CN113412112B - 作为c-MET抑制剂的有机磷取代化合物及其治疗用途 - Google Patents

作为c-MET抑制剂的有机磷取代化合物及其治疗用途 Download PDF

Info

Publication number
CN113412112B
CN113412112B CN201980091722.3A CN201980091722A CN113412112B CN 113412112 B CN113412112 B CN 113412112B CN 201980091722 A CN201980091722 A CN 201980091722A CN 113412112 B CN113412112 B CN 113412112B
Authority
CN
China
Prior art keywords
mmol
triazolo
compound
alkyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980091722.3A
Other languages
English (en)
Chinese (zh)
Other versions
CN113412112A (zh
Inventor
张顿
彭继荣
迈克尔·尼古拉斯·格雷科
迈克尔·约翰·科斯坦佐
迈克尔·艾伦·格林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beta Pharma Inc
Original Assignee
Beta Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beta Pharma Inc filed Critical Beta Pharma Inc
Publication of CN113412112A publication Critical patent/CN113412112A/zh
Application granted granted Critical
Publication of CN113412112B publication Critical patent/CN113412112B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5004—Acyclic saturated phosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980091722.3A 2018-12-14 2019-12-14 作为c-MET抑制剂的有机磷取代化合物及其治疗用途 Active CN113412112B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862779960P 2018-12-14 2018-12-14
US62/779,960 2018-12-14
PCT/US2019/066414 WO2020124060A1 (en) 2018-12-14 2019-12-14 Organophosphorus-substituted compounds as c-met inhibitors and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
CN113412112A CN113412112A (zh) 2021-09-17
CN113412112B true CN113412112B (zh) 2024-06-11

Family

ID=71077551

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980091722.3A Active CN113412112B (zh) 2018-12-14 2019-12-14 作为c-MET抑制剂的有机磷取代化合物及其治疗用途

Country Status (15)

Country Link
US (1) US12258365B2 (https=)
EP (1) EP3893872B1 (https=)
JP (1) JP2022513215A (https=)
KR (1) KR20210111779A (https=)
CN (1) CN113412112B (https=)
AU (1) AU2019395282A1 (https=)
BR (1) BR112021011547A2 (https=)
CA (1) CA3122575A1 (https=)
EA (1) EA202191541A1 (https=)
IL (1) IL283589A (https=)
MX (1) MX2021006982A (https=)
SG (1) SG11202105872RA (https=)
TW (1) TW202039500A (https=)
WO (1) WO2020124060A1 (https=)
ZA (1) ZA202104000B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116969955B (zh) * 2023-09-25 2023-12-19 中国药科大学 一种[1,2,4]三唑[4,3-b]哒嗪类化合物及其制法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101443331A (zh) * 2006-05-11 2009-05-27 辉瑞产品公司 适用作抗癌药的三唑并吡嗪衍生物
CN101878215A (zh) * 2007-11-29 2010-11-03 辉瑞大药厂 C-met/hgfr抑制剂的多晶型
CN106928232A (zh) * 2015-12-31 2017-07-07 上海医药集团股份有限公司 喹啉类化合物及其盐的晶型、制备方法、组合物与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20170103T1 (hr) 2005-12-21 2017-03-24 Janssen Pharmaceutica N.V. Triazolopiridazini kao modulatori tirozin kinaze
UY32049A (es) 2008-08-14 2010-03-26 Takeda Pharmaceutical Inhibidores de cmet
EA030141B1 (ru) 2009-12-31 2018-06-29 Хатчисон Медифарма Лимитед Определенные триазолопиридины и триазолопиразины, их композиции и способы их применения
ES2598530T3 (es) 2010-07-14 2017-01-27 Betta Pharmaceuticals Co., Ltd. Nuevos derivados heterocíclicos condensados útiles como inhibidores de la tirosina quinasa c-Met
TWI520962B (zh) * 2012-06-29 2016-02-11 As the c-Met tyrosine kinase inhibitors novel fused pyridine derivatives
CN103122000B (zh) * 2012-09-03 2013-12-25 中美冠科生物技术（太仓）有限公司 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101443331A (zh) * 2006-05-11 2009-05-27 辉瑞产品公司 适用作抗癌药的三唑并吡嗪衍生物
CN101878215A (zh) * 2007-11-29 2010-11-03 辉瑞大药厂 C-met/hgfr抑制剂的多晶型
CN106928232A (zh) * 2015-12-31 2017-07-07 上海医药集团股份有限公司 喹啉类化合物及其盐的晶型、制备方法、组合物与应用

Also Published As

Publication number Publication date
CN113412112A (zh) 2021-09-17
EP3893872B1 (en) 2024-07-17
KR20210111779A (ko) 2021-09-13
EA202191541A1 (ru) 2022-01-21
TW202039500A (zh) 2020-11-01
WO2020124060A1 (en) 2020-06-18
SG11202105872RA (en) 2021-07-29
EP3893872A4 (en) 2022-08-10
EP3893872A1 (en) 2021-10-20
US12258365B2 (en) 2025-03-25
MX2021006982A (es) 2021-09-10
AU2019395282A1 (en) 2021-07-08
ZA202104000B (en) 2022-08-31
BR112021011547A2 (pt) 2021-08-31
CA3122575A1 (en) 2020-06-18
US20220064194A1 (en) 2022-03-03
IL283589A (en) 2021-07-29
JP2022513215A (ja) 2022-02-07

Similar Documents

Publication Publication Date Title
CN112300194B (zh) 一类稠环吡啶酮类化合物、制备方法和用途
CN112300173B (zh) 一类含氮多环类化合物、制备方法和用途
CN111704611B (zh) 一类芳基螺环类shp2抑制剂化合物、制备方法和用途
CN115433179A (zh) 苯并嘧啶类化合物及其医药用途
JP5414794B2 (ja) Ｃ−ｍｅｔの阻害剤として有用なアミドフェノキシインダゾール
CN112300196A (zh) 一类哌啶稠环类化合物、制备方法和用途
CN116354988A (zh) 四环类化合物及其医药用途
BR112018014536B1 (pt) Derivados de amônio, processo para sua preparação, composição farmacêutica contendo os mesmos, combinação e seu uso
CN111961034A (zh) 用作ret激酶抑制剂的化合物及其应用
CN114072404B (zh) Ret选择性抑制剂及其制备方法和用途
CN110799505B (zh) 用于治疗癌症、视网膜病症和心肌病的三取代嘧啶化合物和组合物
CN114685487A (zh) 一类嘧啶并杂环类化合物、制备方法和用途
CN115340559A (zh) Shp2磷酸酶杂环类抑制剂的制备及其应用
WO2022253152A1 (zh) 7-硝基-8-羟基喹啉衍生物、其制备方法及其医药用途
CN110950867A (zh) 一种fgfr4激酶抑制剂及其制备方法和用途
WO2022213980A1 (zh) Tyk2抑制剂及其用途
CN120530110A (zh) 杂环化合物、药物组合物及其应用
CN113412112B (zh) 作为c-MET抑制剂的有机磷取代化合物及其治疗用途
CN118632843A (zh) 一种吡啶类衍生物及其用途
WO2024245331A1 (zh) 三并环类化合物、其制备方法和应用
WO2023011446A1 (zh) 一种新型磺酰胺类menin-MLL相互作用抑制剂、其制备方法及医药用途
JP2024510306A (ja) Ｃｔｌａ－４低分子分解剤及びその使用
CN115340561A (zh) Shp2磷酸酶稠环类抑制剂的制备及其应用
CN114728980A (zh) 吡唑类化合物
CN113735844B (zh) 2-甲酰基喹啉羧酰胺类化合物及其医药用途

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant