CN1132566C - 在胶囊中填充囊芯的方法和由该方法制得的固体剂型 - Google Patents
在胶囊中填充囊芯的方法和由该方法制得的固体剂型 Download PDFInfo
- Publication number
- CN1132566C CN1132566C CN95196811A CN95196811A CN1132566C CN 1132566 C CN1132566 C CN 1132566C CN 95196811 A CN95196811 A CN 95196811A CN 95196811 A CN95196811 A CN 95196811A CN 1132566 C CN1132566 C CN 1132566C
- Authority
- CN
- China
- Prior art keywords
- capsule
- dosage forms
- solid dosage
- core
- moisture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
Abstract
Description
Claims (52)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35813794A | 1994-12-16 | 1994-12-16 | |
US08/358,137 | 1994-12-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1170346A CN1170346A (zh) | 1998-01-14 |
CN1132566C true CN1132566C (zh) | 2003-12-31 |
Family
ID=23408454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN95196811A Expired - Lifetime CN1132566C (zh) | 1994-12-16 | 1995-11-09 | 在胶囊中填充囊芯的方法和由该方法制得的固体剂型 |
Country Status (14)
Country | Link |
---|---|
US (1) | US6080426A (zh) |
EP (1) | EP0797424B1 (zh) |
JP (1) | JP3670016B2 (zh) |
KR (1) | KR100468335B1 (zh) |
CN (1) | CN1132566C (zh) |
AT (1) | ATE194486T1 (zh) |
CA (1) | CA2205553C (zh) |
DE (1) | DE69518006T2 (zh) |
DK (1) | DK0797424T3 (zh) |
ES (1) | ES2150017T3 (zh) |
GR (1) | GR3034491T3 (zh) |
MX (1) | MX9703773A (zh) |
PT (1) | PT797424E (zh) |
WO (1) | WO1996018370A1 (zh) |
Families Citing this family (64)
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CA2205553C (en) * | 1994-12-16 | 2009-04-07 | Warner-Lambert Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
US6245350B1 (en) | 1994-12-16 | 2001-06-12 | Warner-Lambert Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
FR2757173A1 (fr) * | 1996-12-17 | 1998-06-19 | Warner Lambert Co | Compositions polymeres d'origine non-animale pour la formation de films |
US6428809B1 (en) * | 1999-08-18 | 2002-08-06 | Microdose Technologies, Inc. | Metering and packaging of controlled release medication |
US20030032675A1 (en) * | 2001-02-15 | 2003-02-13 | Franz G. Andrew | Manufacture of thyroid hormone tablets having consistent active moiety amounts |
US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
US7067148B2 (en) * | 2001-02-15 | 2006-06-27 | King Pharmaceutical Research & Development, Inc. | Stabilized pharmaceutical and thyroid hormone compositions and method of preparation |
US20030224047A1 (en) * | 2001-02-15 | 2003-12-04 | Franz G. Andrew | Levothyroxine compositions and methods |
US20030070584A1 (en) * | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
US20030072731A1 (en) * | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing starch or dextrin |
AU4061702A (en) * | 2001-05-15 | 2003-04-03 | Mcneil-Ppc, Inc. | Dip coating compositions containing starch or dextrin |
DE10125883A1 (de) | 2001-05-28 | 2002-12-12 | Serumwerk Bernburg Ag | Arzneimittel enthaltend einen Effektor des Glutathionmetabolismus zusammen mit alpha-Liponsäure im Rahmen der Nierenersatztherapie |
WO2002098403A1 (en) * | 2001-06-01 | 2002-12-12 | Georgetown University | Steroid hormone and non-steroidal anti-inflammatory drug combinations for inducing tumor cell apoptosis |
ITMI20011401A1 (it) * | 2001-07-02 | 2003-01-02 | Altergon Sa | Formulazioni farmaceutiche per ormoni tiroidei |
US20030190349A1 (en) * | 2001-08-10 | 2003-10-09 | Franz G. Andrew | Methods of stabilizing pharmaceutical compositions |
US20030198671A1 (en) * | 2001-08-10 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique plasma AUC properties |
US20030180353A1 (en) * | 2001-08-10 | 2003-09-25 | Franz G. Andrew | Stabilized pharmaceutical compositions |
US20030198667A1 (en) * | 2001-08-10 | 2003-10-23 | Franz Andrew G. | Methods of producing dispersible pharmaceutical compositions |
US20030203967A1 (en) * | 2001-08-14 | 2003-10-30 | Franz G. Andrew | Levothyroxine compositions having unique Tmax properties |
US20030199587A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique Cmax properties |
US20030199586A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Unique levothyroxine aqueous materials |
US20030195253A1 (en) * | 2001-08-14 | 2003-10-16 | Franz G. Andrew | Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration |
US20030198672A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique triidothyronine plasma AUC properties |
US20040253312A1 (en) | 2001-09-28 | 2004-12-16 | Sowden Harry S. | Immediate release dosage form comprising shell having openings therein |
US20040146559A1 (en) * | 2002-09-28 | 2004-07-29 | Sowden Harry S. | Dosage forms having an inner core and outer shell with different shapes |
US8309118B2 (en) * | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
US20030190359A1 (en) * | 2001-10-29 | 2003-10-09 | Franz G. Andrew | Levothyroxine compositions having unique triiodothyronine Tmax properties |
US20030166732A1 (en) * | 2002-02-27 | 2003-09-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ambroxol for the treatment of painful conditions in the mouth and pharyngeal cavity |
US6946156B2 (en) * | 2002-05-15 | 2005-09-20 | Mcneil-Ppc, Inc. | Process for enrobing a core |
US7169450B2 (en) | 2002-05-15 | 2007-01-30 | Mcneil-Ppc, Inc. | Enrobed core |
US7429619B2 (en) * | 2002-08-02 | 2008-09-30 | Mcneil Consumer Healthcare | Polyacrylic film forming compositions |
EP1396263A1 (en) * | 2002-08-09 | 2004-03-10 | Warner-Lambert Company | Film coating for tablets and caplets |
RU2005108577A (ru) | 2002-09-28 | 2006-06-10 | МакНЕЙЛ-ППС, ИНК. (US) | Дозированные формы с модифицированным высвобождением |
US20050079213A1 (en) * | 2003-06-06 | 2005-04-14 | Unilab Pharmatech Ltd | Pharmaceutical compositions |
CA2533150C (en) * | 2003-07-25 | 2013-03-12 | Warner Chilcott Company, Inc. | A doxycycline metal complex in a solid dosage form |
ATE354354T1 (de) * | 2003-07-30 | 2007-03-15 | Merrion Res I Ltd | Verfahren und maschine für die automatische herstellung von magensaftresistenten kapseln |
US7879354B2 (en) | 2004-01-13 | 2011-02-01 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US8067029B2 (en) * | 2004-01-13 | 2011-11-29 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US20050202079A1 (en) * | 2004-03-15 | 2005-09-15 | Mylan Pharmaceuticals Inc. | Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation |
US20080102116A1 (en) * | 2004-09-13 | 2008-05-01 | Perrigo Company | Quick Dissolve Medicament and Method of Manufacturing |
AU2006206359B2 (en) * | 2005-01-21 | 2011-03-31 | Allergan Pharmaceuticals International Limited | A tetracycline metal complex in a solid dosage form |
US20060222699A1 (en) * | 2005-03-29 | 2006-10-05 | Jonathan Gilinski | Flavored vegetarian cellulose capsule and methods for producing said capsule. |
US20070072910A1 (en) * | 2005-09-29 | 2007-03-29 | Smith Michael L | Compositions and methods for lowering plasma concentrations of low density lipoproteins in humans |
BRPI0710029A2 (pt) * | 2006-03-28 | 2011-08-02 | Mcneil Ppc Inc | revestimentos não-homogêneos para formas de dosagem |
EP2066307B1 (en) | 2006-09-15 | 2012-07-04 | Capsugel Belgium NV | Rapidly disintegrating dosage form |
WO2008042802A2 (en) * | 2006-09-29 | 2008-04-10 | Sensient Pharmaceutical Technologies Inc. | Wet edible pearlescent film coatings |
US20080145493A1 (en) * | 2006-12-14 | 2008-06-19 | Sensient Colors Inc. | Pearlescent pigment compositions and methods for making and using the same |
US20100172991A1 (en) * | 2007-06-08 | 2010-07-08 | Henry Joseph Horacek | Extended Release Formulation and Methods of Treating Adrenergic Dysregulation |
MX2009013384A (es) | 2007-06-08 | 2010-01-25 | Addrenex Pharmaceuticals Inc | Formulacion de liberacion extendida, y metodo para tratar disregulacion adrenergica. |
US20100092548A1 (en) * | 2008-08-28 | 2010-04-15 | Viva Pharmaceuticals Inc. | Chewable softgel capsules |
KR20110103987A (ko) * | 2008-12-01 | 2011-09-21 | 인베이스크 테라퓨틱, 인크. | 레닌-안지오텐신 알도스테론계 억제제 및 리포산 화합물을 포함하는 조성물, 및 레닌-안지오텐신 알도스테론계 관련 질환의 치료를 위한 이의 용도 |
CN103068375B (zh) | 2010-08-18 | 2017-02-15 | 麦克内尔-Ppc股份有限公司 | 改善性能的片剂套管 |
US9119793B1 (en) | 2011-06-28 | 2015-09-01 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for doxycycline |
CN102688212B (zh) * | 2012-05-29 | 2013-08-07 | 北京均大高科科技孵化器有限公司 | 一种单硝酸异山梨酯缓释片及其制备方法 |
US20140141075A1 (en) | 2012-11-21 | 2014-05-22 | Warner Chilcott Company, Llc | 5-aminosalicylic acid capsule formulation |
US10842802B2 (en) | 2013-03-15 | 2020-11-24 | Medicis Pharmaceutical Corporation | Controlled release pharmaceutical dosage forms |
CN103461336B (zh) * | 2013-09-26 | 2015-08-05 | 卞佳林 | 一种多杀菌素和灰黄霉素复合微囊杀虫剂 |
CN103461335B (zh) * | 2013-09-26 | 2015-08-05 | 卞佳林 | 一种多杀菌素和灰黄霉素复合微囊杀虫剂的制备方法 |
EP3167869A1 (en) | 2015-11-16 | 2017-05-17 | Capsugel Belgium NV | Tamperproof oral dosage form |
EP3167870B1 (en) | 2015-11-16 | 2024-01-03 | Capsugel Belgium NV | Tamperproof oral dosage form |
BR112019000111A2 (pt) | 2016-07-06 | 2019-04-09 | Qualicaps Co., Ltd. | cápsula sólida tendo resistência melhorada, e método para a sua fabricação |
RU2749902C2 (ru) * | 2018-10-31 | 2021-06-18 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Фармацевтическая композиция для лечения инфекционно-воспалительных заболеваний |
CN110279890A (zh) * | 2019-04-15 | 2019-09-27 | 首都医科大学附属北京世纪坛医院 | 基于脂质体的地塞米松/米诺环素在peek表面的修饰方法及应用 |
EP3805577A1 (en) * | 2019-10-11 | 2021-04-14 | Hilti Aktiengesellschaft | Threadlike package |
Citations (5)
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US3258115A (en) * | 1965-05-12 | 1966-06-28 | Scherer Corp R P | Two-piece hard gelatin capsule |
GB1496737A (en) * | 1974-06-12 | 1977-12-30 | Scherer Corp R P | Capsule especially for medicaments |
US4466844A (en) * | 1983-09-19 | 1984-08-21 | Cosden Technology, Inc. | Gripper for capsule welder |
EP0225565A2 (de) * | 1985-12-06 | 1987-06-16 | Boehringer Ingelheim Kg | Teilbare Kapsel |
EP0435726A2 (en) * | 1989-12-29 | 1991-07-03 | Bristol-Myers Squibb Company | Capsule and caplet combination |
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CA2205553C (en) * | 1994-12-16 | 2009-04-07 | Warner-Lambert Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
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-
1995
- 1995-11-09 CA CA002205553A patent/CA2205553C/en not_active Expired - Lifetime
- 1995-11-09 PT PT95939890T patent/PT797424E/pt unknown
- 1995-11-09 MX MX9703773A patent/MX9703773A/es unknown
- 1995-11-09 DE DE69518006T patent/DE69518006T2/de not_active Expired - Lifetime
- 1995-11-09 JP JP51881996A patent/JP3670016B2/ja not_active Expired - Fee Related
- 1995-11-09 DK DK95939890T patent/DK0797424T3/da active
- 1995-11-09 KR KR1019970704011A patent/KR100468335B1/ko not_active IP Right Cessation
- 1995-11-09 AT AT95939890T patent/ATE194486T1/de active
- 1995-11-09 WO PCT/US1995/014651 patent/WO1996018370A1/en active IP Right Grant
- 1995-11-09 ES ES95939890T patent/ES2150017T3/es not_active Expired - Lifetime
- 1995-11-09 EP EP95939890A patent/EP0797424B1/en not_active Expired - Lifetime
- 1995-11-09 CN CN95196811A patent/CN1132566C/zh not_active Expired - Lifetime
-
1996
- 1996-01-11 US US08/585,549 patent/US6080426A/en not_active Expired - Lifetime
-
2000
- 2000-09-26 GR GR20000402180T patent/GR3034491T3/el unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3258115A (en) * | 1965-05-12 | 1966-06-28 | Scherer Corp R P | Two-piece hard gelatin capsule |
GB1496737A (en) * | 1974-06-12 | 1977-12-30 | Scherer Corp R P | Capsule especially for medicaments |
US4466844A (en) * | 1983-09-19 | 1984-08-21 | Cosden Technology, Inc. | Gripper for capsule welder |
EP0225565A2 (de) * | 1985-12-06 | 1987-06-16 | Boehringer Ingelheim Kg | Teilbare Kapsel |
EP0435726A2 (en) * | 1989-12-29 | 1991-07-03 | Bristol-Myers Squibb Company | Capsule and caplet combination |
Also Published As
Publication number | Publication date |
---|---|
ES2150017T3 (es) | 2000-11-16 |
ATE194486T1 (de) | 2000-07-15 |
JPH11500326A (ja) | 1999-01-12 |
DK0797424T3 (da) | 2000-10-23 |
KR100468335B1 (ko) | 2005-09-02 |
PT797424E (pt) | 2000-10-31 |
GR3034491T3 (en) | 2000-12-29 |
WO1996018370A1 (en) | 1996-06-20 |
CA2205553A1 (en) | 1996-06-20 |
DE69518006D1 (de) | 2000-08-17 |
CN1170346A (zh) | 1998-01-14 |
DE69518006T2 (de) | 2000-12-21 |
JP3670016B2 (ja) | 2005-07-13 |
MX9703773A (es) | 1997-08-30 |
US6080426A (en) | 2000-06-27 |
EP0797424B1 (en) | 2000-07-12 |
CA2205553C (en) | 2009-04-07 |
EP0797424A1 (en) | 1997-10-01 |
KR980700050A (ko) | 1998-03-30 |
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