CN113473981A - 含肉桂酸的组合物以及其使用方法 - Google Patents

含肉桂酸的组合物以及其使用方法 Download PDF

Info

Publication number
CN113473981A
CN113473981A CN202080016447.1A CN202080016447A CN113473981A CN 113473981 A CN113473981 A CN 113473981A CN 202080016447 A CN202080016447 A CN 202080016447A CN 113473981 A CN113473981 A CN 113473981A
Authority
CN
China
Prior art keywords
patient
cinnamic acid
composition
day
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080016447.1A
Other languages
English (en)
Chinese (zh)
Inventor
K·帕汉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rush University Medical Center
Original Assignee
Rush University Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rush University Medical Center filed Critical Rush University Medical Center
Publication of CN113473981A publication Critical patent/CN113473981A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202080016447.1A 2019-02-25 2020-02-25 含肉桂酸的组合物以及其使用方法 Pending CN113473981A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962810055P 2019-02-25 2019-02-25
US62/810,055 2019-02-25
PCT/US2020/019568 WO2020176432A1 (en) 2019-02-25 2020-02-25 Compositions including cinnamic acid and methods of use thereof

Publications (1)

Publication Number Publication Date
CN113473981A true CN113473981A (zh) 2021-10-01

Family

ID=72238701

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080016447.1A Pending CN113473981A (zh) 2019-02-25 2020-02-25 含肉桂酸的组合物以及其使用方法

Country Status (9)

Country Link
US (1) US12478598B2 (https=)
EP (1) EP3930704A4 (https=)
JP (1) JP2022521233A (https=)
KR (1) KR20210130772A (https=)
CN (1) CN113473981A (https=)
AU (1) AU2020229316A1 (https=)
CA (1) CA3130761A1 (https=)
EA (1) EA202192199A1 (https=)
WO (1) WO2020176432A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202002639D0 (en) * 2020-02-25 2020-04-08 Ucl Business Ltd Therapy
CN116390761A (zh) * 2020-10-28 2023-07-04 拉什大学医学中心 肉桂酸苄酯组合物在治疗甘氨酸脑病和尿素循环障碍中的应用
KR20240112921A (ko) * 2021-12-01 2024-07-19 사바 헬스케어 리미티드 약제학적 제제 및 그 제조 방법
JP2025503457A (ja) * 2021-12-16 2025-02-04 ザ ユナイテッド ステイツ ガバメント アズ リプレゼンティド バイ ザ デパートメント オブ ヴェテランズ アフェアーズ 神経系損傷及び障害の治療のための安息香酸塩
WO2024201533A1 (en) * 2023-03-31 2024-10-03 Sava Healthcare Limited A parenteral composition of cinnamic acid

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030090970A (ko) * 2002-05-24 2003-12-01 한국과학기술연구원 신남산 이합체, 그 제조방법 및 퇴행성 뇌질환 치료를위한 그의 용도
US20160331714A1 (en) * 2014-01-17 2016-11-17 Rush University Medical Center The use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders
CN107207403A (zh) * 2014-09-29 2017-09-26 塞尔利克斯生物私人有限公司 用于治疗多发性硬化的组合物和方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016081365A1 (en) * 2014-11-19 2016-05-26 Rush University Medical Center Compositions and methods for treating lysosomal disorders
ES2936094T3 (es) 2016-06-13 2023-03-14 Syneurx Int Taiwan Corp Cocristales de benzoato de sodio y usos de los mismos
EA202090666A1 (ru) * 2017-10-06 2020-08-05 Раш Юниверсити Медикал Сентер Применение содержащей бензоат композиции для лечения глициновой энцефалопатии
GB202002639D0 (en) 2020-02-25 2020-04-08 Ucl Business Ltd Therapy
CN116390761A (zh) * 2020-10-28 2023-07-04 拉什大学医学中心 肉桂酸苄酯组合物在治疗甘氨酸脑病和尿素循环障碍中的应用
CN116723870A (zh) * 2021-01-20 2023-09-08 拉什大学医学中心 球形细胞脑白质营养不良症或克拉伯病的改良治疗

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030090970A (ko) * 2002-05-24 2003-12-01 한국과학기술연구원 신남산 이합체, 그 제조방법 및 퇴행성 뇌질환 치료를위한 그의 용도
CN1627940A (zh) * 2002-05-24 2005-06-15 韩国科学技术研究院 肉桂酸二聚体,它们的制剂及其在治疗神经变性病中的应用
US20160331714A1 (en) * 2014-01-17 2016-11-17 Rush University Medical Center The use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders
CN107207403A (zh) * 2014-09-29 2017-09-26 塞尔利克斯生物私人有限公司 用于治疗多发性硬化的组合物和方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DIREN BEYOĞLU，等: "The glycine deportation system and its pharmacological consequences", PHARMACOL THER, vol. 135, no. 02, 31 August 2012 (2012-08-31), pages 4 *

Also Published As

Publication number Publication date
US12478598B2 (en) 2025-11-25
WO2020176432A1 (en) 2020-09-03
KR20210130772A (ko) 2021-11-01
AU2020229316A1 (en) 2021-09-16
JP2022521233A (ja) 2022-04-06
EP3930704A1 (en) 2022-01-05
EA202192199A1 (ru) 2021-12-17
US20220133664A1 (en) 2022-05-05
CA3130761A1 (en) 2020-09-03
EP3930704A4 (en) 2022-11-16

Similar Documents

Publication Publication Date Title
CN113473981A (zh) 含肉桂酸的组合物以及其使用方法
AU2022200277A1 (en) The use of a benzoate containing composition to treat glycine encephalopathy
US9968582B2 (en) Use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders
JPH0761923A (ja) アルツハイマー病治療剤
US20230255910A1 (en) Use of a cinnamein composition for the treatment of glycine encephalopathy and urea cycle disorders
EP4331583A1 (en) Blood carnitine-increasing agent
US20240082184A1 (en) Improved treatment for globoid cell leukodsytrophy or krabbe disease
EP3999051B1 (en) Inhalation dosage forms of glycerol tribenzoate and/or glycerol dibenzoate for use in the treatment of huntington's disease
WO2017113775A1 (zh) 甘油三酯类化合物在制备治疗神经退行性疾病药物中的应用
HK40075156B (en) Inhalation dosage forms of glycerol tribenzoate and/or glycerol dibenzoate for use in the treatment of huntington's disease
HK40075156A (en) Inhalation dosage forms of glycerol tribenzoate and/or glycerol dibenzoate for use in the treatment of huntington's disease
CN121243175A (zh) 烟碱联合阿立哌唑在双相抑郁中的应用及产品
HK40098307A (zh) 三苯甲酸甘油酯和苯丁酸甘油酯的给予用於治疗神经退行性疾病和尿素循环障碍
HK40101082A (zh) 球形细胞脑白质营养不良症或克拉伯病的改良治疗

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination