CN113272427A - 免疫细胞的多重基因组编辑以增强功能性和对抑制环境的抵抗力 - Google Patents
免疫细胞的多重基因组编辑以增强功能性和对抑制环境的抵抗力 Download PDFInfo
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| WO2023081900A1 (en) * | 2021-11-08 | 2023-05-11 | Juno Therapeutics, Inc. | Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods |
| EP4433067A2 (en) * | 2021-11-17 | 2024-09-25 | The Regents Of The University Of California | Gene targets for t-cell-based immunotherapy to overcome suppressive factors |
| WO2023215278A1 (en) * | 2022-05-03 | 2023-11-09 | The Broad Institute, Inc. | Modified immune cells and methods for use thereof |
| WO2024076750A2 (en) * | 2022-10-07 | 2024-04-11 | Whitehead Institute For Biomedical Research | Engineered macrophages for use in treating cancer |
| EP4353741A1 (en) * | 2022-10-14 | 2024-04-17 | ONK Therapeutics Limited | Double knockout natural killer cells |
| JP2025536042A (ja) * | 2022-11-10 | 2025-10-30 | オーエヌケイ セラピューティクス リミテッド | 免疫調節薬を用いた併用療法 |
| CN115948341B (zh) * | 2022-11-28 | 2025-05-16 | 上海恩凯细胞技术有限公司 | 敲低nkg2a基因的car-免疫细胞及其用途 |
| US12257304B2 (en) | 2023-03-03 | 2025-03-25 | Arsenal Biosciences, Inc. | Systems targeting PSMA and CA9 |
| CN116590237B (zh) * | 2023-05-29 | 2023-10-31 | 上海贝斯昂科生物科技有限公司 | 一种遗传修饰的自然杀伤细胞及其制备和用途 |
| WO2025035310A1 (zh) * | 2023-08-11 | 2025-02-20 | 香港北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140120622A1 (en) * | 2012-10-10 | 2014-05-01 | Sangamo Biosciences, Inc. | T cell modifying compounds and uses thereof |
| CN105378067A (zh) * | 2013-05-13 | 2016-03-02 | 塞勒克提斯公司 | 工程化用于免疫治疗的高活性t细胞的方法 |
| US20180273903A1 (en) * | 2016-12-30 | 2018-09-27 | Celularity, Inc. | Genetically modified natural killer cells |
Family Cites Families (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US4870287A (en) | 1988-03-03 | 1989-09-26 | Loma Linda University Medical Center | Multi-station proton beam therapy system |
| US5851795A (en) | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
| US6416998B1 (en) | 1992-09-02 | 2002-07-09 | Baylor College Of Medicine | Plasmid encoding a modified steroid hormone |
| US5846945A (en) | 1993-02-16 | 1998-12-08 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| AU7326594A (en) | 1993-07-09 | 1995-02-06 | Synergen, Inc. | Recombinant ctla4 polypeptides and methods for making the same |
| GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| PT814838E (pt) | 1995-03-08 | 2003-09-30 | Scripps Research Inst | Sistema de apresentacao de antigenio e activacao de celulas t |
| US5763270A (en) | 1995-06-07 | 1998-06-09 | Genemedicine, Inc. | Plasmid for delivery of nucleic acids to cells and methods of use |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| WO1997034634A1 (en) | 1996-03-20 | 1997-09-25 | Sloan-Kettering Institute For Cancer Research | Single chain fv constructs of anti-ganglioside gd2 antibodies |
| US5760395A (en) | 1996-04-18 | 1998-06-02 | Universities Research Assoc., Inc. | Method and apparatus for laser-controlled proton beam radiology |
| DE69737070T2 (de) | 1996-05-23 | 2007-06-21 | The Scripps Research Institute, La Jolla | Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten |
| US5739169A (en) | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
| US5844905A (en) | 1996-07-09 | 1998-12-01 | International Business Machines Corporation | Extensions to distributed MAC protocols with collision avoidance using RTS/CTS exchange |
| WO1998042752A1 (en) | 1997-03-21 | 1998-10-01 | Brigham And Women's Hospital Inc. | Immunotherapeutic ctla-4 binding peptides |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| PT1584685E (pt) | 1998-02-05 | 2011-06-17 | Glaxosmithkline Biolog Sa | Derivados de antigénios associados a tumores da família mage, utilizados para a preparação de proteínas de fusão com epítopos auxiliares t e de composições para vacinação |
| WO2000014257A1 (en) | 1998-09-04 | 2000-03-16 | Sloan-Kettering Institute For Cancer Research | Fusion receptors specific for prostate-specific membrane antigen and uses thereof |
| US6410319B1 (en) | 1998-10-20 | 2002-06-25 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| SG143018A1 (en) | 1998-12-23 | 2008-06-27 | Pfizer | Human monoclonal antibodies to ctla-4 |
| US6790662B1 (en) | 1999-03-12 | 2004-09-14 | Ortho-Mcneil Pharmaceutical, Inc. | Method of isolating CD8+ cells, and related hybridoma cells antibodies and polypeptides |
| TR200103018T2 (tr) | 1999-04-19 | 2002-02-21 | Beecham Biologicals S.A. Smithkline | İmmünostimülatör oligonükleotid ve saponin içeren katkı bileşikleri. |
| EP1212422B1 (en) | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| AU2001265346A1 (en) | 2000-06-02 | 2001-12-17 | Memorial Sloan-Kettering Cancer Center | Artificial antigen presenting cells and methods of use thereof |
| JP5312721B2 (ja) | 2000-11-07 | 2013-10-09 | シティ・オブ・ホープ | Ｃｄ１９特異的再指向免疫細胞 |
| US20040071671A1 (en) | 2001-02-20 | 2004-04-15 | Leturcq Didier J. | Cell therapy method for the treatment of tumors |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| AU2003263653A1 (en) | 2002-09-27 | 2004-04-19 | Daewoong Co., Ltd. | A vaccine enhancing the protective immunity to hepatitis c virus using plasmid dna and recombinant adenovirus |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
| EP2216342B1 (en) | 2003-07-31 | 2015-04-22 | Immunomedics, Inc. | Anti-CD19 antibodies |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| GB2432835B (en) | 2004-09-08 | 2009-04-08 | Wisconsin Alumni Res Found | Culturing human embryonic stem cells |
| EP2439273B1 (en) | 2005-05-09 | 2019-02-27 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
| EP3147296A1 (en) | 2005-11-14 | 2017-03-29 | Merial, Inc. | Gene therapy for renal failure |
| ZA200804673B (en) | 2005-12-13 | 2009-11-25 | Univ Kyoto | Nuclear reprogramming factor |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| JP2009531303A (ja) | 2006-03-01 | 2009-09-03 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | リンパ球枯渇剤をｃｔｌおよびサイトカインと組合せる癌処置 |
| KR20090060450A (ko) | 2006-10-04 | 2009-06-12 | 얀센 파마슈티카 엔.브이. | 불활성화 인공 항원 제시 세포의 제조 및 세포 치료법에서 이들의 용도 |
| WO2008118820A2 (en) | 2007-03-23 | 2008-10-02 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| DK2856876T3 (en) | 2007-03-30 | 2018-04-03 | Memorial Sloan Kettering Cancer Center | Constitutive expression of co-stimulatory ligands on adoptively transmitted T lymphocytes |
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| US8479118B2 (en) | 2007-12-10 | 2013-07-02 | Microsoft Corporation | Switching search providers within a browser search box |
| RU2531758C2 (ru) | 2008-02-11 | 2014-10-27 | Куретек Лтд. | Моноклональные антитела для лечения опухолей |
| US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| JP5173594B2 (ja) | 2008-05-27 | 2013-04-03 | キヤノン株式会社 | 管理装置、画像形成装置及びそれらの処理方法 |
| EP3279314A1 (en) | 2008-06-04 | 2018-02-07 | Cellular Dynamics International, Inc. | Methods for the production of ips cells using non-viral approach |
| US8119129B2 (en) | 2008-08-01 | 2012-02-21 | Bristol-Myers Squibb Company | Combination of anti-CTLA4 antibody with dasatinib for the treatment of proliferative diseases |
| CN107988261A (zh) | 2008-08-12 | 2018-05-04 | 细胞动力国际有限公司 | 产生ips细胞的方法 |
| MX2011002250A (es) | 2008-08-25 | 2011-08-17 | Amplimmune Inc | Antagonistas de muerte celular programada-1 y métodos de uso de los mismos. |
| CA2741090C (en) | 2008-10-24 | 2018-10-16 | Wisconsin Alumni Research Foundation | Pluripotent stem cells obtained by non-viral reprogramming |
| KR101813464B1 (ko) | 2009-06-05 | 2018-01-30 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | Ｔ 세포 및 조혈 세포의 재프로그래밍 |
| AU2010279913B2 (en) | 2009-08-07 | 2016-04-28 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| US8889394B2 (en) | 2009-09-07 | 2014-11-18 | Empire Technology Development Llc | Multiple domain proteins |
| WO2011056971A2 (en) | 2009-11-04 | 2011-05-12 | Cellular Dynamics International, Inc. | Episomal reprogramming with chemicals |
| JP2013512251A (ja) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Ｐｄ−ｌ１／ｐｄ−ｌ２の同時阻害 |
| WO2011090221A1 (en) | 2010-01-22 | 2011-07-28 | Kyoto University | Method for improving induced pluripotent stem cell generation efficiency |
| LT3053932T (lt) | 2010-02-19 | 2020-11-10 | Xencor, Inc. | Nauji ctla4-ig imunoadhezinai |
| JP6208580B2 (ja) | 2010-05-17 | 2017-10-04 | サンガモ セラピューティクス， インコーポレイテッド | 新規のｄｎａ結合タンパク質及びその使用 |
| CA2802249A1 (en) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| NZ743310A (en) | 2011-03-23 | 2022-11-25 | Fred Hutchinson Cancer Center | Method and compositions for cellular immunotherapy |
| US8398282B2 (en) | 2011-05-12 | 2013-03-19 | Delphi Technologies, Inc. | Vehicle front lighting assembly and systems having a variable tint electrowetting element |
| JP6368243B2 (ja) | 2011-11-11 | 2018-08-08 | フレッド ハッチンソン キャンサー リサーチ センター | がんのためのサイクリンａ１に標的化されたｔ細胞免疫療法 |
| EP2814846B1 (en) | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
| JP6251734B2 (ja) | 2012-05-03 | 2017-12-27 | フレッド ハッチンソン キャンサー リサーチ センター | 親和性増強型ｔ細胞受容体およびその作製方法 |
| HUE064187T2 (hu) | 2012-05-25 | 2024-02-28 | Cellectis | Eljárás immunterápiára alkalmas allogén és immunszupresszív-rezisztens T-sejt módosítására |
| JP2014022858A (ja) | 2012-07-17 | 2014-02-03 | Murata Mfg Co Ltd | 電力増幅器 |
| IL293944A (en) | 2012-08-20 | 2022-08-01 | Hutchinson Fred Cancer Res | Method and preparations for cellular immunotherapy |
| CN104853766A (zh) | 2012-10-02 | 2015-08-19 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
| US9308236B2 (en) | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| CN105682683A (zh) | 2013-08-02 | 2016-06-15 | 阿杜罗生物科技控股有限公司 | 结合cd27激动剂以及免疫检查点抑制以用于免疫刺激 |
| PT3702373T (pt) | 2013-09-13 | 2022-09-27 | Beigene Switzerland Gmbh | Anticorpos anti-pd1 e a sua utilização como agentes terapêuticos e de diagnóstico |
| EP4043556B1 (en) | 2015-06-30 | 2024-02-07 | Cellectis | Methods for improving functionality in nk cell by gene inactivation using specific endonuclease |
| JP6974681B2 (ja) | 2015-07-29 | 2021-12-01 | オーエヌケー セラピューティクス リミテッド | 細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株 |
| IL257105B (en) * | 2015-07-31 | 2022-09-01 | Univ Minnesota | Modified cells and methods of therapy |
| JP2019505498A (ja) | 2015-12-16 | 2019-02-28 | ザ・ウォルター・アンド・エリザ・ホール・インスティテュート・オブ・メディカル・リサーチ | Ｎｋ細胞におけるサイトカイン誘導性ｓｈ２タンパク質の阻害 |
| AU2017341736B2 (en) | 2016-10-12 | 2022-09-08 | Feldan Bio Inc. | Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same |
| WO2018115189A1 (en) * | 2016-12-21 | 2018-06-28 | Cellectis | Stably enginereed proteasome inhibitor resistant immune cells for immunotherapy |
| WO2019106163A1 (en) * | 2017-12-01 | 2019-06-06 | Cellectis | Reprogramming of genetically engineered primary immune cells |
-
2019
- 2019-11-27 BR BR112021010297-3A patent/BR112021010297A2/pt unknown
- 2019-11-27 EA EA202191463A patent/EA202191463A1/ru unknown
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- 2019-11-27 MX MX2021006208A patent/MX2021006208A/es unknown
- 2019-11-27 EP EP19827952.3A patent/EP3887518A2/en active Pending
- 2019-11-27 CN CN201980088334.XA patent/CN113272427A/zh active Pending
- 2019-11-27 WO PCT/US2019/063641 patent/WO2020113029A2/en not_active Ceased
- 2019-11-27 JP JP2021530101A patent/JP7672702B2/ja active Active
- 2019-11-27 US US17/309,408 patent/US20220031749A1/en active Pending
- 2019-11-27 AU AU2019386140A patent/AU2019386140A1/en active Pending
-
2021
- 2021-05-25 IL IL283428A patent/IL283428A/en unknown
-
2024
- 2024-07-31 JP JP2024124210A patent/JP2024153823A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140120622A1 (en) * | 2012-10-10 | 2014-05-01 | Sangamo Biosciences, Inc. | T cell modifying compounds and uses thereof |
| CN105378067A (zh) * | 2013-05-13 | 2016-03-02 | 塞勒克提斯公司 | 工程化用于免疫治疗的高活性t细胞的方法 |
| US20180273903A1 (en) * | 2016-12-30 | 2018-09-27 | Celularity, Inc. | Genetically modified natural killer cells |
Non-Patent Citations (6)
| Title |
|---|
| ARABELLA YOUNG等: "A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment", CANCER RES, vol. 78, no. 4, pages 1003 - 1016 * |
| D. R. SHOOK等: "Natural killer cell engineering for cellular therapy of cancer", TISSUE ANTIGENS, vol. 78, no. 6, pages 409 - 415, XP055145407, DOI: 10.1111/j.1399-0039.2011.01796.x * |
| MIN JUNG KIM等: "Association of CD47 with Natural Killer Cell-Mediated Cytotoxicity of Head-and-Neck Squamous Cell Carcinoma Lines", TUMOR BIOLOGY, vol. 29, no. 1, pages 28 - 34, XP055347764, DOI: 10.1159/000132568 * |
| REBECCA B DELCONTE等: "CIS is a potent checkpoint in NK cell–mediated tumor immunity", NATURE IMMUNOLOGY, vol. 17, pages 816 - 824, XP055769133, DOI: 10.1038/ni.3470 * |
| STEPHEN J. BLAKE 等: "Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy", CANCER DISCOV, vol. 6, no. 4, 3 April 2016 (2016-04-03), pages 446 - 459, XP055344484, DOI: 10.1158/2159-8290.CD-15-0944 * |
| ZHANG, Q.等: "Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity", NAT IMMUNOL, vol. 19, 18 June 2018 (2018-06-18), pages 723 - 732, XP036533618, DOI: 10.1038/s41590-018-0132-0 * |
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| IL283428A (en) | 2021-07-29 |
| SG11202105609RA (en) | 2021-06-29 |
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| EA202191463A1 (ru) | 2021-10-13 |
| JP2024153823A (ja) | 2024-10-29 |
| WO2020113029A2 (en) | 2020-06-04 |
| KR20210096638A (ko) | 2021-08-05 |
| BR112021010297A2 (pt) | 2021-08-24 |
| JP7672702B2 (ja) | 2025-05-08 |
| US20220031749A1 (en) | 2022-02-03 |
| AU2019386140A1 (en) | 2021-06-24 |
| EP3887518A2 (en) | 2021-10-06 |
| CA3121027A1 (en) | 2020-06-04 |
| MX2021006208A (es) | 2021-10-01 |
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