CN113358652A - Universal small-sized mobile phone shooting and analyzing device for detecting lateral flow test paper - Google Patents

Universal small-sized mobile phone shooting and analyzing device for detecting lateral flow test paper Download PDF

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Publication number
CN113358652A
CN113358652A CN202110628048.7A CN202110628048A CN113358652A CN 113358652 A CN113358652 A CN 113358652A CN 202110628048 A CN202110628048 A CN 202110628048A CN 113358652 A CN113358652 A CN 113358652A
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flow test
mobile phone
lateral flow
test paper
camera
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Chinese (zh)
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刘智
姚林熠
刘培
刘伟
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Wuhan Yiban Technology Co ltd
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Wuhan Yiban Technology Co ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84Systems specially adapted for particular applications
    • G01N21/8483Investigating reagent band
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04MTELEPHONIC COMMUNICATION
    • H04M1/00Substation equipment, e.g. for use by subscribers
    • H04M1/72Mobile telephones; Cordless telephones, i.e. devices for establishing wireless links to base stations without route selection
    • H04M1/724User interfaces specially adapted for cordless or mobile telephones
    • H04M1/72403User interfaces specially adapted for cordless or mobile telephones with means for local support of applications that increase the functionality
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04NPICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/70Circuitry for compensating brightness variation in the scene
    • H04N23/74Circuitry for compensating brightness variation in the scene by influencing the scene brightness using illuminating means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/02Mechanical
    • G01N2201/022Casings
    • G01N2201/0221Portable; cableless; compact; hand-held

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Signal Processing (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Multimedia (AREA)
  • Human Computer Interaction (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention discloses a universal small mobile phone shooting and analyzing device for detecting lateral flow test paper, which comprises a smart mobile phone, a lateral flow test paper analyzer, a power supply device, a 45-degree inclined mirror surface, an LED lamp source and a mobile phone shooting device base, wherein a telescopic clamping groove below the mobile phone shooting device base can be used for fixing the smart mobile phone; a movable shading box is arranged above a base of the mobile phone shooting device, the position of the movable shading box and a camera of the smart phone can be adjusted through a sliding groove, and a clamping groove of a lateral flow test paper analyzer is arranged on a box body of the movable shading box and can be used for fixing the lateral flow test paper analyzer; a45-degree inclined mirror surface is arranged in the movable shading box. Picture signal reads analysis program software in writing into in ordinary smart mobile phone, can accomplish the quantitative analysis of sidestream test paper and detect through this application, and the technical feature and the advantage that this device has are applicable to very much and popularize and apply on a large scale.

Description

Universal small-sized mobile phone shooting and analyzing device for detecting lateral flow test paper
Technical Field
The invention relates to the technical field of real-time quantitative instant detection of biological test paper, in particular to a universal small-sized mobile phone shooting and analyzing device for detecting lateral flow test paper.
Background
The lateral flow test paper detection technology such as early pregnancy test paper, nucleic acid test paper, blood glucose test paper and other detection devices greatly simplifies the traditional detection procedures such as Polymerase Chain Reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) (patents US201662425839P, ZL 201810413748.2). Moreover, the detection technology adopts paper as a main preparation material, and has a series of advantages of simple production, convenient use, low price, environmental protection and the like (ZL 201810591801.8). The traditional lateral flow test paper detection technology mainly judges and indicates the content of a target object in a sample to be detected by using indicator particles such as chromogenic particles (such as nano gold, carbon nano rods, magnetic nano particles and the like), and can directly observe a detection result by naked eyes. But quantitative analysis and poor accuracy in identifying relatively weak signals are difficult to achieve by direct visual observation.
In order to realize quantitative analysis of real-time detection, researchers have utilized physical properties (light, heat, and magnetism) of different color-developing particles, respectively shoot optical signals of nanogold and carbon nanoparticles with a camera, record and analyze thermal signals of nanogold with a thermal imager, and obtain magnetic signals of magnetic nanoparticles with a magnetic signal reader (patent US201715802120), and then obtain the relationship between the concentration of a target and a detection signal, and perform quantitative analysis. However, these methods still suffer from the disadvantages of large background noise, small scanning range, long distance, need of expensive and large-scale detection instruments, and professional technical personnel, and are not suitable for applications in remote areas with shortage of medical resources.
With the rapid development of smart phone technology in recent years, many mobile phones have integrated a high-definition photographing function, have a high-performance processor, and can perform analysis processing of image software. Therefore, by combining with the smart phone technology, the lateral flow test paper detection can realize portable, real-time and intelligent optical quantitative detection and analysis (CN2017101961584, CN 2018113041934). Therefore, the mobile phone photographing-based detection and analysis method does not need expensive auxiliary equipment, and is expected to be widely applied to paper-based biological information detection in remote areas, resource-deficient areas and the like. However, the existing additional shooting device for the smart phone is often designed with a supporting shell aiming at a specific mobile phone, so that the mobile phones with different sizes, cameras, positions and numbers are difficult to match, and the shooting and analysis of the optical signals of the lateral flow test paper are not facilitated due to the different light intensities of the flash lamps (CN 201710218782X). Therefore, a universal small mobile phone photographing device for detecting the lateral flow test paper is needed to be developed.
The above information disclosed in this background section is only for enhancement of understanding of the background of the invention and therefore it may contain information that does not form the prior art that is already known in this country to a person of ordinary skill in the art.
Disclosure of Invention
In order to solve the defects of the prior art, the invention provides a universal small mobile phone shooting and analyzing device for detecting the lateral flow test paper.
The principle and technical solution of the present invention will be explained below.
The universal small mobile phone shooting and analyzing device for detecting the lateral flow test paper comprises a smart phone, a lateral flow test paper analyzer, a power supply device, a 45-degree inclined mirror surface, an LED lamp source and a mobile phone shooting device base, wherein a telescopic clamping groove below the mobile phone shooting device base can fix the smart phone and adjust the relative position of a camera;
the mobile phone shooting device is characterized in that a movable shading box is arranged above a base, and the position of the mobile shading box and a smart phone camera can be adjusted through a sliding groove
A clamping groove of a lateral flow test paper analyzer is arranged on a box body of the movable shading box, and the clamping groove can fix the lateral flow test paper analyzer and adjust the relative position of a detection area;
a 45-degree inclined mirror surface is arranged in the movable shading box, and signals in the lateral flow test paper detection area can be reflected to the position of the camera for shooting, so that the shooting distance can be ensured, and the volume of the shooting device can be greatly reduced;
the power supply device is fixed in the rear cavity of the 45-degree inclined mirror surface, and the LED lamp source below the 45-degree inclined mirror surface directly irradiates the lateral flow test paper detection area to provide a stable light source.
Preferably, program software for intelligently reading and analyzing signals in the lateral flow test strip detection zone is arranged in the smart phone.
Preferably, a mirror surface with an inclination angle of 45 degrees is arranged above the movable shading box, a power supply device is arranged in a cavity above the mirror surface, and an LED light source is arranged below the mirror surface.
Preferably, 45 slope mirror surface can reflect the position of camera and shoot the sidestream test paper detection zone signal, can guarantee to shoot the distance and can reduce the shooting device volume again greatly.
Preferably, a sliding groove is formed above the mobile phone shooting device base, and a telescopic clamping groove is formed below the mobile phone shooting device base.
Preferably, the sliding groove is matched with a movable shading box for adjusting the position of the movable shading box corresponding to the camera of the smart phone, so that the sliding groove is suitable for smart phones with cameras at different positions.
Preferably, the telescopic clamping groove is matched with a smart phone, and the smart phones with different width types are fixed through the telescopic clamping groove of the telescopic clamping groove.
The main innovation of the invention is that:
1. the invention can clearly obtain and analyze the detection signal of the lateral flow test paper by utilizing the intelligent mobile phone, thereby providing a portable and real-time optical detection technical device with data analysis.
2. The movable shading box has a shading effect, the lower surface of the movable shading box is tightly attached to the back surface of the smart phone, the influence of an external environment light source can be shielded, the movable shading box and the mobile phone shooting device base can adjust the positions of the movable shading box and the smart phone camera from two dimensions, and the universality of the smart phone shooting device is higher.
3. The movable shading box is internally provided with the inclined mirror surface, so that the shooting distance can be ensured, and the volume of the shooting device can be greatly reduced.
The invention has the following beneficial effects:
the invention can adjust the reasonable position of the side flow test paper detection zone, uses the telescopic clamping groove and the sliding groove to flexibly adjust the positions of the shading box and the mobile phone camera, greatly improves the universality and portability of the universal small mobile phone shooting and analyzing device, adopts the LED lamp strip to irradiate the detection zone, has more uniform irradiation light source, and effectively improves the shooting effect.
The above description is only an overview of the technical solutions of the present invention, and in order to make the technical means of the present invention more clearly apparent, and to make the implementation of the content of the description possible for those skilled in the art, and to make the above and other objects, features and advantages of the present invention more obvious, the following description is given by way of example of the specific embodiments of the present invention.
Drawings
Various other advantages and benefits of the present invention will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. It is obvious that the drawings described below are only some embodiments of the invention, and that for a person skilled in the art, other drawings can be derived from them without inventive effort. Also, like parts are designated by like reference numerals throughout the drawings.
In the drawings:
FIG. 1 is a schematic diagram of a system configuration of a universal compact mobile phone imaging analysis device for detecting lateral flow test strips according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of a general compact phone camera according to one embodiment of the invention;
fig. 3 is a schematic diagram of optical path transmission of a universal compact mobile phone camera according to an embodiment of the invention.
In the figure: 1. a movable light shielding box; 2. a lateral flow test paper analyzer; 3. a smart phone; 4. a power supply device; 5. a 45-degree inclined mirror surface; 6. a card slot; (ii) a 8. An LED light source; 9. a sliding groove; 10. a mobile phone shooting device base; 11. a telescopic clamping groove.
The invention is further explained below with reference to the figures and examples.
Detailed Description
Specific embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. While specific embodiments of the invention are shown in the drawings, it should be understood that the invention may be embodied in various forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
It should be noted that certain terms are used throughout the description and claims to refer to particular components. As one skilled in the art will appreciate, various names may be used to refer to a component. This specification and claims do not intend to distinguish between components that differ in name but not function. In the following description and in the claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. The description which follows is a preferred embodiment of the invention, but is made for the purpose of illustrating the general principles of the invention and not for the purpose of limiting the scope of the invention. The scope of the present invention is defined by the appended claims.
For the purpose of facilitating understanding of the embodiments of the present invention, the following description will be made by taking specific embodiments as examples with reference to the accompanying drawings, and the drawings are not to be construed as limiting the embodiments of the present invention.
Referring to fig. 1-3, a general small-sized mobile phone shooting and analyzing device for detecting lateral flow test paper comprises a smart phone 3, a lateral flow test paper analyzer 2, a power supply device 4, a 45-degree inclined mirror 5, an LED light source 8, and a mobile phone shooting device base 10, and is characterized in that: the telescopic clamping groove 11 below the mobile phone shooting device base 10 can fix the smart phone 3 and adjust the relative position of the camera;
the mobile phone shooting device is characterized in that a movable shading box 1 is arranged above a base 10 of the mobile phone shooting device, and the position of the movable shading box 1 and a camera of the smart phone 3 can be adjusted through a sliding groove 9
A clamping groove 6 of the lateral flow test paper analyzer 2 is arranged on a box body of the movable shading box 1, and the lateral flow test paper analyzer 2 can be fixed and the relative position of a detection area can be adjusted;
a 45-degree inclined mirror surface 5 is arranged in the movable shading box 1, and can reflect signals in a lateral flow test paper detection area to a camera position for shooting, so that the shooting distance can be ensured, and the volume of a shooting device can be greatly reduced;
the power supply device 4 is fixed in the rear cavity of the 45-degree inclined mirror surface 5, and the LED lamp source 8 below the 45-degree inclined mirror surface 5 directly irradiates the lateral flow test paper detection area to provide a stable light source.
In this embodiment, program software for intelligently reading and analyzing signals in the lateral flow test strip detection zone is further disposed in the smart phone 3.
In this embodiment, further, a mirror surface with an inclination angle of 45 ° is disposed above the movable light shielding box 1, a power supply device 4 is disposed in a cavity above the mirror surface, and an LED light source 8 is disposed below the mirror surface.
In this embodiment, further, 45 slope mirror surface 5 can reflect the position of camera to the sidestream test paper detection zone signal and take a picture, can guarantee to shoot the distance and can reduce the shooting device volume greatly again.
In this embodiment, further, a sliding groove 9 is disposed above the mobile phone photographing device base 10, and a retractable slot 11 is disposed below the mobile phone photographing device base 10.
In this embodiment, further, the sliding groove 9 is matched with the movable light shielding box 1, and is used for adjusting the position of the movable light shielding box 1 corresponding to the camera of the smart phone 3, so as to be suitable for the smart phone 3 with cameras at different positions.
In this embodiment, further, the smart phone 3 is matched with the retractable card slot 11, and the smart phone 3 with different width types is fixed by the retractable card slot of the retractable card slot 11.
In the preferred embodiment of the universal small mobile phone shooting and analyzing device for detecting the lateral flow test paper, different types of smart mobile phones 3 can be directly fixed through the telescopic clamping grooves 11 in the mobile phone shooting device base 10, the relative positions of the camera of the smart mobile phone 3 and the movable shading box 1 in the mobile phone shooting device base 10 can be adjusted through the movable shading box 1, and the camera of the smart mobile phone 3 and the movable shading box 1 can be matched with the smart mobile phones 3 of different models; by arranging the 45-degree inclined mirror 5, a signal in the test paper detection area can be transmitted to the camera, so that the enough shooting distance can be ensured, and the volume of the shooting device can be greatly reduced; through setting up LED light source 8, directly provide stable light source for the sidestream test paper detection zone and do not influence smart mobile phone 3 and shoot, guarantee the stability that smart mobile phone 3 shot and obtain reliable sidestream test paper detection analysis result.
Although the embodiments of the present invention have been described above with reference to the accompanying drawings, the present invention is not limited to the above-described embodiments and application fields, and the above-described embodiments are illustrative, instructive, and not restrictive. Those skilled in the art, having the benefit of this disclosure, may effect numerous modifications thereto without departing from the scope of the invention as defined by the appended claims.

Claims (7)

1. A analysis device is shot to general small-size cell-phone for detecting to side flow test paper, shoot device base (10), its characterized in that including smart mobile phone (3), side flow test paper analysis appearance (2), power supply unit (4), 45 slope mirror surface (5), LED lamp source (8) and cell-phone: the telescopic clamping groove (11) below the mobile phone shooting device base (10) can fix the smart mobile phone (3) and adjust the relative position of the camera;
a movable shading box (1) is arranged above a base (10) of the mobile phone shooting device, and the position of the movable shading box (1) and a camera of the smart phone (3) can be adjusted through a sliding groove (9)
A clamping groove (6) of the lateral flow test paper analyzer (2) is arranged on a box body of the movable shading box (1), and the lateral flow test paper analyzer (2) can be fixed and the relative position of the detection area can be adjusted;
a 45-degree inclined mirror surface (5) is arranged in the movable shading box (1), and signals in the lateral flow test paper detection area can be reflected to the position of a camera for shooting, so that the shooting distance can be ensured, and the volume of the shooting device can be greatly reduced;
the power supply device (4) is fixed in the emptying cavity behind the 45-degree inclined mirror surface (5), and the LED lamp source (8) below the 45-degree inclined mirror surface (5) directly irradiates the lateral flow test paper detection area to provide a stable light source.
2. The universal compact phone camera assay device for testing lateral flow test strips according to claim 1, wherein: program software for intelligently reading and analyzing signals of the lateral flow test paper detection zone is arranged in the smart phone (3).
3. The universal compact phone camera assay device for testing lateral flow test strips according to claim 1, wherein: a mirror surface with an inclination angle of 45 degrees is arranged on the upper portion in the movable shading box (1), a power supply device (4) is arranged in a cavity above the mirror surface, and an LED light source (8) is arranged below the mirror surface.
4. The universal compact phone camera assay device for testing lateral flow test strips according to claim 1, wherein: 45 slope mirror surface (5) can reflect the position of camera and shoot side stream test paper detection zone signal, can guarantee to shoot the distance and can reduce the shooting device volume greatly again.
5. The universal compact phone camera assay device for testing lateral flow test strips according to claim 1, wherein: a sliding groove (9) is formed in the upper portion of the mobile phone shooting device base (10), and a telescopic clamping groove (11) is formed in the lower portion of the mobile phone shooting device base (10).
6. The universal compact phone camera assay device for testing lateral flow test strips according to claim 1, wherein: the sliding groove (9) is matched with a movable shading box (1) and used for adjusting the position of the movable shading box (1) corresponding to the camera of the smart phone (3) so as to be suitable for the smart phone (3) with the cameras at different positions.
7. The universal compact phone camera assay device for testing lateral flow test strips according to claim 1, wherein: the smart mobile phone (3) is matched with the telescopic clamping groove (11), and the smart mobile phones (3) with different width types are fixed through clamping groove telescopic rods of the telescopic clamping groove (11).
CN202110628048.7A 2021-06-06 2021-06-06 Universal small-sized mobile phone shooting and analyzing device for detecting lateral flow test paper Pending CN113358652A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114235717A (en) * 2021-12-09 2022-03-25 香港中文大学(深圳) Universal optical detection system for quantitative analysis of optical sensor

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CN112129750A (en) * 2020-08-17 2020-12-25 天津大学 Mobile phone shooting and analyzing device for detecting lateral flow test paper
CN212904531U (en) * 2020-06-24 2021-04-06 武汉铢寸科技有限公司 Portable fluorescence microscopic detector based on mobile phone

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Publication number Priority date Publication date Assignee Title
CN104807822A (en) * 2015-04-23 2015-07-29 广州博厚医疗技术有限公司 Handheld analyzer and detection method
KR101579045B1 (en) * 2015-09-11 2015-12-18 전남대학교산학협력단 Diagnostic Kit
CN107121542A (en) * 2017-04-28 2017-09-01 厦门大学 A kind of immunity-chromatography test strip quantitative detection system and method based on mobile phone
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114235717A (en) * 2021-12-09 2022-03-25 香港中文大学(深圳) Universal optical detection system for quantitative analysis of optical sensor

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