个平行样，并用灭菌三角耙涂匀，置于37℃恒温箱中培养48h后按照GB/T4789.2的方法进行活菌计数，抗菌性能检测结果见表1。
表1.抑菌铜基合金功能性复合敷料的抑菌性能
注：ATCC25923即金黄色葡萄球菌，ATCC27853即铜绿假单胞菌，ATCC22019即近平滑念珠菌，MRSA即耐甲氧西林金黄色葡萄球菌
将本实施例制备的抑菌铜基合金功能性复合敷料按照《GB/T16886.5-2017医疗器械生物学评价第5部分：体外细胞毒性试验》测试方法进行检测，采用L929小鼠成纤维细胞作为体外细胞毒性试验的工作细胞株。
本实施例提供的敷料在试验过程中，样品底下及周围细胞形态均正常，无毒性倾向性，毒性等级为0级，满足检测要求，通过检测。
20只SD大鼠随机分组，用取皮打孔器制作2.5×2.5cm全厚皮层缺损模型。实验组：创面覆盖本实施例制备的抑菌铜基合金功能性复合敷料并搭载实施例1中所述的中空负压引流装置；对照组：覆盖普通的医用PU海绵敷料搭载实施例1所述的中空负压引流装置。两组的负压值均设置为100mmHg，术后连续10天对创面进行大鼠的创面进行观测，计算创面的面积收缩率与愈合速率，比较实验组和对照组之间的瘢痕形成和粘连情况。
见附图1，分别为创面组织在第3天、第5天、第7天、第9天的炎性细胞变化情况，结果显示：实验组的创面收缩率及愈合速率较对照组明显高，且实验组的组织学观测显示炎性细胞浸润少；实验组与创面的粘连情况优于对照组，且实验组的创面未发生感染现象。
实施例3：
本实施例的功能性复合海绵的配方及制作方式与实施例1相同，本实施例的高分子聚合物混纺或纺丝溶液为透明质酸，透明质酸的质量为5.5g。本实施例用于制备铜基合金生物支架的铜基合金粉末为Cu-10wt％Fe，是通过Cu-10wt％Fe合金粉末混合预热堆放后经选择性激光熔化3D打印技术制成Cu-10wt％Fe合金微丝(直径50μm)网络生物支架，生产的支架的孔隙直径为150μm。
本实施例采用实施例2中的相关检测方法及标准对本实施例制备的抑菌铜基合金功能性复合敷料的抗菌性能进行了检测，结果见表2：
表2.抑菌铜基合金功能性复合敷料的抑菌性能
注：ATCC25923即金黄色葡萄球菌，ATCC27853即铜绿假单胞菌，ATCC22019即近平滑念珠菌，MRSA即耐甲氧西林金黄色葡萄球菌
本实施例还采用实施例2中的方法对本实施例制备的抑菌铜基合金功能性复合敷料的体外细胞毒性和体内试验进行了测试，体外细胞毒性测试结果显示样品底下及周围细胞形态均正常，无毒性倾向性，毒性等级为0级，满足检测要求，通过检测。见附图2，体内试验结果显示：实验组的创面收缩率及愈合速率较对照组高，且实验组的组织学观测显示炎性细胞、成纤维细胞浸润少；实验组与创面的粘连情况优于对照组，且实验组的创面未发生感染现象。
见附图3，为本实施例与实施例2在30min内相较空白对照组的杀菌效果，可见本实施例与实施例2中的复合辅料均可发挥优异的杀菌作用。见附图4，可见实例2和实例3中的L929小鼠成纤维细胞在5天内的存活率均高于70％，表明二者的生物相容性均良好。
如上即为本发明的实施例。上述实施例以及实施例中的具体参数仅是为了清楚表述发明验证过程，并非用以限制本发明的专利保护范围，本发明的专利保护范围仍然以其权利要求书为准，凡是运用本发明的说明书及附图内容所作的等同结构变化，同理均应包含在本发明的保护范围内。
Claims (4)
1.抑菌铜基合金功能性复合敷料，其特征在于，由功能性复合海绵和铜基合金生物支架组成，所述功能性复合海绵与创面接触的一面涂覆有高分子聚合物混纺或纺丝溶液，所述功能性复合海绵为PU海绵，包括如下质量份数的化学成分：聚酯多元醇100份，甲苯二异氰酸酯100份，发泡剂50份，灭菌纯水700份，氧化铜1份，磷酸锆1份，氧化锌1份，1,2-苯并异噻唑-3-酮1份，二甲胺基/N,N-二甲基-N-苯基-(N-氟二氯甲硫基)-磺酰胺1份，N-苯并咪唑-2-基氨基甲酸甲酯1份，戊唑醇1份，2-[(二氯氟甲基)-硫]-1H-异吲哚-1,3-(2H)-二酮1份，聚丙烯酸钠2份；所述铜基合金生物支架由多种铜基合金粉末混合预热堆放后经选择性激光熔化3D打印技术制成，所述铜基合金生物支架为50μm铜基合金微丝网络生物支架。
2.根据权利要求1所述的抑菌铜基合金功能性复合敷料，其特征在于，所述铜基合金粉末包括Cu-20wt％Fe和Cu-10wt％Fe中的任意一种，Cu-20wt％Fe中纯铁与电解铜的质量配比为2:3，Cu-10wt％Fe中纯铁与电解铜的质量配比为1:4。
3.根据权利要求2所述的抑菌铜基合金功能性复合敷料，其特征在于，所述高分子聚合物混纺或纺丝溶液包括如下质量的成分中的任意一种：1.5g聚乳酸，2.5g左旋聚乳酸，5.5g透明质酸，4.5g明胶。
4.根据权利要求1所述的抑菌铜基合金功能性复合敷料，其特征在于，所述铜基合金生物支架包含不同直径的孔，孔径大小为70～150μm。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110900550.9A CN113616420B (zh) | 2021-08-06 | 2021-08-06 | 抑菌铜基合金功能性复合敷料 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110900550.9A CN113616420B (zh) | 2021-08-06 | 2021-08-06 | 抑菌铜基合金功能性复合敷料 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113616420A CN113616420A (zh) | 2021-11-09 |
| CN113616420B true CN113616420B (zh) | 2023-03-31 |
Family
ID=78383073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110900550.9A Active CN113616420B (zh) | 2021-08-06 | 2021-08-06 | 抑菌铜基合金功能性复合敷料 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113616420B (zh) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102921035A (zh) * | 2012-11-09 | 2013-02-13 | 无锡中科光远生物材料有限公司 | 一种用于深度感染性伤口的抗菌敷料 |
| CN105031713A (zh) * | 2015-08-27 | 2015-11-11 | 华南理工大学 | 一种3d生物打印的医用敷料及其制备方法 |
| CN107847633A (zh) * | 2015-04-23 | 2018-03-27 | 佛罗里达大学研究基金会公司 | 用于增强愈合的双层设备 |
| AU2018300758A1 (en) * | 2017-07-12 | 2020-01-16 | Smith & Nephew Plc | Wound care materials, devices and uses |
| CN111214695A (zh) * | 2020-01-10 | 2020-06-02 | 中美医药科技河北有限公司 | 一种共价反应制备的新型的3d结构生物高分子材料及其合成方法 |
| CN112472997A (zh) * | 2020-11-26 | 2021-03-12 | 山东第一医科大学附属省立医院(山东省立医院) | 一种用于膝关节炎症的敷护材料 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10328261B4 (de) * | 2003-06-23 | 2007-10-25 | Beiersdorf Ag | Desinfizierende Auflage mit Silberbeschichtung und ihre Verwendung |
| CN102526810B (zh) * | 2012-02-22 | 2014-04-09 | 四川大学 | 人工皮肤替代材料及制备方法 |
| JP6748095B2 (ja) * | 2015-02-24 | 2020-08-26 | ボティス バイオマテリアルズ ゲーエムベーハー | コラーゲン含有創傷被覆材及び該被覆材を製造する方法 |
| TWI597080B (zh) * | 2015-07-01 | 2017-09-01 | Negative pressure treatment device | |
| CN206219490U (zh) * | 2016-11-28 | 2017-06-06 | 北京锦源汇智科技有限公司 | 带纤维网布的聚氨酯发泡制品 |
| CN208552236U (zh) * | 2017-11-13 | 2019-03-01 | 广东泰宝医疗器械技术研究院有限公司 | 一种透气防粘连敷料 |
| CN108677347A (zh) * | 2017-12-28 | 2018-10-19 | 元祥金属工业股份有限公司 | 具铜合金丝之复合纤维抗菌布及其制造方法 |
| GB2579601A (en) * | 2018-12-05 | 2020-07-01 | Copper Clothing Ltd | Antimicrobial material |
| CN113172237A (zh) * | 2021-04-26 | 2021-07-27 | 广州柔岩科技有限公司 | 一种抗菌材料增材、制备方法及其应用 |
-
2021
- 2021-08-06 CN CN202110900550.9A patent/CN113616420B/zh active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102921035A (zh) * | 2012-11-09 | 2013-02-13 | 无锡中科光远生物材料有限公司 | 一种用于深度感染性伤口的抗菌敷料 |
| CN107847633A (zh) * | 2015-04-23 | 2018-03-27 | 佛罗里达大学研究基金会公司 | 用于增强愈合的双层设备 |
| CN105031713A (zh) * | 2015-08-27 | 2015-11-11 | 华南理工大学 | 一种3d生物打印的医用敷料及其制备方法 |
| AU2018300758A1 (en) * | 2017-07-12 | 2020-01-16 | Smith & Nephew Plc | Wound care materials, devices and uses |
| CN111214695A (zh) * | 2020-01-10 | 2020-06-02 | 中美医药科技河北有限公司 | 一种共价反应制备的新型的3d结构生物高分子材料及其合成方法 |
| CN112472997A (zh) * | 2020-11-26 | 2021-03-12 | 山东第一医科大学附属省立医院(山东省立医院) | 一种用于膝关节炎症的敷护材料 |
Non-Patent Citations (1)
| Title |
|---|
| 廖俊琳等.《3D生物打印在组织工程软骨再生与重建应用中的研究进展》.中南大学学报（医学版）.2017,第42卷(第42期),221-225. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113616420A (zh) | 2021-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Tabaii et al. | Transparent nontoxic antibacterial wound dressing based on silver nano particle/bacterial cellulose nano composite synthesized in the presence of tripolyphosphate | |
| CN105311668B (zh) | 一种细菌纤维素复合氧化亚铜抗菌敷料及其制备方法 | |
| Chen et al. | Three-dimensional layered nanofiber sponge with in situ grown silver-metal organic framework for enhancing wound healing | |
| CN103536954B (zh) | 一种交联海藻酸-细菌纤维素海绵及其制备方法 | |
| CN111303449B (zh) | 可降解的电活性细菌纤维素/MXene复合水凝胶及制备与应用 | |
| CN101664563B (zh) | 一种抗菌水凝胶敷料的制备方法 | |
| CN104195369B (zh) | 一种Zn-Ca系锌合金及其制备方法与应用 | |
| CN102702727A (zh) | 一种抗菌复合材料的制备方法 | |
| Dong et al. | Cu/Zn galvanic couples composite antibacterial dressings prepared by template-assisted magnetron sputtering | |
| CN102657893A (zh) | 一种医用纳米纤维海绵材料及其制备方法和应用 | |
| CN104906623B (zh) | 一种纤维素基敷料及其制备方法和应用 | |
| Zhang et al. | Fabrication and durable antibacterial properties of 3D porous wet electrospun RCSC/PCL nanofibrous scaffold with silver nanoparticles | |
| CN102727926A (zh) | 一种多聚糖与纳米细菌纤维素的复合伤口敷料的制备方法 | |
| Zhang et al. | An integrated smart sensor dressing for real-time wound microenvironment monitoring and promoting angiogenesis and wound healing | |
| CN105903057A (zh) | 纳米银杂化丝胶多孔凝胶抗菌材料的制备方法及其产品和应用 | |
| CN108283727A (zh) | 一种纳米纤维敷料及其制备方法 | |
| CN105641740A (zh) | 全面治疗皮肤创伤的生物营养敷料及其制备方法 | |
| CN104815355B (zh) | 表面具有纳米纤维多孔结构的羟基磷灰石/聚酰胺复合生物材料及其制备方法 | |
| CN101912638A (zh) | 纳米载银-二氧化硅导尿管及其生产方法 | |
| CN104587515B (zh) | 一种具有抗感染功能的医用创面敷料 | |
| CN104327297A (zh) | 一种用于人工皮肤的多孔纳米银聚氨酯薄膜及其制备方法 | |
| CN102294047A (zh) | 一种基于纤维素纤维织物改性的抗菌敷料及其制备方法 | |
| Costa de Oliveira Souza et al. | Nanostructured cellulose–gellan–xyloglucan–lysozyme dressing seeded with mesenchymal stem cells for deep second-degree burn treatment | |
| Cui et al. | Developments of polyurethane in biomedical applications: A review | |
| CN113616420B (zh) | 抑菌铜基合金功能性复合敷料 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |