CN113512112A - 针对细胞内抗原的单结构域抗体 - Google Patents

针对细胞内抗原的单结构域抗体 Download PDF

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CN113512112A
CN113512112A CN202110795272.5A CN202110795272A CN113512112A CN 113512112 A CN113512112 A CN 113512112A CN 202110795272 A CN202110795272 A CN 202110795272A CN 113512112 A CN113512112 A CN 113512112A
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seq
sdab
sdabs
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amino acid
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S·辛格
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Singer Molecular Medicine Ltd
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Singer Molecular Medicine Ltd
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CN202110795272.5A 2015-11-02 2016-11-02 针对细胞内抗原的单结构域抗体 Withdrawn CN113512112A (zh)

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US201562249868P 2015-11-02 2015-11-02
US62/249,868 2015-11-02
CN201680063523.8A CN108350064B (zh) 2015-11-02 2016-11-02 针对细胞内抗原的单结构域抗体

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US (4) US10369223B2 (https=)
EP (1) EP3371215A4 (https=)
JP (2) JP6918005B2 (https=)
KR (1) KR20180069064A (https=)
CN (2) CN113512112A (https=)
AR (1) AR106556A1 (https=)
AU (1) AU2016349876B2 (https=)
BR (1) BR112018008840B1 (https=)
CA (1) CA3002239A1 (https=)
IL (1) IL258742B (https=)
MX (1) MX2018005154A (https=)
RU (3) RU2742248C2 (https=)
TW (1) TWI746473B (https=)
WO (1) WO2017079314A2 (https=)

Families Citing this family (6)

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US20170267784A1 (en) 2014-10-23 2017-09-21 Singh Molecular Medicine, Llc Single domain antibodies directed against intracellular antigens
CN113557246B (zh) * 2019-07-24 2023-09-01 韩国基础科学支援研究院 靶向αvβ3整联蛋白的单域抗体
CN111234019B (zh) * 2020-01-16 2022-06-24 佛山汉腾生物科技有限公司 抗ctla-4纳米抗体、药物组合物及其应用
CN111184864B (zh) * 2020-01-20 2022-01-14 武汉大学 Alox12特异性抑制剂在制备治疗非酒精性脂肪肝病和/或ⅱ型糖尿病的药物中的应用
CN113214392B (zh) * 2020-12-30 2022-07-01 中国人民解放军海军军医大学 抗水母毒素纳米抗体ky031、制备方法及用途
CN115414482A (zh) * 2022-07-13 2022-12-02 同济大学 Stat3信号通路抑制剂的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016183A1 (en) * 1999-08-30 2001-03-08 U.S. Army Medical Research Institute Of Infectious Diseases Monoclonal antibodies and vaccines against epitopes on the ebola virus glycoprotein
JP2004315394A (ja) * 2003-04-14 2004-11-11 Japan Science & Technology Agency レストンエボラウイルスに対するモノクローナル抗体及びこれを用いたレストンエボラウイルスの検出方法
CN1636063A (zh) * 2001-11-01 2005-07-06 健方公司 针对人免疫缺陷病毒的遗传疫苗
WO2010037402A1 (en) * 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
AU642171B2 (en) * 1989-10-05 1993-10-14 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Monoclonal antibodies to segments of HIV-1 reverse transcriptase
AU687010B2 (en) 1992-07-17 1998-02-19 Dana-Farber Cancer Institute Method of intracellular binding of target molecules
FR2706486B1 (fr) 1993-06-16 1995-09-01 Rhone Poulenc Rorer Sa Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques.
US5645836A (en) * 1995-04-14 1997-07-08 Research Development Foundation Anti-AIDS immunotoxins
EP1204674A4 (en) 1999-07-27 2005-06-01 Abgenix Inc METHODS AND COMPOUNDS FOR PREVENTING POLYPEPTIDE COLLECTIONS ASSOCIATED WITH NEUROLOGICAL DISORDERS
CN1184484C (zh) 1999-12-20 2005-01-12 恩益禧电子股份有限公司 用来精确测量阻抗的装置及方法
DE10019157A1 (de) 2000-04-18 2001-11-15 Stefan Duebel Verfahren zum Einbringen von Liganden in lebende Zellen
CA2441903C (en) 2000-05-26 2012-07-31 National Research Council Of Canada Single-domain brain-targeting antibody fragments derived from llama antibodies
US20040052762A1 (en) 2001-09-10 2004-03-18 Hua Yu Stat3 agonists and antagonists and therapeutic uses thereof
JP2002253239A (ja) * 2001-02-27 2002-09-10 Jo Chiba ヒト免疫不全ウイルスの逆転写酵素の活性を阻害するポリペプチドをコードする遺伝子およびその利用
RU2186106C1 (ru) * 2001-03-29 2002-07-27 Вирусологический центр Научно-исследовательского института микробиологии Штамм гибридных клеток э4/n-6g5 животных mus musculus l., продуцирующих моноклональные антитела к вирусу эбола
JP4213586B2 (ja) * 2001-09-13 2009-01-21 株式会社抗体研究所 ラクダ抗体ライブラリーの作製方法
CA2471645A1 (en) * 2002-01-03 2003-07-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Immunoconjugates useful for treatment of tumours
GB0226727D0 (en) 2002-11-15 2002-12-24 Medical Res Council Intrabodies
WO2003077945A1 (en) 2002-03-14 2003-09-25 Medical Research Council Intracellular antibodies
WO2003086276A2 (en) * 2002-04-05 2003-10-23 Selective Genetics, Inc. Compositions and methods for portal specific gene delivery and treatment of infection
RU2455312C2 (ru) * 2002-11-08 2012-07-10 Аблинкс Н.В. Однодоменные антитела, направленные против фактора некроза опухолей альфа, и их применение
US20060034845A1 (en) 2002-11-08 2006-02-16 Karen Silence Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
EP1900753B1 (en) 2002-11-08 2017-08-09 Ablynx N.V. Method of administering therapeutic polypeptides, and polypeptides therefor
WO2004041863A2 (en) 2002-11-08 2004-05-21 Ablynx N.V. Single domain antibodies directed against interferon- gamma and uses therefor
EP1558645B1 (en) 2002-11-08 2011-07-27 Ablynx N.V. Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation
GB0226729D0 (en) 2002-11-15 2002-12-24 Medical Res Council Intracellular antibodies
US7638122B2 (en) 2003-03-07 2009-12-29 University Of South Florida Stat3 antagonists and their use as vaccines against cancer
WO2005009224A2 (en) * 2003-07-24 2005-02-03 The Curators Of The University Of Missouri Methods and compositions for evaluation and modulations of fertility
US20050226863A1 (en) 2003-11-20 2005-10-13 Massachusetts Institute Of Technology Single-domain antibodies and uses thereof
FR2874017B1 (fr) * 2004-08-06 2006-11-24 Bio Rad Pasteur Sa Peptides vih-1 modifies et leur utilisation en detection d'anticorps anti-vih
US20060147997A1 (en) * 2004-11-30 2006-07-06 Virosys Pharmaceuticals, Inc. PenetraBodies: receptor-mediated targeted delivery of functionally-active human antibody fragments into cytosol for the treatment of chronic infections and diseases
US8188223B2 (en) 2005-05-18 2012-05-29 Ablynx N.V. Serum albumin binding proteins
DE102005023617A1 (de) 2005-05-21 2006-11-23 Aspre Ag Verfahren zum Mischen von Farben in einem Display
EP2077863A4 (en) 2006-10-31 2010-10-06 Domantis Ltd intrabodies
US20100166734A1 (en) * 2006-12-20 2010-07-01 Edward Dolk Oral delivery of polypeptides
EP2008666A1 (en) 2007-06-29 2008-12-31 Institut Pasteur Use of VHH antibodies for the preparation of peptide vectors for delivering a substance of interest and their applications
KR20090001043A (ko) * 2007-06-29 2009-01-08 주식회사 에스엔피 제네틱스 Ａｌｏｘ１２ 및 ａｌｏｘ１５ 다형성과 아스피린 유도성천식과의 연관성
KR20090001043U (ko) 2007-07-26 2009-02-02 김기인 공간 보호 책상
US20110195509A1 (en) 2007-09-06 2011-08-11 Drew Pardoll Treatment of th17-mediated autoimmune disease via inhibition of stat 3
CA2699385A1 (en) * 2007-09-14 2009-03-19 Ventana Medical Systems, Inc. Prostate cancer biomarkers
ES2447844T3 (es) * 2008-04-03 2014-03-13 Vib Vzw Anticuerpos de dominio individual capaces de modular la actividad BACE1
WO2009150539A2 (en) * 2008-06-10 2009-12-17 Institut Pasteur Variable domains of camelid heavy-chain antibodies directed against androctonus autralis hector toxins
EP2143735A1 (en) 2008-07-10 2010-01-13 Institut Pasteur Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins
US20100136584A1 (en) * 2008-09-22 2010-06-03 Icb International, Inc. Methods for using antibodies and analogs thereof
WO2010033913A1 (en) 2008-09-22 2010-03-25 Icb International, Inc. Antibodies, analogs and uses thereof
US20110172398A1 (en) * 2009-10-02 2011-07-14 Boehringer Ingelheim International Gmbh Bispecific binding molecules for anti-angiogenesis therapy
WO2011051327A2 (en) 2009-10-30 2011-05-05 Novartis Ag Small antibody-like single chain proteins
US20130177979A1 (en) 2010-06-22 2013-07-11 University Of Central Florida Research Foundation, Inc. Methods and compositions for cell permeable stat3 inhibitor
SG10201805064SA (en) * 2011-06-23 2018-07-30 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
CN118955699A (zh) * 2012-10-18 2024-11-15 洛克菲勒大学 广泛中和性抗hiv抗体
CN105658230B (zh) 2013-08-29 2020-04-21 希望之城 细胞穿透缀合物及其使用方法
EP2873680A1 (en) 2013-11-13 2015-05-20 F.Hoffmann-La Roche Ag Oligopeptide and methods for producing conjugates thereof
EP2873679A1 (en) 2013-11-13 2015-05-20 F.Hoffmann-La Roche Ag Camelid single-domain antibody directed against amyloid bêta and methods for producing conjugates thereof
EP2899208A1 (en) 2014-01-28 2015-07-29 F.Hoffmann-La Roche Ag Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing conjugates thereof
US20160115247A1 (en) 2014-10-23 2016-04-28 Singh Biotechnology, Llc Single domain antibodies directed against intracellular antigens
CN104829710A (zh) * 2015-03-26 2015-08-12 中国人民解放军军事医学科学院微生物流行病研究所 一种抗埃博拉病毒的免疫球蛋白F(ab′)2及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016183A1 (en) * 1999-08-30 2001-03-08 U.S. Army Medical Research Institute Of Infectious Diseases Monoclonal antibodies and vaccines against epitopes on the ebola virus glycoprotein
CN1636063A (zh) * 2001-11-01 2005-07-06 健方公司 针对人免疫缺陷病毒的遗传疫苗
JP2004315394A (ja) * 2003-04-14 2004-11-11 Japan Science & Technology Agency レストンエボラウイルスに対するモノクローナル抗体及びこれを用いたレストンエボラウイルスの検出方法
WO2010037402A1 (en) * 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JULIE A. WILSON ET AL.: ""Vaccine Potential of Ebola Virus VP24, VP30, VP35, and VP40 Proteins"", 《VIROLOGY》, vol. 286 *
SARAH A. GOODCHILD ET AL.: ""Isolation and characterisation of Ebolavirus-specific recombinant antibody fragments from murine and shark immune libraries"", 《MOLECULAR IMMUNOLOGY》, vol. 48, pages 2028 *
洪梦佳 等: ""单域抗体的研究进展"", 《药物生物技术》, vol. 25, no. 6, pages 556 - 560 *

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