CN113613642B - 取代的氨基-硫醇和氨基-二硫化物化合物及其用途 - Google Patents

取代的氨基-硫醇和氨基-二硫化物化合物及其用途 Download PDF

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Publication number
CN113613642B
CN113613642B CN202080024298.3A CN202080024298A CN113613642B CN 113613642 B CN113613642 B CN 113613642B CN 202080024298 A CN202080024298 A CN 202080024298A CN 113613642 B CN113613642 B CN 113613642B
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compound
cystamine
cysteamine
deuterated
levels
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Chinese (zh)
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CN113613642A (zh
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兰詹·多希尔
C·巴拉托雷
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202080024298.3A 2019-03-26 2020-03-26 取代的氨基-硫醇和氨基-二硫化物化合物及其用途 Active CN113613642B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962823892P 2019-03-26 2019-03-26
US62/823892 2019-03-26
PCT/US2020/025067 WO2020198529A1 (en) 2019-03-26 2020-03-26 Substituted amino-thiol and amino-disulfide compounds, and uses thereof

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CN113613642A CN113613642A (zh) 2021-11-05
CN113613642B true CN113613642B (zh) 2024-08-06

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US (1) US12391643B2 (enExample)
EP (1) EP3946298A4 (enExample)
JP (1) JP7538541B2 (enExample)
CN (1) CN113613642B (enExample)
WO (1) WO2020198529A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220265583A1 (en) * 2019-07-30 2022-08-25 The Regents Of The University Of California Methods and composition for treating respiratory obstructive diseases
CN115745857B (zh) * 2022-10-28 2025-10-17 中国医学科学院放射医学研究所 一类口服给药的活性氧响应的硫酯类化合物、合成方法及用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103442704A (zh) * 2011-02-23 2013-12-11 拉瓦勒大学 用于治疗帕金森病的胱胺类似物
CN107106875A (zh) * 2014-11-05 2017-08-29 霍里森罕见药有限公司 使用半胱胺组合物治疗亨廷顿氏病的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254730A (en) * 1992-01-14 1993-10-19 Kilgore James L Production of amino acids and amino acid derivatives bearing isotopic hydrogen labels
EA201600089A1 (ru) 2006-01-27 2017-01-30 Те Риджентс Оф Те Юниверсити Оф Калифорния Покрытые энтеросолюбильной оболочкой цистеамин и цистамин и их производные
US7750168B2 (en) * 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
TWI478710B (zh) * 2007-11-30 2015-04-01 Univ California 使用半胱胺產物治療非酒精性脂肪肝炎（ｎａｓｈ）之方法
US8530479B2 (en) * 2009-08-10 2013-09-10 Daljit Singh Dhanoa Deuterium-enriched alkyl sulfonamides
CN109310653A (zh) * 2016-03-17 2019-02-05 硫创治疗公司 用于控制释放半胱胺和系统治疗半胱胺敏感性病症的组合物
US20220265583A1 (en) * 2019-07-30 2022-08-25 The Regents Of The University Of California Methods and composition for treating respiratory obstructive diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103442704A (zh) * 2011-02-23 2013-12-11 拉瓦勒大学 用于治疗帕金森病的胱胺类似物
CN107106875A (zh) * 2014-11-05 2017-08-29 霍里森罕见药有限公司 使用半胱胺组合物治疗亨廷顿氏病的方法

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JP2022525148A (ja) 2022-05-11
US12391643B2 (en) 2025-08-19
US20220135524A1 (en) 2022-05-05
JP7538541B2 (ja) 2024-08-22
WO2020198529A1 (en) 2020-10-01
EP3946298A4 (en) 2023-01-25
EP3946298A1 (en) 2022-02-09
CN113613642A (zh) 2021-11-05

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