CN113336975A - 一种溶解聚羟基脂肪酸酯的方法 - Google Patents

一种溶解聚羟基脂肪酸酯的方法 Download PDF

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CN113336975A
CN113336975A CN202110703301.0A CN202110703301A CN113336975A CN 113336975 A CN113336975 A CN 113336975A CN 202110703301 A CN202110703301 A CN 202110703301A CN 113336975 A CN113336975 A CN 113336975A
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polyhydroxyalkanoate
methanesulfonic acid
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dissolving
room temperature
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CN113336975B (zh
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康世民
梁建豪
庞翊淇
刘越钊
陈素霞
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Dongying Huazhi New Chemical Material Co ltd
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Dongguan University of Technology
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Abstract

本发明提供了一种溶解聚羟基脂肪酸酯的方法，包括如下步骤：将含有聚羟基脂肪酸酯和甲磺酸溶剂置于反应容器中，在室温至50℃条件下搅拌或者漩涡振荡混合10‑60min，聚羟基脂肪酸酯完全溶解到甲磺酸溶剂中。本发明提供的方法以低挥发溶剂甲磺酸来溶解聚羟基脂肪酸酯，在室温下（无加热）溶解度达到1g/5 mL（或者200g/L)；而在加热达到50度后可以加速溶解，溶解度最高达到1g/2 mL（或者500g/L)。

Description

一种溶解聚羟基脂肪酸酯的方法
技术领域
本发明涉及聚羟基脂肪酸酯溶解领域，具体涉及一种溶解聚羟基脂肪酸酯的方法。
背景技术
聚羟基脂肪酸酯(polyhydroxyalkanoates, PHA)是很多微生物合成的一种细胞内聚酯，是一种天然的高分子生物材料。由于聚羟基脂肪酸酯同时具有良好的生物相容性能、生物可降解性和塑料的热加工性能，所以它同时可作为生物医用材料和生物可降解包装材料。此外，聚羟基脂肪酸酯还具有非线性光学性、压电性、气体相隔性很多高附加值性能。因此，聚羟基脂肪酸酯具有广阔的应用前景。
由于聚羟基脂肪酸酯的结晶度非常高，因此聚羟基脂肪酸酯在常规溶剂中的溶解度非常低。通常情况下，氯仿和二氯甲烷被认为是聚羟基脂肪酸酯比较好的溶剂，但在常温条件下，聚羟基脂肪酸酯在氯仿中的溶解度只有约40-50 g/L，在二氯甲烷中溶解度约为35-45 g/L。工业上常用有机溶剂萃取法（利用聚羟基脂肪酸酯溶解在有机溶剂中而将它从细菌细胞中萃取分离出来）实现聚羟基脂肪酸酯的分离提纯。但是，由于聚羟基脂肪酸酯在氯仿、二氯甲烷等溶剂中的低溶解度，导致分离过程中所需溶剂量巨大，导致成本非常高。此外，氯仿、二氯甲烷等溶剂具有沸点低、易挥发、有毒的缺点，操作过程容易造成大量溶剂损失，并具有环境污染风险。另一方面，在聚羟基脂肪酸酯制备降解材料或者精细化学品过程中，聚羟基脂肪酸酯的高浓度溶解也非常重要。因此，开发一种低挥发溶剂实现聚羟基脂肪酸酯的高效溶解具有重要意义。
发明内容
本发明提出了一种溶解聚羟基脂肪酸酯的方法，克服了现有机溶剂对聚羟基脂肪酸酯溶解度低、沸点低、易挥发易损失等的缺点，开发以低挥发溶剂甲磺酸来高效溶解聚羟基脂肪酸酯。
实现本发明的技术方案是：
一种溶解聚羟基脂肪酸酯的方法，包括如下步骤：将含有聚羟基脂肪酸酯和甲磺酸溶剂置于反应容器中，在室温至50℃条件下搅拌或者漩涡振荡混合10-60min，聚羟基脂肪酸酯完全溶解到甲磺酸溶剂中。
优选地，所述萃取提纯的温度为室温至50℃。温度升高有利于加快溶解，但温度过高（如>60度）增加了溶解能耗。
优选地，聚羟基脂肪酸酯和甲磺酸溶剂的质量体积比为1：（2-15），g/ mL。
本发明的有益效果是：本发明提供的方法以低挥发溶剂甲磺酸来溶解聚羟基脂肪酸酯，在室温下（无加热）溶解度达到1g/5 mL（或者200g/L)；而在加热达到50度后可以加速溶解，溶解度最高达到1g/2 mL（或者500g/L)。与之对比的，常用的氯仿溶剂在室温条件下聚羟基脂肪酸酯溶解度只有40-50 g/L。因此，与常规氯仿溶剂相比，甲磺酸溶剂可使聚羟基脂肪酸酯的溶剂度明显提高，且整个过程没有易挥发、有毒气体产生。本发明提供一个简单方便工艺实现聚羟基脂肪酸酯的高浓度溶解，具有工业化应用前景。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1为0.2 g聚羟基脂肪酸酯溶解于3 mL甲磺酸溶剂。
图2为0.2 g聚羟基脂肪酸酯溶解于2 mL甲磺酸溶剂。
图3为0.2 g聚羟基脂肪酸酯1 mL甲磺酸溶剂。
图4为0.2 g聚羟基脂肪酸酯溶解于0.4 mL甲磺酸溶剂。
具体实施方式
下面将结合本发明实施例，对本发明的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有付出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
一种溶解聚羟基脂肪酸酯的方法，所述方法如下：
取0.2 g聚羟基脂肪酸酯和3 mL甲磺酸溶剂放入10 mL试管中。试管在室温下漩涡振荡混合器中混合25分钟，聚羟基脂肪酸酯溶解，得倒淡黄色透明溶液（见图1）。
实施例2
取0.2 g聚羟基脂肪酸酯和2 mL甲磺酸溶剂放入10mL试管中。试管在室温下漩涡振荡混合器中混合40分钟，聚羟基脂肪酸酯溶解，得倒淡黄色透明溶液（见图2）。
实施例3
取0.2 g聚羟基脂肪酸酯和1 mL甲磺酸溶剂放入10 mL试管中。试管在室温下漩涡振荡混合器中混合60分钟，聚羟基脂肪酸酯溶解，得倒淡黄色透明溶液（见图3）。
实施例4
取0.2 g聚羟基脂肪酸酯和0.4 mL甲磺酸溶剂放入10 mL试管中。试管在漩涡振荡混合器中混合10分钟，然后试管放入50度的反应器中加热10分钟中，聚羟基脂肪酸酯溶解，冷却至室温后得倒黄色透明溶液（见图4）。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (6)

1.一种溶解聚羟基脂肪酸酯的方法，其特征在于：以甲磺酸为溶剂溶解聚羟基脂肪酸酯。
2.根据权利要求1所述的方法，其特征在于：将聚羟基脂肪酸酯和甲磺酸置于反应容器中，在室温条件下搅拌或者漩涡振荡混合，聚羟基脂肪酸酯完全溶解到甲磺酸溶剂中。
3.根据权利要求2所述的方法，其特征在于：所述将聚羟基脂肪酸酯和甲磺酸置于反应容器中，在室温到50℃下搅拌或者漩涡振荡混合10-60min。
4.根据权利要求1-3任一项所述的方法，其特征在于：所述聚羟基脂肪酸酯和甲磺酸的质量体积比为1：（2-15），g/mL。
5.根据权利要求4所述的方法，其特征在于：所述聚羟基脂肪酸酯在室温下溶解度达到200g/L。
6.根据权利要求4所述的方法，其特征在于：所述聚羟基脂肪酸酯在50℃下溶解度达到500g/L。
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19712702A1 (de) * 1997-03-26 1998-10-01 Buna Sow Leuna Olefinverb Gmbh Verfahren zur Gewinnung von Polyhydroxyalkanoaten
WO2006103699A1 (en) * 2005-03-31 2006-10-05 Council Of Scientific & Industrial Research A process for the extraction of polyhydroxyalkanoates from bacteria
WO2010000719A1 (de) * 2008-07-02 2010-01-07 Basf Se Verfahren zur isolierung von polyhydroxyalkanoaten
CN105028398A (zh) * 2015-07-09 2015-11-11 江苏擎宇化工科技有限公司 一种聚羟基脂肪酸酯接枝有机多胺分散剂的应用及其制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19712702A1 (de) * 1997-03-26 1998-10-01 Buna Sow Leuna Olefinverb Gmbh Verfahren zur Gewinnung von Polyhydroxyalkanoaten
WO2006103699A1 (en) * 2005-03-31 2006-10-05 Council Of Scientific & Industrial Research A process for the extraction of polyhydroxyalkanoates from bacteria
WO2010000719A1 (de) * 2008-07-02 2010-01-07 Basf Se Verfahren zur isolierung von polyhydroxyalkanoaten
CN102083885A (zh) * 2008-07-02 2011-06-01 巴斯夫欧洲公司 分离聚羟基链烷酸酯的方法
CN105028398A (zh) * 2015-07-09 2015-11-11 江苏擎宇化工科技有限公司 一种聚羟基脂肪酸酯接枝有机多胺分散剂的应用及其制备方法

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