CN100335117C - Chinese medicinal lotion for new-borne baby's removing jaundice - Google Patents
Chinese medicinal lotion for new-borne baby's removing jaundice Download PDFInfo
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- CN100335117C CN100335117C CNB2005100195621A CN200510019562A CN100335117C CN 100335117 C CN100335117 C CN 100335117C CN B2005100195621 A CNB2005100195621 A CN B2005100195621A CN 200510019562 A CN200510019562 A CN 200510019562A CN 100335117 C CN100335117 C CN 100335117C
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Abstract
The present invention relates to traditional Chinese medicinal lotion for treating newborn babies' jaundice. The present invention comprises raw materials of the following parts by weight: 6 to 30 parts of oriental wormwood, 4 to 20 parts of rhubarb, 4 to 20 parts of gardenia fruit, 1 to 5 parts of bupleurum root, 1 to 5 parts of curcuma root, 2 to 10 parts of lysimachia, 2 to 10 parts of plantain seed, 2 to 10 parts of largehead atractylodes rhizome, 2 to 10 parts of pilose asiabell root, 2 to 10 parts of tuckahoe, 4 to 20 parts of licorice root, 2 to 10 parts of endothelium corneae gigeriae galli, 1 to 5 parts of aurantii, 2 to 10 parts of malt, 2 to 10 parts of danshen root and proper amounts of transdermal agent. The traditional Chinese medicinal lotion for treating newborn babies' jaundice of the present invention directly enters blood after being absorbed by skin; the present invention has the advantages of enhancing the functions of the spleen and stomach, improving the excretion capacities of the liver and gallbladder, promoting normal excretion of bile, rapidly removing jaundice and overcoming the difficulty of oral application of medicine for newborn babies. Therefore, the present invention is a treatment method for treating newborn babies' jaundice, which has the advantages of no hurt, obvious effect, easy popularization and simple and convenient operation.
Description
Technical field
The invention belongs to new-borne baby's removing jaundice Chinese medicine washing liquid.
Background technology
Neonatal jaundice is the early stage modal symptom of neonate, because the neonatal period bilirubin metabolism, has 60% term infant that physiologic jaundice may take place approximately; When blood mesobilirubin concentration＞205 μ mol/L, claim hyperbilirubinemia (pathological jaundice).Grow imperfection because of the neonate blood brain barrier, when blood mesobilirubin value acquires a certain degree, can enter in the brain, cause bilirubin encephalopathy by blood brain barrier; Bilirubin encephalopathy mortality rate height, according to statistics, suffering from this sick neonate has 50%～70% to die from acute stage, has 70%～90% the nervous system sequela to occur in the survivor; Therefore should give early intervention to neonatal jaundice.In recent years, both at home and abroad all carried out comparatively deep research to pathological jaundice and to the intervention of neonatal jaundice with high risk factor.Domestic having by the method for oral Chinese and western drugs or by neonate comforted method of touching or the report that passes through the method early intervention neonatal jaundice of glycerin relieving constipation.Interrelated data shows, China's FTNB serum bilirubin peak value appears at gave birth to the back the 4th～5 day, and at present domesticly do not see have pair neonate the document announcement of early intervention to occur neonatal jaundice being undertaken by washout in preceding 3 days at the serum bilirubin peak value as yet.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of early intervention neonatal jaundice, prevention blood of neonate mesobilirubin value increases, avoids neonate to produce the Chinese medicine washing liquid of bilirubin encephalopathy.
The present invention solves the problems of the technologies described above with following technical scheme:
The weight portion of each raw material of Chinese medicine washing liquid of the present invention is:
Herba Artemisiae Scopariae 6～30 Radix Et Rhizoma Rhei 4～20 Fructus Gardeniae 4～20 Radix Bupleuri 1～5 Radix Curcumae 1～5 Herba Lysimachiae 2～10
Semen Plantaginis 2～10 Rhizoma Atractylodis Macrocephalaes 2～10 Radix Codonopsis 2～10 Poria 2～10 Radix Glycyrrhizaes 4～20 Endothelium Corneum Gigeriae Galli 2～10
Fructus Aurantii 1～5 Fructus Hordei Germinatus 2～10 Radix Salviae Miltiorrhizaes 2～10 transdermal agents are an amount of
Preparation method one: above-mentioned magistral medicines except that transdermal agent, is boiled behind the bubble, and the leaching medicinal liquid extracts 2 times repeatedly; Merge extractive liquid, also concentrates, and adds ethanol and mixes thoroughly, quietly puts, precipitates, and filters, and alcohol extract adds water and an amount of transdermal agent, mix thoroughly, and packing, sterilization is promptly.
Preparation method two: above-mentioned magistral medicines except that transdermal agent, is ground into coarse powder, and it is moistening to add an amount of alcoholic solution, is placed to drenchedly, adds ethanol again, and percolate is collected in the quiet back of putting; With the percolate recovered alcohol, add water and a small amount of transdermal agent is mixed thoroughly, packing, sterilization is promptly.
New-borne baby's removing jaundice Chinese medicine washing liquid of the present invention, medicine absorb through skin and directly enter blood, and blood circulation promoting strengthens spleen and stomach function, improves the liver and gall discharge capacity, promote bile normally to drain, and jaundice is disappeared rapidly, and overcome the difficulty of neonate oral drugs.Be a kind of non-invasive, effective, be easy to promote, the Therapeutic Method of new-borne baby's removing jaundice easy and simple to handle.
The specific embodiment
New-borne baby's removing jaundice Chinese medicine lotion prescription of the present invention is:
Herba Artemisiae Scopariae 6～30 Radix Et Rhizoma Rhei 4～20 Fructus Gardeniae 4～20 Radix Bupleuri 1～5 Radix Curcumae 1～5 Herba Lysimachiae 2～10
Semen Plantaginis 2～10 Rhizoma Atractylodis Macrocephalaes 2～10 Radix Codonopsis 2～10 Poria 2～10 Radix Glycyrrhizaes 4～20 Endothelium Corneum Gigeriae Galli 2～10
Fructus Aurantii 1～5 Fructus Hordei Germinatus 2～10 Radix Salviae Miltiorrhizaes 2～10 transdermal agents are an amount of
Function and side separate: in the side is monarch drug with Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, SHANZHIZI, function of gallbladder promoting, antiinflammatory are arranged, protects the liver, the jaundice eliminating effect, and with Radix Bupleuri, Radix Curcumae, Fructus Aurantii, Radix Salviae Miltiorrhizae is a ministerial drug, and circulation of qi promoting is arranged, resolving depression, and invigorating blood circulation effect, it is sensible to help QI and blood.With the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Poria, Radix Glycyrrhizae, Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli is adjuvant drug, invigorating the spleen and replenishing QI is arranged, the function of spleen and stomach regulating function helps the sound of neonate digestive function, promotes the biliary drainage of neonate, be equipped with Herba Lysimachiae again, Semen Plantaginis, Radix Glycyrrhizae is a messenger drug, and relieving stranguria by diuresis is arranged, make water channel unobstructed, guiding bile is drained from water channel.In addition, Radix Salviae Miltiorrhizae is expanded microcirculation in addition, strengthens capillary permeability, and Endothelium Corneum Gigeriae Galli has the effect of expansion liver, bile duct smooth muscle again, makes to accumulate in the intravital bilirubin quickening of neonate discharge, and jaundice disappears rapidly.
When preparing washing liquid of the present invention, can adopt water to carry or the method for alcohol extraction: when adopting the water extracting method, above-mentioned Chinese medicine put into extract pot, add water and cross powder, soak post-heating and boil, leaching medicinal liquid, medicinal residues add water again by extracting 2 times with quadrat method.Merge extractive liquid, also concentrates, and the ethanol that adds 2 times of amounts is mixed thoroughly, quietly puts 48 hours precipitations, and filtering precipitate, alcohol extract add water and add an amount of transdermal agent, mix thoroughly, and packing is sterilized promptly.
When adopting pure extracting method, above-mentioned Chinese medicine powder is broken into coarse powder, puts into rustless steel container, it is moistening to add an amount of 50% alcoholic solution, is placed to fully drenchedly, and then adds 75% ethanol to container top, leave standstill the back and collect percolate, till shoaling to the percolate color.The percolate recovered alcohol to there not being the alcohol flavor, is added water and adds an amount of transdermal agent and mix thoroughly, and packing, sterilization are promptly.
This product character is pale brown color liquid, and bitter in the mouth is little sweet.
Below be to use the clinical observation on the therapeutic effect of this new-borne baby's removing jaundice Chinese medicine washing liquid:
1, physical data: year March in October, 2004 to 2005 is in the neonate of the court obstetrics births totally 80 examples, wherein male 48 examples, and women 32 examples, men and women's ratio is 1.5: 1; Minimum birth of age jaundice time 12 hours appear, maximum birth 3 days.Two groups of infants are divided into two groups of A, B at random, every group 40 example.
2, observation item: the umbilical blood bilirubin, skin jaundice degree (+++, ++ ,+,-), liver function test (total bilirubin, bilirubin direct, unconjugated bilirubin), skin is surveyed bilirubin.
3, Therapeutic Method: A group is washed once with new-borne baby's removing jaundice Chinese medicine washing liquid of the present invention every day, and each 1 bottle (500ml) adds 10-50 warm water washout whole body doubly, or puts into basin and soaked logotype three days each 10～20 minutes; Oral phenobarbital 10mg of while, Tid.B organizes not washout, only oral phenobarbital 10mg, Tid.
4, clinical evaluation: clinical produce effects: xanthochromia (-), skin is surveyed bilirubin value＜18u, total bilirubin＜160mmol; Effectively: xanthochromia (+), skin is surveyed bilirubin value 18～25u, total bilirubin＜205mmol; Invalid: xanthochromia (++～+++), skin is surveyed bilirubin value＞25u, total bilirubin＞205mmol.
5, two groups of Comparison of therapeutic of result see Table 1.
Table 1 liang group neonatal jaundice infant treatment efficacy result contrast
| Group | The example number | Clinical cure | Produce effects | Take a turn for the better | Invalid | Total effective rate (%) |
| The A group | 40 | 28 | 6 | 4 | 2 | 95 |
| The B group | 40 | 15 | 10 | 8 | 7 | 82.5 |
Annotate: two groups relatively, x
2=8.0, P＜0.05
6, conclusion
The external of new-borne baby's removing jaundice Chinese medicine washing liquid has significant curative effect to neonatal jaundice, and neonate external washout with traditional Chinese herbs jaundice eliminating is better than matched group (P＜0.05), and total effective rate reaches 95%.
The discrimination method of the new-borne baby's removing jaundice Chinese medicine washing liquid of producing with the inventive method is:
(1) get this product 10ml and put evaporate to dryness in the water-bath, residue adds acetone 2ml, makes dissolving, get supernatant and make need testing solution, other gets the jasminoidin reference substance, adds acetone and makes solution that every 1ml contains 0.5mg product solution in contrast, according to the thin layer chromatography test, drawing above-mentioned two kinds of each 10ul of solution puts respectively on same silicon thigh G plate, with chloroform-methanol (3: 1) is developing solvent, launches, and taking-up is dried, spray is with 50% ethanol solution of sulfuric acid, and it is clear to add the colour developing of thermic speckle in 100 ℃.The speckle that on test sample chromatograph and the corresponding position of reference substance chromatograph, shows same color.
(2) get this product 20ml, the jolting that adds diethyl ether is extracted 2 times, and each 15ml merges ether extracted liquid, is concentrated into 1ml as need testing solution, other gets the Radix Et Rhizoma Rhei control medicinal material 0.2g 10ml that adds diethyl ether, and jolting 20 minutes filters, filtrate is concentrated into 1ml, and medical material solution is tested according to thin layer chromatography in contrast.Draw above-mentioned two kinds of each 5ul of solution, put respectively on same silica gel g thin-layer plate, with benzene-ethyl acetate-methanol (7.5: 2.4: 0.1) is that developing solvent launches, takes out, dries, put under the ultra-violet lamp (365nm) and inspect, in the test sample chromatograph with on the corresponding position of control medicinal material chromatograph, show the fluorescence speckle of same color.
[inspection]
Relative density 〉=0.95
PH should be 4～6
Other should meet " relevant every regulation under Chinese pharmacopoeia version (appendix I) in 2000 the mixture item.
Embodiment 1
[prescription]
Herba Artemisiae Scopariae 6kg Radix Et Rhizoma Rhei 4kg SHANZHIZI 4kg Radix Bupleuri 1kg
Radix Curcumae 1kg Herba Lysimachiae 2kg Semen Plantaginis 2kg Rhizoma Atractylodis Macrocephalae 2kg
Radix Codonopsis 2kg Poria 2kg Radix Glycyrrhizae 4kg Endothelium Corneum Gigeriae Galli 2kg
Fructus Aurantii 1kg Fructus Hordei Germinatus 2kg Radix Salviae Miltiorrhizae 2kg Herba Menthae 25g
[method for making]
Above-mentioned ten Chinese medicine of the five flavours except that Herba Menthae are put into and are extracted pot, add water and cross powder, steeped 2 hours, and heated and boiled 2 hours, leaching medicinal liquid, medicinal residues add water again by extracting 2 times with quadrat method.Merge extractive liquid, also is concentrated into 10,000 milliliters, adds 20,000 ml ethanols and mixes all, quietly puts 48 hours precipitations, and filtering precipitate, alcohol extract add water and be made into 50,000 milliliters, add Herba Menthae and mix thoroughly, is sub-packed in 250 milliliters of bottles, and totally 200 bottles, 100 ℃ sterilization 30 minutes is promptly down.
Embodiment 2
[prescription]
Herba Artemisiae Scopariae 25kg Radix Et Rhizoma Rhei 20kg SHANZHIZI 10kg Radix Bupleuri 3kg
Radix Curcumae 4kg Herba Lysimachiae 5kg Semen Plantaginis 5kg art 5kg
Radix Codonopsis 5kg Poria 6kg Radix Glycyrrhizae 8kg Endothelium Corneum Gigeriae Galli 5kg
Fructus Aurantii 2kg Fructus Hordei Germinatus 4kg Radix Salviae Miltiorrhizae 8kg Herba Menthae 35g
[method for making]
Ten Chinese medicine of the five flavours except that Herba Menthae steep, boil method with embodiment 1.Merge extractive liquid, also is concentrated into 30,000 milliliters, adds 60,000 ml ethanols and mixes all, quietly puts 48 hours precipitations, and filtering precipitate, alcohol extract add water and be made into 140,000 milliliters, add Herba Menthae and mix all, are sub-packed in 500 milliliters of bottles, totally 280 bottles, sterilize 30 minutes down promptly for 100 ℃.
Embodiment 3
[prescription]
Herba Artemisiae Scopariae 15kg Radix Et Rhizoma Rhei 10kg SHANZHIZI 20kg Radix Bupleuri 5kg
Radix Curcumae 2kg Herba Lysimachiae 9kg Semen Plantaginis 9kg art 10kg
Radix Codonopsis 10kg Poria 10kg Radix Glycyrrhizae 20kg Endothelium Corneum Gigeriae Galli 8kg
Fructus Aurantii 5kg Fructus Hordei Germinatus 10kg Radix Salviae Miltiorrhizae 6kg Herba Menthae 30g
[method for making]
Above prescription drug except that Herba Menthae is ground into coarse powder, put into rustless steel container, it is moistening to add concentration and be 50% alcoholic solution 20kg, placed 12 hours, make it fully drenched, and then adding 75% ethanol to container top, quiet putting after 48 hours collected percolate, till shoaling to the percolate color.The percolate recovered alcohol to there not being the alcohol flavor, is added water and is made into 130,000 milliliters, add Herba Menthae and mix thoroughly, be sub-packed in 250 milliliters the bottle, totally 520 bottles, 100 ℃ of sterilizations 30 minutes promptly.
Embodiment 4
[prescription]
Herba Artemisiae Scopariae 30kg Radix Et Rhizoma Rhei 15kg SHANZHIZI 15kg Radix Bupleuri 4kg
Radix Curcumae 5kg Herba Lysimachiae 10kg Semen Plantaginis 10kg Rhizoma Atractylodis Macrocephalae 10kg
Radix Codonopsis 10kg Poria 10kg Radix Glycyrrhizae 15kg Endothelium Corneum Gigeriae Galli 10kg
Fructus Aurantii 4kg Fructus Hordei Germinatus 8kg Radix Salviae Miltiorrhizae 10kg Herba Menthae 40g
[method for making]
Above prescription drug except that Herba Menthae is ground into coarse powder, put into rustless steel container, it is moistening to add concentration and be 50% alcoholic solution 25kg, placed 12 hours, make it fully drenched, and then adding 75% ethanol to container top, quiet putting after 48 hours collected percolate, till shoaling to the percolate color.The percolate recovered alcohol to there not being the alcohol flavor, is added water and is made into 150,000 milliliters, add Herba Menthae and mix all, be sub-packed in 250 milliliters the bottle, totally 600 bottles, sterilize 30 minutes promptly for 100 ℃.
Claims (2)
1. the preparation method of a new-borne baby's removing jaundice Chinese medicine washing liquid is characterized in that:
The weight portion of each raw material is: Herba Artemisiae Scopariae 6～30 Radix Et Rhizoma Rhei 4～20 Fructus Gardeniae 4～20 Radix Bupleuri 1～5 Radix Curcumae 1～5 Herba Lysimachiae 2～10 Semen Plantaginiss 2～10 Rhizoma Atractylodis Macrocephalaes 2～10 Radix Codonopsis 2～10 Poria 2～10 Radix Glycyrrhizaes 4～20 Endothelium Corneum Gigeriae Galli 2～10 Fructus Aurantiis 1～5 Fructus Hordei Germinatus 2～10 Radix Salviae Miltiorrhizaes 2～10 transdermal agents are an amount of;
Preparation method is: above-mentioned magistral medicines boils behind the bubble except that transdermal agent, and the leaching medicinal liquid extracts 2 times repeatedly; Merge extractive liquid, also concentrates, and adds ethanol and mixes thoroughly, quietly puts, precipitates, and filters, and alcohol extract adds water and transdermal agent, mix thoroughly, and packing, sterilization promptly gets product.
2. the preparation method of a new-borne baby's removing jaundice Chinese medicine washing liquid is characterized in that:
The weight portion of each raw material is: Herba Artemisiae Scopariae 6～30 Radix Et Rhizoma Rhei 4～20 Fructus Gardeniae 4～20 Radix Bupleuri 1～5 Radix Curcumae 1～5 Herba Lysimachiae 2～10 Semen Plantaginiss 2～10 Rhizoma Atractylodis Macrocephalaes 2～10 Radix Codonopsis 2～10 Poria 2～10 Radix Glycyrrhizaes 4～20 Endothelium Corneum Gigeriae Galli 2～10 Fructus Aurantiis 1～5 Fructus Hordei Germinatus 2～10 Radix Salviae Miltiorrhizaes 2～10 transdermal agents are an amount of:
Preparation method is: above-mentioned magistral medicines all is ground into coarse powder except that transdermal agent, and it is moistening to add an amount of alcoholic solution, is placed to drenchedly, adds ethanol again, and percolate is collected in the quiet back of putting; With the percolate recovered alcohol, add water and an amount of transdermal agent is mixed thoroughly, packing, sterilization is promptly.
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| CNB2005100195621A CN100335117C (en) | 2005-10-01 | 2005-10-01 | Chinese medicinal lotion for new-borne baby's removing jaundice |
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| CN100335117C true CN100335117C (en) | 2007-09-05 |
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Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100391480C (en) * | 2006-05-31 | 2008-06-04 | 武汉市海格尔科技有限公司 | Hydrophilic gel pleximetric paste and its preparation |
| CN102302601A (en) * | 2011-08-23 | 2012-01-04 | 刘世发 | Children jaundice medicine and preparation method thereof |
| CN103055300A (en) * | 2013-02-18 | 2013-04-24 | 成都科创佳思科技有限公司 | Traditional Chinese medical composition for treating neonatal jaundice |
| CN103071075A (en) * | 2013-02-18 | 2013-05-01 | 成都科创佳思科技有限公司 | Chinese patent medicine for treating neonatal jaundice |
| CN103169922B (en) * | 2013-02-25 | 2014-05-14 | 张艳英 | Traditional Chinese medicine for treating pathologic jaundice of neonate and preparation method thereof |
| CN103990081B (en) * | 2014-06-17 | 2015-05-06 | 陈红 | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating infant jaundice |
| CN104623018A (en) * | 2015-01-14 | 2015-05-20 | 南宁市第一人民医院 | Novel traditional Chinese medicine lotion for removing jaundice of newborn and preparation method of novel traditional Chinese medicine lotion |
| CN104971110A (en) * | 2015-06-30 | 2015-10-14 | 谭清平 | Chinese herbal capsule used for treating neonatal jaundice |
| CN104984303A (en) * | 2015-07-31 | 2015-10-21 | 山东省立医院 | Traditional Chinese medicine composite for treating child jaundice |
| CN106902331A (en) * | 2015-12-18 | 2017-06-30 | 王文学 | A kind of medicine for treating icterus neonatorum |
| CN105477547A (en) * | 2015-12-18 | 2016-04-13 | 张秀丽 | Traditional Chinese medicine for treating cholestatic jaundice of babies |
| CN105944032B (en) * | 2016-06-27 | 2020-09-08 | 上海长海医院 | Traditional Chinese medicine composition for treating intrahepatic cholestatic jaundice diseases and application thereof |
| CN107715056A (en) * | 2017-10-25 | 2018-02-23 | 邱林 | A kind of Chinese medicine for treating infantile jaundice |
| CN107837373A (en) * | 2017-12-22 | 2018-03-27 | 苏州斯尔斯特新材料科技有限公司 | A kind of medicine for treating jaundice and preparation method thereof |
| CN109550030A (en) * | 2019-01-18 | 2019-04-02 | 河南中医药大学 | A kind of dipping Chinese medicine for preventing and treating icterus neonatorum |
| CN109925472A (en) * | 2019-03-21 | 2019-06-25 | 南宁市第一人民医院 | Novel neonate removing jaundice Chinese medicinal lotion and preparation method thereof |
| CN111358903A (en) * | 2020-05-09 | 2020-07-03 | 吕桂霞 | Medicinal powder for treating jaundice and preparation method thereof |
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| CN1575808A (en) * | 2003-07-29 | 2005-02-09 | 金宇 | Medicine for treating hepatitis B and hepatic ascites and preparation and using method thereof |
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|---|---|---|---|---|
| CN1575808A (en) * | 2003-07-29 | 2005-02-09 | 金宇 | Medicine for treating hepatitis B and hepatic ascites and preparation and using method thereof |
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