CN113384701A - 使用内皮素-b受体激动剂治疗神经精神病症的组合物和方法 - Google Patents

使用内皮素-b受体激动剂治疗神经精神病症的组合物和方法 Download PDF

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CN113384701A
CN113384701A CN202110467579.2A CN202110467579A CN113384701A CN 113384701 A CN113384701 A CN 113384701A CN 202110467579 A CN202110467579 A CN 202110467579A CN 113384701 A CN113384701 A CN 113384701A
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brain
endothelin
receptor
irl
receptor agonist
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A·古拉尼
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Midwestern University Glendale
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Midwestern University Glendale
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2285Endothelin, vasoactive intestinal contractor [VIC]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN202110467579.2A 2013-07-08 2014-07-08 使用内皮素-b受体激动剂治疗神经精神病症的组合物和方法 Pending CN113384701A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361843702P 2013-07-08 2013-07-08
US61/843702 2013-07-08
US201361902935P 2013-11-12 2013-11-12
US61/902935 2013-11-12
CN201480049491.7A CN105682741A (zh) 2013-07-08 2014-07-08 使用内皮素-b受体激动剂治疗神经精神病症的组合物和方法

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CN201480049491.7A Division CN105682741A (zh) 2013-07-08 2014-07-08 使用内皮素-b受体激动剂治疗神经精神病症的组合物和方法

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CN113384701A true CN113384701A (zh) 2021-09-14

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CN202110467579.2A Pending CN113384701A (zh) 2013-07-08 2014-07-08 使用内皮素-b受体激动剂治疗神经精神病症的组合物和方法
CN201480049491.7A Pending CN105682741A (zh) 2013-07-08 2014-07-08 使用内皮素-b受体激动剂治疗神经精神病症的组合物和方法

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US (2) US10561704B2 (https=)
EP (1) EP3019242B1 (https=)
JP (2) JP6928450B2 (https=)
CN (2) CN113384701A (https=)
AU (1) AU2014287427B2 (https=)
BR (1) BR112016000431A8 (https=)
CA (2) CA2917325C (https=)
ES (1) ES2825101T3 (https=)
PL (1) PL3019242T3 (https=)
WO (1) WO2015006324A2 (https=)

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AU2010241564B2 (en) 2009-04-30 2014-07-31 Midwestern University Novel therapeutic treatments using centhaquin
BR112020022395A2 (pt) * 2018-05-03 2021-04-13 Midwestern University Alterações em receptores de endotelina em seguida a hemorragia e ressuscitação por centaquina
US20240207356A1 (en) * 2022-12-26 2024-06-27 Pharmazz, Inc. Composition and method for wound healing and repair of damaged nerves
KR20260005957A (ko) * 2023-04-26 2026-01-12 바이오셀즈(베이징) 바이오테크 코., 엘티디. 폴리펩티드 및 이의 응용
US20250000934A1 (en) 2023-06-28 2025-01-02 Pharmazz, Inc. Lyophilized sovateltide-based injectable formulation and method for preparation thereof

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WO2002043654A2 (en) * 2000-12-01 2002-06-06 Milos Pekny Pharmaceutical composition and method for treatment of brain injury, spinal cord injury, stroke, neurodegenerative disease and other conditions
CN101888851A (zh) * 2007-08-21 2010-11-17 美国中西部大学 使用内皮缩血管肽b受体激动剂治疗中风或脑血管意外的组合物

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AU2014287427B2 (en) 2019-11-21
US10561704B2 (en) 2020-02-18
US20160151450A1 (en) 2016-06-02
WO2015006324A2 (en) 2015-01-15
ES2825101T3 (es) 2021-05-14
PL3019242T3 (pl) 2021-02-08
JP2016523969A (ja) 2016-08-12
JP7385924B2 (ja) 2023-11-24
CA3171883C (en) 2024-03-05
BR112016000431A8 (pt) 2018-01-23
CA3171883A1 (en) 2015-01-15
EP3019242A4 (en) 2017-01-25
JP6928450B2 (ja) 2021-09-01
AU2014287427A1 (en) 2016-02-11
JP2021020945A (ja) 2021-02-18
CA2917325C (en) 2023-09-05
EP3019242B1 (en) 2020-08-19
CN105682741A (zh) 2016-06-15
EP3019242A2 (en) 2016-05-18
US20200353031A1 (en) 2020-11-12
CA2917325A1 (en) 2015-01-15
WO2015006324A3 (en) 2015-11-05
WO2015006324A8 (en) 2016-01-28

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