CN113332180A - Composition rich in zeaxanthin and almond oil and application thereof - Google Patents
Composition rich in zeaxanthin and almond oil and application thereof Download PDFInfo
- Publication number
- CN113332180A CN113332180A CN202110522818.XA CN202110522818A CN113332180A CN 113332180 A CN113332180 A CN 113332180A CN 202110522818 A CN202110522818 A CN 202110522818A CN 113332180 A CN113332180 A CN 113332180A
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- Prior art keywords
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- zeaxanthin
- composition
- almond oil
- skin
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- Pending
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Classifications
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- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention relates to a composition rich in zeaxanthin and almond oil and application thereof, wherein the composition comprises the following components: 65-95 parts of almond oil, 2-15 parts of zeaxanthin, 1-8 parts of lutein, 1-8 parts of lycopene, 0.5-5 parts of tocopherol and 0.2-1 part of natural flower essential oil. The composition provided by the invention has the advantages of good color, fineness, moistening and stable effect, is natural, non-irritant and mild to the skin, can provide nutrients absorbed by the skin, reduces the water loss of the skin, eliminates skin surface inflammation, accelerates skin cell regeneration, has more remarkable blue light resistance, oxidation resistance and other effects than single components, and effectively improves the skin problem.
Description
Technical Field
The invention relates to the technical field of almond oil production, in particular to a composition rich in zeaxanthin and almond oil and application thereof.
Background
With the coming of the digital era, electronic products gradually permeate into the lives of people, mobile phones, computers and the like become necessities for life, but the electronic products bring convenience and bring a substance of 'blue light'. Blue light is light with higher energy at a wavelength between 400nm and 480nm, is part of a visible spectrum, and has stronger penetrating power than ultraviolet rays. The combination of short-wave blue light and yellow luminous bodies enables an LED (light emitting diode) to generate white light, the use frequency of the LED is exponentially increased in recent years, and the LED is increasingly applied to the fields of low-energy bulbs, computers, mobile phones and the like, so that the time of receiving blue light irradiation by people is greatly prolonged. Blue light can penetrate the dermis of the skin and has phototoxicity, so that the fiber cells in the dermis are damaged, the extracellular matrix is reduced, and the skin is aged prematurely. The skin can generate oxidative stress after receiving blue light irradiation, and high-activity oxygen free radicals are generated in mitochondria to cause oxidative damage of cells; blue light also causes a decrease in skin cell activity to reduce the self-healing power of the skin, and inhibits the secretion of melatonin, resulting in insomnia.
Zeaxanthin is used as a fat-soluble carotenoid, the absorption spectrum of the zeaxanthin is between 446-450nm, the zeaxanthin can absorb blue light and has the effect of resisting blue light damage, and the carotenoid of the same kind, such as lutein, can also absorb blue light and has the synergistic effect of zeaxanthin to resist blue light. Meanwhile, the zeaxanthin also has strong antioxidation, 11 conjugated double bonds are arranged in a molecular structure, and a hydroxyl group is arranged at the tail end, so that the structure determines the antioxidation activity of the zeaxanthin, and the singlet oxygen is quenched to protect a photosensitive cell layer caused by active oxygen from being damaged by light. However, the double bond structure makes the chemical property of the product very unstable, and the degradation or isomerization of the zeaxanthin is easily caused by illumination, oxygen, temperature and the like, so that the product produced by taking the zeaxanthin as the raw material has fewer varieties, and the property of insolubility in water also limits the application of the product. The almond oil is the most mild accepted vegetable oil, contains rich substances such as unsaturated fatty acid, mineral substances, protein, vitamin and the like, has high vitamin E content, and can effectively resist free radicals, inhibit the generation of lipid peroxide and remove chloasma. The almond oil can provide nutrient substances absorbed by the skin, can reduce the water loss of the skin, nourish the skin, eliminate skin surface inflammation and accelerate the regeneration of skin cells, and is a good skin protection humectant. However, unsaturated fatty acid components are easily oxidized, which is also a main cause of short shelf life of the grease.
Zeaxanthin is used as a substance with a remarkable blue light resistance effect, is usually prepared into a sealing substance such as a capsule due to the unstable property of the zeaxanthin, and the zeaxanthin is cooperated with lutein to act on the macular degeneration of the eyes, and the zeaxanthin is usually used as a main effective component, and functional components are taken to reach the retina or other tissues through the blood circulation of a human body to exert the effect, so that the needed time is long, the zeaxanthin is low in dosage, certain loss is generated through the circulation, the dosage reaching the action site is less, and the zeaxanthin can effectively exert the effect only by being regularly taken for a long time. The oral carotenoid is not high in efficiency, the protective effect on skin can be effectively improved through external application, for example, a patent with application number 202010743429.5 discloses a repair skin cream with a blue light resisting function and a preparation method thereof, the blue light resisting auxiliary agent is prepared by compounding pretreated lutein and silanediol salicylate, and the obtained repair skin cream has a good blue light resisting effect. But the existing external blue-light resistant products taking zeaxanthin as a main component are few; the existing skin care oil mostly takes white oil as base oil, is not easy to be absorbed by skin, and most products achieve certain efficacy by adding chemical components, have irritation to skin, are not widely applicable to people, and consumers are more and more pursuing natural, green and natural products.
Disclosure of Invention
In order to solve the technical problems, the invention provides a composition rich in zeaxanthin and almond oil and application thereof. In order to solve the above-mentioned technical problems,
the technical scheme adopted by the invention is as follows:
a composition rich in zeaxanthin almond oil comprises the following raw materials in parts by weight: 65-95 parts of almond oil, 2-15 parts of zeaxanthin, 1-8 parts of lutein, 1-8 parts of lycopene, 0.5-5 parts of tocopherol and 0.2-1 part of natural flower essential oil.
Preferably, the composition further comprises the following raw materials in parts by weight: 85 parts of almond oil, 8 parts of zeaxanthin, 3 parts of lutein, 3 parts of lycopene, 2 parts of tocopherol and 0.5 part of natural flower essential oil.
The preparation method of the composition rich in the zeaxanthin almond oil comprises the following steps:
s1, mixing the raw materials according to the parts by weight;
s2, homogenizing by a homogenizer;
s3 filtering, packaging and sealing to obtain the composition.
Preferably, the step S2 is carried out at a homogenization temperature of 30-50 ℃, a homogenization speed of 8500-9500r/min and a homogenization time of 5-20 min.
Preferably, the homogenizing temperature of the step S2 is 40 ℃, the homogenizing speed is 9000r/min, and the homogenizing time is 15 min. The composition rich in the zeaxanthin and the almond oil or the composition rich in the zeaxanthin and the almond oil prepared by the method are applied to food, medicine or skin care products which can moisturize and moisten skin, resist blue light or resist oxidation.
The invention has the beneficial effects that:
according to the invention, the essential components extracted from plants are fully utilized, the light, thin and easily absorbed almond oil is used as base oil, and the zeaxanthin is used as an antioxidant and added into the almond oil, so that the storage stability of oil and fat can be improved, the antioxidant component in the composition can also play a role in protecting the zeaxanthin, the stability of the zeaxanthin is improved, the service life of the composition is prolonged, the action time of functional components can also be effectively prolonged, and the skin of the composition is protected for a long time; the composition has the advantages that the composition is synergistic to obtain the composition with stronger effects of moisturizing and moistening the skin, resisting blue light and resisting oxidation, the biological activity of the composition is efficiently utilized through external application, the cells are prevented from being damaged by free radicals, the skin is prevented from being damaged by blue light, meanwhile, the product is rich in nutrient components and high in safety, is mild, comfortable and non-irritating, can be used for supplying nutrient substances, simultaneously reduces the water loss of the skin, lightens fine wrinkles, keeps elasticity and has a good effect on skin care.
Detailed Description
To facilitate an understanding of the invention, exemplary embodiments of the invention are described below, and it is to be understood that the described embodiments are only a few, but not all, embodiments of the invention.
A composition rich in zeaxanthin and almond oil is mainly prepared from the following raw materials in parts by weight: 65-95 parts of almond oil, 2-15 parts of zeaxanthin, 1-8 parts of lutein, 1-8 parts of lycopene, 0.5-5 parts of tocopherol and 0.2-1 part of natural flower essential oil.
The almond oil is green mild vegetable oil extracted from almonds as raw materials, contains rich unsaturated fatty acid, protein, vitamin, mineral substances and the like, and the unsaturated fatty acid accounts for more than 90 percent of the total fatty acid, can adjust skin permeability, nourish and tenderize skin, accelerate skin cell regeneration and increase skin moisture; the vitamin E, the vitamin A, the protein, the mineral substance and other components can effectively relieve the skin pruritus phenomenon and eliminate the symptoms of redness, swelling, dryness and inflammation. The almond oil can restore the skin to be smooth and tender, is warm in nature, can be used by infants, can eliminate striae gravidarum after long-term use, can strengthen the oxygen carrying function of cells and eliminate carbonic acid accumulation by matching with massage, and has the effects of easing pain and relieving stimulation. In the invention, the almond oil accounts for 65-95 parts by weight, preferably 75-90 parts by weight, and more preferably 85 parts by weight.
Zeaxanthin is used as a fat-soluble carotenoid, the absorption peak value of the zeaxanthin is between 446-450nm, and the zeaxanthin can absorb blue light and has the effect of resisting blue light damage. The molecular structure of the zeaxanthin antioxidant compound has 11 conjugated double bonds and the tail end has a hydroxyl group, so that the structure determines the antioxidant activity of zeaxanthin and can protect a photoreceptor cell layer from light damage caused by active oxygen. The zeaxanthin can provide red, orange and other colors, can improve the storage stability of the vegetable oil, and the composition with the functions of moisturizing and moisturizing the skin, resisting blue light and resisting oxidation is obtained by combining the zeaxanthin and the almond oil and integrating the activity, so that the composition has a good effect on caring the skin. In the present invention, the zeaxanthin is 2 to 15 parts by weight, preferably 5 to 10 parts by weight, and more preferably 8 parts by weight.
The lutein and lycopene belong to carotenoids, and have synergistic effect with zeaxanthin in resisting blue light, and can increase color of the composition. In the present invention, the weight parts of lutein and lycopene are 1-8 parts, preferably 1-5 parts, and more preferably 3 parts.
The tocopherol has an excellent antioxidant effect, and in the present invention, the weight part of the tocopherol is 0.5 to 5 parts, preferably 1 to 3 parts, and more preferably 2 parts.
The natural flower essential oil is plant essential oil obtained by distilling and extracting plant flowers, has pleasant fragrance, has a certain conditioning effect, can increase the fragrance in the almond oil, and has a certain effect on relieving emotion. In the invention, the natural flower essence is rose essential oil, jasmine essential oil, gardenia essential oil or lavender essential oil, and the weight part of the natural flower essence is 0.2-1 part, preferably 0.3-0.8 part, and more preferably 0.5 part.
Example 1
A composition rich in zeaxanthin and almond oil comprises the following components: 70 parts of almond oil, 6 parts of zeaxanthin, 3 parts of lutein, 3 parts of lycopene, 1.5 parts of tocopherol and 0.3 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 20min at the temperature of 30 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Example 2
A composition rich in zeaxanthin and almond oil comprises the following components: 80 parts of almond oil, 8 parts of zeaxanthin, 4 parts of lutein, 4 parts of lycopene, 2 parts of tocopherol and 0.6 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 15min at the temperature of 40 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Example 3
A composition rich in zeaxanthin and almond oil comprises the following components: 90 parts of almond oil, 12 parts of zeaxanthin, 6 parts of lutein, 6 parts of lycopene, 2.5 parts of tocopherol and 0.8 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 20min at the temperature of 50 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Example 4
A composition rich in zeaxanthin and almond oil comprises the following components: 75 parts of almond oil, 8 parts of zeaxanthin, 4 parts of lutein, 4 parts of lycopene, 1 part of tocopherol and 0.3 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 15min at the temperature of 40 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Example 5
A composition rich in zeaxanthin and almond oil comprises the following components: 95 parts of almond oil, 15 parts of zeaxanthin, 8 parts of lutein, 8 parts of lycopene, 4 parts of tocopherol and 1 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 20min at the temperature of 40 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Example 6
A composition rich in zeaxanthin and almond oil comprises the following components: 85 parts of almond oil, 8 parts of zeaxanthin, 3 parts of lutein, 3 parts of lycopene, 2 parts of tocopherol and 0.5 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 15min at the temperature of 40 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Comparative example 1
A composition rich in zeaxanthin and almond oil comprises the following components: 85 parts of almond oil, 8 parts of zeaxanthin, 2 parts of tocopherol and 0.5 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 15min at the temperature of 40 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Comparative example 2
A composition rich in zeaxanthin and almond oil comprises the following components: 85 parts of almond oil, 3 parts of lutein, 3 parts of lycopene, 2 parts of tocopherol and 0.5 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 15min at the temperature of 40 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Comparative example 3
A composition rich in zeaxanthin and almond oil comprises the following components: 85 parts of almond oil, 2 parts of tocopherol and 0.5 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 15min at the temperature of 40 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Comparative example 4
The composition comprises the following components: 85 parts of white oil, 8 parts of zeaxanthin, 3 parts of lutein, 3 parts of lycopene, 2 parts of tocopherol and 0.5 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 15min at the temperature of 40 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Comparative example 5
The composition comprises the following components: 85 parts of wheat germ oil, 8 parts of zeaxanthin, 3 parts of lutein, 3 parts of lycopene, 2 parts of tocopherol and 0.5 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 15min at the temperature of 40 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Comparative example 6
The composition comprises the following components: 85 parts of peony seed oil, 8 parts of zeaxanthin, 3 parts of lutein, 3 parts of lycopene, 2 parts of tocopherol and 0.5 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 15min at the temperature of 40 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Comparative example 7
The composition comprises the following components: 85 parts of rose hip oil, 8 parts of zeaxanthin, 3 parts of lutein, 3 parts of lycopene, 2 parts of tocopherol and 0.5 part of natural flower essential oil.
The preparation method of the composition comprises the following steps: mixing the raw materials according to the parts by weight, stirring for 15min at the temperature of 40 ℃ by using a handheld homogenizer at the rotating speed of 9000r/min, uniformly blending, filtering, packaging and sealing to obtain the composition.
Example 7
Stability investigation under storage conditions such as light, temperature, humidity and the like is carried out on the composition rich in the zeaxanthin almond oil and pure almond oil without other substances, the peroxide value of oil and fat and the retention rate of the zeaxanthin during storage are respectively measured, the influence of the zeaxanthin on the storage stability of the composition is explored, and meanwhile, the composition is verified to have a certain effect on improving the stability of the zeaxanthin. The smaller the change of peroxide value and the change of zeaxanthin retention rate, the better the stability.
Measuring the absorbance of the composition at a wavelength of 446nm by sucking 1 μ l of the composition, and the blank is the composition without adding zeaxanthin; the control group is an absolute ethanol solution of zeaxanthin under the same storage conditions, and the blank is an absolute ethanol solution. Zeaxanthin retention was calculated as follows: retention rate (%) ═ At/A0×100
In the formula AtThe absorbance of the zeaxanthin at the storage time of t days; a. the0The absorbance of zeaxanthin before storage.
Light stability experiment: placing the same amount of the composition and pure almond oil in a brown wide-mouth bottle, and storing at room temperature in a dark place; equal amounts of the composition and pure almond oil were placed in a clear jar and stored under room temperature daylight and the peroxide value of the samples was determined by titration.
Temperature stability test: placing equal amount of the composition and pure almond oil in a brown wide-mouth bottle, respectively placing at room temperature and 60 deg.C in the dark, and measuring the peroxide value of the sample by titration method.
Air stability test: placing equal amount of the composition and pure almond oil in a brown wide-mouth bottle, respectively sealing at room temperature, placing in an open place in a dark place, and measuring the peroxide value of the sample by a titration method.
Humidity stability test: respectively preparing saturated potassium acetate and potassium chloride solutions, correspondingly setting the relative humidity to be 23% and 86%, placing the same amount of the composition and pure almond oil in a brown wide-mouth bottle, respectively placing the wide-mouth bottle and the pure almond oil in a closed container filled with the saturated solutions, keeping the wide-mouth bottle and the pure almond oil in the dark, and measuring the peroxide value of a sample by a titration method.
TABLE 1 light stability test results
TABLE 2 temperature stability test results
TABLE 3 air stability test results
Table 4 humidity stability test results
TABLE 5 zeaxanthin retention test results
As can be seen from tables 1 to 5, the oxidation degree of the composition is lower than that of the composition in the comparative example and pure almond oil under the same storage condition, because zeaxanthin has conjugated unsaturated double bonds, can provide hydrogen atoms and electrons, has strong ability of absorbing free radicals, and can inhibit lipid peroxidation so as to delay oxidative deterioration of oil. Meanwhile, compared with other types of oil, the almond oil has stronger protection effect on the zeaxanthin, and the rich vitamin E, mineral substances, protein and other components can effectively inhibit the degradation or isomerization of the zeaxanthin, so that the bioactive action time of the composition is longer, and the skin is protected for a longer time. The results in the table also show that the composition needs to be stored in a cool and dry place in a sealing way when being used daily, so that the phenomenon that the service life is shortened due to accelerated oxidation of light, moisture and the like is avoided.
Example 8
The blue light irradiation can generate high-activity oxygen free radicals in mitochondria, the free radicals have strong electron-capturing capability, and when the free radicals are excessive, the high-activity oxygen free radicals can damage proteins, nucleic acids and biological membranes, damage normal cells and tissues of a human body, and accelerate aging and pigmentation. The invention detects the scavenging capacity of the composition on free radicals through DPPH free radical and ABTS free radical scavenging tests and verifies the antioxidant effect of the composition.
Preparing 10mg/ml composition solution with anhydrous ethanol, precisely sucking 2ml composition solution and 2ml 0.2mmol/L DPPH ethanol solution, mixing, reacting in dark for 30min, and measuring absorbance A at 517nm1(ii) a The blank test group uses 2ml ethanol solution to replace DPPH ethanol solution, other operations are not changed, and the obtained absorbance is A2(ii) a The control test group was prepared by replacing the composition solution with 2ml of distilled water, and the absorbance obtained was A3. The DPPH radical clearance rate of the sample is calculated according to the following formula: clearance (%) - (1- (A)1-A2)/A3]×100
Mixing 7mmol/L ABTS solution 5ml and 88 μ L potassium persulfate solution 2.6mmol/L, standing at room temperature in dark place for 15 hr, diluting with ultrapure water until the absorbance of the solution is 0.7 at 734nm wavelength to obtain ABTS+The solution. Preparing 10mg/ml composition solution with anhydrous ethanol, and sucking 2ml composition solution and 2ml ABTS+The solution was mixed well, reacted for 30min in the dark and the absorbance A was measured at 734nm1(ii) a Blank group 2ml ethanol solution instead of ABTS+Solution, unchanged from the other operations, absorbance obtained is A2(ii) a Comparison testThe test group uses 2ml of distilled water to replace the composition solution, other operations are not changed, and the obtained absorbance is A3. The clearance of the sample to ABTS free radicals is calculated according to the following formula: clearance (%) - (1- (A)1-A2)/A3]×100
TABLE 6 table of verification results of antioxidant efficacy of zeaxanthin-rich almond oil compositions
Group of | DPPH radical scavenging ratio (%) | ABTS radical scavenging ratio (%) |
Example 4 | 87.83 | 91.45 |
Example 5 | 91.45 | 95.66 |
Example 6 | 88.72 | 91.89 |
Comparative example 1 | 74.35 | 78.26 |
Comparative example 2 | 60.88 | 62.65 |
Comparative example3 | 52.34 | 55.01 |
Comparative example 4 | 55.22 | 57.36 |
As can be seen from table 6, the compositions rich in zeaxanthin and almond oil have stronger scavenging ability for free radicals, but free radical scavenging rates of the compositions without zeaxanthin such as comparative examples 2 and 3 and without almond oil such as comparative example 4 are inferior to those of the compositions, indicating that the compositions can be synergistic, have better antioxidant effect, and can resist oxidative damage caused by blue light.
Example 9
Human dermal fibroblasts in good logarithmic growth phase state are cultured at a density of about 5X 103One cell/well is inoculated in a 96-well culture plate, a flat-bottom disinfection plate dissolved in the dimethyl sulfoxide solution of the composition is covered on a cell microplate, LED (476nm, 1900lux) blue light is used for irradiating for 8 hours above a culture dish at a distance of 30cm, a blank control group is cells which are not exposed to the blue light under the same condition, and CellTiter96 is used for detecting the cell survival rate to verify the blue light resistance effect of the composition. Cell viability (%) - (experimental well absorbance/control well absorbance x 100
TABLE 7 table of blue light resistance efficacy verification results for zeaxanthin-rich almond oil compositions
Group of | Human dermal fiber cell survival (%) |
Example 4 | 90.54 |
Example 5 | 95.23 |
Example 6 | 91.74 |
Comparative example 1 | 70.91 |
Comparative example 2 | 64.32 |
Comparative example 3 | 37.64 |
Comparative example 4 | 44.70 |
From table 7, it can be seen that the composition of the present invention has a protective effect on cells under blue light irradiation, and the protective effect of the single functional component on the cells is inferior to that of the composition, which indicates that the composition synergistically enhances the skin's resistance to blue light.
Example 10
30 SD rats are taken and depilated at the front edge of the spinal column for 24h in an experiment, the depilated area of the back skin at the left side and the right side is 3cm multiplied by 5cm, the left side and the right side form a control by themselves, the compositions of the embodiment 6, the comparative example 1, the comparative example 2 and the comparative example 3 are respectively coated on the sample area with the same dosage 1h before irradiation, and the sterile water with the same amount is coated on the blank control area. An LED lamp is hung 30cm above the skin of the unhairing area of the rat for blue light irradiation, the irradiation is carried out for 6 hours every day for 4 weeks, and the skin state of the unhairing area of the rat is observed.
TABLE 8 evaluation of skin condition of dehaired area of rat
The skin state of a skin-removed area of a rat can show the damage effect of blue light on the skin more intuitively, and it can be known from table 8 that a blank group without the composition is obviously aged by light, such as rough skin, loss of gloss and elasticity and the like, the composition has a certain protective effect on the skin and obviously improves the light aging phenomenon caused by the blue light, the protective effect of the composition on the skin is obvious compared with the protective effect of single functional components, and the skin of the skin-removed area is not red and swollen, red spots and the like, so that the safety of the composition is shown.
Claims (6)
1. A composition rich in zeaxanthin almond oil is characterized in that: the composition comprises the following raw materials in parts by weight: 65-95 parts of almond oil, 2-15 parts of zeaxanthin, 1-8 parts of lutein, 1-8 parts of lycopene, 0.5-5 parts of tocopherol and 0.2-1 part of natural flower essential oil.
2. The zeaxanthin-enriched almond oil composition of claim 1, wherein: the composition comprises the following raw materials in parts by weight: 85 parts of almond oil, 8 parts of zeaxanthin, 3 parts of lutein, 3 parts of lycopene, 2 parts of tocopherol and 0.5 part of natural flower essential oil.
3. A process for the preparation of a zeaxanthin-enriched almond oil composition according to claim 1 or 2, characterized in that it comprises the steps of:
s1, mixing the raw materials according to the parts by weight;
s2 homogenizing by a homogenizer;
s3 filtering, packaging and sealing to obtain the composition.
4. The zeaxanthin-enriched almond oil composition of claim 1, wherein: the step S2 is carried out at a homogenizing temperature of 30-50 ℃, a homogenizing speed of 8500-9500r/min and a homogenizing time of 5-20 min.
5. The zeaxanthin-enriched almond oil composition of claim 1, wherein: the homogenizing temperature of the step S2 is 40 ℃, the homogenizing speed is 9000r/min, and the homogenizing time is 15 min.
6. Use of a composition enriched in zeaxanthin almond oil as defined in any one of claims 1 to 2 or prepared by a process as defined in any one of claims 3 to 5 in a food or pharmaceutical or skin care product which moisturizes the skin, resists blue light or resists oxidation.
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CN108142585A (en) * | 2017-12-18 | 2018-06-12 | 江丽瑜 | Functional edible oil with protective effect on cancer risk and preparation method thereof |
CN110403857A (en) * | 2018-04-26 | 2019-11-05 | 王勤华 | A kind of soothing oil |
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