CN113444173A - 金黄色葡萄球菌α-毒素特异性抗体及其应用 - Google Patents

金黄色葡萄球菌α-毒素特异性抗体及其应用 Download PDF

Info

Publication number
CN113444173A
CN113444173A CN202010664920.9A CN202010664920A CN113444173A CN 113444173 A CN113444173 A CN 113444173A CN 202010664920 A CN202010664920 A CN 202010664920A CN 113444173 A CN113444173 A CN 113444173A
Authority
CN
China
Prior art keywords
antibody
amino acid
ser
seq
substantially similar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010664920.9A
Other languages
English (en)
Chinese (zh)
Inventor
赵子渊
张瀞文
曹一孚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xingmeng Biomedical Suzhou Co ltd
Original Assignee
Xingmeng Biomedical Suzhou Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xingmeng Biomedical Suzhou Co ltd filed Critical Xingmeng Biomedical Suzhou Co ltd
Publication of CN113444173A publication Critical patent/CN113444173A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/56938Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/305Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
    • G01N2333/31Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/315Assays involving biological materials from specific organisms or of a specific nature from bacteria from Streptococcus (G), e.g. Enterococci
    • G01N2333/3156Assays involving biological materials from specific organisms or of a specific nature from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae [Pneumococcus]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN202010664920.9A 2020-03-25 2020-07-10 金黄色葡萄球菌α-毒素特异性抗体及其应用 Pending CN113444173A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062994744P 2020-03-25 2020-03-25
US62/994,744 2020-03-25

Publications (1)

Publication Number Publication Date
CN113444173A true CN113444173A (zh) 2021-09-28

Family

ID=75223147

Family Applications (4)

Application Number Title Priority Date Filing Date
CN202010664920.9A Pending CN113444173A (zh) 2020-03-25 2020-07-10 金黄色葡萄球菌α-毒素特异性抗体及其应用
CN202010663921.1A Pending CN113444171A (zh) 2020-03-25 2020-07-10 金黄色葡萄球菌α-毒素特异性抗体及其应用
CN202010664832.9A Pending CN113444172A (zh) 2020-03-25 2020-07-10 金黄色葡萄球菌α-毒素特异性抗体及其应用
CN202110321155.5A Active CN113444174B (zh) 2020-03-25 2021-03-25 金黄色葡萄球菌α-毒素特异性抗体及其应用

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN202010663921.1A Pending CN113444171A (zh) 2020-03-25 2020-07-10 金黄色葡萄球菌α-毒素特异性抗体及其应用
CN202010664832.9A Pending CN113444172A (zh) 2020-03-25 2020-07-10 金黄色葡萄球菌α-毒素特异性抗体及其应用
CN202110321155.5A Active CN113444174B (zh) 2020-03-25 2021-03-25 金黄色葡萄球菌α-毒素特异性抗体及其应用

Country Status (8)

Country Link
US (1) US11530256B2 (enExample)
EP (1) EP3895762A3 (enExample)
JP (1) JP7765191B2 (enExample)
KR (1) KR20210119913A (enExample)
CN (4) CN113444173A (enExample)
BR (1) BR102021005680A2 (enExample)
SG (1) SG10202103015VA (enExample)
TW (1) TWI877334B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117106077A (zh) * 2022-04-28 2023-11-24 珠海泰诺麦博制药股份有限公司 特异性结合金黄色葡萄球菌Hla毒素的全人源单克隆抗体

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115785281B (zh) * 2022-09-27 2024-07-19 兴盟生物医药(苏州)有限公司 含有狂犬病病毒g蛋白的融合蛋白的制备方法及应用
CN117771379B (zh) * 2023-10-25 2024-08-30 珠海泰诺麦博制药股份有限公司 特异性结合金黄色葡萄球菌Hla毒素的全人源抗体与抗生素的组合

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
EP2284193A1 (en) 2009-08-10 2011-02-16 Kenta Biotech AG Human monoclonal antibody against S. aureus derived apha-toxin and its use in treating or preventing abscess formation
PT2673373T (pt) * 2011-02-08 2018-12-05 Medimmune Llc Anticorpos que ligam especificamente a toxina alfa de staphylococcus aureus e métodos de utilização
US20140286960A1 (en) 2011-07-28 2014-09-25 Cangene Corporation Staphlococcus aureus alpha-hemolysin antibodies
WO2013093693A1 (en) * 2011-12-22 2013-06-27 Rinat Neuroscience Corp. Staphylococcus aureus specific antibodies and uses thereof
US20160244511A1 (en) * 2013-10-17 2016-08-25 Arsanis Biosciences Gmbh Cross-reactive staphylococcus aureus antibody sequences
WO2016044588A1 (en) 2014-09-19 2016-03-24 The Regents Of The University Of Michigan Staphylococcus aureus materials and methods
MA41613A (fr) * 2015-02-23 2018-01-02 Abbvie Stemcentrx Llc Récepteurs antigéniques chimériques anti-dll3 et procédés d'utilisation desdits récepteurs
TWI781130B (zh) 2017-01-03 2022-10-21 美商再生元醫藥公司 抗金黃色葡萄球菌溶血素a毒素之人類抗體
CN109384844B (zh) 2017-08-04 2020-12-18 中国人民解放军军事医学科学院基础医学研究所 一种抗金黄色葡萄球菌α溶血素单克隆抗体及应用
CN109400704B (zh) 2018-11-14 2020-07-21 珠海泰诺麦博生物技术有限公司 一种抗金黄色葡萄球菌α-溶血素的抗体及其应用
CN109705213B (zh) * 2018-12-04 2023-04-18 上海长征医院 抗金黄色葡萄球菌毒素抗体及其用途
US11345744B2 (en) 2019-05-07 2022-05-31 William R Church Antibody specific to Staphylococcus aureus, therapeutic method and detection method using same
CN110437334B (zh) 2019-07-26 2020-12-01 西南医科大学 全人源抗金黄色葡萄球菌α-溶血素重组抗体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117106077A (zh) * 2022-04-28 2023-11-24 珠海泰诺麦博制药股份有限公司 特异性结合金黄色葡萄球菌Hla毒素的全人源单克隆抗体

Also Published As

Publication number Publication date
CN113444171A (zh) 2021-09-28
EP3895762A3 (en) 2022-01-12
CN113444174A (zh) 2021-09-28
BR102021005680A2 (pt) 2022-03-08
EP3895762A2 (en) 2021-10-20
CN113444172A (zh) 2021-09-28
SG10202103015VA (en) 2021-10-28
CN113444174B (zh) 2025-11-28
US11530256B2 (en) 2022-12-20
JP7765191B2 (ja) 2025-11-06
TW202202519A (zh) 2022-01-16
KR20210119913A (ko) 2021-10-06
TWI877334B (zh) 2025-03-21
US20210317193A1 (en) 2021-10-14
JP2021155416A (ja) 2021-10-07

Similar Documents

Publication Publication Date Title
JP7057843B2 (ja) GUCY2cに特異的な抗体及びその使用
US11440964B2 (en) Method for treating a pathological condition involving the activation or proliferation of CD127 positive cells with an anti-CD127 antibody
US20220056140A1 (en) Anti hla-g specific antibodies
US9758586B2 (en) Chimeric rabbit/human ROR1 antibodies
JP6797111B2 (ja) イヌpd−l1と結合するpd−l1抗体
EP3712170A1 (en) Cd96 antibody, antigen-binding fragment and pharmaceutical use thereof
CN110267989B (zh) 抗cd40抗体、其抗原结合片段及其医药用途
US20080038256A1 (en) Anti-hgf/sf humanized antibody and method for the preparation thereof
KR20210099027A (ko) 항-cd40 항체, 이의 항원-결합 단편 및 약학적 용도
CN113444174B (zh) 金黄色葡萄球菌α-毒素特异性抗体及其应用
US20230192861A1 (en) Anti-pd-l1/anti-b7-h3 multispecific antibodies and uses thereof
KR20230017226A (ko) Cd40 결합 단백질
KR102231685B1 (ko) 인간 항-il-32 항체
US20240075158A1 (en) Complex of anti-il-4r antibody or antigen-binding fragment thereof and medical use thereof
AU2020223205A1 (en) Compositions and methods for using bispecific antibodies to bind complement and a target antigen
CN113416249B (zh) 针对破伤风毒素的组合物
KR20250114286A (ko) 개과 악성종양에 대한 면역제
KR20210158693A (ko) 항 pcsk9 항체 및 이의 용도
HK40051457A (en) Anti-cd40 antibody, antigen binding fragment and pharmaceutical use thereof
EA039325B1 (ru) Конструкции биспецифических антител, связывающиеся с дпб3 (dll3) и кд3 (cd3)

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20210928