CN113604346A - Detection device with reagent and method for detecting nucleic acid by using detection device - Google Patents
Detection device with reagent and method for detecting nucleic acid by using detection device Download PDFInfo
- Publication number
- CN113604346A CN113604346A CN202111025146.8A CN202111025146A CN113604346A CN 113604346 A CN113604346 A CN 113604346A CN 202111025146 A CN202111025146 A CN 202111025146A CN 113604346 A CN113604346 A CN 113604346A
- Authority
- CN
- China
- Prior art keywords
- reagent
- cover part
- test tube
- section
- detection device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 62
- 238000001514 detection method Methods 0.000 title claims abstract description 49
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 23
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 23
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims abstract description 11
- 238000000071 blow moulding Methods 0.000 claims abstract description 6
- 238000003825 pressing Methods 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 238000000151 deposition Methods 0.000 abstract description 2
- 241000711573 Coronaviridae Species 0.000 description 4
- 241000700605 Viruses Species 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention provides a detection device with a reagent and a use method for detecting nucleic acid by using the detection device, belonging to the technical field of detection. It has solved the current nucleic acid detection problem with high costs. The detection device with the reagent comprises a test tube, wherein the reagent is arranged in the test tube, the test tube is manufactured by adopting a blow molding process, the test tube comprises a tube body part, a large cover part and a small cover part, the large cover part is connected with the tube body part, and the small cover part is connected with the large cover part; the large cover part is disassembled, an opening is formed on the pipe body part, and the disassembled large cover part can be buckled with the pipe body part and cover the opening; the small cover part is detached, and a dropping hole is formed on the large cover part. The test tube of the detection device filled with the reagent is manufactured by adopting a blow molding process, and has the advantages of high production efficiency and low manufacturing cost. Not only have the body portion of depositing reagent and sample in the test tube, still have and cover the uncovered lid of body portion, detection device alright go into reagent in the test tube when leaving the factory like this, and reagent can not reveal moreover.
Description
Technical Field
The invention belongs to the technical field of detection, relates to a detection device, and particularly relates to a detection device filled with a reagent.
The invention belongs to the technical field of detection, relates to a detection device, and particularly relates to a use method for detecting nucleic acid by using the detection device filled with a reagent.
Background
The substance for nucleic acid detection is a nucleic acid of a virus. 2019 the novel coronavirus (2019-nCoV) is widely spread in the world, and after the novel coronavirus infects a human body, the novel coronavirus can firstly propagate in a respiratory tract system, so that whether the human body is infected with the virus can be judged by detecting virus nucleic acid in sputum and nasopharyngeal swab.
The brief process of nucleic acid detection is that firstly, a nasopharynx swab collects a specimen, then the specimen is put into a test tube, an appropriate amount of reagent is put into the test tube, the required reaction time is reduced by shaking, and finally a little reagent is taken out by a dropper for nucleic acid detection.
Although the conventional detection apparatus and detection method can detect nucleic acids, those skilled in the art would expect to reduce 2019 costs for detecting novel coronaviruses.
Disclosure of Invention
The invention provides a detection device filled with a reagent, and the technical problem to be solved by the invention is how to reduce the detection cost of nucleic acid.
The invention provides a use method for detecting nucleic acid by using a detection device, and the technical problem to be solved by the invention is how to reduce the detection cost of nucleic acid.
The technical problem to be solved by the invention can be realized by the following technical scheme: a detection device filled with a reagent comprises a test tube, wherein the reagent is filled in the test tube, and the detection device is characterized in that the test tube is manufactured by adopting a blow molding process, and comprises a tube body part, a large cover part and a small cover part, wherein the large cover part is connected with the tube body part, and the small cover part is connected with the large cover part; the large cover part is disassembled, an opening is formed on the pipe body part, and the disassembled large cover part can be buckled with the pipe body part and cover the opening; the small cover part is detached, and a dropping hole is formed on the large cover part.
Compared with the prior art, the test tube of the detection device filled with the reagent is manufactured by adopting a blow molding process, and has the advantages of high production efficiency and low manufacturing cost. Not only have the body portion of depositing reagent and sample in the test tube, still have and cover the uncovered lid of body portion, detection device alright go into reagent in the test tube when leaving the factory like this, and reagent can not reveal moreover.
By illustrating the use method of detecting nucleic acid by using the detection device, the functions and advantages of all parts are explained, the large cover part is removed in the first step, the test tube is erected when the large cover part is removed, the reagent is ensured to be positioned in the tube body part, and the reagent is prevented from being lost. Secondly, loading a sample, namely placing the nasopharyngeal swab sample into the tube body and fastening the large cover part on the tube body, so that the possibility of reagent splashing is remarkably reduced, namely the detection device in the state is still suitable for long-distance transfer, such as transportation from a collection site to a detection laboratory through a vehicle; meanwhile, the sample is immersed in the reagent in the state, and the sample reacts with the reagent in the transportation process, so that the storage time of a laboratory is reduced, and the time required by detection is shortened. Thirdly, taking out a small amount of reagent, removing the small cover part and the inverted test tube, and dripping the reagent in a droplet shape from the dripping hole; the size of the drip hole is adjusted according to the viscosity of the reagent and the test tube is extruded adaptively.
In summary, the use of the detection device for detecting nucleic acids reduces the cost of nucleic acid detection by reducing the cost of manufacturing the test tube and eliminating the need for pipetting reagents. The detection of nucleic acids using the detection device also reduces the length of time required for detection. The detection device filled with the reagent is particularly suitable for being applied to large-scale personnel nucleic acid detection scenes.
In the above detection device containing a reagent, the tube body has a housing section, a partial area of a side wall of the housing section is a pressing area protruding outward, and the wall thickness of the pressing area is smaller than that of the rest area of the housing section.
In the above-described detection device containing a reagent, one end of the large lid portion has a first connection section extending obliquely inward, the thickness of the first connection section gradually decreases from the outside to the inside, and the inner end of the first connection section is connected to the tube body portion.
In the above detection device with a reagent, the thinnest part of the first connecting section has a thickness of 0.15mm-0.25 mm.
In the above detection device containing a reagent, the body portion has a neck-reducing section, the first connection section is connected to the neck-reducing section, and the diameter of the port in the first connection section is smaller than that of the neck-reducing section.
In the above device, the neck section has an annular limiting region protruding outwards, and pressing the large lid portion forces the inner end of the first connecting section to pass over the annular limiting region.
In the above-mentioned detection device with a reagent, one end of the small lid portion has a second connection section extending obliquely inward, the thickness of the second connection section gradually decreases from the outside to the inside, and the second connection section of the small lid portion is connected to the other end of the large lid portion.
In the above detecting device with a reagent, the test tube further includes a sheet-shaped side ear portion, and the inner side of the side ear portion is connected to the neck section and the large cap portion of the tube body portion.
In the above-described detection apparatus containing a reagent, the thickness of the region of the side ear portion connected to the tube body portion is gradually reduced from the outside to the inside.
Drawings
FIG. 1 is a schematic perspective view of a detecting unit containing a reagent.
FIG. 2 is a schematic front view of the detecting unit containing the reagent.
Fig. 3 is a schematic sectional structure view of a-a in fig. 2.
Fig. 4 is an enlarged view of a portion C of fig. 3.
Fig. 5 is an enlarged view of a portion of the structure at D in fig. 3.
Fig. 6 is a schematic sectional structure view of B-B in fig. 2.
Fig. 7 is a schematic view showing a structure in which the detached cap portion is fastened to the body portion.
Fig. 8 is a schematic structural view of the small lid portion removed and in an inverted state.
In the figure, 1, a tube body part; 1a, opening the mouth; 1b, a containing section; 1c, a necking section; 1d, a pressing area; 1e, an annular limiting area; 2. a large cover part; 2a, a liquid dropping hole; 2b, a first connecting section; 2c, a reduction section; 2d, an annular raised area; 3. a small cover part; 3a, a handle area; 3b, a second connecting section; 4. a first annular groove; 5. a second annular groove; 6. a side ear; 20. and (3) a reagent.
Detailed Description
The following are specific embodiments of the present invention and are further described with reference to the drawings, but the present invention is not limited to these embodiments.
As shown in fig. 1 to 6, the detecting unit includes a test tube and a reagent 20 contained in the test tube. The detecting device is used for detecting nucleic acid, and then the reagent 20 is a nucleic acid detecting reagent 20, such as lysis solution or modified magnetic beads, see CN101481400B, CN101665785B, CN 110129312A.
The test tube is made by adopting a blow molding process and is of an integrated structure. The test tube is from bottom to top be body portion 1, big cap portion 2 and little cap portion 3 in proper order. The large cover part 2 is disassembled, an opening 1a is formed on the tube body part 1, and the disassembled large cover part 2 can be buckled with the tube body part 1 and cover the opening 1 a; the small lid part 3 is removed and a dropping hole 2a is formed in the large lid part 2.
After the body portion 1 is blow molded, the reagent 20 is put into the test tube, and the test tube is finally sealed, so that the reagent 20 is prevented from leaking and losing, and a sheet-shaped knob area 3a is formed on the small cap portion 3. The handle area 3a is convenient for the experimenter to hold with fingers, and then the small cover part 3 is dismounted by means of snapping or rotating, and of course, the small cover part 3 can also be dismounted by means of cutting with a cutter.
The tube body part 1 is sequentially provided with an accommodating section 1b and a neck-reducing section 1c from bottom to top, the neck-reducing section 1c is provided with an opening 1a, and the reagent 20 and the sample enter the accommodating section 1b through the opening 1 a. The partial area of the side wall of the containing section 1b protrudes outwards, the protruding area is called as a pressing area 1d, and as the material for forming the pressing area 1d in the tube blank is stretched to be larger, the wall thickness of the pressing area 1d is smaller than that of the rest area of the containing section 1b, namely, the pressing area 1d is easier to be pressed and deformed, so that the volume reduction of the inner cavity of the tube body part 1 is convenient to control, and the agent 20 is better controlled to be discharged from the drip holes 2a at the drip intervals.
One end of the large lid portion 2 has a first connection section 2b extending obliquely inward, and the first connection section 2b of the large lid portion 2 is connected to the neck section 1c of the pipe body portion 1. The wall thickness of the first connecting section 2b can be controlled by controlling the inward inclined extension length of the first connecting section 2b, and the wall thickness of the first connecting section 2b is gradually reduced from outside to inside as the material for forming the first connecting section 2b in the tube blank is stretched to be longer, so that the wall thickness of the first connecting section 2b is smaller than the rest area of the large cover part 2; the thinnest part of the first connecting section 2b is 0.15mm-0.25mm in thickness; that is, the first connecting section 2b is more easily torn or cut at the thinnest portion, thereby facilitating the detachment of the large cap portion 2 from the body portion 1.
The diameter of the inner port of the first connecting section 2b is smaller than that of the neck section 1c, and when the large cover part 2 is sleeved on the neck section 1c, the soft first connecting section 2b is equivalent to a sealing lip, so that the sealing performance between the large cover part 2 and the pipe body part 1 is improved.
The neck section 1c is provided with an annular limiting area 1e protruding towards the outer side, and the inner end of the first connecting section 2b can be forced to cross the annular limiting area 1e by pressing the large cover part 2, so that the large cover part 2 is prevented from naturally falling off and the large cover part 2 is prevented from falling off when the pressing area 1d is squeezed. The annular limiting area 1e is close to the top surface, a first annular groove 4 is formed between the annular limiting area 1e and the first connecting section 2b, and when the large cover part 2 is detached in a breaking or screwing mode, the large cover part is usually torn at the bottom surface of the first annular groove 4 and is provided with a smoother tearing edge; when the cutter is used for cutting, the cutter is embedded into the first annular groove 4, so that the cutting stability of the cutter is improved; the outer side surface of the annular limiting region 1e also has a guiding function, so that the large cover part 2 is sleeved on the neck section 1c more easily, and the large cover part 2 is prevented from being embedded into the neck section 1 c.
The large lid portion 2 has a tapered portion 2c in a conical shape, which is advantageous in forming a small dropping hole 2a and ensuring smooth flow of the reagent 20 when discharged.
One end of the small cover part 3 is provided with a second connecting section 3b which extends obliquely inwards, the thickness of the second connecting section 3b is gradually reduced from outside to inside, and the second connecting section 3b of the small cover part 3 is connected with the other end of the large cover part 2; the thinnest part of the second connecting section 3b is 0.2mm-0.3mm in thickness. The large lid portion 2 has an annular convex region 2d protruding outward, and a second annular groove 5 is formed between the annular convex region 2d and the second coupling section 3 b. The above structure serves to improve the possibility of tearing at the second annular groove 5 when the small cap 3 is broken or screwed.
The test tube is still including being flaky side ear 6, and the inboard of side ear 6 is connected with the necking down section 1c and the big lid 2 homogeneous phase of barrel portion 1, and side ear 6 realizes improving the joint strength of barrel portion 1 and big lid 2, reduces the unexpected tear possibility of test tube in barrel portion 1 and big lid 2 junction. The figures in the specification show that the number of the side ears 6 is one, and the number of the side ears 6 can be two according to actual conditions. The thickness of the connecting area of the side ear part 6 and the pipe body part 1 is gradually reduced from outside to inside, so that the connecting area of the side ear part 6 and the pipe body part 1 and the large cover part 2 is smaller in thickness, and the side ear part 6 can be detached by being broken.
The method for detecting nucleic acid by using the detection device is carried out according to the following sequence steps, wherein the large cover part 2 is removed in the first step, and a test tube is erected when the large cover part 2 is removed; secondly, assembling a sample, namely putting the sample into the tube body 1 from the opening 1a of the tube body 1, sleeving the large cover part 2 on the necking section 1c of the tube body 1, and fastening the large cover part 2 and the tube body 1; and thirdly, extracting the reagent 20, namely removing the small cover part 3, inverting the test tube to enable the dropping hole 2a to face downwards, holding the test tube on the tube body part 1, squeezing the pressing area 1d by using a thumb, reasonably controlling the pressing force to enable the reagent 20 to drop from the dropping hole 2a in a droplet shape, and extracting the reagent 20 with the required dropping number according to actual conditions.
Claims (10)
1. The detection device filled with the reagent comprises a test tube, wherein the reagent (20) is arranged in the test tube, and is characterized in that the test tube is manufactured by adopting a blow molding process, the test tube comprises a tube body part (1), a large cover part (2) and a small cover part (3), the large cover part (2) is connected with the tube body part (1), and the small cover part (3) is connected with the large cover part (2); the large cover part (2) is disassembled, an opening (1 a) is formed on the pipe body part (1), and the large cover part (2) which is disassembled can be buckled with the pipe body part (1) and cover the opening (1 a); the small cover part (3) is removed, and a dropping hole (2 a) is formed on the large cover part (2).
2. The reagent-containing test device according to claim 1, wherein the body portion (1) has a housing section (1 b), and a partial region of a side wall of the housing section (1 b) is a pressing region (1 d) protruding outward, and a wall thickness of the pressing region (1 d) is smaller than that of the rest region of the housing section (1 b).
3. The reagent-containing test device according to claim 1, wherein one end of the large lid portion (2) has a first connecting section (2 b) extending obliquely inward, the thickness of the first connecting section (2 b) is gradually reduced from outside to inside, and the inner end of the first connecting section (2 b) is connected to the tube body portion (1).
4. The reagent-containing test device according to claim 3, wherein the thinnest portion of the first connecting section (2 b) has a thickness of 0.15mm to 0.25 mm.
5. The reagent-containing test device according to claim 3, wherein the body portion (1) has a neck-down portion (1 c), and the first connecting portion (2 b) is connected to the neck-down portion (1 c), and the diameter of the port in the first connecting portion (2 b) is smaller than the diameter of the neck-down portion (1 c).
6. The reagent-containing test device according to claim 5, wherein the neck section (1 c) has an annular stopper region (1 e) protruding outward, and pressing the large lid section (2) forces the inner end of the first connecting section (2 b) to pass over the annular stopper region (1 e).
7. The reagent-containing measuring device according to any one of claims 1 to 6, wherein one end of the small lid part (3) has a second connecting section (3 b) extending obliquely inward, the thickness of the second connecting section (3 b) is gradually reduced from the outside to the inside, and the second connecting section (3 b) of the small lid part (3) is connected to the other end of the large lid part (2).
8. The reagent-containing test device according to any one of claims 1 to 6, wherein the cuvette further comprises a side ear (6) in a sheet form, and the inside of the side ear (6) is connected to both the neck-reduced section (1 c) of the body portion (1) and the large lid portion (2).
9. The reagent-containing test device of claim 8, wherein the inner region of the side ear (6) tapers in thickness from the outside to the inside.
10. A method of using a nucleic acid detecting apparatus according to any one of claims 1 to 9, characterized in that the method is carried out by the following steps in this order,
the first step is to detach the large cover part (2), and erect the test tube when the large cover part (2) is detached;
secondly, loading a sample, namely placing the sample into the tube body part (1) and fastening the large cover part (2) on the tube body part (1);
thirdly, extracting the reagent (20), removing the small cover part (3) and inverting the test tube, and squeezing the tube body part (1) to drip the reagent (20) in a droplet shape from the dripping hole (2 a).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111025146.8A CN113604346B (en) | 2021-09-02 | 2021-09-02 | Detection device containing reagent and method for detecting nucleic acid using detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111025146.8A CN113604346B (en) | 2021-09-02 | 2021-09-02 | Detection device containing reagent and method for detecting nucleic acid using detection device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113604346A true CN113604346A (en) | 2021-11-05 |
| CN113604346B CN113604346B (en) | 2023-11-17 |
Family
ID=78309906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111025146.8A Active CN113604346B (en) | 2021-09-02 | 2021-09-02 | Detection device containing reagent and method for detecting nucleic acid using detection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113604346B (en) |
Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4865215A (en) * | 1987-06-02 | 1989-09-12 | Wells Robert A | Reclosable self-opening can end |
| US5266266A (en) * | 1988-02-09 | 1993-11-30 | Nason Frederic L | Specimen test unit |
| WO1995011083A2 (en) * | 1993-10-22 | 1995-04-27 | Abbott Laboratories | Reaction tube and method of use to minimize contamination |
| US20040161788A1 (en) * | 2003-02-05 | 2004-08-19 | Shuqi Chen | Sample processing |
| JP2007040710A (en) * | 2005-07-29 | 2007-02-15 | Mizuho Medy Co Ltd | Extraction container for specimen detection |
| WO2007100500A2 (en) * | 2006-02-14 | 2007-09-07 | Iquum, Inc. | Sample processing |
| CN201381015Y (en) * | 2009-01-09 | 2010-01-13 | 徐文癸 | Hose container with tear-off structure |
| JP2012150058A (en) * | 2011-01-20 | 2012-08-09 | Toppan Printing Co Ltd | Reagent container, and detection kit |
| JP2014044103A (en) * | 2012-08-27 | 2014-03-13 | Mitsubishi Chemical Medience Corp | Immunoassay device and immunoassay method |
| CN205974498U (en) * | 2016-08-29 | 2017-02-22 | 杭州天迈生物科技有限公司 | Visual leakproofness nucleic acid amplifys and test paper detection device |
| CN209382486U (en) * | 2018-12-01 | 2019-09-13 | 张淙柏 | A kind of pop can teared cap structure |
| CN112986604A (en) * | 2021-02-20 | 2021-06-18 | 东台市苏亚士博医疗器械有限公司 | Antigen detection open reagent dropper and biological sampling method |
| CN112986603A (en) * | 2021-02-20 | 2021-06-18 | 东台市苏亚士博医疗器械有限公司 | Anti-leakage reagent dropper for antigen detection and biological sampling method |
| CN113281145A (en) * | 2021-05-24 | 2021-08-20 | 厦门小竺医疗器械有限公司 | Reagent pre-filled storage tube for detection and detection method |
| CN215664848U (en) * | 2021-09-02 | 2022-01-28 | 台州市祥珑食品容器科技股份有限公司 | High-barrier container with contents |
| CN215856089U (en) * | 2021-09-02 | 2022-02-18 | 浙江仅一医疗科技有限公司 | Detection device with reagent |
-
2021
- 2021-09-02 CN CN202111025146.8A patent/CN113604346B/en active Active
Patent Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4865215A (en) * | 1987-06-02 | 1989-09-12 | Wells Robert A | Reclosable self-opening can end |
| US5266266A (en) * | 1988-02-09 | 1993-11-30 | Nason Frederic L | Specimen test unit |
| WO1995011083A2 (en) * | 1993-10-22 | 1995-04-27 | Abbott Laboratories | Reaction tube and method of use to minimize contamination |
| US20040161788A1 (en) * | 2003-02-05 | 2004-08-19 | Shuqi Chen | Sample processing |
| JP2007040710A (en) * | 2005-07-29 | 2007-02-15 | Mizuho Medy Co Ltd | Extraction container for specimen detection |
| WO2007100500A2 (en) * | 2006-02-14 | 2007-09-07 | Iquum, Inc. | Sample processing |
| US20080003564A1 (en) * | 2006-02-14 | 2008-01-03 | Iquum, Inc. | Sample processing |
| CN201381015Y (en) * | 2009-01-09 | 2010-01-13 | 徐文癸 | Hose container with tear-off structure |
| JP2012150058A (en) * | 2011-01-20 | 2012-08-09 | Toppan Printing Co Ltd | Reagent container, and detection kit |
| JP2014044103A (en) * | 2012-08-27 | 2014-03-13 | Mitsubishi Chemical Medience Corp | Immunoassay device and immunoassay method |
| CN205974498U (en) * | 2016-08-29 | 2017-02-22 | 杭州天迈生物科技有限公司 | Visual leakproofness nucleic acid amplifys and test paper detection device |
| CN209382486U (en) * | 2018-12-01 | 2019-09-13 | 张淙柏 | A kind of pop can teared cap structure |
| CN112986604A (en) * | 2021-02-20 | 2021-06-18 | 东台市苏亚士博医疗器械有限公司 | Antigen detection open reagent dropper and biological sampling method |
| CN112986603A (en) * | 2021-02-20 | 2021-06-18 | 东台市苏亚士博医疗器械有限公司 | Anti-leakage reagent dropper for antigen detection and biological sampling method |
| CN113281145A (en) * | 2021-05-24 | 2021-08-20 | 厦门小竺医疗器械有限公司 | Reagent pre-filled storage tube for detection and detection method |
| CN215664848U (en) * | 2021-09-02 | 2022-01-28 | 台州市祥珑食品容器科技股份有限公司 | High-barrier container with contents |
| CN215856089U (en) * | 2021-09-02 | 2022-02-18 | 浙江仅一医疗科技有限公司 | Detection device with reagent |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113604346B (en) | 2023-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4494452B2 (en) | Container lid for liquid sample | |
| KR900009014B1 (en) | Blood sampling tube | |
| US7824921B1 (en) | Self resealing elastomeric closure | |
| US4250893A (en) | Sample collection device | |
| CN215856089U (en) | Detection device with reagent | |
| JP2000189407A (en) | Assembly for component separation of fluid sample | |
| JP2686433B2 (en) | Blood collection assembly and method of collecting a sample using the assembly | |
| US5259956A (en) | Tube liquid dispenser | |
| CN210095742U (en) | Novel self-service peripheral blood sampling device | |
| CN113604346A (en) | Detection device with reagent and method for detecting nucleic acid by using detection device | |
| WO2023179635A1 (en) | Integrated reaction test tube, packaging method therefor, and use method and use thereof | |
| JP2002019855A (en) | Adapter and container with adapter | |
| CN213567462U (en) | Reclosed septum cap for medical sample transport and handling | |
| JP2001161669A (en) | Assembly for collection | |
| CN219039069U (en) | Integrated reagent tube | |
| CN113281145A (en) | Reagent pre-filled storage tube for detection and detection method | |
| CN217521168U (en) | Sample collecting bottle for collecting samples and adding samples | |
| CN216584980U (en) | Sample sampler is gathered to pharynx swab | |
| CN217189659U (en) | Mixed sample adding device for in vitro diagnosis | |
| CN218422867U (en) | Dropper | |
| CN212800348U (en) | Reagent bottle for respiratory tract virus detection | |
| CN219699972U (en) | Sample collection reagent pipe | |
| JPH0618945U (en) | Vacuum blood collection tube | |
| CN217543121U (en) | Sample collecting bottle with cover body | |
| CN214794481U (en) | Ammonia test detection device for leucorrhea BV test |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |