CN113365979A - 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途 - Google Patents

含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途 Download PDF

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Publication number
CN113365979A
CN113365979A CN201980090023.7A CN201980090023A CN113365979A CN 113365979 A CN113365979 A CN 113365979A CN 201980090023 A CN201980090023 A CN 201980090023A CN 113365979 A CN113365979 A CN 113365979A
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formula
compound
pharmaceutical composition
capsid protein
pharmaceutically acceptable
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CN201980090023.7A
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CN113365979B (zh
Inventor
张寅生
敖汪伟
李元
王辉
沈杭州
倪杰
张欢
吴杰
张立
曹凯
陆鹏
刘戌时
汪杰
赵天笑
葛兴枫
卢丹丹
陈硕
马雪琴
施伟
王晓金
徐宏江
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

式I或者式II所示的化合物、其立体异构体、互变异构体、几何异构体、溶剂化物、活性代谢物、水合物、前药或药学上可接受的盐、其药物组合物及医药用途，包括用于治疗受益于衣壳蛋白装配抑制的疾病的用途，尤其是乙型肝炎病毒感染引起的疾病。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201980090023.7A 2019-01-25 2019-09-27 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途 Active CN113365979B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019100734652 2019-01-25
CN201910073465 2019-01-25
PCT/CN2019/108483 WO2020151252A1 (zh) 2019-01-25 2019-09-27 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途

Publications (2)

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CN113365979A true CN113365979A (zh) 2021-09-07
CN113365979B CN113365979B (zh) 2023-09-22

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Country Status (10)

Country Link
US (1) US20220185774A1 (zh)
EP (1) EP3915972A4 (zh)
JP (1) JP2022518258A (zh)
KR (1) KR20210119452A (zh)
CN (1) CN113365979B (zh)
AU (1) AU2019424375B2 (zh)
CA (1) CA3127393A1 (zh)
EA (1) EA202092159A1 (zh)
SG (1) SG11202107774QA (zh)
WO (1) WO2020151252A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111868026B (zh) 2018-03-30 2022-11-25 正大天晴药业集团股份有限公司 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途
AU2019272481B2 (en) 2018-05-25 2024-03-21 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 2,3-dihydro-1H-pyrrolizine-7-formamide derivative and application thereof
WO2021058001A1 (zh) * 2019-09-29 2021-04-01 正大天晴药业集团股份有限公司 N杂五元环化合物的晶型及其应用
US20230212117A2 (en) * 2019-09-29 2023-07-06 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Crystalline form of capsid protein assembly inhibitor containing n hetero five-membered ring, and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105431413A (zh) * 2013-07-25 2016-03-23 爱尔兰詹森科学公司 经乙醛酰胺取代的吡咯酰胺衍生物及其作为药物用于治疗乙型肝炎的用途
CN105658624A (zh) * 2013-10-23 2016-06-08 爱尔兰詹森科学公司 甲酰胺衍生物及其作为药物用于治疗乙型肝炎的用途
WO2018039531A1 (en) * 2016-08-26 2018-03-01 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
WO2018050110A1 (zh) * 2016-09-18 2018-03-22 正大天晴药业集团股份有限公司 新型衣壳蛋白装配抑制剂
CN109153640A (zh) * 2016-03-09 2019-01-04 埃默里大学 用抗病毒剂消除乙型肝炎病毒
CN111868026A (zh) * 2018-03-30 2020-10-30 正大天晴药业集团股份有限公司 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
EP3759109B1 (en) * 2018-02-26 2023-08-30 Gilead Sciences, Inc. Substituted pyrrolizine compounds as hbv replication inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105431413A (zh) * 2013-07-25 2016-03-23 爱尔兰詹森科学公司 经乙醛酰胺取代的吡咯酰胺衍生物及其作为药物用于治疗乙型肝炎的用途
CN105658624A (zh) * 2013-10-23 2016-06-08 爱尔兰詹森科学公司 甲酰胺衍生物及其作为药物用于治疗乙型肝炎的用途
CN109153640A (zh) * 2016-03-09 2019-01-04 埃默里大学 用抗病毒剂消除乙型肝炎病毒
WO2018039531A1 (en) * 2016-08-26 2018-03-01 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
WO2018050110A1 (zh) * 2016-09-18 2018-03-22 正大天晴药业集团股份有限公司 新型衣壳蛋白装配抑制剂
CN111868026A (zh) * 2018-03-30 2020-10-30 正大天晴药业集团股份有限公司 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途

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Publication number Publication date
AU2019424375A1 (en) 2021-09-02
CA3127393A1 (en) 2020-07-30
SG11202107774QA (en) 2021-08-30
EA202092159A1 (ru) 2020-12-15
AU2019424375B2 (en) 2023-07-13
KR20210119452A (ko) 2021-10-05
JP2022518258A (ja) 2022-03-14
EP3915972A4 (en) 2022-12-21
EP3915972A1 (en) 2021-12-01
WO2020151252A1 (zh) 2020-07-30
US20220185774A1 (en) 2022-06-16
CN113365979B (zh) 2023-09-22

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