CN113383954A - 一种具有增强免疫、活血养颜作用的组合物及其应用 - Google Patents
一种具有增强免疫、活血养颜作用的组合物及其应用 Download PDFInfo
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Abstract
本发明涉及一种具有增强免疫、活血养颜作用的组合物，按重量份数计，包括：人参提取物1‑20份；红枣提取物50‑150份；龙眼肉提取物20‑80份；枸杞子提取物1‑20份；陈皮提取物0.1‑5份；金银花提取物5‑20份；玫瑰花提取物2‑20份；桂花提取物5‑20份；甘草提取物0.1‑5份。本发明还涉及一种包括如上所述组合物的食品。本发明的组合物中，人参大补元气、生津养血，红枣益气养血，龙眼肉补心养血，枸杞子益精补肾，陈皮理气健脾，金银花清热解毒，玫瑰花行气和血，桂花疏肝理气，甘草调和诸药，从而调节五脏，扶正固本，平衡气血阴阳，共奏益气补心、活血养颜之功效，进而舒缓情志，提高机体免疫力，悦泽人面。
Description
技术领域
本发明涉及功能食品领域，尤其涉及一种具有增强免疫、活血养颜作用的组合物及其应用。
背景技术
气血是构成人体和维持人体生命活动的最基本物质。气为血之帅，气血相互依存，气行则血行，气滞则血瘀，瘀久则耗气伤阴，经络不通，气血不能上荣于面。在中医方面，中药内服、食疗，调整脏腑功能，使气血旺盛，不仅从根本上解决损美问题，更能改善机体亚健康状态，在一定程度上做到了防治未病，促成真正意义上的具有生命活力的美感，突显出中医学基础理论指导之下的整体养颜优势。
专利CN 106110130 A公开了一种以人参、当归、黄芪、黄柏、麻黄、鸡内金、地龙、苦参、刺五加、鱼腥草、决明子、远志、龟甲、地枫皮、百部组成的益气养血口服液，具有促进气血阴阳平衡，共奏益气养血之功效，体内阴阳达到平衡，提高患者的免疫功能，改善患者的临床症状，恢复身体健康。该专利中选用的黄柏、麻黄、地龙、苦参、地枫皮、百部原料按照卫生部规定，不可用于普通食品和保健食品中，有较大的安全隐患。
专利CN 110651932 A公开了一种以人参、白术、白茯苓、当归、川芎、白芍药、熟地黄、炙甘草组成的补气养血饮料，通过文火熬制原料，用胶体磨细磨后，得到原料药浆料，再将其用水稀释后加入黄原胶，超声处理，均质，加入甜味剂调味后，得到补气养颜饮料。具有益气补血，美容养颜效果。该专利制得的饮料为原料药浆产品，存在功效成分不富集的缺点，每日饮用量500mL，存在饮用量大、不方便的缺点。
本发明旨在基于中医理论，选用药食同源草本原料，合理配伍，开发天然，安全，可口的，具有增强免疫、活血养颜的功能食品。
发明内容
本发明的目的是针对现有技术中的不足，提供一种具有增强免疫、活血养颜作用的组合物及其应用。
为实现上述目的，本发明采取的技术方案是：
本发明的第一方面提供一种具有增强免疫、活血养颜作用的组合物，按重量份数计，包括：
优选地，按重量份数计，包括：
优选地，所述人参提取物由5年或5年以下人工种植的人参经水提取后冷冻干燥而制得的。
优选地，所述红枣提取物、所述龙眼肉提取物、所述枸杞子提取物、所述陈皮提取物、所述金银花提取物、所述玫瑰花提取物、所述桂花提取物或所述甘草提取物的制备步骤包括：
S1、将原料粉碎后，按重量份数计，加入10-15倍的水，并于85℃-100℃加热，提取60-90分钟，过滤，取滤液；
S2、按重量份数计，向滤饼中加入10-15倍的水，并于80℃-100℃加热，再次提取60-90分钟，过滤，取滤液；
S3、合并两次滤液并浓缩，喷雾干燥或冷冻干燥后即得。
本发明的第二方面是提供一种包括如上所述组合物的食品。
优选地，所述食品的形式包括：饮料、冲剂或糖果中的至少一种。
优选地，所述食品还包括：食品配料、食品添加剂、浓缩果汁、果粉中的一种或多种。
本发明采用以上技术方案，与现有技术相比，具有如下技术效果：
本发明的组合物具有协同增效作用，可发挥增强免疫和活血养颜的功效；其中，人参大补元气、生津养血，为君药；红枣益气养血，龙眼肉补心养血，二者有助于加强本方通畅气血经脉作用，共为臣药；枸杞子益精补肾，陈皮理气健脾，金银花清热解毒，三者有助于增强本方益精、排毒作用，共为佐药；玫瑰花行气和血，桂花疏肝理气，甘草调和诸药，三者有助于本方益气和中，协调平衡，共为使药，从而组合物调节五脏，扶正固本，平衡气血阴阳，共奏益气补心、活血养颜之功效，进而舒缓情志，提高机体免疫力，悦泽人面。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动的前提下所获得的所有其他实施例，都属于本发明保护的范围。
需要说明的是，在不冲突的情况下，本发明中的实施例及实施例中的特征可以相互组合。
下面结合具体实施例对本发明作进一步说明，但不作为本发明的限定。
实施例1
本实施例提供一种具有增强免疫、活血养颜作用的组合物，包括：
将上述提取物混合后，用水定容至30mL；
其中，人参冻干粉的总皂苷含量为7.02％，批号200601；
红枣速溶粉，批号201113；
龙眼肉速溶粉，批号201013；
枸杞子速溶粉，批号200323；
陈皮冻干粉，批号190408；
金银花速溶粉，批号200103；
玫瑰花冻干粉，批号200507；
桂花速溶粉的多酚含量为18.45％，毛蕊花糖苷含量为13.20％，批号200216；
甘草速溶粉，批号191216。
实施例2
本实施例提供一种具有增强免疫、活血养颜作用的组合物，与实施例1的区别在于：
实施例3
本实施例提供一种具有增强免疫、活血养颜作用的组合物，与实施例1的区别在于：
对比例1
本对比例提供一种具有增强免疫、活血养颜作用的组合物，与实施例1的区别在于：
对比例2
本对比例提供一种具有增强免疫、活血养颜作用的组合物，与实施例1的区别在于：
检测实施例
通过成年女性志愿者在正常情况下连续食用2周上述组合物，以评估对身体免疫力和面部皮肤的改善效果；
各试验组受试者每日口服受试物，每组30位成年健康女性，一日1次，一次30mL，连续14日，受试前后志愿者进行自我评估测试问卷，结果如下：
表1受试者免疫力相关状态评估结果(总体有效率，％)
| 组别 | 缓解疲劳 | 缓解畏寒肢冷 | 减少感冒 | 减少口腔溃疡 |
| 实施例1 | 76.77％ | 70.00％ | 53.33％ | 53.33％ |
| 实施例2 | 70.00％ | 63.33％ | 43.33％ | 36.67％ |
| 实施例3 | 73.33％ | 66.67％ | 46.67％ | 36.67％ |
| 对比例1 | 56.67％ | 50.00％ | 33.33％ | 26.67％ |
| 对比例2 | 16.67％ | 16.67％ | 13.33％ | 13.33％ |
| 协同系数q | 1.20 | 1.20 | 1.26 | 1.46 |
注：评价方法为受试者主观评价，以10分制对指标进行评判，分值越大，感觉越强烈；“有效果”定义为降低值区间：[-10,0)；“无作用”定义为降低值区间：[0,10]。
协同系数q按照金氏公式计算：q＝E(A+B)÷(EA+EB-EA×EB)；其中，EA与EB分别为A和B单独使用时的效果，E(A+B)为两者合用时的效果；此处，A为对比例1，B为对比例2，A+B即为实施例1。q<0.55为明显拮抗；0.55≤q<0.85为拮抗；0.85≤q<1.15为单纯相加；1.15≤q<20为增强；q>20为明显增强。
可见，实施例1对缓解疲劳的总体有效率为76.77％，且总体有效率高于对比例1和对比例2，协同系数为1.20(增强)，提示组合物具有协同增效作用；实施例1对缓解畏寒肢冷的总体有效率为70.00％，且总体有效率高于对比例1和对比例2，协同系数为1.20(增强)，提示组合物具有协同增效作用；实施例1对减少感冒的总体有效率为53.33％，且总体有效率高于对比例1和对比例2，协同系数为1.26(增强)，提示组合物具有协同增效作用；实施例1对减少口腔溃疡的总体有效率为53.33％，且总体有效率高于对比例1和对比例2，协同系数为1.46(增强)，提示组合物具有协同增效作用；实施例1对缓解疲劳、缓解畏寒肢冷、减少感冒和减少口腔溃疡的总体有效率均高于实施例2和实施例3。
表2受试者面部皮肤相关状态评估结果(总体有效率，％)
| 组别 | 提亮肤色 | 红润肤色 | 光滑细腻 | 均一肤色 | 提升弹性 | 美白皮肤 |
| 实施例1 | 83.33％ | 73.33％ | 83.33％ | 76.67％ | 73.33％ | 73.33％ |
| 实施例2 | 76.67％ | 66.67％ | 66.67％ | 63.33％ | 60.00％ | 66.67％ |
| 实施例3 | 80.00％ | 70.00％ | 66.67％ | 66.67％ | 63.33％ | 70.00％ |
| 对比例1 | 43.33％ | 40.00％ | 43.33％ | 36.67％ | 33.33％ | 30.00％ |
| 对比例2 | 43.33％ | 36.67％ | 33.33％ | 33.33％ | 30.00％ | 46.67％ |
| 协同系数q | 1.23 | 1.18 | 1.34 | 1.33 | 1.38 | 1.17 |
注：评价方法为受试者主观评价，以10分制对指标进行评判，分值越大，皮肤状况越好；“有效果”定义为增加值区间：(0,10]；“无作用”定义为增加值区间：[-10,0]。
协同系数q按照金氏公式计算：q＝E(A+B)÷(EA+EB-EA×EB)；其中，EA与EB分别为A和B单独使用时的效果；E(A+B)为两者合用时的效果；此处，A为对比例1，B为对比例2，A+B即为实施例1。q<0.55为明显拮抗；0.55≤q<0.85为拮抗；0.85≤q<1.15为单纯相加；1.15≤q<20为增强；q>20为明显增强。
可见，实施例1对提亮面部肤色的总体有效率为83.33％，且总体有效率高于对比例1和对比例2，协同系数为1.23(增强)，提示组合物具有协同增效作用；实施例1对红润面部脸色的总体有效率为73.33％，且总体有效率高于对比例1和对比例2，协同系数为1.18(增强)，提示组合物具有协同增效作用；实施例1对光滑细腻面部皮肤的总体有效率为83.33％，且总体有效率高于对比例1和对比例2，协同系数为1.34(增强)，提示组合物具有协同增效作用；实施例1对均一面部肤色的总体有效率为76.67％，且总体有效率高于对比例1和对比例2，协同系数为1.33(增强)，提示组合物具有协同增效作用；实施例1对提升面部皮肤弹性的总体有效率为73.33％，且总体有效率高于对比例1和对比例2，协同系数为1.38(增强)，提示组合物具有协同增效作用；实施例1对美白面部皮肤的总体有效率为73.33％，且总体有效率高于对比例1和对比例2，协同系数为1.17(增强)，提示组合物具有协同增效作用；实施例1对提亮面部肤色、红润面部脸色、光滑细腻面部皮肤、均一面部肤色、提升面部皮肤弹性和美白面部皮肤的总体有效率均高于实施例2和实施例3。
表3受试者其他身体状态评估结果(总体有效率，％)
| 组别 | 改善睡眠 | 改善情绪 | 增强食欲 | 增强记忆 |
| 实施例1 | 70.00％ | 73.33％ | 56.67％ | 66.67％ |
| 实施例2 | 60.00％ | 63.33％ | 43.33％ | 50.00％ |
| 实施例3 | 66.67％ | 66.67％ | 46.67％ | 53.33％ |
| 对比例1 | 50.00％ | 53.33％ | 26.67％ | 33.33％ |
| 对比例2 | 16.67％ | 20.00％ | 10.00％ | 13.33％ |
| 协同系数q | 1.20 | 1.17 | 1.67 | 1.58 |
注：评价方法为受试者主观评价，以10分制对指标进行评判，分值越大，感觉越强烈；“有效果”定义为降低值区间：[-10,0)；“无作用”定义为降低值区间：[0,10]。
协同系数q按照金氏公式计算：q＝E(A+B)÷(EA+EB-EA×EB)；其中，EA与EB分别为A和B单独使用时的效果，E(A+B)为两者合用时的效果；此处，A为对比例1，B为对比例2，A+B即为实施例1。q<0.55为明显拮抗；0.55≤q<0.85为拮抗；0.85≤q<1.15为单纯相加；1.15≤q<20为增强；q>20为明显增强。
可见，实施例1对改善睡眠的总体有效率为70.00％，且总体有效率高于对比例1和对比例2，协同系数为1.20(增强)，提示组合物具有协同增效作用；实施例1对改善情绪的总体有效率为73.33％，且总体有效率高于对比例1和对比例2，协同系数为1.17(增强)，提示组合物具有协同增效作用；实施例1对增强食欲的总体有效率为56.67％，且总体有效率高于对比例1和对比例2，协同系数为1.67(增强)，提示组合物具有协同增效作用；实施例1对增强记忆的总体有效率为66.67％，且总体有效率高于对比例1和对比例2，协同系数为1.58(增强)，提示组合物具有协同增效作用；实施例1对改善睡眠、改善情绪、增强食欲和增强记忆的总体有效率均高于实施例2和实施例3。
综上所述，本发明的组合物具有协同增效作用，可发挥增强免疫和活血养颜的功效；其中，人参大补元气、生津养血，为君药；红枣益气养血，龙眼肉补心养血，二者有助于加强本方通畅气血经脉作用，共为臣药；枸杞子益精补肾，陈皮理气健脾，金银花清热解毒，三者有助于增强本方益精、排毒作用，共为佐药；玫瑰花行气和血，桂花疏肝理气，甘草调和诸药，三者有助于本方益气和中，协调平衡，共为使药，从而组合物调节五脏，扶正固本，平衡气血阴阳，共奏益气补心、活血养颜之功效，进而舒缓情志，提高机体免疫力，悦泽人面。
以上所述仅为本发明较佳的实施例，并非因此限制本发明的实施方式及保护范围，对于本领域技术人员而言，应当能够意识到凡运用本发明说明书内容所作出的等同替换和显而易见的变化所得到的方案，均应当包含在本发明的保护范围内。
Claims (7)
1.一种具有增强免疫、活血养颜作用的组合物，其特征在于，按重量份数计，包括：
2.根据权利要求1所述的组合物，其特征在于，按重量份数计，包括：
3.根据权利要求1所述的组合物，其特征在于，所述人参提取物由5年或5年以下人工种植的人参经水提取后冷冻干燥而制得的。
4.根据权利要求1所述的组合物，其特征在于，所述红枣提取物、所述龙眼肉提取物、所述枸杞子提取物、所述陈皮提取物、所述金银花提取物、所述玫瑰花提取物、所述桂花提取物或所述甘草提取物的制备步骤包括：
S1、将原料粉碎后，按重量份数计，加入10-15倍的水，并于85℃-100℃加热，提取60-90分钟，过滤，取滤液；
S2、按重量份数计，向滤饼中加入10-15倍的水，并于80℃-100℃加热，再次提取60-90分钟，过滤，取滤液；
S3、合并两次滤液并浓缩，喷雾干燥或冷冻干燥后即得。
5.一种包括如权利要求1-4任一项所述组合物的食品。
6.根据权利要求5所述的食品，其特征在于，所述食品的形式包括：饮料、冲剂或糖果中的至少一种。
7.根据权利要求5所述的食品，其特征在于，所述食品还包括：食品配料、食品添加剂、浓缩果汁、果粉中的一种或多种。
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