CN113260353A - 氟维司群药物组合物、其制备方法及应用 - Google Patents
氟维司群药物组合物、其制备方法及应用 Download PDFInfo
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- CN113260353A CN113260353A CN202080007455.XA CN202080007455A CN113260353A CN 113260353 A CN113260353 A CN 113260353A CN 202080007455 A CN202080007455 A CN 202080007455A CN 113260353 A CN113260353 A CN 113260353A
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Images
Classifications
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- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
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Abstract
氟维司群药物组合物、其制备方法及应用。所述氟维司群药物组合物包括氟维司群固体粒子,其中所述的氟维司群固体粒子的粒径为Dv(10)选自0.400微米~6.000微米、Dv(50)选自0.700微米~6.000微米且Dv(90)选自1.000微米~6.000微米,条件是:Dv(10)不为0.400微米、Dv(50)不为0.700微米并且Dv(90)不为1.000微米。氟维司群药物组合物长效缓释,施用方便,给药体积减小,注射疼痛度大大降低,市场化前景良好。
Description
PCT国内申请,说明书已公开。
Claims (10)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (5)
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CN2019112625444 | 2019-12-11 | ||
CN201911262544 | 2019-12-11 | ||
CN202010590154 | 2020-06-24 | ||
CN2020105901546 | 2020-06-24 | ||
PCT/CN2020/135311 WO2021115389A1 (zh) | 2019-12-11 | 2020-12-10 | 氟维司群药物组合物、其制备方法及应用 |
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US (1) | US20220370359A1 (zh) |
EP (1) | EP4074304A4 (zh) |
JP (1) | JP2023504867A (zh) |
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KR20230094172A (ko) * | 2021-12-20 | 2023-06-27 | 주식회사 삼양홀딩스 | 용해도가 개선된 풀베스트란트의 약학 조성물 및 그 제조 방법 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1553815A (zh) * | 2001-07-07 | 2004-12-08 | 用于肌内给药的氟维司群药物制剂 | |
CN109310621A (zh) * | 2016-05-06 | 2019-02-05 | 伊格尔制药公司 | 氟维司群制剂和其使用方法 |
WO2019094650A1 (en) * | 2017-11-08 | 2019-05-16 | Eagle Pharmaceuticals, Inc | Fulvestrant formulations and methods of their use |
Family Cites Families (4)
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GB0000313D0 (en) * | 2000-01-10 | 2000-03-01 | Astrazeneca Uk Ltd | Formulation |
EP2616078B1 (en) * | 2010-09-16 | 2019-12-25 | Shimoda Biotech (Pty) Ltd | Fulvestrant compositions and methods of use |
BR112014028376A2 (pt) * | 2012-06-08 | 2018-04-24 | Hoffmann La Roche | métodos para o tratamento de um distúrbio hiperproliferativo, para a determinação dos compostos, para monitorar, para optimizar a eficácia terapêutica e de identificação de um biomarcador; formulação farmacêutica; utilização de uma combinação terapêutica e de gdc-0032, artigo de manufatura, produto e invenção |
CN107789320B (zh) * | 2016-08-31 | 2021-06-22 | 鲁南制药集团股份有限公司 | 一种氟维司群缓释注射液及其制备工艺 |
-
2020
- 2020-12-10 JP JP2022534277A patent/JP2023504867A/ja active Pending
- 2020-12-10 EP EP20900538.8A patent/EP4074304A4/en active Pending
- 2020-12-10 CN CN202080007455.XA patent/CN113260353A/zh active Pending
- 2020-12-10 WO PCT/CN2020/135311 patent/WO2021115389A1/zh unknown
- 2020-12-10 US US17/757,245 patent/US20220370359A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1553815A (zh) * | 2001-07-07 | 2004-12-08 | 用于肌内给药的氟维司群药物制剂 | |
CN109310621A (zh) * | 2016-05-06 | 2019-02-05 | 伊格尔制药公司 | 氟维司群制剂和其使用方法 |
WO2019094650A1 (en) * | 2017-11-08 | 2019-05-16 | Eagle Pharmaceuticals, Inc | Fulvestrant formulations and methods of their use |
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JP2023504867A (ja) | 2023-02-07 |
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US20220370359A1 (en) | 2022-11-24 |
WO2021115389A1 (zh) | 2021-06-17 |
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