CN113350420A - Oral liquid for strengthening body resistance and resisting cancer and preparation method thereof - Google Patents

Abstract

The invention discloses a body resistance strengthening and anticancer oral liquid, which comprises the following components: 90g of radix pseudostellariae, 60g of poria cocos, 72g of angelica sinensis, 72g of radix paeoniae alba, 60g of ligusticum wallichii, 90g of radix rehmanniae preparata, 180g of astragalus membranaceus, 90g of hairyvein agrimony, 90g of glossy privet fruit, 60g of fructus psoraleae, 60g of mulberry, 90g of wolfberry fruit, 90g of radix polygoni multiflori preparata, 90g of radix achyranthis bidentatae, 90g of caulis spatholobi, 90g of fried chicken's gizzard-membrane, 0.5g of ethylparaben, 1g of stevioside, 6-9 g of bentonite and 3-5 g of chitosan hydrochloride are added, and the traditional Chinese medicine is prepared by adding 72g of angelica sinensis, 72g of radix paeoniae alba, 60g of ligusticum wallichii, 180g of astragalus membranaceus, 90g of wolfberry fruit and 90g of caulis spatholobi, so that the anticancer oral liquid has the effects of strengthening body resistance, tonifying qi and blood, invigorating spleen and kidney, improving body constitution, improving disease resistance, overcoming diseases, recovering health, meanwhile, the oral liquid is adopted, so that alopecia of a patient is prevented, leucocyte and bone marrow inhibition are reduced, digestion and absorption in vivo are convenient, and an expected effect can be achieved in the treatment process.

Description

Oral liquid for strengthening body resistance and resisting cancer and preparation method thereof

Technical Field

The invention relates to an oral liquid, in particular to an oral liquid for strengthening the body resistance and resisting cancer and a preparation method thereof, belonging to the technical field of oral liquids.

Background

The oral liquid is prepared by extracting effective components from Chinese medicinal decoction, adding correctant and antibacterial agent, and bottling according to ampoule. It is a novel preparation combining three dosage forms of decoction, syrup and injection. Such as pulse-activating decoction oral liquid, Sini decoction oral liquid, ginseng antler royal jelly oral liquid and the like, and is characterized by small dosage, good taste, quick absorption, quick effect taking and easy acceptance by patients.

At present, most of the medicines for treating cancers are orally taken or injected, the oral medicine is difficult to swallow for tumor patients, particularly for partial gastrointestinal and digestive tract cancer patients, and has the phenomena of great side effects such as nausea, vomiting and the like, the medicines are difficult to digest and absorb in vivo, the expected effect is difficult to achieve in the treatment process, and meanwhile, the existing anticancer oral liquid does not have the efficacy of strengthening the body resistance, so that the oral liquid for strengthening the body resistance and resisting the cancers and the preparation method thereof are provided.

Disclosure of Invention

The invention aims to provide an oral liquid for strengthening body resistance and resisting cancer and a preparation method thereof, so as to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme: the oral liquid for strengthening body resistance and resisting cancer comprises the following components: 90g of radix pseudostellariae, 60g of poria cocos, 72g of Chinese angelica, 72g of white paeony root, 60g of ligusticum wallichii, 90g of prepared rehmannia root, 180g of astragalus membranaceus, 90g of hairyvein agrimony, 90g of glossy privet fruit, 60g of fructus psoraleae, 60g of mulberry, 90g of wolfberry fruit, 90g of prepared fleece-flower root, 90g of radix achyranthis bidentatae, 90g of caulis spatholobi, 90g of fried chicken's gizzard-membrane, 0.5g of ethylparaben, 1g of stevioside, 6-9 g of bentonite and 3-5 g of chitosan hydrochloride.

As a preferable technical scheme of the invention, the method comprises the following steps:

s1: putting 90g of radix pseudostellariae, 60g of poria cocos, 72g of angelica sinensis, 72g of radix paeoniae alba, 60g of ligusticum wallichii, 90g of radix rehmanniae preparata, 180g of astragalus membranaceus, 90g of hairyvein agrimony, 90g of glossy privet fruit, 60g of fructus psoraleae, 60g of mulberry, 90g of wolfberry fruit, 90g of radix polygoni multiflori preparata, 90g of radix achyranthis bidentatae, 90g of caulis spatholobi and 90g of fried chicken's gizzard-membrane into a container, adding water to soak for 1.5-2 hours, directly heating with hot steam to extract aromatic water by about 150ml, and collecting in another container for later use;

s2: adding 7 times of water, extracting under reflux until the extractive solution is almost colorless, and concentrating under reduced pressure to about 6000ml (1:7 of feed liquid concentration); transferring into a precipitation tank, adding bentonite and chitosan hydrochloride, carrying out heat preservation and precipitation at 80-85 ℃ for 12-24 h, extracting supernatant, carrying out precipitation filtration, and combining filtrate and supernatant;

s3: concentrating under reduced pressure to about 800ml, cooling and precipitating for 10-12 h, centrifuging, adding hydroxyphenyl ethanes, stevioside and purified water into the clear liquid to about 800ml, boiling for 30 min for sterilization, cooling to room temperature, adding aromatic water and purified water to 1000ml, stirring, filtering, and bottling to obtain the oral liquid.

Compared with the prior art, the invention has the beneficial effects that:

1. according to the oral liquid for strengthening body resistance and resisting cancer and the preparation method thereof, 72g of angelica sinensis, 72g of white paeony root, 60g of ligusticum wallichii, 180g of astragalus membranaceus, 90g of wolfberry fruit and 90g of caulis spatholobi are added, so that the oral liquid for resisting cancer has the effect of strengthening body resistance, can build up body, improve disease resistance, overcome diseases and restore health, is in an oral liquid form, prevents alopecia of a patient, reduces leucocyte and bone marrow inhibition, is convenient to digest and absorb in vivo, and can achieve an expected effect in a treatment process.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention provides a body resistance strengthening and anticancer oral liquid and a technical scheme of a preparation method thereof, wherein the oral liquid comprises the following components:

the oral liquid for strengthening body resistance and resisting cancer comprises the following components: 90g of radix pseudostellariae, 60g of poria cocos, 72g of Chinese angelica, 72g of white paeony root, 60g of ligusticum wallichii, 90g of prepared rehmannia root, 180g of astragalus membranaceus, 90g of hairyvein agrimony, 90g of glossy privet fruit, 60g of fructus psoraleae, 60g of mulberry, 90g of wolfberry fruit, 90g of prepared fleece-flower root, 90g of radix achyranthis bidentatae, 90g of caulis spatholobi, 90g of fried chicken's gizzard-membrane, 0.5g of ethylparaben, 1g of stevioside, 6-9 g of bentonite and 3-5 g of chitosan hydrochloride.

The preparation method comprises the following steps:

s1: putting 90g of radix pseudostellariae, 60g of poria cocos, 72g of angelica sinensis, 72g of radix paeoniae alba, 60g of ligusticum wallichii, 90g of radix rehmanniae preparata, 180g of astragalus membranaceus, 90g of hairyvein agrimony, 90g of glossy privet fruit, 60g of fructus psoraleae, 60g of mulberry, 90g of wolfberry fruit, 90g of radix polygoni multiflori preparata, 90g of radix achyranthis bidentatae, 90g of caulis spatholobi and 90g of fried chicken's gizzard-membrane into a container, adding water to soak for 1.5-2 hours, directly heating with hot steam to extract aromatic water by about 150ml, and collecting in another container for later use;

s2: adding 7 times of water, extracting under reflux until the extractive solution is almost colorless, and concentrating under reduced pressure to about 6000ml (1:7 of feed liquid concentration); transferring into a precipitation tank, adding bentonite and chitosan hydrochloride, carrying out heat preservation and precipitation at 80-85 ℃ for 12-24 h, extracting supernatant, carrying out precipitation filtration, and combining filtrate and supernatant;

s3: concentrating under reduced pressure to about 800ml, cooling and precipitating for 10-12 h, centrifuging, adding hydroxyphenyl ethanes, stevioside and purified water into the clear liquid to about 800ml, boiling for 30 min for sterilization, cooling to room temperature, adding aromatic water and purified water to 1000ml, stirring, filtering, and bottling to obtain the oral liquid.

According to the invention, by adding 72g of angelica sinensis, 72g of radix paeoniae alba, 60g of ligusticum wallichii, 180g of astragalus mongholicus, 90g of wolfberry fruit and 90g of caulis spatholobi, the anticancer oral liquid has the effect of strengthening body resistance, can build up health, improve disease resistance, overcome diseases and restore health, and meanwhile, the oral liquid is adopted, so that alopecia is prevented, leucocyte and bone marrow inhibition are reduced, the oral liquid is convenient to digest and absorb in vivo, and the expected effect can be achieved in the treatment process. .

The first embodiment is as follows: the effective medicine content identification method of the invention comprises the following steps: grinding the appropriate amount of the product, collecting about 10g, adding 30ml of methanol, ultrasonic treating for 30 min, filtering, evaporating the filtrate to dryness, adding I% into the residue

Dissolving sodium bicarbonate solution 30ml, adjusting pH to 2-3 with dilute hydrochloric acid, shaking and extracting with ethyl acetate 2 times (20 ml each time), mixing ethyl ether solution, volatilizing, dissolving the residue with methanol lml to obtain test solution, collecting ferulic acid control, adding methanol to obtain lmg solution per lml, collecting control solution, performing thin layer chromatography, sucking 10ul of the above solutions, respectively dropping on the same silica gel G thin layer plate, spreading with cyclohexane-dichloromethane-ethyl acetate-formic acid (4:1:1:0.1) as developing agent, taking out, air drying, and inspecting under ultraviolet lamp (365mn) to show fluorescent spot of the same color in the test chromatogram at the position corresponding to the control chromatogram.

Example two: the second method for identifying the effective drug content of the invention comprises the following steps: taking a proper amount of the product, grinding, taking about 20G, adding 40ml of ethanol, carrying out ultrasonic treatment for 30 minutes, filtering, evaporating filtrate, adding 20ml of water into residue, dissolving, filtering, shaking and extracting filtrate for 2 times by using water saturated n-butyl alcohol, 20ml each time, combining n-butyl alcohol solution, evaporating, dissolving residue by using methanol lml, taking paeoniflorin as a test solution, adding methanol to prepare a solution containing lmg per lml, taking a control solution, carrying out thin-layer chromatography test, sucking 20ul of the test sample solution, taking 10ul of the control solution, respectively dropping on a same silica gel G thin-layer plate, developing by using chloroform-ethyl acetate-methanol-formic acid (40:5:10:0.2) as a developing agent, taking out, airing, spraying 5% vanillin sulfuric acid solution, heating at 105 ℃ until spots develop clearly, in the chromatogram of the test sample, at a position corresponding to the control solution, spots of the same color appeared.

Example three: the third method for identifying the effective medicine content of the invention comprises the following steps: taking a proper amount of the product, grinding, taking about 10g, adding 30ml of ethanol, carrying out ultrasonic treatment for 30 minutes, drying the filtrate by distillation, adding 15ml of 0.3% sodium hydroxide bath solution into residues for dissolving, filtering, adjusting the pH value of the filtrate to 5-6 by using dilute hydrochloric acid, shaking and extracting by using 15ml of ethyl acetate, taking ethyl acetate solution by separation, filtering by using filter paper paved with a proper amount of anhydrous sodium sulfate, drying the filtrate by distillation, and adding 1ml of ethyl acetate solution into the residues for dissolving to obtain a sample bath solution. Taking 2G of radix astragali as reference material, preparing reference material solution by the same method, testing according to thin-layer color syntax (general rule 0502), sucking 10ul of each of the two solutions, respectively dropping on the same silica gel G thin-layer root, developing with chloroform-methanol (10:1) as developing agent, taking out, air drying, fumigating in ammonia vapor, inspecting under ultraviolet lamp (365mn), and displaying fluorescent spots of the same color on the corresponding position of the chromatogram of the reference material.

Example four: the fourth method for identifying the effective medicine content of the invention is as follows: taking 10g of the product, grinding, adding 30ml of methanol, carrying out ultrasonic treatment for 30 minutes, filtering, drying by distillation, adding 40ml of water into residues, dissolving, extracting by shaking with 20ml of ethyl acetate, separating ethyl acetate solution, and concentrating to Iml to obtain a test solution. Taking another fructus Lycii as reference material 0.5G, preparing reference material solution by the same method, testing by thin layer chromatography (general rule 0502), sucking 10ul of each of the above two solutions, respectively dropping on the same silica gel G thin layer plate, developing with ethyl acetate N-bombycis methane-formic acid (3:2:1) as developing agent, taking out, air drying, and inspecting under ultraviolet lamp (365 nm). In the chromatogram of the test solution, fluorescent spots with the same color appear at the corresponding positions of the chromatogram of the reference solution.

Example five: the fifth method for identifying the effective medicine content of the invention comprises the following steps: grinding 10g of the product, adding 40ml of ethanol, sonicating for 30 minutes, filtering, evaporating the filtrate to dryness, adding 10ml of water into the residue to dissolve, shaking with 10m of ethyl acetate 1, volatilizing the ethyl acetate solution, adding 1ml of methanol into the residue to dissolve, taking the residue as a test solution, adding 2g of the control drug of the Sargentodoxa cuneata, and preparing the control drug solution by the same method. Testing 10ul of the above solutions by thin layer chromatography (general rule 0502), respectively dropping on the same silica gel GF254 thin layer plate, developing with Diachlor Spropyl G (8:1.2:0.3:0.5) as developing agent, taking out, air drying, and inspecting under ultraviolet lamp (254mn) to show fluorescence spots of the same color in the chromatogram of the test solution at the position corresponding to the chromatogram of the control solution.

In the description of the present invention, it is to be understood that the indicated orientations or positional relationships are based on the orientations or positional relationships shown in the embodiments and are only for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the indicated devices or elements must have a specific orientation, be constructed and operated in a specific orientation, and thus are not to be construed as limiting the present invention.

In the present invention, unless otherwise explicitly specified or limited, for example, it may be fixedly attached, detachably attached, or integrated; can be mechanically or electrically connected; the terms may be directly connected or indirectly connected through an intermediate, and may be communication between two elements or interaction relationship between two elements, unless otherwise specifically limited, and the specific meaning of the terms in the present invention will be understood by those skilled in the art according to specific situations.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (2)

1. The oral liquid for strengthening body resistance and resisting cancer is characterized by comprising the following components: 90g of radix pseudostellariae, 60g of poria cocos, 72g of Chinese angelica, 72g of white paeony root, 60g of ligusticum wallichii, 90g of prepared rehmannia root, 180g of astragalus membranaceus, 90g of hairyvein agrimony, 90g of glossy privet fruit, 60g of fructus psoraleae, 60g of mulberry, 90g of wolfberry fruit, 90g of prepared fleece-flower root, 90g of radix achyranthis bidentatae, 90g of caulis spatholobi, 90g of fried chicken's gizzard-membrane, 0.5g of ethylparaben, 1g of stevioside, 6-9 g of bentonite and 3-5 g of chitosan hydrochloride.

2. The method for preparing oral liquid for strengthening body resistance and resisting cancer according to claim 1, wherein the oral liquid comprises: the method comprises the following steps:

s1: putting 90g of radix pseudostellariae, 60g of poria cocos, 72g of angelica sinensis, 72g of radix paeoniae alba, 60g of ligusticum wallichii, 90g of radix rehmanniae preparata, 180g of astragalus membranaceus, 90g of hairyvein agrimony, 90g of glossy privet fruit, 60g of fructus psoraleae, 60g of mulberry, 90g of wolfberry fruit, 90g of radix polygoni multiflori preparata, 90g of radix achyranthis bidentatae, 90g of caulis spatholobi and 90g of fried chicken's gizzard-membrane into a container, adding water to soak for 1.5-2 hours, directly heating with hot steam to extract aromatic water by about 150ml, and collecting in another container for later use;

s2: adding 7 times of water, extracting under reflux until the extractive solution is almost colorless, and concentrating under reduced pressure to about 6000ml (1:7 of feed liquid concentration); transferring into a precipitation tank, adding bentonite and chitosan hydrochloride, carrying out heat preservation and precipitation at 80-85 ℃ for 12-24 h, extracting supernatant, carrying out precipitation filtration, and combining filtrate and supernatant;

s3: concentrating under reduced pressure to about 800ml, cooling and precipitating for 10-12 h, centrifuging, adding hydroxyphenyl ethanes, stevioside and purified water into the clear liquid to about 800ml, boiling for 30 min for sterilization, cooling to room temperature, adding aromatic water and purified water to 1000ml, stirring, filtering, and bottling to obtain the oral liquid.