CN113520927A - Skin care lotion with whitening effect and preparation method thereof - Google Patents
Skin care lotion with whitening effect and preparation method thereof Download PDFInfo
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- CN113520927A CN113520927A CN202010287734.8A CN202010287734A CN113520927A CN 113520927 A CN113520927 A CN 113520927A CN 202010287734 A CN202010287734 A CN 202010287734A CN 113520927 A CN113520927 A CN 113520927A
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- 239000006210 lotion Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 55
- 239000004909 Moisturizer Substances 0.000 claims abstract description 5
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- 230000001681 protective effect Effects 0.000 description 1
- STWNGMSGPBZFMX-UHFFFAOYSA-N pyridine-3-carboxamide Chemical compound NC(=O)C1=CC=CN=C1.NC(=O)C1=CC=CN=C1 STWNGMSGPBZFMX-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a skin lotion with whitening effect and a preparation method thereof. Experiments prove that the skin moisturizer has good effects of removing free radicals, improving skin color, controlling grease secretion and improving red blood streak by adding the whitening composition, can achieve the integral whitening effect, and has wide application prospect in the field of skin care products.
Description
Technical Field
The invention belongs to the field of daily chemicals, and particularly relates to whitening skin lotion and a preparation method thereof.
Background
The safety and efficacy of cosmetics are issues of intense interest to consumers and skin care product developers. At present, a plurality of whitening methods exist, and if the skin problems are rapidly and effectively improved in a short time and the face appearance is improved, scientific beautifying and skin care products are needed.
Most of the whitening products on the market take nicotinamide and VC as main whitening agents. Niacinamide is a water-soluble vitamin and is a member of the vitamin B group. Nicotinamide can inhibit the transfer of melanin, and make skin slowly whiten and more bright. The high-content nicotinamide product has a certain sensitization rate. Meanwhile, melanin produced by the skin has a protective effect on the skin, and excessive inhibition of the production or formation of melanin may have an adverse effect on the skin. For example, the "chalking event by creosol" in Japan is the chalking phenomenon caused by severe destruction of skin melanin after the skin care agent is used. In addition, the other main whitening component VC is easy to discolor and unstable.
The realization of low whitening efficiency through a single approach is one of the problems of the conventional whitening products. Therefore, the development of safe and efficient skin whitening compositions and skin care preparations is a problem to be solved in the art.
Disclosure of Invention
The skin care composition with the whitening effect is formed by compounding plant components such as giant knotweed rhizome extract, pepper extract and the like and nicotinamide, and is also compounded with cosmetic auxiliary materials to form a skin care aqua. The skin care product not only solves the problem of sensitization risk caused by large usage amount of whitening nicotinamide, improves the product safety, but also has the synergistic effect of all the components, and has multiple skin care effects of removing free radicals, improving red blood streak, balancing skin color, balancing grease and the like. The problems of single whitening way and unobvious effect are solved.
According to the present invention, the skin moisturizer comprises dipropylene glycol, xanthan gum, disodium EDTA, and a whitening composition.
According to the present invention, the whitening composition includes niacinamide, giant knotweed rhizome extract and pepper extract.
According to some embodiments of the present invention, the dipropylene glycol is used in an amount of 1 to 5wt%, the xanthan gum is used in an amount of 0.01 to 0.2wt%, the disodium EDTA is used in an amount of 0.01 to 0.1wt%, and the whitening composition is used in an amount of 0.5 to 20 wt%, based on the total weight of the skin moisturizer.
According to some embodiments of the present invention, the dipropylene glycol is present in an amount of 2 to 4wt%, the xanthan gum is present in an amount of 0.05 to 0.1wt%, the disodium EDTA is present in an amount of 0.02 to 0.08wt%, and the whitening composition is present in an amount of 3 to 10 wt%, based on the total weight of the skin moisturizer.
According to the invention, the whitening composition comprises the following raw materials in parts by weight: 1-10 parts of nicotinamide, 0.01-5 parts of giant knotweed extract and 0.01-0.2 part of pepper extract.
According to the invention, the nicotinamide is used in an amount of 1 to 10 parts by weight, and may be, for example, 1, 1.1, 1.5, 2, 2.2, 2.3, 2.4, 2.5, 2.8, 3, 3.1, 3.2, 3.5, 3.8, 4, 4.5, 5, 5.5, 5.8, 6, 6.4, 6.5, 7, 7.4, 7.6, 7.8, 8, 8.8, 9, 9.5, 10 parts by weight, and also values between the aforementioned values.
According to the invention, the polygonum cuspidatum extract is used in an amount of 0.01-5 parts by weight, such as 0.01, 0.02, 0.03, 0.05, 0.1, 0.2, 0.3, 0.6, 0.8, 0.9, 1, 1.1, 1.5, 2, 2.2, 2.3, 2.4, 2.5, 2.8, 3, 3.1, 3.2, 3.5, 3.8, 4, 4.5, 5 parts by weight, and values in between.
According to the invention, the pepper extract is used in an amount of 0.01-0.2 parts by weight, which may be, for example, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.08, 0.09, 0.1, 0.15, 0.2 parts by weight, and values in between.
According to some embodiments of the invention, the whitening composition comprises the following raw materials in parts by weight: 2-6 parts of nicotinamide, 0.1-4 parts of giant knotweed extract and 0.1-0.2 part of pepper extract.
According to some embodiments of the invention, the whitening composition further comprises 1, 3-propanediol.
According to some embodiments of the invention, the whitening composition further comprises PEG-40 hydrogenated castor oil.
According to some further embodiments of the present invention, the whitening composition comprises the following raw materials in parts by weight: 1-10 parts of nicotinamide, 0.01-5 parts of giant knotweed extract, 0.01-0.2 part of pepper extract, 0.01-5 parts of 1, 3-propylene glycol and 0.02-0.5 part of PEG-40 hydrogenated castor oil.
According to the invention, the 1, 3-propanediol is used in an amount of 0.01 to 5 parts by weight, and may be, for example, 0.01, 0.05, 0.1, 0.2, 0.3, 0.5, 0.6, 0.8, 0.9, 1, 1.1, 1.5, 1.8, 2, 2.2, 2.3, 2.4, 2.5, 2.8, 3, 3.1, 3.2, 3.5, 3.8, 4, 4.5, 5 parts by weight, and also values in between the above-mentioned values.
According to the invention, the PEG-40 hydrogenated castor oil is used in an amount of 0.02 to 0.5 parts by weight, and may be, for example, 0.02, 0.03, 0.05, 0.06, 0.1, 0.15, 0.2, 0.25, 0.3, 0.33, 0.35, 0.4, 0.45, 0.47, 0.48, 0.5 parts by weight, and points between the above values.
According to some preferred embodiments of the present invention, the whitening composition comprises 2 to 6 parts by weight of niacinamide, 0.1 to 4 parts by weight of polygonum cuspidatum extract, 0.1 to 0.2 part by weight of pepper extract, 0.25 to 5 parts by weight of 1, 3-propanediol, and 0.2 to 0.4 part by weight of PEG-40 hydrogenated castor oil.
According to the present invention, the whitening composition may be prepared by the steps of:
(1) mixing the pepper extract with 1, 3-propylene glycol and PEG-40 hydrogenated castor oil, and dissolving to obtain mixed solution;
(2) adding nicotinamide and giant knotweed rhizome extract into the mixed solution obtained in the step (1), and uniformly stirring.
According to the invention, the skin lotion with whitening effect also comprises a preservative.
According to the invention, the skin lotion with whitening effect can be prepared by the method comprising the following steps:
(1) adding water, EDTA disodium, dipropylene glycol and xanthan gum into an emulsification tank, and heating and stirring to 80-85 ℃;
(2) cooling to 45-60 deg.C under stirring, adding the whitening composition, and stirring.
According to the invention, the skin care composition is formed by compounding the nicotinamide with the plant source polygonum cuspidatum extract and the plant source pepper extract, and the skin care water is formed by compounding the auxiliary materials of cosmetics, so that the problems of poor whitening effect and possible safety caused by the independent use of the nicotinamide are solved, the effects of removing free radicals, removing red blood streaks and controlling oil can be achieved while whitening through the compounding and synergy of various components, and the skin care composition has a wide application prospect in skin care products.
Description of the drawings:
FIG. 1 is a graph showing the radical scavenging effect of example 4 and comparative examples 1 to 5;
FIG. 2 is a chart of the results of the VISIA test on the skin tone of the skin lotion of example 8;
FIG. 3 is a chart of the results of a VISIA test conducted on the condition of redness of skin care lotion of example 8;
FIG. 4 is a chart of the results of the VISIA test conducted by subjects on the skin tone of the skin of the comparative example 6;
FIG. 5 is a chart showing the results of VISIA test on the condition of red blood streaks of skin care lotion prepared by a subject in comparative example 6;
FIG. 6 is a chart showing the results of the VISIA test on the oil and fat secretion of skin lotion obtained in example 8;
FIG. 7 is a VISIA test result chart of the skin care water oil secretion condition of the test subject in comparative example 6.
The specific implementation mode is as follows:
the present invention will be described in detail with reference to the following embodiments, which will become more apparent by describing the embodiments and processes of the present invention. It should be understood by those skilled in the art that the detailed description is only a part of the examples, but not all examples, and is intended to illustrate the invention and not to limit the scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The examples were carried out under the conventional conditions, unless otherwise specified. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
Table main raw material and source
| Name (R) | Standard Chinese name | Suppliers of goods |
| Dipropylene glycol | Dipropylene glycol | Chemistry of Dow |
| Chinese gum | Xanthan gum | CPKelco |
| EDTA disodium salt | EDTA disodium salt | AkzoNobel |
| Microcare® PE | Phenoxyethanol | THOR |
| Nicotinamide | Nicotinamide | DSM |
| Polygonum cuspidatum extract | Water, butanediol, and rhizoma Polygoni Cuspidati (POLYGONUM CUSPIDATUM) extract | Shanghai Jia Ye |
| Pepper extract | Fructus Piperis (Piper NIGRUM) extract | Beijing Xinnuo Jiucangheng |
| 1, 3-propanediol | 1, 3-propanediol | (DuPont) |
| PEG-40 hydrogenated Castor oil | PEG-40 hydrogenated Castor oil | BASF |
| Notoginseng radix extract | Water, butanediol, and Notoginseng radix (PANAX NONONOGONSENG) root extract | Shanghai Jia Ye |
| VC Ethyl Ether | 3-O-Ethylascorbic acid | Beijing Xinnuo Jiucangheng |
Example 1
Weighing the following raw materials in parts by weight:
1 part by weight of nicotinamide, 5 parts by weight of giant knotweed extract, 0.01 part by weight of pepper extract, 0.01 part by weight of 1, 3-propylene glycol and 0.02 part by weight of PEG-40 hydrogenated castor oil;
mixing the above fructus Piperis extract with 1, 3-propylene glycol and PEG-40 hydrogenated castor oil, and dissolving to obtain mixed solution;
adding nicotinamide and giant knotweed rhizome extract into the mixed solution, and uniformly stirring to obtain the whitening composition A.
Example 2
Weighing the following raw materials in parts by weight:
10 parts of nicotinamide, 0.01 part of giant knotweed rhizome extract, 0.2 part of pepper extract, 5 parts of 1, 3-propylene glycol and 0.4 part of PEG-40 hydrogenated castor oil.
Mixing the above fructus Piperis extract with 1, 3-propylene glycol and PEG-40 hydrogenated castor oil, and dissolving to obtain mixed solution;
and adding the nicotinamide and the polygonum cuspidatum extract into the obtained mixed solution, and uniformly stirring to obtain the whitening composition B.
Example 3
Weighing the following raw materials in parts by weight:
3 parts of nicotinamide, 3 parts of giant knotweed rhizome extract, 0.1 part of pepper extract, 2.5 parts of 1, 3-propylene glycol and 0.2 part of PEG-40 hydrogenated castor oil,
mixing the above fructus Piperis extract with 1, 3-propylene glycol and PEG-40 hydrogenated castor oil, and dissolving to obtain mixed solution;
adding nicotinamide and giant knotweed rhizome extract into the mixed solution, and uniformly stirring to obtain the whitening composition C.
Example 4
Weighing the following raw materials in parts by weight:
6 parts of nicotinamide, 5 parts of giant knotweed rhizome extract, 0.2 part of pepper extract, 5 parts of 1, 3-propylene glycol, 0.4 part of PEG-40 hydrogenated castor oil,
mixing the above fructus Piperis extract with 1, 3-propylene glycol and PEG-40 hydrogenated castor oil, and dissolving to obtain mixed solution;
and adding the nicotinamide and the polygonum cuspidatum extract into the obtained mixed solution, and uniformly stirring to obtain the whitening composition D.
Comparative example 1
Weighing the following raw materials in parts by weight:
2 parts of nicotinamide, 9 parts of giant knotweed rhizome extract, 0.2 part of pepper extract, 5 parts of 1, 3-propylene glycol, 0.4 part of PEG-40 hydrogenated castor oil,
mixing the above fructus Piperis extract with 1, 3-propylene glycol and PEG-40 hydrogenated castor oil, and dissolving to obtain mixed solution;
adding nicotinamide and rhizoma Polygoni Cuspidati extract into the mixed solution, and stirring to obtain skin care composition.
Comparative example 2
Weighing the following raw materials in parts by weight:
3 parts of nicotinamide, 8 parts of giant knotweed rhizome extract, 0.2 part of pepper extract, 5 parts of 1, 3-propylene glycol, 0.4 part of PEG-40 hydrogenated castor oil,
mixing the above fructus Piperis extract with 1, 3-propylene glycol and PEG-40 hydrogenated castor oil, and dissolving to obtain mixed solution;
adding nicotinamide and rhizoma Polygoni Cuspidati extract into the mixed solution, and stirring to obtain skin care composition.
Comparative example 3
Weighing the following raw materials in parts by weight:
6 parts of nicotinamide, 5 parts of pseudo-ginseng extract, 0.2 part of pepper extract, 5 parts of 1, 3-propylene glycol, 0.4 part of PEG-40 hydrogenated castor oil,
mixing the above fructus Piperis extract with 1, 3-propylene glycol and PEG-40 hydrogenated castor oil, and dissolving to obtain mixed solution;
Adding nicotinamide and Notoginseng radix extract into the mixed solution, and stirring to obtain skin care composition.
Comparative example 4
Weighing the following raw materials in parts by weight:
6.0 parts of nicotinamide, 5.2 parts of giant knotweed extract, 5 parts of 1, 3-propylene glycol, 0.4 part of PEG-40 hydrogenated castor oil,
mixing the above fructus Piperis extract with 1, 3-propylene glycol and PEG-40 hydrogenated castor oil, and dissolving to obtain mixed solution;
adding nicotinamide and rhizoma Polygoni Cuspidati extract into the mixed solution, and stirring to obtain skin care composition.
Comparative example 5
Weighing the following raw materials in parts by weight:
VC ethyl ether 0.2 weight parts, giant knotweed rhizome extract 8.2 weight parts, pepper extract 0.3 weight parts, 1, 3-propylene glycol 7.5 weight parts, PEG-40 hydrogenated castor oil 0.6 weight parts,
mixing the above fructus Piperis extract with 1, 3-propylene glycol and PEG-40 hydrogenated castor oil, and dissolving to obtain mixed solution;
adding VC ethyl ether and rhizoma Polygoni Cuspidati extract into the mixed solution, and stirring to obtain skin care composition.
Efficacy evaluation test
Experiment for eliminating free radicals in vitro
1. Experimental methods
(1) DPPH free radical (DPPH) scavenging experiments
DPPH is a very stable nitrogen-centered radical, is very stable in organic solvents, is purple in color, has a characteristic absorption peak at 517nm, and when it encounters a radical scavenger, the lone electron of DPPH is paired, resulting in a lighter color and a lower absorbance at the maximum absorption wavelength. Therefore, the effect of removing DPPH can be evaluated by measuring the change in absorbance.
20mg of DPPH (Sigma Co.) was weighed out accurately, and the volume was adjusted to a 250ml volumetric flask using absolute ethanol to obtain a 20mmol/L DPPH solution, and the compositions prepared in example 4 and comparative example were diluted with distilled water to obtain test solutions having different concentrations, respectively. Respectively taking 2ml of test solution with different concentrations and 2ml of 20mmol/L DPPH, uniformly mixing, reacting for 30min, measuring the change of absorbance at the wavelength of 517nm, replacing a contrast solvent with absolute ethyl alcohol, and calculating the inhibition rate according to the following formula.
Inhibition (%) = [1- (Ai-Aj)/Ac ] × 100.
In the formula, Ai is the absorbance of a mixed solution consisting of 2ml of DPPH solution and 2ml of test solutions with different concentrations; aj is the absorbance of a mixed solution consisting of 2ml of test solutions with different concentrations and 2ml of absolute ethyl alcohol; ac was the absorbance of a mixture of 2ml of DPPH solution and 2ml of absolute ethanol.
(2) Hydroxy radical (. OH) scavenging experiments
The hydroxyl free radical is the most active free radical in active oxygen, can almost react with any biomacromolecule in living cells, has extremely high reaction speed, and is the free radical which has the greatest harm to organisms. The clearance rate of the hydroxyl radical is determined by measuring the product obtained by salicylic acid capturing the hydroxyl radical, and if a substance with the function of clearing the hydroxyl radical is added into the reaction system, the absorbance value of the reaction liquid can be reduced. The amount of hydroxyl radicals and the ability of the substance to be determined to scavenge hydroxyl radicals can therefore be described spectrophotometrically. The specific experimental process is as follows:
The compositions prepared in the above examples and comparative examples were diluted 50-fold. Hydroxyl radicals are generated by the Fenton reaction, OH oxidizes salicylic acid to generate 2, 3-dihydroxybenzoic acid with characteristic absorption at 510nm, and the OH clearance is determined by measuring the product obtained by capturing OH with salicylic acid. 3ml of 2mmol/L FeSO4 and 3ml of 1mmol/L H2O2 were added to a 25ml colorimetric cylinder, shaken, then 3ml of 6mmol/L salicylic acid was added, shaken, heated in a water bath at 37 ℃ for 15min, taken out, and the absorbance A0 was measured. Then respectively adding 0.2ml, 0.4ml, 0.6ml, 0.8ml and 1.0ml of the whitening composition with the concentration of 2%, then respectively adding 0.8ml, 0.6ml, 0.4ml, 0.2ml and 0ml of distilled water, shaking up, continuing to heat in a water bath for 15min, taking out and measuring the absorbance Ax. In order to eliminate the decrease of absorbance value of the system caused by adding 1.0ml of the composition and distilled water, the same method is adopted, the absorbance value A00 is measured after keeping the temperature for 15min, then 1ml of distilled water is added, the absorbance Axx is measured after shaking up, and the decrease of A is A00-Axx.
The composition has the following clearance rate to OH: OH clearance (%) =100(a 0-Ax-a decrease)/a 0.
(3) Superoxide anion radical scavenging experiment
Taking 4.5ml of 0.05mol/L Tris-HCl buffer solution with pH 8.2, placing the solution in a water bath at 25 ℃ for preheating for 20min, respectively adding 1ml of the compositions prepared in the above examples and comparative examples and 0.4ml of 25mmol/L pyrogallol solution, uniformly mixing, reacting in the water bath at 25 ℃ for 5min, adding 1.0ml of 8mol/L HCl to terminate the reaction, taking the Tris-HCl buffer solution as a reference, measuring absorbance at 299nm, and calculating the clearance rate. Blank controls replaced the sample with 1ml of deionized water and three replicates for each treatment.
Formula for calculating clearance: superoxide anion radical clearance (%) =100(a1-a2)/a1, wherein a1 is the average absorbance of the blank and a2 is the average absorbance of the whitening composition.
2. The results of the experiment are shown in FIG. 1.
The results shown in the figure demonstrate that the examples of the present invention have a certain scavenging capacity for DPPH, hydroxyl radicals and superoxide anion radicals. The inventors repeated the above experiments with other examples to arrive at the same conclusion.
Example 5 preparation of whitening skin lotion
Raw materials and dosage:
| name (R) | Standard Chinese name | Amount (wt%) |
| Example 1 whitening composition | —— | 8 |
| Dipropylene glycol | Dipropylene glycol | 2.5 |
| Chinese gum | Xanthan gum | 0.1 |
| EDTA disodium salt | EDTA disodium salt | 0.05 |
| Microcare® PE | Phenoxyethanol | 0.5 |
| Water (W) | Water (W) | 88.85 |
The preparation method comprises the following steps: (1) adding water, EDTA disodium, dipropylene glycol and xanthan gum into an emulsification tank, and heating and stirring to 80-85 ℃;
(2) cooling to 60 ℃ under stirring, adding the whitening composition and phenoxyethanol obtained in the example 1, and stirring uniformly.
Example 6 preparation of whitening skin lotion
Raw materials and dosage:
| name (R) | Standard Chinese name | Amount (wt%) |
| Example 2 whitening composition | —— | 0.5 |
| Dipropylene glycol | Dipropylene glycol | 1.0 |
| Chinese gum | Xanthan gum | 0.01 |
| EDTA disodium salt | EDTA disodium salt | 0.01 |
| Microcare® PE | Phenoxyethanol | 0.4 |
| Water (W) | Water (W) | 98.08 |
The preparation method comprises the following steps: (1) adding water, EDTA disodium, dipropylene glycol and xanthan gum into an emulsification tank, and heating and stirring to 80-85 ℃;
(2) cooling to 55 deg.C under stirring, adding the whitening composition of example 2 and phenoxyethanol, and stirring.
Example 7 preparation of whitening skin lotion
Raw materials and dosage:
| name (R) | Standard Chinese name | Amount (wt%) |
| Example 3 whitening composition | —— | 20.0 |
| Dipropylene glycol | Dipropylene glycol | 5.0 |
| Chinese gum | Xanthan gum | 0.2 |
| EDTA disodium salt | EDTA disodium salt | 0.1 |
| Microcare® PE | Phenoxyethanol | 1.0 |
| Water (W) | Water (W) | 73.7 |
The preparation method comprises the following steps: (1) adding water, EDTA disodium, dipropylene glycol and xanthan gum into an emulsification tank, and heating and stirring to 80-85 ℃;
(2) cooling to 45 ℃ under stirring, adding the whitening composition of the example 3 and phenoxyethanol, and stirring uniformly.
EXAMPLE 8 preparation of whitening skin lotion
Raw materials and dosage:
| name (R) | Standard Chinese name | Amount (wt%) |
| Example 4 whitening composition | —— | 6.0 |
| Dipropylene glycol | Dipropylene glycol | 3.0 |
| Chinese gum | Xanthan gum | 0.08 |
| EDTA disodium salt | EDTA disodium salt | 0.03 |
| Microcare® PE | Phenoxyethanol | 0.5 |
| Water (W) | Water (W) | 90.39 |
The preparation method comprises the following steps: (1) adding water, EDTA disodium, dipropylene glycol and xanthan gum into an emulsification tank, and heating and stirring to 80-85 ℃;
(2) cooling to 50 ℃ under stirring, adding the whitening composition of the example 4 and phenoxyethanol, and stirring uniformly.
Comparative example 6
The same as example 8 except that the whitening composition was not added.
Efficacy testing
First, the content of the rubrobiotic, the skin color condition and the red blood streak test
The test is carried out by adopting a single-center, random, double-blind and self-face left-right contrast method, and 38 testees with dark yellow skin color are screened for test. The tested skin lotion is used by the subject on the left face and the right face respectively within 6 weeks in the morning and at night every day, and the dosage is based on the actual dosage required for applying the skin lotion on the face. VISIA-CR was taken as a facial image and MX18 instrumental measurement 3 times before and at weeks 2 and 6 after the start of the test. Before each test, a subject needs to clean the face with clear water and then sits in a room with constant temperature and humidity for 30min, the face cannot be wiped with paper, and the test is carried out after the face is naturally dried; analyzing the improvement condition of the facial erythema and melanin of the subjects through the measurement result of the MX18 instrument; and analyzing the skin color condition and the improvement condition of the red blood streak before and after the skin care lotion is used by the subject through a VISIA-CR skin test result graph.
1. Melanin content MI value
The experimental method comprises the following steps: the melanin content MI values were measured 3 times in the cheek regions of the subjects at weeks 0, 2 and 6, respectively, and averaged.
The apparatus used was: mexameter MX18
And (3) testing period: 6 weeks
The results of the experiments are shown in the following table:
| average value of melanin content | Example 5 | Example 6 | Example 7 | Example 8 | Comparative example 6 |
| |
129 | 140 | 130 | 132 | 126 |
| Week 2 | 131 | 138 | 125 | 129 | 124 |
| Week 6 | 110 | 131 | 99 | 108 | 119 |
| Rate of change of melanin content | Example 5 | Example 6 | Example 7 | Example 8 | Comparative example 6 |
| Week 2 | 1.55% | -1.43% | -3.85% | -2.27% | -1.59% |
| Week 6 | -14.73% | -6.43% | -23.85% | -18.18% | -5.56% |
2. EI value of red pigment content
The experimental method comprises the following steps: at weeks 0, 2 and 6, 3 measurements of the EI value of the red pigment content were made in the cheek regions of the subjects, and averaged.
The apparatus used was: mexameter MX18
The results of the experiments are shown in the following table:
| average value of red pigment content | Example 5 | Example 6 | Example 7 | Example 8 | Comparative example 6 |
| |
242 | 225 | 229 | 241 | 236 |
| Week 2 | 236 | 229 | 230 | 243 | 235 |
| Week 6 | 225 | 217 | 210 | 208 | 238 |
| Rate of change of red pigment content | Example 5 | Example 6 | Example 7 | Example 8 | Comparative example 6 |
| Week 2 | -2.48% | 1.78% | 0.44% | 0.83% | -0.42% |
| Week 6 | -7.02% | -3.56% | -8.30% | -13.69% | 0.85% |
The results show that the embodiments of the invention have improved skin melanin and red pigment contents, and especially, the embodiments 7 and 8 have more obvious improvement on skin melanin and red pigment contents.
3. Skin color condition, redness and oil secretion test
The experimental method comprises the following steps: VISIA-CR was used to observe the skin color and red blood streak improvement in subjects at 0 week 2 week 6 week.
The apparatus used was: VISIA-CR skin tester
Introduction of corresponding light sources:
integral skin color evenness: standard Natural light 2
Red blood streak: red Areas Red region
And (3) testing period: 6 weeks
And (3) testing a sample: example 8 and comparative example 6 skin lotions
The experimental results are shown in the attached drawings.
The VISIA picture result shows that the example 8 of the invention has certain improvement effect on the skin color condition and the red blood streak of the subject, and the inventor uses other examples to prepare the skin lotion for testing, so that the same effect is achieved.
Second, oil secretion test
In addition, the inventor also unexpectedly finds that the whitening skin care lotion has a certain inhibition effect on skin oil secretion, so that 30 subjects with relatively strong skin oil secretion are screened out and divided into 2 groups, and 15 persons in each group; the test samples were used face-wide using a single-center, randomized, double-blind, placebo-controlled approach. One group used the sample of example 8 and the other group used the sample of comparative example 6, each once a day, in the morning and evening, based on the amount actually required for applying to the face. VISIA-CR was taken 3 times before the start of the test and at weeks 2 and 6 after the start of the test. Before each test, a subject needs to clean the face with clear water, sits still in a room with constant temperature and humidity for 30min, cannot wipe the face with paper, and shoots the face with a VISIA-CR skin tester after naturally drying; the oil secretion condition of the subjects before and after the skin lotion is used is analyzed through a VISIA-CR skin test result chart.
The apparatus used was: VISIA-CR skin tester
Introduction of corresponding light sources:
oil secretion: porphyrin light
And (3) testing period: 6 weeks
The experimental results are as follows:
as can be seen from the results of VISIA images, example 8 exhibited a certain improvement effect on the secretion of fats of the subjects, whereas comparative example 6 exhibited a poor improvement effect on the secretion of fats.
The skin lotion disclosed by the invention realizes the integral whitening effect by adding the whitening composition, is safe and non-irritant, and has a wide application prospect in the field of skin care products.
Claims (9)
1. A skin moisturizer with whitening effect comprises dipropylene glycol, xanthan gum, disodium EDTA and a whitening composition, wherein the whitening composition comprises niacinamide, giant knotweed rhizome extract and pepper extract.
2. The skin lotion with whitening efficacy according to claim 1, wherein the dipropylene glycol is used in an amount of 1-5wt%, the xanthan gum is used in an amount of 0.01-0.2wt%, the disodium EDTA is used in an amount of 0.01-0.1wt%, and the whitening composition is used in an amount of 0.5-20 wt%, based on the total weight of the skin lotion.
3. The skin lotion with whitening effect according to claim 2, which is characterized by comprising the following raw materials in parts by weight based on the total weight of the whitening composition: 1-10 parts of nicotinamide, 0.01-5 parts of giant knotweed extract and 0.01-0.2 part of pepper extract.
4. The skin lotion with whitening effect according to claim 3, which is characterized by comprising the following raw materials in parts by weight based on the total weight of the whitening composition: 2-6 parts of nicotinamide, 0.1-4 parts of giant knotweed extract and 0.1-0.2 part of pepper extract.
5. The skin lotion with whitening efficacy according to claim 3 or 4, wherein the whitening composition further comprises 1, 3-propanediol and/or PEG-40 hydrogenated castor oil.
6. The skin lotion with whitening effect according to claim 5, wherein the whitening composition comprises the following raw materials in parts by weight based on the total weight of the whitening composition: 1-10 parts of nicotinamide, 0.01-5 parts of giant knotweed extract, 0.01-0.2 part of pepper extract, 0.01-5 parts of 1, 3-propylene glycol and 0.02-0.5 part of PEG-40 hydrogenated castor oil.
7. The skin lotion with whitening effect according to claim 6, wherein the whitening composition comprises the following raw materials in parts by weight: 2-6 parts of nicotinamide, 0.1-4 parts of giant knotweed rhizome extract, 0.1-0.2 part of pepper extract, 0.25-5 parts of 1, 3-propylene glycol and 0.2-0.4 part of PEG-40 hydrogenated castor oil.
8. The skin lotion with whitening efficacy according to any one of claims 5 to 7, wherein the whitening composition is prepared by a method comprising the steps of:
(1) mixing the pepper extract with 1, 3-propylene glycol and PEG-40 hydrogenated castor oil, and dissolving to obtain mixed solution;
(2) and (2) adding the nicotinamide and the polygonum cuspidatum extract into the mixed solution obtained in the step (1), and uniformly stirring.
9. A method of preparing a lotion according to any of claims 1 to 8 comprising the steps of:
(1) adding water, EDTA disodium, dipropylene glycol and xanthan gum into an emulsification tank, and heating and stirring to 80-85 ℃;
(2) cooling to 45-60 deg.C under stirring, adding the whitening composition, and stirring.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107049824A (en) * | 2017-06-27 | 2017-08-18 | 上海新高姿化妆品有限公司 | A kind of composition with white-skinned face function and its application in cosmetics |
| CN107684536A (en) * | 2017-10-23 | 2018-02-13 | 宇妥藏药股份有限公司 | A kind of whitening moisturizing face masque and preparation method thereof |
| US20180207077A1 (en) * | 2017-01-26 | 2018-07-26 | L'oreal | Microemulsion compositions comprising polydatin and method of use |
| CN108815037A (en) * | 2018-08-02 | 2018-11-16 | 广州航美化妆品有限公司 | A kind of whitening shines face skin care compositions and its application in cosmetics |
| CN110974720A (en) * | 2019-12-31 | 2020-04-10 | 珠海伊斯佳科技股份有限公司 | Whitening and skin-brightening composition, whitening and skin-brightening cosmetic, whitening and skin-brightening lotion and preparation method thereof, and whitening and skin-brightening emulsion and preparation method thereof |
-
2020
- 2020-04-13 CN CN202010287734.8A patent/CN113520927A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180207077A1 (en) * | 2017-01-26 | 2018-07-26 | L'oreal | Microemulsion compositions comprising polydatin and method of use |
| CN107049824A (en) * | 2017-06-27 | 2017-08-18 | 上海新高姿化妆品有限公司 | A kind of composition with white-skinned face function and its application in cosmetics |
| CN107684536A (en) * | 2017-10-23 | 2018-02-13 | 宇妥藏药股份有限公司 | A kind of whitening moisturizing face masque and preparation method thereof |
| CN108815037A (en) * | 2018-08-02 | 2018-11-16 | 广州航美化妆品有限公司 | A kind of whitening shines face skin care compositions and its application in cosmetics |
| CN110974720A (en) * | 2019-12-31 | 2020-04-10 | 珠海伊斯佳科技股份有限公司 | Whitening and skin-brightening composition, whitening and skin-brightening cosmetic, whitening and skin-brightening lotion and preparation method thereof, and whitening and skin-brightening emulsion and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社, pages: 140 * |
| 珠曼: "《珠曼护肤系列之--赋活精华液》", pages 4, Retrieved from the Internet <URL:https://mp.weixin.qq.com/s?src=11×tamp=1705457822&ver=5023&signature=05-3tt*bfca7pRXy5QEu-TsE-D9cf2cDqdvQtV661KlYXVnjFtmZ3iOVhyooBczsd0oa0TW2GXRJFvKhBJgQo8xNA8pFcDjafz21jpWiqeEF1TUCQSyuMqgkHvgwpZ3N&new=1> * |
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