SG11202107774QA - N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition and uses thereof - Google Patents

N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition and uses thereof

Info

Publication number
SG11202107774QA
SG11202107774QA SG11202107774QA SG11202107774QA SG11202107774QA SG 11202107774Q A SG11202107774Q A SG 11202107774QA SG 11202107774Q A SG11202107774Q A SG 11202107774QA SG 11202107774Q A SG11202107774Q A SG 11202107774QA SG 11202107774Q A SG11202107774Q A SG 11202107774QA
Authority
SG
Singapore
Prior art keywords
heterocyclic
pharmaceutical composition
membered ring
capsid protein
protein assembly
Prior art date
Application number
SG11202107774QA
Inventor
Yinsheng Zhang
Wangwei Ao
Yuan Li
Hui Wang
hangzhou Shen
Jie Ni
Huan Zhang
Jie Wu
Li Zhang
Kai Cao
Peng Lu
Xushi Liu
Jie Wang
Tianxiao Zhao
Xingfeng Ge
Dandan Lu
Shuo Chen
Xueqin Ma
Wei Shi
Xiaojin Wang
Hongjiang Xu
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Publication of SG11202107774QA publication Critical patent/SG11202107774QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
SG11202107774QA 2019-01-25 2019-09-27 N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition and uses thereof SG11202107774QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910073465 2019-01-25
PCT/CN2019/108483 WO2020151252A1 (en) 2019-01-25 2019-09-27 N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition and uses thereof

Publications (1)

Publication Number Publication Date
SG11202107774QA true SG11202107774QA (en) 2021-08-30

Family

ID=71735881

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202107774QA SG11202107774QA (en) 2019-01-25 2019-09-27 N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition and uses thereof

Country Status (10)

Country Link
US (1) US20220185774A1 (en)
EP (1) EP3915972A4 (en)
JP (1) JP7479384B2 (en)
KR (1) KR20210119452A (en)
CN (1) CN113365979B (en)
AU (1) AU2019424375B2 (en)
CA (1) CA3127393A1 (en)
EA (1) EA202092159A1 (en)
SG (1) SG11202107774QA (en)
WO (1) WO2020151252A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115974753A (en) 2018-03-30 2023-04-18 正大天晴药业集团股份有限公司 N-containing heterocyclic five-membered ring compound and application
CN113549079A (en) 2018-05-25 2021-10-26 正大天晴药业集团股份有限公司 2, 3-dihydro-1H-pyrrolizine-7-formamide derivatives and application thereof
AU2020355384A1 (en) * 2019-09-29 2022-05-05 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Crystalline form of capsid protein assembly inhibitor containing N hetero five-membered ring, and application thereof
WO2021058001A1 (en) * 2019-09-29 2021-04-01 正大天晴药业集团股份有限公司 Crystal form of five-membered n heterocyclic compound, and application thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3603B1 (en) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
LT3024819T (en) 2013-07-25 2018-06-11 Janssen Sciences Ireland Uc Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
JP6452119B2 (en) * 2013-10-23 2019-01-16 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Carboxamide derivatives and their use as pharmaceuticals for the treatment of hepatitis B
EA201892034A1 (en) 2016-03-09 2019-04-30 Эмори Юниверсити ELIMINATION OF HEPATITIS B VIRUS WITH THE HELP OF ANTI-VIRUS AGENTS
JOP20190024A1 (en) * 2016-08-26 2019-02-19 Gilead Sciences Inc Substituted pyrrolizine compounds and uses thereof
CN113429341A (en) * 2016-09-18 2021-09-24 正大天晴药业集团股份有限公司 Novel capsid protein assembly inhibitors
CN111788204B (en) * 2018-02-26 2023-05-05 吉利德科学公司 Substituted pyrrolizine compounds as inhibitors of HBV replication
CN115974753A (en) * 2018-03-30 2023-04-18 正大天晴药业集团股份有限公司 N-containing heterocyclic five-membered ring compound and application

Also Published As

Publication number Publication date
US20220185774A1 (en) 2022-06-16
EP3915972A4 (en) 2022-12-21
KR20210119452A (en) 2021-10-05
AU2019424375A1 (en) 2021-09-02
JP7479384B2 (en) 2024-05-08
JP2022518258A (en) 2022-03-14
CA3127393A1 (en) 2020-07-30
WO2020151252A1 (en) 2020-07-30
EA202092159A1 (en) 2020-12-15
AU2019424375B2 (en) 2023-07-13
CN113365979B (en) 2023-09-22
CN113365979A (en) 2021-09-07
EP3915972A1 (en) 2021-12-01

Similar Documents

Publication Publication Date Title
SG11202009150RA (en) N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition thereof, and use thereof
SG11202107774QA (en) N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition and uses thereof
EP3835296A4 (en) Ketoamide compound and preparation method, pharmaceutical composition, and use thereof
EP3741374A4 (en) Mtor inhibitor, pharmaceutical composition and use thereof
EP3412669A4 (en) Tricyclic compound for bromodomain-containing protein inhibitor and preparation, pharmaceutical composition, and application thereof
EP3805264A4 (en) Anti-interleukin-17a antibody, pharmaceutical composition thereof and use thereof
EP3753943A4 (en) Heterocyclic compound, application thereof and pharmaceutical composition comprising same
EP3719017A4 (en) Compound functioning as bromodomain protein inhibitor, and composition
EP3782998A4 (en) Substituted pyrrolotriazine compound, pharmaceutical composition thereof and use thereof
EP3805234A4 (en) Aromatic heterocyclic compound, and pharmaceutical composition and use thereof
EP3880671A4 (en) Novel compound as protein kinase inhibitor, and pharmaceutical composition comprising thereof
EP3964512A4 (en) CASEIN KINASE 1epsilon INHIBITOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
EP4023227A4 (en) Pharmaceutical composition and application thereof
GB201911517D0 (en) Pharmaceutical composition
EP3868371A4 (en) Novel pharmaceutical composition
EP3697411A4 (en) Novel pharmaceutical composition and use thereof
EP3849992A4 (en) Cd73 inhibitors and pharmaceutical uses thereof
EP3770148A4 (en) Receptor inhibitor, pharmaceutical composition comprising same, and use thereof
EP3942968A4 (en) Detachable five-star leg
EP3777866A4 (en) Pharmaceutical composition and application thereof
GB2590189B (en) Lycorine derivative, and pharmaceutical composition and use thereof
DK3399040T3 (en) PROCEDURE FOR THE PREPARATION OF PORCINE CIRCOVIRUS TYPE 2 CAPSID PROTEIN AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME
IL276783A (en) Novel compound and pharmaceutical composition compirisng same
EP3950677A4 (en) Quinolyl-containing compound and pharmaceutical composition, and use thereof
EP3817744A4 (en) Ivosidenib forms and pharmaceutical compositions